Functional aspects of the tear film lipid layer.

PubWeight™: 2.06‹?› | Rank: Top 2%

🔗 View Article (PMID 15106912)

Published in Exp Eye Res on March 01, 2004

Authors

A J Bron1, J M Tiffany, S M Gouveia, N Yokoi, L W Voon

Author Affiliations

1: Nuffield Laboratory of Ophthalmology, Department of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, UK. anthony.bron@eye.ox.ac.uk

Articles citing this

The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Invest Ophthalmol Vis Sci (2011) 2.44

The international workshop on meibomian gland dysfunction: report of the diagnosis subcommittee. Invest Ophthalmol Vis Sci (2011) 1.80

Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum. J Lipid Res (2009) 1.51

The international workshop on meibomian gland dysfunction: report of the subcommittee on tear film lipids and lipid-protein interactions in health and disease. Invest Ophthalmol Vis Sci (2011) 1.46

On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids. Invest Ophthalmol Vis Sci (2008) 1.36

Understanding and analyzing meibomian lipids--a review. Curr Eye Res (2008) 1.34

The Meibomian puzzle: combining pieces together. Prog Retin Eye Res (2009) 1.27

A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation. Exp Eye Res (2007) 1.19

Mechanisms of murine lacrimal gland repair after experimentally induced inflammation. Invest Ophthalmol Vis Sci (2008) 1.14

Culture, immortalization, and characterization of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci (2010) 1.11

Lipidomics of human Meibomian gland secretions: Chemistry, biophysics, and physiological role of Meibomian lipids. Prog Lipid Res (2011) 1.06

The role of omega-3 dietary supplementation in blepharitis and meibomian gland dysfunction (an AOS thesis). Trans Am Ophthalmol Soc (2008) 1.03

Enhanced Edar signalling has pleiotropic effects on craniofacial and cutaneous glands. PLoS One (2009) 1.02

Decreased tear lipocalin concentration in patients with meibomian gland dysfunction. Br J Ophthalmol (2005) 0.99

A novel technique of contrast-enhanced optical coherence tomography imaging in evaluation of clearance of lipids in human tears. PLoS One (2014) 0.98

[Meibomian glands. Part I: anatomy, embryology and histology of the Meibomian glands]. Ophthalmologe (2009) 0.97

Tear lipocalin: structure and function. Ocul Surf (2011) 0.97

Absence of ductal hyper-keratinization in mouse age-related meibomian gland dysfunction (ARMGD). Aging (Albany NY) (2013) 0.95

The three-neuron corneal reflex circuit and modulation of second-order corneal responsive neurons. Exp Brain Res (2007) 0.94

Systane lubricant eye drops in the management of ocular dryness. Clin Ophthalmol (2011) 0.94

High resolution microscopy of the lipid layer of the tear film. Ocul Surf (2011) 0.94

Changes in gene expression in human meibomian gland dysfunction. Invest Ophthalmol Vis Sci (2011) 0.93

Ligand binding site of tear lipocalin: contribution of a trigonal cluster of charged residues probed by 8-anilino-1-naphthalenesulfonic acid. Biochemistry (2008) 0.91

Dynamics and function of the tear film in relation to the blink cycle. Prog Retin Eye Res (2014) 0.91

Tear film lipids. Exp Eye Res (2013) 0.91

Meibomian lipid films and the impact of temperature. Invest Ophthalmol Vis Sci (2010) 0.91

Mass spectrometric identification of phospholipids in human tears and tear lipocalin. Invest Ophthalmol Vis Sci (2012) 0.90

Total cholesterol and lipoprotein composition are associated with dry eye disease in Korean women. Lipids Health Dis (2013) 0.90

[Meibomian glands. Part II: physiology, characteristics, distribution and function of meibomian oil]. Ophthalmologe (2009) 0.89

Comparison of the Schirmer I test with and without topical anesthesia for diagnosing dry eye. Int J Ophthalmol (2012) 0.89

Eye blink frequency during different computer tasks quantified by electrooculography. Eur J Appl Physiol (2006) 0.89

[Meibomian glands : part IV. Functional interactions in the pathogenesis of meibomian gland dysfunction (MGD)]. Ophthalmologe (2009) 0.86

Four characteristics and a model of an effective tear film lipid layer (TFLL). Ocul Surf (2013) 0.86

Immunohistochemical analysis of secretoglobin SCGB 2A1 expression in human ocular glands and tissues. Histochem Cell Biol (2006) 0.86

