Published in Genome Res on April 01, 2004
Integration of text- and data-mining using ontologies successfully selects disease gene candidates. Nucleic Acids Res (2005) 2.46
Basic local alignment search tool. J Mol Biol (1990) 659.07
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Prediction of complete gene structures in human genomic DNA. J Mol Biol (1997) 58.76
A genomic perspective on protein families. Science (1997) 50.51
The Pfam protein families database. Nucleic Acids Res (2000) 42.28
Human-mouse alignments with BLASTZ. Genome Res (2003) 35.49
Database of homology-derived protein structures and the structural meaning of sequence alignment. Proteins (1991) 32.50
Hidden Markov models in computational biology. Applications to protein modeling. J Mol Biol (1994) 31.57
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
The Gene-Finder computer tools for analysis of human and model organisms genome sequences. Proc Int Conf Intell Syst Mol Biol (1997) 3.29
A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet (1995) 2.10
Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet (1996) 1.96
Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. J Biol Chem (2000) 1.88
Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet (1996) 1.61
Gene and genome duplication. Curr Opin Genet Dev (2001) 1.47
A protective role for kidney apolipoprotein E. Regulation of mesangial cell proliferation and matrix expansion. J Biol Chem (2001) 1.23
Evidence of gene-gene interactions in the genetic susceptibility to renal impairment after unilateral nephrectomy. J Am Soc Nephrol (2000) 1.07
Postnatal development and progression of renal dysplasia in cyclooxygenase-2 null mice. Kidney Int (2000) 1.06
End-stage renal failure in African Americans: insights in kidney disease susceptibility. Nephrol Dial Transplant (2002) 1.03
Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer. J Clin Invest (1997) 1.00
Linkage heterogeneity of end-stage renal disease on human chromosome 10. Kidney Int (2002) 0.97
Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. J Immunol (2000) 0.94
Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. Mamm Genome (1999) 0.91
An integrated genetic linkage map with 1,137 markers constructed from five F2 crosses of autoimmune disease-prone and -resistant inbred rat strains. Genomics (2000) 0.91
Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Biochem Biophys Res Commun (1997) 0.88
Transfer of the Rf-1 region from FHH onto the ACI background increases susceptibility to renal impairment. Physiol Genomics (2002) 0.84
An array of insights: application of DNA chip technology in the study of cell biology. Trends Cell Biol (2003) 0.82
Congenic strain confirms putative quantitative trait locus for body weight in the rat. Mamm Genome (1998) 0.79
Hormonal genomics. Endocr Rev (2002) 0.79
A table-driven, full-sensitivity similarity search algorithm. J Comput Biol (2003) 0.77
Evaluation of markers on human chromosome 10, including the homologue of the rodent Rf-1 gene, for linkage to ESRD in black patients. Am J Kidney Dis (1999) 0.77
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans. PLoS Biol (2007) 6.18
The External RNA Controls Consortium: a progress report. Nat Methods (2005) 4.24
Rat Genome Database (RGD): mapping disease onto the genome. Nucleic Acids Res (2002) 4.04
The Rat Genome Database (RGD): developments towards a phenome database. Nucleic Acids Res (2005) 2.77
BayesCall: A model-based base-calling algorithm for high-throughput short-read sequencing. Genome Res (2009) 2.69
Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem (2001) 2.56
Genomic variation in natural populations of Drosophila melanogaster. Genetics (2012) 2.33
Characterization of human plasma-derived exosomal RNAs by deep sequencing. BMC Genomics (2013) 2.27
The completion of the Mammalian Gene Collection (MGC). Genome Res (2009) 2.21
Distribution and functional impact of DNA copy number variation in the rat. Nat Genet (2008) 2.20
Enabling a community to dissect an organism: overview of the Neurospora functional genomics project. Adv Genet (2007) 2.19
iTools: a framework for classification, categorization and integration of computational biology resources. PLoS One (2008) 2.18
Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Cell Metab (2012) 2.18
Low nucleotide diversity in chimpanzees and bonobos. Genetics (2003) 2.16
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature (2011) 1.98
Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. Carcinogenesis (2012) 1.84
Motor commands contribute to human position sense. J Physiol (2006) 1.73
RGD: a comparative genomics platform. Hum Genomics (2011) 1.68
Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat. Physiol Genomics (2007) 1.57
Guidelines for operative vaginal birth. J Obstet Gynaecol Can (2004) 1.57
Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell (2013) 1.53
Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage. Am J Physiol Regul Integr Comp Physiol (2013) 1.47
Genomics in clinical practice: lessons from the front lines. Sci Transl Med (2013) 1.38
Nucleotide diversity in gorillas. Genetics (2004) 1.28
Gene targeting in the rat: advances and opportunities. Trends Genet (2010) 1.25
Identifying multiple causative genes at a single GWAS locus. Genome Res (2013) 1.25
Circumventing heterozygosity: sequencing the amplified genome of a single haploid Drosophila melanogaster embryo. Genetics (2011) 1.24
Using multiple ontologies to integrate complex biological data. Comp Funct Genomics (2005) 1.18
Phylogenetics of rat inbred strains. Mamm Genome (2003) 1.15
Signals of motor command bias joint position sense in the presence of feedback from proprioceptors. J Appl Physiol (1985) (2008) 1.13
BAC resources for the rat genome project. Genome Res (2004) 1.12
Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease. J Alzheimers Dis (2011) 1.11
RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J Am Soc Nephrol (2005) 1.09
Creation and characterization of a renin knockout rat. Hypertension (2011) 1.09
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB J (2012) 1.07
Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. Am J Physiol Renal Physiol (2008) 1.06
Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. Physiol Genomics (2009) 1.06
Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster. Genome Res (2011) 1.05
Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. Am J Physiol Cell Physiol (2006) 1.03
Genetic basis of the impaired renal myogenic response in FHH rats. Am J Physiol Renal Physiol (2012) 1.02
Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: a meta-analysis. Neurology (2013) 1.02
Comparative genomics for detecting human disease genes. Adv Genet (2008) 0.98
Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. J Mol Cell Cardiol (2005) 0.98
Rab38 modulates proteinuria in model of hypertension-associated renal disease. J Am Soc Nephrol (2013) 0.98
Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats. Am J Physiol Renal Physiol (2005) 0.98
Initial characterization of a rat model of diabetic nephropathy. Diabetes (2004) 0.97
Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol (2012) 0.96
Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains. Am J Physiol Heart Circ Physiol (2011) 0.95
2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. J Cardiovasc Transl Res (2015) 0.94
Mutation of csk, encoding the C-terminal Src kinase, reduces Pseudomonas aeruginosa internalization by mammalian cells and enhances bacterial cytotoxicity. Microb Pathog (2002) 0.94
Cross-mapping events in miRNAs reveal potential miRNA-mimics and evolutionary implications. PLoS One (2011) 0.93
Identification of hypertension susceptibility loci on rat chromosome 12. Hypertension (2012) 0.92
The effect of chronic pain on health related quality of life amongst intensive care survivors. Aust Crit Care (2004) 0.92
Differentiation and neurological benefit of the mesenchymal stem cells transplanted into the rat brain following intracerebral hemorrhage. Neurol Res (2006) 0.91
Patient experiences following cardiothoracic surgery: an interview study. Eur J Cardiovasc Nurs (2005) 0.90
A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin. J Invest Dermatol (2012) 0.90
Interaction of Pseudomonas aeruginosa with human tear fluid components. Curr Eye Res (2005) 0.90
