Hemoglobin Einstein: semisynthetic deletion in the B-helix of the alpha-chain.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 2286774)

Published in Protein Sci on May 01, 2004

Authors

Sonati Srinivasulu1, Belur N Manjula, Ronald L Nagel, Ching-Hsuan Tsai, Chien Ho, Muthuchidambaran Prabhakaran, Seetharama A Acharya

Author Affiliations

1: Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Articles cited by this

RASMOL: biomolecular graphics for all. Trends Biochem Sci (1995) 33.76

Stereochemistry of cooperative effects in haemoglobin. Nature (1970) 13.71

The crystal structure of human deoxyhaemoglobin at 1.74 A resolution. J Mol Biol (1984) 4.49

Structure of human oxyhaemoglobin at 2.1 A resolution. J Mol Biol (1983) 2.50

Proton nuclear magnetic resonance studies on hemoglobin: cooperative interactions and partially ligated intermediates. Adv Protein Chem (1992) 1.21

New effectors of human hemoglobin: structure and function. Biochemistry (1990) 1.19

Chain-selective isotopic labeling for NMR studies of large multimeric proteins: application to hemoglobin. Biophys J (2000) 1.15

A proton nuclear magnetic resonance study of the quaternary structure of human homoglobins in water. Biochemistry (1975) 1.06

Hemoglobin Grady: the first example of a variant with elongated chains due to an insertion of residues. Proc Natl Acad Sci U S A (1974) 0.99

Preparation of isolated chains of human hemoglobin. Methods Enzymol (1981) 0.98

Nuclear magnetic resonance studies of hemoglobins. VII. Tertiary structure around ligand binding site in carbonmonoxyhemoglobin. Biochemistry (1972) 0.96

Proton nuclear Overhauser effect investigation of the heme pockets in ligated hemoglobin: conformational differences between oxy and carbonmonoxy forms. Biochemistry (1985) 0.95

A proton nuclear Overhauser effect investigation of the subunit interfaces in human normal adult hemoglobin. Biochim Biophys Acta (1987) 0.95

The D-helix in myoglobin and in the beta subunit of hemoglobin is required for the retention of heme. Biochemistry (1995) 0.95

Effects of amino acid substitutions at beta 131 on the structure and properties of hemoglobin: evidence for communication between alpha 1 beta 1- and alpha 1 beta 2-subunit interfaces. Biochemistry (2002) 0.95

Semisynthesis of hemoglobin. Methods Enzymol (1994) 0.93

Hyperunstable hemoglobin Koriyama anti-Hb Gun Hill insertion of five residues in the beta chain. Hemoglobin (1988) 0.91

The N-terminal sequence affects distant helix interactions in hemoglobin. Implications for mutant proteins from studies on recombinant hemoglobin felix. J Biol Chem (1998) 0.89

Site-directed mutagenesis in hemoglobin: functional and structural role of inter- and intrasubunit hydrogen bonds as studied with 37 beta and 145 beta mutations. Biochemistry (1992) 0.88

Semisynthetic hemoglobin A: reconstitution of functional tetramer from semisynthetic alpha-globin. Biochemistry (1989) 0.88

Permissible discontinuity region of the alpha-chain of hemoglobin: noncovalent interaction of heme and the complementary fragments alpha 1-30 and alpha 31-141. Biochemistry (1986) 0.85

Probing the importance of the amino-terminal sequence of the beta- and gamma-chains to the properties of normal adult and fetal hemoglobins. Biochemistry (2001) 0.84

Synthetic potential of Staphylococcus aureus V8-protease: an approach toward semisynthesis of covalent analogs of alpha-chain of hemoglobin S. J Cell Biochem (1986) 0.83

The hybridization of donkey and mouse hemoglobins. Proc Natl Acad Sci U S A (1962) 0.82

Molecular basis of the inhibition of beta s-chain-dependent polymerization by mouse alpha-chain. Semisynthesis of chimeras of human and mouse alpha-chains. J Biol Chem (1993) 0.81

Probing the conformation of hemoglobin presbyterian in the R-state. J Protein Chem (2003) 0.81

