Published in Biophys J on March 01, 1992
KcsA: it's a potassium channel. J Gen Physiol (2001) 3.23
Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+). J Gen Physiol (1999) 3.03
Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature (2010) 2.63
Principles of conduction and hydrophobic gating in K+ channels. Proc Natl Acad Sci U S A (2010) 2.47
Gating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanism. J Gen Physiol (1999) 2.35
Voltage sensitivity and gating charge in Shaker and Shab family potassium channels. J Gen Physiol (1999) 2.27
The interaction of Na+ and K+ in voltage-gated potassium channels. Evidence for cation binding sites of different affinity. J Gen Physiol (1998) 1.89
A quantitative description of KcsA gating I: macroscopic currents. J Gen Physiol (2007) 1.78
Kinetic structure of large-conductance Ca2+-activated K+ channels suggests that the gating includes transitions through intermediate or secondary states. A mechanism for flickers. J Gen Physiol (1998) 1.74
Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction. J Gen Physiol (2006) 1.71
Allosteric effects of permeating cations on gating currents during K+ channel deactivation. J Gen Physiol (1997) 1.70
State-independent block of BK channels by an intracellular quaternary ammonium. J Gen Physiol (2006) 1.57
The pore structure and gating mechanism of K2P channels. EMBO J (2011) 1.56
A mutation in the pore of the sodium channel alters gating. Biophys J (1995) 1.34
On the structural basis of modal gating behavior in K(+) channels. Nat Struct Mol Biol (2010) 1.29
Relationship between pore occupancy and gating in BK potassium channels. J Gen Physiol (2006) 1.24
The cytosolic inactivation domains of BKi channels in rat chromaffin cells do not behave like simple, open-channel blockers. Biophys J (1997) 1.20
Determinants of voltage-dependent gating and open-state stability in the S5 segment of Shaker potassium channels. J Gen Physiol (1999) 1.18
Collapse of conductance is prevented by a glutamate residue conserved in voltage-dependent K(+) channels. J Gen Physiol (2000) 1.16
Single channel seeks permeant ion for brief but intimate relationship. J Gen Physiol (1997) 1.12
Pore mutations alter closing and opening kinetics in Shaker K+ channels. J Physiol (1998) 1.06
External barium influences the gating charge movement of Shaker potassium channels. Biophys J (1997) 1.04
Permeant ion-dependent changes in gating of Kir2.1 inward rectifier potassium channels. J Gen Physiol (2001) 1.02
Effects of intracellular Mg2+ on channel gating and steady-state responses of the NMDA receptor in cultured rat neurons. J Physiol (1996) 1.00
Rectifying conductance substates in a large conductance Ca(2+)-activated K+ channel: evidence for a fluctuating barrier mechanism. J Gen Physiol (1996) 0.99
Fast and slow gating are inherent properties of the pore module of the K+ channel Kcv. J Gen Physiol (2009) 0.98
Selectivity filter gating in large-conductance Ca(2+)-activated K+ channels. J Gen Physiol (2012) 0.98
The link between ion permeation and inactivation gating of Kv4 potassium channels. Biophys J (2003) 0.97
Steady-state and closed-state inactivation properties of inactivating BK channels. Biophys J (2002) 0.96
Ionic permeation and conduction properties of neuronal KCNQ2/KCNQ3 potassium channels. Biophys J (2004) 0.95
Control of outer vestibule dynamics and current magnitude in the Kv2.1 potassium channel. J Gen Physiol (2002) 0.94
Delayed rectifier current of bullfrog sympathetic neurons: ion-ion competition, asymmetrical block and effects of ions on gating. J Physiol (1997) 0.92
Saturation and microsecond gating of current indicate depletion-induced instability of the MaxiK selectivity filter. J Gen Physiol (2007) 0.92
A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels. Cell (2016) 0.92
Influence of permeant ions on gating in cyclic nucleotide-gated channels. J Gen Physiol (2003) 0.88
Cations affect the rate of gating charge recovery in wild-type and W434F Shaker channels through a variety of mechanisms. J Gen Physiol (2002) 0.87