A Simple Novel Technique of Infrared Meibography by Means of Spectral-Domain Optical Coherence Tomography: A Cross-Sectional Clinical Study. PLoS One (2016) 0.86

The relation of functional visual acuity measurement methodology to tear functions and ocular surface status. Jpn J Ophthalmol (2011) 0.85

Temperature-induced transitions in the structure and interfacial rheology of human meibum. Biophys J (2012) 0.85

How to promote and preserve eyelid health. Clin Ophthalmol (2012) 0.84

The sustained effect (12 months) of a single-dose vectored thermal pulsation procedure for meibomian gland dysfunction and evaporative dry eye. Clin Ophthalmol (2016) 0.84

Factors regulating eye blink rate in young infants. Optom Vis Sci (2010) 0.83

Computed tear film and osmolarity dynamics on an eye-shaped domain. Math Med Biol (2015) 0.83

[Meibomian glands : part III. Dysfunction - argument for a discrete disease entity and as an important cause of dry eye]. Ophthalmologe (2009) 0.83

The lid wiper and muco-cutaneous junction anatomy of the human eyelid margins: an in vivo confocal and histological study. J Anat (2011) 0.82

[Sjögren's syndrome. Current aspects from a rheumatological point of view]. Z Rheumatol (2006) 0.82

Tear film interferometry and corneal surface roughness. Invest Ophthalmol Vis Sci (2014) 0.82

Identification and comparison of the polar phospholipids in normal and dry eye rabbit tears by MALDI-TOF mass spectrometry. Invest Ophthalmol Vis Sci (2006) 0.81

Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease. Clin Ophthalmol (2012) 0.81

Detection of BrdU-label retaining cells in the lacrimal gland: implications for tissue repair. Cell Tissue Res (2011) 0.81

Advanced glycation end product (AGE) modified proteins in tears of diabetic patients. Mol Vis (2010) 0.81

Neurotransmitter influence on human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci (2011) 0.80

Review: The Lacrimal Gland and Its Role in Dry Eye. J Ophthalmol (2016) 0.80

Regional differences in rat conjunctival ion transport activities. Am J Physiol Cell Physiol (2012) 0.80

The effect of topical amiloride eye drops on tear quantity in rabbits. Mol Vis (2010) 0.80

Meibomian gland cells display a differentiation-dependent composition of desmosomes. Histochem Cell Biol (2016) 0.79

Tear lipids interfacial rheology: effect of lysozyme and lens care solutions. Optom Vis Sci (2010) 0.79

Measurement of central corneal thickness and pre-corneal tear film thickness of rabbits using the Scheimpflug system. Int J Ophthalmol (2013) 0.79

Turnover rate of tear-film lipid layer determined by fluorophotometry. Br J Ophthalmol (2009) 0.79

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research. Invest Ophthalmol Vis Sci (2017) 0.78

Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction. J Lipid Res (2014) 0.78

Intra-observer and inter-observer repeatability of ocular surface interferometer in measuring lipid layer thickness. BMC Ophthalmol (2015) 0.77

Tear film dynamics with evaporation, wetting, and time-dependent flux boundary condition on an eye-shaped domain. Phys Fluids (1994) (2014) 0.77

Effect of topically applied epithelial sodium channel inhibitors on tear production in normal mice and in mice with induced aqueous tear deficiency. J Ocul Pharmacol Ther (2012) 0.77

Effects of mycophenolate mofetil on proliferation and mucin-5AC expression in human conjunctival goblet cells in vitro. Mol Vis (2010) 0.77

Organization of lipids in the tear film: a molecular-level view. PLoS One (2014) 0.77

Ocular Surface as Barrier of Innate Immunity. Open Ophthalmol J (2015) 0.76

[Testosterone reduces the expression of keratinization-promoting genes in murine Meibomian glands]. Ophthalmologe (2013) 0.76

A MODEL FOR THE TEAR FILM AND OCULAR SURFACE TEMPERATURE FOR PARTIAL BLINKS. Interfacial Phenom Heat Transf (2015) 0.76

Surface tension in human pathophysiology and its application as a medical diagnostic tool. Bioimpacts (2015) 0.76

Surface Properties of Squalene/Meibum Films and NMR Confirmation of Squalene in Tears. Int J Mol Sci (2015) 0.76

A Randomized, Controlled Treatment Trial of Eyelid-Warming Therapies in Meibomian Gland Dysfunction. Ophthalmol Ther (2014) 0.76

