Published in J Gen Virol on May 01, 2004
Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84
Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling. Proc Natl Acad Sci U S A (2006) 2.63
Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses. J Virol (2007) 2.44
The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nat Rev Microbiol (2008) 2.08
Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor. Proc Natl Acad Sci U S A (2006) 1.96
VirHostNet: a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks. Nucleic Acids Res (2008) 1.71
NF-kappaB activation in melanoma. Pigment Cell Res (2006) 1.55
Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection. J Virol (2005) 1.53
Phosphatidylinositol 3-kinase-, actin-, and microtubule-dependent transport of Semliki Forest Virus replication complexes from the plasma membrane to modified lysosomes. J Virol (2010) 1.52
Viral subversion of apoptotic enzymes: escape from death row. Annu Rev Microbiol (2008) 1.41
Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication. J Virol (2009) 1.30
Hepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication. J Virol (2005) 1.22
Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy. J Virol (2012) 1.21
Autophagy, antiviral immunity, and viral countermeasures. Biochim Biophys Acta (2009) 1.20
Rotavirus nonstructural protein 1 suppresses virus-induced cellular apoptosis to facilitate viral growth by activating the cell survival pathways during early stages of infection. J Virol (2010) 1.18
Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription. J Virol (2005) 1.13
Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway. J Virol (2007) 1.10
African swine fever virus uses macropinocytosis to enter host cells. PLoS Pathog (2012) 1.10
M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A. J Virol (2006) 1.05
Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation. J Virol (2005) 1.05
The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS One (2011) 1.05
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Nat Chem Biol (2011) 1.04
Make yourself at home: viral hijacking of the PI3K/Akt signaling pathway. Viruses (2013) 1.03
Intracellular events and cell fate in filovirus infection. Viruses (2011) 1.01
Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death. J Virol (2008) 0.99
Vaccinia-induced epidermal growth factor receptor-MEK signalling and the anti-apoptotic protein F1L synergize to suppress cell death during infection. Cell Microbiol (2009) 0.98
Expression of the RAE-1 family of stimulatory NK-cell ligands requires activation of the PI3K pathway during viral infection and transformation. PLoS Pathog (2011) 0.96
Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism. J Virol (2009) 0.94
Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency. J Gen Virol (2009) 0.94
Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. J Cell Biol (2012) 0.94
Influenza virus and cell signaling pathways. Med Sci Monit (2011) 0.93
Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus. J Virol (2010) 0.91
Roles of host and viral microRNAs in human cytomegalovirus biology. Virus Res (2010) 0.91
Toward system-level understanding of baculovirus-host cell interactions: from molecular fundamental studies to large-scale proteomics approaches. Front Microbiol (2012) 0.90
Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans. Gastroenterology (2012) 0.89
Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts. Exp Mol Med (2010) 0.89
The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase. PLoS Pathog (2014) 0.88
Activation of Akt by the bacterial inositol phosphatase, SopB, is wortmannin insensitive. PLoS One (2011) 0.86
Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization. J Virol (2015) 0.86
Pharmacological manipulation of the akt signaling pathway regulates myxoma virus replication and tropism in human cancer cells. J Virol (2010) 0.86
Genome scale transcriptomics of baculovirus-insect interactions. Viruses (2013) 0.85
Herpes simplex virus type 1 latency-associated transcript inhibits apoptosis and promotes neurite sprouting in neuroblastoma cells following serum starvation by maintaining protein kinase B (AKT) levels. J Gen Virol (2009) 0.84
Dose dependent activation of retinoic acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma. PLoS One (2013) 0.83
The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome. J Virol (2011) 0.83
Role for the phosphatidylinositol 3-kinase-Akt-TOR pathway during sindbis virus replication in arthropods. J Virol (2012) 0.83
Influenza A virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein. J Biol Chem (2012) 0.83
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside. Virology (2015) 0.82
Src kinase and Syk activation initiate PI3K signaling by a chimeric latent membrane protein 1 in Epstein-Barr virus (EBV)+ B cell lymphomas. PLoS One (2012) 0.82
Role of AKT kinase in measles virus replication. J Virol (2009) 0.82
The involvement of survival signaling pathways in rubella-virus induced apoptosis. Virol J (2005) 0.82
Heterologous SH3-p85beta inhibits influenza A virus replication. Virol J (2010) 0.81
Sindbis virus replication, is insensitive to rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells. Biochem Biophys Res Commun (2011) 0.81
Phosphatidylinositol 3-kinase regulates macrophage responses to double-stranded RNA and encephalomyocarditis virus. J Innate Immun (2009) 0.81
Host cell factors as antiviral targets in arenavirus infection. Viruses (2012) 0.81
Phenotypic differences between healthy effector CTL and leukemic LGL cells support the notion of antigen-triggered clonal transformation in T-LGL leukemia. J Leukoc Biol (2007) 0.81
A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. PLoS One (2010) 0.80
Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway during porcine circovirus type 2 infection facilitates cell survival and viral replication. J Virol (2012) 0.80
Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal. World J Diabetes (2015) 0.80
Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis. PLoS One (2010) 0.80
Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins. J Virol (2014) 0.79
Death waits for no man--does it wait for a virus? How enteroviruses induce and control cell death. Cytokine Growth Factor Rev (2014) 0.79
Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activity. J Virol (2014) 0.79
Early Steps of Jaagsiekte Sheep Retrovirus-Mediated Cell Transformation Involve the Interaction between Env and the RALBP1 Cellular Protein. J Virol (2015) 0.79
Dissection and integration of the autophagy signaling network initiated by bluetongue virus infection: crucial candidates ERK1/2, Akt and AMPK. Sci Rep (2016) 0.77
Computer-aided targeting of the PI3K/Akt/mTOR pathway: toxicity reduction and therapeutic opportunities. Int J Mol Sci (2014) 0.77
Structural and Biophysical Characterization of the Interactions between Calmodulin and the Pleckstrin Homology Domain of Akt. J Biol Chem (2015) 0.77
Small molecule inhibitors of HCV replication from pomegranate. Sci Rep (2014) 0.76
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT). J Neurovirol (2015) 0.76
The Interplay Between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt. J Biol Chem (2016) 0.75
Macrophage Expression of Inflammatory Genes in Response to EMCV Infection. Biomolecules (2015) 0.75
Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes. Front Microbiol (2015) 0.75
Analysis of PI3K pathway components in human cancers. Oncol Lett (2016) 0.75
Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) reveals pathway differences between pigs with alternate genotypes for a major host response QTL. BMC Genomics (2016) 0.75
Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway. PLoS One (2016) 0.75
Role of the phosphatidylinositol-3-kinase/Akt/target of rapamycin pathway during ambidensovirus infection of insect cells. J Gen Virol (2015) 0.75
THE REPLICATION OF JCV DNA IN THE G144 OLIGODENDROCYTE CELL LINE IS DEPENDENT UPON AKT. J Virol (2017) 0.75
Transcriptome Differences in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs in Response to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection. Int J Mol Sci (2017) 0.75