Shigellosis: innate mechanisms of inflammatory destruction of the intestinal epithelium, adaptive immune response, and vaccine development.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMID 15030306)

Published in Crit Rev Immunol on January 01, 2003

Authors

Armelle Phalipon1, P J Sansonetti

Author Affiliations

1: Unité de Pathogenie Microbienne Moléculaire, INSERM U389, Institut Pasteur, 28 Rue du Dr Roux, 75015 Paris, France. phalipon@pasteur.fr

Articles citing this

Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Genome Biol (2007) 2.11

Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ. Nature (2013) 1.79

Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 1.15

New concepts of microbial translocation in the neonatal intestine: mechanisms and prevention. Clin Perinatol (2010) 1.08

Shigella: a model of virulence regulation in vivo. Gut Microbes (2012) 1.04

Community-based safety, immunogenicity, and transmissibility study of the Shigella sonnei WRSS1 vaccine in Israeli volunteers. Infect Immun (2005) 0.88

Safety and colonization of two novel VirG(IcsA)-based live Shigella sonnei vaccine strains in rhesus macaques (Macaca mulatta). Comp Med (2008) 0.83

Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages. Respir Res (2010) 0.81

Initiation of an inflammatory response in resident intestinal lamina propria cells -use of a human organ culture model. PLoS One (2014) 0.77

Applying mathematical tools to accelerate vaccine development: modeling Shigella immune dynamics. PLoS One (2013) 0.77

Gut-Homing Conventional Plasmablasts and CD27(-) Plasmablasts Elicited after a Short Time of Exposure to an Oral Live-Attenuated Shigella Vaccine Candidate in Humans. Front Immunol (2014) 0.77

The route less taken: pulmonary models of enteric Gram-negative infection. Pathog Dis (2013) 0.75

A Role for FimH in Extraintestinal Pathogenic Escherichia coli Invasion and Translocation through the Intestinal Epithelium. Infect Immun (2017) 0.75

Articles by these authors

(truncated to the top 100)

Involvement of a plasmid in the invasive ability of Shigella flexneri. Infect Immun (1982) 13.55

Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysis. Infect Immun (1986) 9.35

Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull World Health Organ (1999) 8.93

Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. J Bacteriol (1993) 8.75

Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin. Proc Natl Acad Sci U S A (1989) 7.00

Cloning of plasmid DNA sequences involved in invasion of HeLa cells by Shigella flexneri. Infect Immun (1985) 6.74

Alterations in the pathogenicity of Escherichia coli K-12 after transfer of plasmid and chromosomal genes from Shigella flexneri. Infect Immun (1983) 6.43

Shigella sonnei plasmids: evidence that a large plasmid is necessary for virulence. Infect Immun (1981) 6.40

Shigella flexneri induces apoptosis in infected macrophages. Nature (1992) 6.26

Entry of Shigella flexneri into HeLa cells: evidence for directed phagocytosis involving actin polymerization and myosin accumulation. Infect Immun (1987) 5.92

Intracellular and cell-to-cell spread of Listeria monocytogenes involves interaction with F-actin in the enterocytelike cell line Caco-2. Infect Immun (1990) 5.84

Characterization of virulence plasmids and plasmid-associated outer membrane proteins in Shigella flexneri, Shigella sonnei, and Escherichia coli. Infect Immun (1983) 4.82

Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. J Cell Biol (1999) 4.20

MxiD, an outer membrane protein necessary for the secretion of the Shigella flexneri lpa invasins. Mol Microbiol (1993) 4.17

IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole. EMBO J (1992) 3.84

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri. EMBO Rep (2001) 3.55

Shigella flexneri enters human colonic Caco-2 epithelial cells through the basolateral pole. Infect Immun (1992) 3.43

IpaB mediates macrophage apoptosis induced by Shigella flexneri. Mol Microbiol (1994) 3.27

Localization of plasmid loci necessary for the entry of Shigella flexneri into HeLa cells, and characterization of one locus encoding four immunogenic polypeptides. J Gen Microbiol (1987) 3.05

MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins. J Bacteriol (1992) 3.00

Molecular comparison of virulence plasmids in Shigella and enteroinvasive Escherichia coli. Ann Microbiol (Paris) (1983) 2.93

Intracellular growth of Listeria monocytogenes as a prerequisite for in vivo induction of T cell-mediated immunity. J Immunol (1987) 2.90

Identification of a chromosomal gene controlling temperature-regulated expression of Shigella virulence. Proc Natl Acad Sci U S A (1988) 2.81

Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. J Biol Chem (1998) 2.75

Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement. J Bacteriol (1993) 2.62

icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread. Mol Microbiol (1992) 2.57

Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis. J Exp Med (1994) 2.53

Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures. Mol Microbiol (1995) 2.52

Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri. J Clin Invest (1994) 2.47

Nucleotide sequence of the invasion plasmid antigen B and C genes (ipaB and ipaC) of Shigella flexneri. Microb Pathog (1988) 2.43

Plasmid-mediated invasiveness of "Shigella-like" Escherichia coli. Ann Microbiol (Paris) (1982) 2.38

A comparative study of the actin-based motilities of the pathogenic bacteria Listeria monocytogenes, Shigella flexneri and Rickettsia conorii. J Cell Sci (1999) 2.32

Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor. Infect Immun (1989) 2.30

SepA, the major extracellular protein of Shigella flexneri: autonomous secretion and involvement in tissue invasion. Mol Microbiol (1995) 2.27

DNA hybridization technique to detect Shigella species and enteroinvasive escherichia coli. J Clin Microbiol (1984) 2.24

IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells. EMBO J (1999) 2.20

Plasmid-mediated early killing of eucaryotic cells by Shigella flexneri as studied by infection of J774 macrophages. Infect Immun (1987) 2.17

Secretion of Ipa proteins by Shigella flexneri: inducer molecules and kinetics of activation. Infect Immun (1997) 2.15

Contribution of superoxide dismutase and catalase activities to Shigella flexneri pathogenesis. Infect Immun (1990) 2.14

Correlation of the virulence of Klebsiella pneumoniae K1 and K2 with the presence of a plasmid encoding aerobactin. Infect Immun (1986) 2.12

Cytoskeletal rearrangements and the functional role of T-plastin during entry of Shigella flexneri into HeLa cells. J Cell Biol (1995) 2.06

Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells. J Immunol (2000) 2.05

A nonvirulent mutant of Listeria monocytogenes does not move intracellularly but still induces polymerization of actin. Infect Immun (1990) 2.00

The two-component regulatory system ompR-envZ controls the virulence of Shigella flexneri. J Bacteriol (1990) 1.96

Polymorphonuclear leukocyte transmigration promotes invasion of colonic epithelial monolayer by Shigella flexneri. J Clin Invest (1994) 1.95

Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway. EMBO J (1995) 1.95

Genetic determinants of Shigella pathogenicity. Annu Rev Microbiol (1988) 1.94

Role of Shiga toxin in the pathogenesis of bacillary dysentery, studied by using a Tox- mutant of Shigella dysenteriae 1. Infect Immun (1988) 1.94

Identification of a clone of Escherichia coli O103:H2 as a potential agent of hemolytic-uremic syndrome in France. J Clin Microbiol (1993) 1.94

SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri. Mol Microbiol (1997) 1.93

Invasive enteric pathogens. Rev Infect Dis (1983) 1.91

Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin. EMBO J (1997) 1.90

The unrelated surface proteins ActA of Listeria monocytogenes and IcsA of Shigella flexneri are sufficient to confer actin-based motility on Listeria innocua and Escherichia coli respectively. Mol Microbiol (1995) 1.87

Mechanism of Shigella entry into epithelial cells. Curr Opin Microbiol (1999) 1.87

Identification and characterization of B-cell epitopes of IpaC, an invasion-associated protein of Shigella flexneri. Infect Immun (1992) 1.86

Characterization of the Shigella flexneri ipgD and ipgF genes, which are located in the proximal part of the mxi locus. Infect Immun (1993) 1.84

In vivo apoptosis in Shigella flexneri infections. Infect Immun (1996) 1.81

Apoptosis as a proinflammatory event: what can we learn from bacteria-induced cell death? Trends Microbiol (1997) 1.81

Vaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602. Infect Immun (1999) 1.80

Positive control of colanic acid synthesis in Escherichia coli by rmpA and rmpB, two virulence-plasmid genes of Klebsiella pneumoniae. Mol Microbiol (1989) 1.69

Bacterial entry into epithelial cells: the paradigm of Shigella. Trends Microbiol (1996) 1.67

Stress fiber-based movement of Shigella flexneri within cells. Infect Immun (1991) 1.63

Unipolar reorganization of F-actin layer at bacterial division and bundling of actin filaments by plastin correlate with movement of Shigella flexneri within HeLa cells. Infect Immun (1992) 1.63

Invasion and the pathogenesis of Shigella infections. Curr Top Microbiol Immunol (1996) 1.60

Plasmid-mediated contact haemolytic activity in Shigella species: correlation with penetration into HeLa cells. Ann Inst Pasteur Microbiol (1988) 1.60

Rho family GTPases control entry of Shigella flexneri into epithelial cells but not intracellular motility. J Cell Sci (1999) 1.53