Impact of Cigarette Smoking on Tear Function and Correlation between Conjunctival Goblet Cells and Tear MUC5AC Concentration in Office Workers. Sci Rep (2016) 0.76

A clinical utility assessment of the automatic measurement method of the quality of Meibomian glands. Biomed Eng Online (2017) 0.75

Sebum/Meibum Surface Film Interactions and Phase Transitional Differences. Invest Ophthalmol Vis Sci (2016) 0.75

Dissecting lipid metabolism in meibomian glands of humans and mice: An integrative study reveals a network of metabolic reactions not duplicated in other tissues. Biochim Biophys Acta (2016) 0.75

Evaluation of corneal topography and biomechanical parameters after use of systemic isotretinoin in acne vulgaris. J Ophthalmol (2014) 0.75

Non-invasive in vivo measurement of the tear film using spatial autocorrelation in a live mammal model. Biomed Opt Express (2010) 0.75

In vivo Confocal Microscopy Evaluation of Meibomian Gland Dysfunction in Dry Eye Patients with Different Symptoms. Chin Med J (Engl) (2016) 0.75

Growth Hormone Influence on the Morphology and Size of the Mouse Meibomian Gland. J Ophthalmol (2016) 0.75

Atomic force microscopy and Langmuir-Blodgett monolayer technique to assess contact lens deposits and human meibum extracts. J Optom (2015) 0.75

Dry eye symptoms are increased in mice deficient in phospholipid transfer protein (PLTP). Am J Pathol (2011) 0.75

Clinical Trial of Thermal Pulsation (LipiFlow) in Meibomian Gland Dysfunction With Preteatment Meibography. Eye Contact Lens (2016) 0.75

Characterization of ocular gland morphology and tear composition of pinnipeds. Vet Ophthalmol (2012) 0.75

Surface Chemistry Interactions of Cationorm with Films by Human Meibum and Tear Film Compounds. Int J Mol Sci (2017) 0.75

Human Meibum Age, Lipid-Lipid Interactions and Lipid Saturation in Meibum from Infants. Int J Mol Sci (2017) 0.75

Proteolytic activity in the meibomian gland: Implications to health and disease. Exp Eye Res (2017) 0.75

Relation of accommodative microfluctuation with dry eye symptoms in short tear break-up time dry eye. PLoS One (2017) 0.75

Meibomian gland loss due to trabeculectomy. Jpn J Ophthalmol (2014) 0.75

Articles by these authors

Subjective visual experience during extracapsular cataract extraction and intraocular lens implantation under retrobulbar anaesthesia. Eye (Lond) (1999) 2.50

The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. Diabetes (2001) 1.74

Characteristics of the human ocular surface epithelium. Prog Retin Eye Res (2001) 1.71

Components responsible for the surface tension of human tears. Curr Eye Res (1999) 1.42

Optic disc morphology on presentation of chronic glaucoma. Eye (Lond) (2002) 1.41

Detection of herpes simplex virus DNA in atypical epithelial keratitis using polymerase chain reaction. Br J Ophthalmol (1999) 1.40

The meibomian glands and tear film lipids. Structure, function, and control. Adv Exp Med Biol (1998) 1.25

MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis. J Biol Chem (2000) 1.22

The contribution of meibomian disease to dry eye. Ocul Surf (2004) 1.22

Assessment of meibomian gland function in dry eye using meibometry. Arch Ophthalmol (1999) 1.16

Individual variations in human meibomian lipid composition. Exp Eye Res (1978) 1.11

Transforming growth factor-beta 1, -beta 2 and -beta 3 mRNA expression in human cornea. Curr Eye Res (1995) 1.07

Fatty acid composition of three strains of Newcastle disease virus. Virology (1969) 1.05

Identification by combined gas chromatography-mass spectrometry of constituent long-chain fatty acids and alcohols from the meibomian glands of the rat and a comparison with human meibomian lipids. J Chromatogr (1987) 1.02

The detection of bacteria and bacterial biofilms in punctal plug holes. Cornea (2001) 1.01

Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system. J Neurochem (2000) 1.01

A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. Biochemistry (2000) 1.00

Ocular surface residence times of artificial tear solutions. Cornea (1992) 1.00

Causes and management of Descemet's membrane detachment associated with cataract surgery--not always a benign problem. Ann Acad Med Singapore (2001) 0.99

The casual level of meibomian lipids in humans. Curr Eye Res (1993) 0.98

Role of tears in maintaining corneal integrity. Trans Ophthalmol Soc U K (1978) 0.97