Inhibition of sickle beta-chain (betaS)-dependent polymerization by nonhuman alpha-chains. A superinhibitory mouse-horse chimeric alpha-chain. J Biol Chem (1997) 0.80

Interspecies hybrid HbS: complete neutralization of Val6(beta)-dependent polymerization of human beta-chain by pig alpha-chains. J Mol Biol (2000) 0.80

Chimeric hemoglobins--hybrids of human and swine hemoglobin: assembly and stability of interspecies hybrids. Protein Sci (1996) 0.80

Conformational studies of alpha-globin in 1-propanol: propensity of the alcohol to limit the sites of proteolytic cleavage. Proc Natl Acad Sci U S A (1987) 0.79

Two new human hemoglobin variants caused by unusual mutational events: Hb Zaïre contains a five residue repetition within the alpha-chain and Hb Duino has two residues substituted in the beta-chain. Hum Genet (1992) 0.78

Product-conformation-driven ligation of peptides by V8 protease. Protein Sci (2002) 0.77

Inhibition of beta(S)-chain dependent polymerization by synergistic complementation of contact site perturbations of alpha-chain: application of semisynthetic chimeric alpha-chains. Protein Eng (1999) 0.77

Oxygen equilibrium studies on carp-human hybrid hemoglobins. Biochemistry (1984) 0.77

Haemoglobin J-Biskra: a new mildly unstable alpha1 gene variant with a deletion of eight residues (alpha50-57, alpha51-58 or alpha52-59) including the distal histidine. Br J Haematol (1998) 0.77

Proteosynthetic activity of immobilized Staphylococcus aureus V8 protease: application in the semisynthesis of molecular variants of alpha-globin. Anal Biochem (1991) 0.76

Articles by these authors

Sickle-cell disease. Lancet (2004) 4.76

Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. J Clin Invest (2005) 3.08

In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI. Proc Natl Acad Sci U S A (2006) 3.04

Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood (2005) 2.76

Noninvasive evaluation of cardiac allograft rejection by cellular and functional cardiac magnetic resonance. JACC Cardiovasc Imaging (2009) 1.79

Quaternary structure of hemoglobin in solution. Proc Natl Acad Sci U S A (2003) 1.77

Human neuroglobin functions as a redox-regulated nitrite reductase. J Biol Chem (2011) 1.70

Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice. J Clin Invest (2004) 1.67

Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells. Proc Natl Acad Sci U S A (2002) 1.61

Magnetic resonance imaging assessment of macrophage accumulation in mouse brain after experimental traumatic brain injury. J Neurotrauma (2009) 1.60

Real-time cardiac MRI without triggering, gating, or breath holding. Conf Proc IEEE Eng Med Biol Soc (2008) 1.53

Liquid-liquid separation in solutions of normal and sickle cell hemoglobin. Proc Natl Acad Sci U S A (2002) 1.50

Real-time cardiac MRI using prior spatial-spectral information. Conf Proc IEEE Eng Med Biol Soc (2009) 1.44

STACS: new active contour scheme for cardiac MR image segmentation. IEEE Trans Med Imaging (2005) 1.39

Longitudinal tracking of recipient macrophages in a rat chronic cardiac allograft rejection model with noninvasive magnetic resonance imaging using micrometer-sized paramagnetic iron oxide particles. Circulation (2008) 1.38

High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells. J Clin Invest (2004) 1.35

Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers. Blood (2006) 1.32

Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren. Am J Trop Med Hyg (2003) 1.31

19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells. Magn Reson Med (2011) 1.27

In vivo detection of acute rat renal allograft rejection by MRI with USPIO particles. Kidney Int (2002) 1.23

Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance. Nat Genet (2010) 1.17

The structure--function relationship of hemoglobin in solution at atomic resolution. Chem Rev (2004) 1.17

Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity. Blood (2002) 1.13

MRI investigations of graft rejection following organ transplantation using rodent models. Methods Enzymol (2004) 1.12

High-resolution cardiac MRI using partially separable functions and weighted spatial smoothness regularization. Conf Proc IEEE Eng Med Biol Soc (2010) 1.12

Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats. J Cereb Blood Flow Metab (2008) 1.12

In support of the BMRB. Nat Struct Mol Biol (2012) 1.09

The kinetics of nucleation and growth of sickle cell hemoglobin fibers. J Mol Biol (2006) 1.09

High-resolution cardiovascular MRI by integrating parallel imaging with low-rank and sparse modeling. IEEE Trans Biomed Eng (2013) 1.07

Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders. Shock (2005) 1.05

Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury. Circulation (2005) 1.05

Metastable mesoscopic clusters in solutions of sickle-cell hemoglobin. Biophys J (2006) 1.04

Two-step mechanism of homogeneous nucleation of sickle cell hemoglobin polymers. Biophys J (2007) 1.02

Ligand-free open-closed transitions of periplasmic binding proteins: the case of glutamine-binding protein. Biochemistry (2010) 1.01

Implications of the genetic epidemiology of globin haplotypes linked to the sickle cell gene in southern Iran. Hum Biol (2006) 1.01

Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function. Protein J (2005) 1.01

Heme degradation and oxidative stress in murine models for hemoglobinopathies: thalassemia, sickle cell disease and hemoglobin C disease. Blood Cells Mol Dis (2008) 1.00

Hemoglobinopathies. Hematology Am Soc Hematol Educ Program (2003) 1.00

Cerebral blood flow at one year after controlled cortical impact in rats: assessment by magnetic resonance imaging. J Neurotrauma (2002) 0.99

Quantitative temporal profiles of penumbra and infarction during permanent middle cerebral artery occlusion in rats. Transl Stroke Res (2010) 0.98

Four-dimensional MR cardiovascular imaging: method and applications. Conf Proc IEEE Eng Med Biol Soc (2011) 0.98

Ligand binding properties and structural studies of recombinant and chemically modified hemoglobins altered at beta 93 cysteine. Biochemistry (2002) 0.97

Quaternary structure of carbonmonoxyhemoglobins in solution: structural changes induced by the allosteric effector inositol hexaphosphate. Biochemistry (2006) 0.97

Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Am J Hematol (2007) 0.97

Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective. Crit Care (2008) 0.97

Murine orthostatic response during prolonged vertical studies: effect on cerebral blood flow measured by arterial spin-labeled MRI. Magn Reson Med (2005) 0.96

Plasma lipids in Iranians with sickle cell disease: hypocholesterolemia in sickle cell anemia and increase of HDL-cholesterol in sickle cell trait. Clin Chim Acta (2005) 0.96

NMR investigation of the dynamics of tryptophan side-chains in hemoglobins. J Mol Biol (2002) 0.96

Superparamagnetic iron oxide particles transactivator protein-fluorescein isothiocyanate particle labeling for in vivo magnetic resonance imaging detection of cell migration: uptake and durability. Transplantation (2003) 0.95

Automatic detection of regional heart rejection in USPIO-enhanced MRI. IEEE Trans Med Imaging (2008) 0.95

Effects of amino acid substitutions at beta 131 on the structure and properties of hemoglobin: evidence for communication between alpha 1 beta 1- and alpha 1 beta 2-subunit interfaces. Biochemistry (2002) 0.95

MRI detection of macrophages labeled using micrometer-sized iron oxide particles. J Magn Reson Imaging (2007) 0.95

Intermolecular interactions, nucleation, and thermodynamics of crystallization of hemoglobin C. Biophys J (2002) 0.95

Sensitive and automated detection of iron-oxide-labeled cells using phase image cross-correlation analysis. Magn Reson Imaging (2008) 0.94

Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells. Blood (2003) 0.94

A new nano-sized iron oxide particle with high sensitivity for cellular magnetic resonance imaging. Mol Imaging Biol (2011) 0.94

Hemoglobin site-mutants reveal dynamical role of interhelical H-bonds in the allosteric pathway: time-resolved UV resonance Raman evidence for intra-dimer coupling. J Mol Biol (2004) 0.94