Fast single-channel measurements resolve the blocking effect of Cs+ on the K+ channel. Biophys J (1994) 0.86
Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel. Pflugers Arch (2005) 0.85
Mechanism of Cd2+ coordination during slow inactivation in potassium channels. Structure (2012) 0.85
Effects of intracellular K+ and Rb+ on gating of embryonic rat telencephalon Ca(2+)-activated K+ channels. Biophys J (1996) 0.84
Barium inhibition of the collapse of the Shaker K(+) conductance in zero K(+). Biophys J (1999) 0.84
A scheme to account for the effects of Rb+ and K+ on inward rectifier K channels of bovine artery endothelial cells. J Gen Physiol (1994) 0.84
Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channels. J Physiol (2005) 0.83
SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore. Biophys J (2017) 0.82
Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevated. J Gen Physiol (2011) 0.81
Influence of permeant ions on voltage sensor function in the Kv2.1 potassium channel. J Gen Physiol (2004) 0.81
Ammonium ions induce inactivation of Kir2.1 potassium channels expressed in Xenopus oocytes. J Physiol (2001) 0.81
A transient outward-rectifying K+ channel current down-regulated by cytosolic Ca2+ in Arabidopsis thaliana guard cells. Proc Natl Acad Sci U S A (1998) 0.81
Mechanisms of cation permeation in cardiac sodium channel: description by dynamic pore model. Biophys J (1999) 0.80
Cesium-associated hypokalemia successfully treated with amiloride. Clin Kidney J (2015) 0.77
Ion conductance of the Ca(2+)-activated maxi-K+ channel from the embryonic rat brain. Biophys J (1997) 0.76
A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating. PLoS One (2013) 0.76
Hysteresis of KcsA potassium channel's activation- deactivation gating is caused by structural changes at the channel's selectivity filter. Proc Natl Acad Sci U S A (2017) 0.75
Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J Gen Physiol (1971) 14.23
Local anaesthetics transiently block currents through single acetylcholine-receptor channels. J Physiol (1978) 10.05
Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys J (1987) 9.64
Correcting single channel data for missed events. Biophys J (1986) 6.06
Single Ca2+-activated nonselective cation channels in neuroblastoma. Nature (1982) 5.42
K+ channels close more slowly in the presence of external K+ and Rb+. Nature (1981) 5.25
A voltage-gated potassium channel in human T lymphocytes. J Physiol (1985) 4.16
Potassium blocks barium permeation through a calcium-activated potassium channel. J Gen Physiol (1988) 3.82
Kinetics of Ca2+-activated K+ channels from rabbit muscle incorporated into planar bilayers. Evidence for a Ca2+ and Ba2+ blockade. J Gen Physiol (1983) 3.72
Multi-ion conduction and selectivity in the high-conductance Ca++-activated K+ channel from skeletal muscle. Biophys J (1986) 3.24
Life time and elementary conductance of the channels mediating the excitatory effects of acetylcholine in Aplysia neurones. J Physiol (1978) 3.05
Kinetics of unliganded acetylcholine receptor channel gating. Biophys J (1986) 2.83
Interaction of permeant ions with channels activated by acetylcholine in Aplysia neurones. J Physiol (1979) 2.80
External monovalent cations that impede the closing of K channels. J Gen Physiol (1986) 2.62
Coupling of voltage-dependent gating and Ba++ block in the high-conductance, Ca++-activated K+ channel. J Gen Physiol (1987) 2.41
Block of sodium conductance and gating current in squid giant axons poisoned with quaternary strychnine. Biophys J (1979) 2.30
Immobilisation of gating charge by a substance that simulates inactivation. Nature (1978) 2.19
Conduction, Blockade and Gating in a Ca -activated K Channel Incorporated into Planar Lipid Bilayers. Biophys J (1984) 1.89
Saxitoxin and ouabain binding activity of isolated skeletal muscle membrane as indicators of surface origin and purity. Biochim Biophys Acta (1983) 1.61
Effects of rubidium, caesium, strontium, barium and lanthanum on ionic currents in myelinated nerve fibres from Xenopus laevis. Acta Physiol Scand (1980) 1.43
