Published in Chem Res Toxicol on March 01, 2004
Isoprostane generation and function. Chem Rev (2011) 1.41
Isoketals form cytotoxic phosphatidylethanolamine adducts in cells. J Lipid Res (2009) 1.10
Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry (2006) 1.02
4-Hydroxy-nonenal-A Bioactive Lipid Peroxidation Product. Biomolecules (2015) 0.91
Phosphatidylethanolamines modified by γ-ketoaldehyde (γKA) induce endoplasmic reticulum stress and endothelial activation. J Biol Chem (2011) 0.91
Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis. Chem Res Toxicol (2010) 0.91
Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation. J Mol Cell Cardiol (2009) 0.87
Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis. Free Radic Biol Med (2009) 0.85
Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells. J Mol Cell Cardiol (2014) 0.85
Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS. Pharmaceutics (2010) 0.84
Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids. Chem Phys Lipids (2014) 0.84
Role of the lipoperoxidation product 4-hydroxynonenal in the pathogenesis of severe malaria anemia and malaria immunodepression. Oxid Med Cell Longev (2015) 0.81
Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. Biochemistry (2014) 0.80
Prevention of arterial stiffening by pyridoxamine in diabetes is associated with inhibition of the pathogenic glycation on aortic collagen. Br J Pharmacol (2009) 0.79
Isolevuglandin adducts in disease. Antioxid Redox Signal (2015) 0.79
5'-O-Alkylpyridoxamines: Lipophilic Analogues of Pyridoxamine Are Potent Scavengers of 1,2-Dicarbonyls. Chem Res Toxicol (2015) 0.76
Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizers. Toxicology (2013) 0.75
Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7. Aging (Albany NY) (2016) 0.75
Pyridoxamine protects against mechanical defects in cardiac ageing in rats: studies on load dependence of myocardial relaxation. Exp Physiol (2014) 0.75
The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine. Elife (2016) 0.75
Reactive Carbonyl Species Scavengers-Novel Therapeutic Approaches for Chronic Diseases. Curr Pharmacol Rep (2017) 0.75
Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med (2011) 3.58
Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study. Crit Care Med (2013) 3.30
Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic Biol Med (2006) 3.04
Isoprostanes: markers and mediators of oxidative stress. FASEB J (2004) 2.83
Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic Biol Med (2002) 2.08
Preterm resuscitation with low oxygen causes less oxidative stress, inflammation, and chronic lung disease. Pediatrics (2009) 1.82
Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders. Hypertension (2005) 1.80
Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease. Ann Neurol (2002) 1.79
Oxidant injury occurs rapidly after cardiac arrest, cardiopulmonary resuscitation, and reperfusion. Crit Care Med (2005) 1.76
Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J Biol Chem (2005) 1.73
Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Circ Res (2005) 1.70
Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ Res (2004) 1.68
Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Proc Natl Acad Sci U S A (2002) 1.63
Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chem Phys Lipids (2004) 1.63
Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem (2004) 1.60
DC isoketal-modified proteins activate T cells and promote hypertension. J Clin Invest (2014) 1.59
Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest (2015) 1.55
The in vivo gene expression signature of oxidative stress. Physiol Genomics (2008) 1.55
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J Gerontol A Biol Sci Med Sci (2007) 1.47
Mass spectrometric quantification of F2-isoprostanes as indicators of oxidant stress. Methods Mol Biol (2002) 1.45
Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. Free Radic Biol Med (2011) 1.42
Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J Gerontol A Biol Sci Med Sci (2005) 1.41
Isoprostane generation and function. Chem Rev (2011) 1.41
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proc Natl Acad Sci U S A (2010) 1.35
Insights into oxidative stress: the isoprostanes. Curr Med Chem (2007) 1.32
Characterization of an animal model of postmenopausal hypertension in spontaneously hypertensive rats. Hypertension (2002) 1.25
Plasma biomarkers of oxidant stress and development of organ failure in severe sepsis. Shock (2011) 1.24
Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo. Proc Natl Acad Sci U S A (2010) 1.23
The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease. Am J Respir Crit Care Med (2002) 1.22
N-acetylcysteine as adjunctive treatment in severe malaria: a randomized, double-blinded placebo-controlled clinical trial. Crit Care Med (2009) 1.20
Superoxide dismutase and oxidative stress in Dahl salt-sensitive and -resistant rats. Am J Physiol Regul Integr Comp Physiol (2002) 1.16
Modification of proteins by isoketal-containing oxidized phospholipids. J Biol Chem (2004) 1.15
Localization of isoketal adducts in vivo using a single-chain antibody. Free Radic Biol Med (2004) 1.15
Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone. Mech Ageing Dev (2009) 1.15
Stability of measurements of biomarkers of oxidative stress in blood over 36 hours. Cancer Epidemiol Biomarkers Prev (2004) 1.14
Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. Free Radic Biol Med (2004) 1.12
Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer. J Urol (2011) 1.11
Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. FASEB J (2002) 1.11
Isoketals form cytotoxic phosphatidylethanolamine adducts in cells. J Lipid Res (2009) 1.10
Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. Crit Care Med (2015) 1.10
Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study. J Gerontol A Biol Sci Med Sci (2007) 1.09
Quantification of dinor, dihydro metabolites of F2-isoprostanes in urine by liquid chromatography/tandem mass spectrometry. Anal Biochem (2005) 1.08