Determination of the solution-bound conformation of an amino acid binding protein by NMR paramagnetic relaxation enhancement: use of a single flexible paramagnetic probe with improved estimation of its sampling space. J Am Chem Soc (2009) 0.94

A comparative NMR study of the polypeptide backbone dynamics of hemoglobin in the deoxy and carbonmonoxy forms. Biochemistry (2007) 0.94

Exogenous iron increases hemoglobin in beta-thalassemic mice. Exp Hematol (2008) 0.94

Mechanisms for sickle red blood cell retention in choroid. Curr Eye Res (2002) 0.93

Inhibition of sickle red cell adhesion and vasoocclusion in the microcirculation by antioxidants. Am J Physiol Heart Circ Physiol (2006) 0.93

Effect of inducible nitric oxide synthase on cerebral blood flow after experimental traumatic brain injury in mice. J Neurotrauma (2008) 0.93

Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate. Biochem J (2005) 0.92

Molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Kurdish population of Western Iran. Blood Cells Mol Dis (2006) 0.92

Short planar gradient coils for MR microscopy using concentric return paths. J Magn Reson (2002) 0.92

Enhanced cellular uptake and long-term retention of chitosan-modified iron-oxide nanoparticles for MRI-based cell tracking. Int J Nanomedicine (2012) 0.91

Polynitroxyl albumin and albumin therapy after pediatric asphyxial cardiac arrest: effects on cerebral blood flow and neurologic outcome. J Cereb Blood Flow Metab (2011) 0.90

Normal and transplanted rat kidneys: diffusion MR imaging at 7 T. Radiology (2004) 0.90

Enhanced molecular volume of conservatively pegylated Hb: (SP-PEG5K)6-HbA is non-hypertensive. Artif Cells Blood Substit Immobil Biotechnol (2005) 0.89

Interfacial and distal-heme pocket mutations exhibit additive effects on the structure and function of hemoglobin. Biochemistry (2008) 0.89

Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia. Crit Care Med (2006) 0.89

Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin. Resuscitation (2008) 0.88

Dynamics of allostery in hemoglobin: roles of the penultimate tyrosine H bonds. J Mol Biol (2005) 0.88

Effector-induced structural fluctuation regulates the ligand affinity of an allosteric protein: binding of inositol hexaphosphate has distinct dynamic consequences for the T and R states of hemoglobin. Biochemistry (2008) 0.88

Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation. Biochem J (2007) 0.87

MRI assessment of cerebral blood flow after experimental traumatic brain injury combined with hemorrhagic shock in mice. J Cereb Blood Flow Metab (2012) 0.87

Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with Intralipid. Biochim Biophys Acta (2013) 0.87

Influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated haemoglobin. Biochem J (2007) 0.87

New look at hemoglobin allostery. Chem Rev (2015) 0.87

PEGylation of human serum albumin: reaction of PEG-phenyl-isothiocyanate with protein. Bioconjug Chem (2008) 0.87

Extension arm facilitated PEGylation of hemoglobin: correlation of the properties with the extent of PEGylation. Protein J (2006) 0.87

Magnetic resonance imaging investigation of macrophages in acute cardiac allograft rejection after heart transplantation. Circ Cardiovasc Imaging (2013) 0.86

A general strategy for the assignment of aliphatic side-chain resonances of uniformly 13C,15N-labeled large proteins. J Am Chem Soc (2005) 0.86

Purification and molecular analysis of hemoglobin by high-performance liquid chromatography. Methods Mol Med (2003) 0.86

Improved subspace estimation for low-rank model-based accelerated cardiac imaging. IEEE Trans Biomed Eng (2014) 0.86

Transgenic mice and hemoglobinopathies. Methods Mol Med (2003) 0.86

PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin. Biochemistry (2009) 0.86

Characterization of the effects of adenosine receptor agonists on cerebral blood flow in uninjured and traumatically injured rat brain using continuous arterial spin-labeled magnetic resonance imaging. J Cereb Blood Flow Metab (2005) 0.86

First-pass perfusion cardiac MRI using the Partially Separable Functions model with generalized support. Conf Proc IEEE Eng Med Biol Soc (2010) 0.86