Multi-ion occupancy alters gating in high-conductance, Ca(2+)-activated K+ channels. J Gen Physiol (1991) 1.40
Rubidium ions and the gating of delayed rectifier potassium channels of frog skeletal muscle. J Physiol (1989) 1.36
Chemical modification of potassium channel gating in frog myelinated nerve by trinitrobenzene sulphonic acid. J Physiol (1983) 1.16
Slow components of potassium tail currents in rat skeletal muscle. J Gen Physiol (1983) 1.09
Inhibitory postsynaptic currents at Aplysia cholinergic synapses: effects of permeant anions and depressant drugs. Proc R Soc Lond B Biol Sci (1982) 1.08
The inward rectification mechanism of the HERG cardiac potassium channel. Nature (1996) 6.29
Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cells. J Gen Physiol (1984) 6.28
Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels. Proc Natl Acad Sci U S A (1991) 5.73
Dynamic rearrangement of the outer mouth of a K+ channel during gating. Neuron (1996) 5.52
Gated access to the pore of a voltage-dependent K+ channel. Neuron (1997) 5.45
Single Ca2+-activated nonselective cation channels in neuroblastoma. Nature (1982) 5.42
Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science (1990) 5.34
Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms. Neuron (1995) 4.62
Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques (1994) 4.24
The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker. Neuron (1991) 3.86
Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channel. Neuron (2001) 3.74
Use-dependent blockers and exit rate of the last ion from the multi-ion pore of a K+ channel. Science (1996) 3.50
Properties of single calcium channels in cardiac cell culture. Nature (1982) 3.30
Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature (2000) 3.26
The internal quaternary ammonium receptor site of Shaker potassium channels. Neuron (1993) 3.15
Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating. J Gen Physiol (1997) 3.13
Relief of Na+ block of Ca2+-activated K+ channels by external cations. J Gen Physiol (1984) 2.91
On the use of thiol-modifying agents to determine channel topology. Neuropharmacology (1996) 2.47
The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge. Neuron (1998) 2.43
N-type inactivation and the S4-S5 region of the Shaker K+ channel. J Gen Physiol (1996) 2.04
Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor. Biophys J (1991) 1.86
Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate. J Gen Physiol (2001) 1.82
The K+ channel of sarcoplasmic reticulum. A new look at Cs+ block. Biophys J (1985) 1.65
A discrete site for general anesthetics on a postsynaptic receptor. Mol Pharmacol (1995) 1.45
Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate. Proc Natl Acad Sci U S A (1997) 1.30
Cysteines in the Shaker K+ channel are not essential for channel activity or zinc modulation. Biophys J (1994) 1.17
Conductance mutations of the nicotinic acetylcholine receptor do not act by a simple electrostatic mechanism. Biophys J (1994) 1.15
Two functionally distinct subsites for the binding of internal blockers to the pore of voltage-activated K+ channels. Proc Natl Acad Sci U S A (1996) 1.13
Permeation in potassium channels: implications for channel structure. Annu Rev Biophys Biophys Chem (1987) 1.11
A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization. Neuron (1992) 1.11
Human cardiac sodium channels expressed in Xenopus oocytes. Am J Physiol (1990) 0.99
Covalent modification of engineered cysteines in the nicotinic acetylcholine receptor agonist-binding domain inhibits receptor activation. Biochem J (1995) 0.91
Calcium channels. Structure and selectivity. Nature (1993) 0.84
Keeping K+ completely comfortable. Nat Struct Biol (2001) 0.82
Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin. J Clin Invest (1989) 0.82
Dimers among friends: ion channel regulation by dimerization of tail domains. Trends Pharmacol Sci (2001) 0.76
Alternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation. Nat Genet (1996) 0.75