Evaluation with an iuc::Tn10 mutant of the role of aerobactin production in the virulence of Shigella flexneri. Infect Immun (1987) 1.48

OmpC is involved in invasion of epithelial cells by Shigella flexneri. Infect Immun (1993) 1.47

Induction of type III secretion in Shigella flexneri is associated with differential control of transcription of genes encoding secreted proteins. EMBO J (1998) 1.46

Shigella subversion of the cellular cytoskeleton: a strategy for epithelial colonization. Infect Immun (1993) 1.45

Movement along actin filaments of the perijunctional area and de novo polymerization of cellular actin are required for Shigella flexneri colonization of epithelial Caco-2 cell monolayers. Infect Immun (1992) 1.43

Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization. EMBO J (1999) 1.35

Bacterial signals and cell responses during Shigella entry into epithelial cells. Cell Microbiol (2000) 1.29

Phosphorylation of IcsA by cAMP-dependent protein kinase and its effect on intracellular spread of Shigella flexneri. Mol Microbiol (1992) 1.29

Regulation of surface presentation of IcsA, a Shigella protein essential to intracellular movement and spread, is growth phase dependent. Infect Immun (1994) 1.25

Secretion of Shigella flexneri Ipa invasins on contact with epithelial cells and subsequent entry of the bacterium into cells are growth stage dependent. Infect Immun (1997) 1.24

IkappaBepsilon-deficient mice: reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis. J Immunol (1999) 1.24

Innate immune responses of epithelial cells following infection with bacterial pathogens. Curr Opin Immunol (2001) 1.21

Presence and expression of aerobactin genes in virulent avian strains of Escherichia coli. Infect Immun (1987) 1.19

The secreted IpaB and IpaC invasins and their cytoplasmic chaperone IpgC are required for intercellular dissemination of Shigella flexneri. Cell Microbiol (1999) 1.19

MxiG, a membrane protein required for secretion of Shigella spp. Ipa invasins: involvement in entry into epithelial cells and in intercellular dissemination. Mol Microbiol (1995) 1.18

SepA, the 110 kDa protein secreted by Shigella flexneri: two-domain structure and proteolytic activity. Microbiology (1998) 1.15

IpgD, a protein secreted by the type III secretion machinery of Shigella flexneri, is chaperoned by IpgE and implicated in entry focus formation. Mol Microbiol (2000) 1.14

Chloroquine-resistant Plasmodium falciparum in Cameroon. Lancet (1985) 1.13

Interferon alpha inhibits a Src-mediated pathway necessary for Shigella-induced cytoskeletal rearrangements in epithelial cells. J Cell Biol (1998) 1.12

Internalization of Shigella flexneri into HeLa cells occurs without an increase in cytosolic Ca2+ concentration. Infect Immun (1989) 1.10

Molecular mechanisms of entry, intracellular multiplication and killing of host cells by shigellae. Curr Top Microbiol Immunol (1988) 1.09

Slaying the Hydra all at once or head by head? Nat Med (1998) 1.08

Molecular and cellular mechanisms of tissue invasion by Shigella flexneri. Ann N Y Acad Sci (1994) 1.07

The pathogenesis of Shigella flexneri infection: lessons from in vitro and in vivo studies. Philos Trans R Soc Lond B Biol Sci (2000) 1.06

Purification of IpaC, a protein involved in entry of Shigella flexneri into epithelial cells and characterization of its interaction with lipid membranes. FEBS Lett (1997) 1.05

Production of IFN-gamma and IL-10 to Shigella invasins by mononuclear cells from volunteers orally inoculated with a Shiga toxin-deleted Shigella dysenteriae type 1 strain. J Immunol (2000) 1.04

Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement. Infect Agents Dis (1993) 1.04

Induction of necrosis in human neutrophils by Shigella flexneri requires type III secretion, IpaB and IpaC invasins, and actin polymerization. Infect Immun (2000) 1.04

Evidence for clathrin mobilization during directed phagocytosis of Shigella flexneri by HEp2 cells. Microb Pathog (1989) 1.04

Trafficking of Shigella lipopolysaccharide in polarized intestinal epithelial cells. J Cell Biol (1999) 1.02

A newborn mouse model for the study of intestinal pathogenesis of shigellosis. Cell Microbiol (2003) 1.00

Lack of cleavage of IcsA in Shigella flexneri causes aberrant movement and allows demonstration of a cross-reactive eukaryotic protein. Infect Immun (1996) 1.00

Invasion of epithelial cells by bacterial pathogens the paradigm of Shigella. Subcell Biochem (2000) 1.00

Construction and evaluation of live attenuated vaccine strains of Shigella flexneri and Shigella dysenteriae 1. Res Microbiol (1991) 0.96