Refractive index of meibomian and other lipids. Curr Eye Res (1986) 0.97

Theoretical aspects of structure and assembly of viral envelops. Curr Top Microbiol Immunol (1975) 0.95

Human ocular mucus. Chemical studies. Exp Eye Res (1981) 0.95

The height and radius of the tear meniscus and methods for examining these parameters. Cornea (2000) 0.95

Models of structure of the envelope of influenza virus. Proc Natl Acad Sci U S A (1970) 0.94

Estimation of the number of surface projections on myxo- and paramyxoviruses. Virology (1970) 0.93

Reflective meniscometry: a new field of dry eye assessment. Cornea (2000) 0.92

A case-control study of the effectiveness of cervical cancer screening in Osaka, Japan. Jpn J Cancer Res (1988) 0.92

Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform. Genomics (2001) 0.92

A mass and solute balance model for tear volume and osmolarity in the normal and the dry eye. Prog Retin Eye Res (2009) 0.92

Lipids in viruses. Adv Lipid Res (1973) 0.91

Angiopoietin-3, a novel member of the angiopoietin family. FEBS Lett (1999) 0.91

Identification of meibomian gland lipids by gas chromatography-mass spectrometry: application to the meibomian lipids of the mouse. J Chromatogr (1984) 0.91

The meibomian lipids of the rabbit. I. Overall composition. Exp Eye Res (1979) 0.90

Attachment of myxoviruses to artificial membranes: electron microscopic studies. Virology (1971) 0.89

An instrument for quantifying meibomian lipid on the lid margin: the Meibometer. Curr Eye Res (1993) 0.89

The effect of magnesium on the intracellular crystallization of rhinovirus. Virology (1969) 0.88

Ophthalmic artery blood flow in patients with internal carotid artery occlusion. Br J Ophthalmol (2004) 0.86

Myxovirus envelope proteins: a directing influence on the fatty acids of membrane lipids. Science (1969) 0.86

Treatment of aberrant facial nerve regeneration with botulinum toxin A. Orbit (2004) 0.85

A comparative genetic map of rat, mouse and human genomes. Exp Anim (1998) 0.84

Immunohistochemical localization of transforming growth factor-beta 1, -beta 2, and -beta 3 latency-associated peptide in human cornea. Invest Ophthalmol Vis Sci (1994) 0.84

Human ocular mucus. Origins and preliminary characterisation. Exp Eye Res (1979) 0.83

Prolonged impairment of peripheral corneal epithelium barrier function after successful trabeculectomy. Am J Ophthalmol (1997) 0.83

Evaluation of digital linear tomosynthesis imaging of the temporomandibular joint: initial clinical experience and evaluation. Dentomaxillofac Radiol (2007) 0.83

The meibomian lipids of the rabbit. II. Detailed composition of the principal esters. Exp Eye Res (1982) 0.82

The role of meibomian secretion in the tears. Trans Ophthalmol Soc U K (1985) 0.82

Polymorphic variation in the CBLB gene in human type 1 diabetes. Genes Immun (2004) 0.82

Lipid synthesis in vitro by rabbit Meibomian gland tissue and its inhibition by tetracycline. Biochim Biophys Acta (1990) 0.81

A longitudinal study of disturbances of the hypothalamic-pituitary-adrenal axis in women with progestin-negative functional hypothalamic amenorrhea. Fertil Steril (2001) 0.81

A rat mutation producing demyelination (dmy) maps to chromosome 17. Mamm Genome (1996) 0.81

The fatty acid composition of incomplete influenza virus. Biochem Biophys Res Commun (1969) 0.80

Factors responsible for tear ferning. Cornea (1991) 0.80

Impairment of ocular surface epithelium barrier function in patients with atopic dermatitis. Br J Ophthalmol (1998) 0.80

Physical properties of stimulated and unstimulated tears. Exp Eye Res (1999) 0.79

Surface tension in tears. Arch Soc Esp Oftalmol (2006) 0.79

Hydrodynamics of meniscus-induced thinning of the tear film. Adv Exp Med Biol (1998) 0.79

Assignment of the human solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 gene (SLC4A10) to 2q23-->q24 by in situ hybridization and radiation hybrid mapping. Cytogenet Cell Genet (2000) 0.79

Fluorophotometric assessment of rabbit corneal epithelial barrier function after rigid contact lens wear. Cornea (1999) 0.79

Lipids in viruses. Adv Lipid Res (1973) 0.79

[Corneal autofluorescence in patients with diabetic retinopathy]. Nippon Ganka Gakkai Zasshi (1995) 0.79