Proportion, risk factors and outcome of lacunar infarction: a hospital-based study in a Chinese population. Cerebrovasc Dis (2009) 0.89
Pseudomonas aeruginosa strains with lipopolysaccharide defects exhibit reduced intracellular viability after invasion of corneal epithelial cells. Exp Eye Res (2002) 0.89
The emerging role for rat models in gene discovery. Mamm Genome (2011) 0.89
Validation of the ABCD3-I score to predict stroke risk after transient ischemic attack. Stroke (2013) 0.88
Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains. Am J Physiol Renal Physiol (2010) 0.88
Hominoid seminal protein evolution and ancestral mating behavior. Am J Primatol (2008) 0.87
BDNF gene polymorphisms are associated with Alzheimer's disease-related depression and antidepressant response. J Alzheimers Dis (2011) 0.87
Differential expression of interferon responsive genes in rodent models of transmissible spongiform encephalopathy disease. Mol Neurodegener (2007) 0.86
Interaction between Rf-1 and Rf-4 quantitative trait loci increases susceptibility to renal damage in double congenic rats. Kidney Int (2005) 0.84
Glycerophosphocholine utilization by Candida albicans: role of the Git3 transporter in virulence. J Biol Chem (2013) 0.84
Inhibitory effect of matrine on blood-brain barrier disruption for the treatment of experimental autoimmune encephalomyelitis. Mediators Inflamm (2013) 0.84
MicroRNA-128 regulates the differentiation of rat bone mesenchymal stem cells into neuron-like cells by Wnt signaling. Mol Cell Biochem (2013) 0.83
Transplantation of human neuro-epithelial-like stem cells derived from induced pluripotent stem cells improves neurological function in rats with experimental intracerebral hemorrhage. Neurosci Lett (2013) 0.82
Absence of Spiroplasma or other bacterial 16s rRNA genes in brain tissue of hamsters with scrapie. J Clin Microbiol (2006) 0.82
Memories of intensive care and experiences of survivors of a critical illness: an interview study. Intensive Crit Care Nurs (2004) 0.82
Transcriptome analysis and kidney research: toward systems biology. Kidney Int (2005) 0.82
Association of thromboxane A2 receptor gene polymorphisms with cerebral infarction in a Chinese population. Neurol Sci (2013) 0.82
Evaluation of vertebrobasilar artery changes in patients with benign paroxysmal positional vertigo. Neuroreport (2013) 0.82
Impact of Collateral Status on Successful Revascularization in Endovascular Treatment: A Systematic Review and Meta-Analysis. Cerebrovasc Dis (2015) 0.81
Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling. J Biol Chem (2012) 0.81
A reference map of the membrane proteome of Enterococcus faecalis. Proteomics (2011) 0.81
Refined mapping of the renal failure RF-3 quantitative trait locus. J Am Soc Nephrol (2010) 0.80
Stalking metal-linked dimers. J Inorg Biochem (2007) 0.80
Intramucosal distribution of WNT signaling components in human esophagus. J Clin Gastroenterol (2009) 0.80
Fine mapping of Lvm1: a quantitative trait locus controlling heart size independently of blood pressure. Pulm Pharmacol Ther (2005) 0.80
A joint association test for multiple SNPs in genetic case-control studies. Genet Epidemiol (2009) 0.79
Promoter polymorphisms of SERPINE1 are associated with the antidepressant response to depression in Alzheimer's disease. Neurosci Lett (2012) 0.79
Cardioprotection during diabetes: the role of mitochondrial DNA. Anesthesiology (2014) 0.79
Stem cell-based therapies for intracerebral hemorrhage in animal model: a meta-analysis. Neurol Sci (2015) 0.78
Identification of hypertension-related QTLs in African American sib pairs. Hypertension (2002) 0.78
Food intake and interdigestive gastrointestinal motility in ghrelin receptor mutant rats. J Gastroenterol (2011) 0.77
Mechanisms of cardioprotection resulting from Brown Norway chromosome 16 substitution in the salt-sensitive Dahl rat. Physiol Genomics (2012) 0.77
A 4.1-Mb congenic region of Rf-4 contributes to glomerular permeability. J Am Soc Nephrol (2012) 0.77
Factors associated with delayed presentation in patients with TIA and minor stroke in China: analysis of data from the China National Stroke Registry (CNSR). Neurol Res (2013) 0.77
Maternal transport policy. J Obstet Gynaecol Can (2005) 0.77