Oxidative injury is a common consequence of BMPR2 mutations. Pulm Circ (2011) 1.06
Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite. Am J Physiol Lung Cell Mol Physiol (2010) 1.06
A kinetic model of rapidly reversible nonphotochemical quenching. Proc Natl Acad Sci U S A (2012) 1.05
Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis. Alcohol Clin Exp Res (2007) 1.05
F2-isoprostanes as an indicator and risk factor for coronary heart disease. Free Radic Biol Med (2010) 1.04
Tart cherry juice decreases oxidative stress in healthy older men and women. J Nutr (2009) 1.04
Isoketals: highly reactive gamma-ketoaldehydes formed from the H2-isoprostane pathway. Chem Phys Lipids (2004) 1.03
Oxidant stress modulates murine allergic airway responses. Free Radic Biol Med (2005) 1.03
Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes. J Neurovirol (2002) 1.02
Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells. Free Radic Biol Med (2009) 1.02
Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry (2006) 1.02
Design principles of photosynthetic light-harvesting. Faraday Discuss (2012) 1.01
Seizure-induced formation of isofurans: novel products of lipid peroxidation whose formation is positively modulated by oxygen tension. J Neurochem (2007) 0.99
Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax (2012) 0.99
Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry. Nat Protoc (2007) 0.99
Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem (2002) 0.99
Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation. J Biol Chem (2003) 0.99
Major metabolite of F2-isoprostane in urine may be a more sensitive biomarker of oxidative stress than isoprostane itself. Am J Clin Nutr (2012) 0.98
Evidence of oxidative stress in full-term healthy infants. Pediatr Res (2004) 0.98
Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes. Free Radic Biol Med (2003) 0.98
Covalent binding of isoketals to ethanolamine phospholipids. Free Radic Biol Med (2004) 0.98
Overexpression of antioxidant enzymes in ApoE-deficient mice suppresses benzo(a)pyrene-accelerated atherosclerosis. Atherosclerosis (2009) 0.97
Copper accumulation and lipid oxidation precede inflammation and myelin lesions in N,N-diethyldithiocarbamate peripheral myelinopathy. Toxicol Appl Pharmacol (2008) 0.97
Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro. J Ocul Pharmacol Ther (2003) 0.97
Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease. J Neurochem (2003) 0.96
Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis. Free Radic Biol Med (2010) 0.95
Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. Free Radic Biol Med (2010) 0.94
Isomer-specific contractile effects of a series of synthetic f2-isoprostanes on retinal and cerebral microvasculature. Free Radic Biol Med (2004) 0.94
Treatment with a γ-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice. J Alzheimers Dis (2011) 0.93
The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4. Chem Res Toxicol (2002) 0.92
Deferoxamine reduces cold-ischemic renal injury in a syngeneic kidney transplant model. Am J Transplant (2003) 0.92
Cimetidine does not prevent lung injury in newborn premature infants. Pediatr Res (2006) 0.91
Models and measurements of energy-dependent quenching. Photosynth Res (2013) 0.91
Lower levels of F2-isoprostanes in serum and livers of long-lived Ames dwarf mice. Biochem Biophys Res Commun (2007) 0.91
Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis. Chem Res Toxicol (2010) 0.91
Measurement of products of docosahexaenoic acid peroxidation, neuroprostanes, and neurofurans. Methods Enzymol (2007) 0.91
Oxidative stress in older adults: effects of physical fitness. Age (Dordr) (2011) 0.91
Are isofurans and neuroprostanes increased after subarachnoid hemorrhage and traumatic brain injury? Antioxid Redox Signal (2011) 0.90
New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense. Am J Respir Crit Care Med (2015) 0.90
Dietary copper enhances the peripheral myelinopathy produced by oral pyrrolidine dithiocarbamate. Toxicol Sci (2005) 0.89
The Shanghai Women's Asthma and Allergy Study: objectives, design, and recruitment results. Am J Epidemiol (2008) 0.89
Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. Free Radic Biol Med (2006) 0.88
Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation. Atherosclerosis (2002) 0.88
A nomenclature system for isofurans. Prostaglandins Other Lipid Mediat (2004) 0.88
Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult. Free Radic Biol Med (2009) 0.87
Dietary iron promotes azoxymethane-induced colon tumors in mice. Nutr Cancer (2004) 0.87
Urinary F2-isoprostane metabolite levels in children with sleep-disordered breathing. Sleep Breath (2006) 0.87
A structure-based model of energy transfer reveals the principles of light harvesting in photosystem II supercomplexes. J Am Chem Soc (2013) 0.87
Dietary fat-influenced development of colon neoplasia in Apc Min mice exposed to benzo(a)pyrene. Toxicol Pathol (2009) 0.87
Inhaled nitric oxide attenuates hyperoxic lung injury in lambs. Pediatr Res (2005) 0.86
Specific determination of cysteine and penicillamine through cyclization to 2-thioxothiazolidine-4-carboxylic acids. Talanta (2002) 0.86
Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med (2007) 0.86
Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias. J Cardiovasc Pharmacol (2007) 0.85
Genetic and environmental influences on oxidative damage assessed in elderly Danish twins. Free Radic Biol Med (2011) 0.85
Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine. Biochemistry (2004) 0.85
Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation. Biochim Biophys Acta (2009) 0.85
Superoxide formation and interaction with nitric oxide modulate systemic arterial pressure and renal function in salt-depleted dogs. Exp Biol Med (Maywood) (2006) 0.85
Nitrogen substituent polarity influences dithiocarbamate-mediated lipid oxidation, nerve copper accumulation, and myelin injury. Chem Res Toxicol (2009) 0.84