Classification of polycystic ovary syndrome into three types according to response to human corticotropin-releasing hormone. Fertil Steril (1999) 0.78

Tear meniscus changes during cotton thread and Schirmer testing. Invest Ophthalmol Vis Sci (2000) 0.78

Effect of beta-blocker eyedrops on corneal epithelial barrier function. Ophthalmologica (2000) 0.78

Characterization of proteoglycans synthesized by rat thyroid cells in culture and their response to thyroid-stimulating hormone. J Biol Chem (1988) 0.78

Human conjunctival epithelial cells express functional Toll-like receptor 5. Br J Ophthalmol (2008) 0.78

Basophils in the giant papillae of chronic allergic keratoconjunctivitis. Br J Ophthalmol (2009) 0.77

The interaction of fetuin with phosphatidylcholine monolayers. Characterization of a lipoprotein membrane system suitable for the attachment of myxoviruses. Biochem J (1970) 0.77

[Investigation of corneal autofluorescence in diabetic patients]. Nippon Ganka Gakkai Zasshi (2000) 0.77

Wettability of the corneal surface: a reappraisal. Curr Eye Res (1986) 0.77

Clinical and ultrastructural findings in mare's tail lines of the corneal epithelium. Br J Ophthalmol (2004) 0.77

[Adverse effects of beta-blocker eye drops on the ocular surface]. Nippon Ganka Gakkai Zasshi (2001) 0.77

Lipids of rabies virus and BHK-21 cell membranes. J Virol (1977) 0.77

Lipid-containing eye drops. Ophthalmologica (1991) 0.77

[Age-related alteration of tear dynamics in normal volunteers]. Nippon Ganka Gakkai Zasshi (1994) 0.77

Incorporation of branched-chain fatty acids into myxoviruses. Proc Natl Acad Sci U S A (1969) 0.77

Fifty-six new microsatellite markers in the rat genetic linkage map. Transplant Proc (1995) 0.76

Tear film instability induced by rigid contact lenses. Cornea (1999) 0.76

Association of precorneal and preconjunctival tear film. Adv Exp Med Biol (1998) 0.75

Population-based case-control study on cancer screening. Environ Health Perspect (1990) 0.75

Thyroid hormone excess stimulates the synthesis of proteoglycan in human skin fibroblasts in culture. Acta Endocrinol (Copenh) (1990) 0.75

[Corneal epithelial disturbance during topical use of latanoprost]. Nippon Ganka Gakkai Zasshi (2000) 0.75

Correlation between genetic and cytogenetic maps of the rat. Mamm Genome (1998) 0.75

[A rat experimental posterior subcapsular cataract model resembling human diabetic cataract]. Nippon Ganka Gakkai Zasshi (1988) 0.75

Sialic acid in normal human tear fluid. Jpn J Ophthalmol (2001) 0.75

Linkage mapping of the mouse nephrosis (nep) gene to chromosome 15. J Vet Med Sci (2001) 0.75

Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genes. Exp Anim (1998) 0.75

[Investigation of the movement and proliferation of basal cells by BrdU immunohistochemistry in control group of diabetic corneal epitheliopathy]. Nippon Ganka Gakkai Zasshi (1988) 0.75

[Corneal endothelial healing in galactosemic rats proliferation of residual endothelial cells]. Nippon Ganka Gakkai Zasshi (1988) 0.75

[Studies on materials for root caries restoration--adherence of plaque bacteria on the materials' surface]. Nihon Shishubyo Gakkai Kaishi (1983) 0.75

Unique occurrence of the 1CF11 carbohydrate epitope in primate saliva. Biosci Biotechnol Biochem (2001) 0.75

Unidirectional phase-Doppler method for particle-size measurements. Appl Opt (2001) 0.75

The interaction between Lyn and FcεRIβ is indispensable for FcεRI-mediated human mast cell activation. Allergy (2012) 0.75

[Effect of latanoprost on the barrier function of corneal epithelium]. Nippon Ganka Gakkai Zasshi (2001) 0.75

[Morphological study of diet-reversal in rat galactose cataract]. Nippon Ganka Gakkai Zasshi (1988) 0.75

Explosive turbulent magnetic reconnection. Phys Rev Lett (2013) 0.75

[Prevention of experimental diabetic corneal endotheliopathy with a new aldose reductase inhibitor]. Nippon Ganka Gakkai Zasshi (1988) 0.75

Enzyme-entrapping behaviors in alginate fibers and their papers. Biotechnol Bioeng (1987) 0.75