Published in Bioorg Med Chem Lett on June 07, 2004
Chemistry, biology, and medicinal potential of narciclasine and its congeners. Chem Rev (2008) 1.61
Synthesis of some members of the hydroxylated phenanthridone subclass of the Amaryllidaceae alkaloid family. J Org Chem (2007) 1.17
Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogues. The next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine. J Org Chem (2010) 1.05
Selective cytotoxicity of pancratistatin-related natural Amaryllidaceae alkaloids: evaluation of the activity of two new compounds. Cancer Cell Int (2007) 1.03
Synthesis of structurally simplified analogues of pancratistatin: truncation of the cyclitol ring. J Org Chem (2009) 0.87
Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation. Bioorg Med Chem Lett (2011) 0.85
Amaryllidaceae isocarbostyril alkaloids and their derivatives as promising antitumor agents. Transl Oncol (2008) 0.83
TOTAL SYNTHESES OF PANCRATISTATIN. A REVIEW. Org Prep Proced Int (2009) 0.78
A solution to the stereochemical problems posed by amaryllidaceae constituents using a highly syn-selective arylcuprate conjugate addition to γ-amino and γ-carbamato-α,β-enoates. Tetrahedron Asymmetry (2006) 0.78
The role of biocatalysis in the asymmetric synthesis of alkaloids. RSC Adv (2013) 0.77
Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide. Bioorg Med Chem Lett (2014) 0.75
Unnatural C-1 homologues of pancratistatin - Synthesis and promising biological activities. Can J Chem (2012) 0.75
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem J (2003) 3.43
Interstitial granulomatous drug reaction to anakinra. J Am Acad Dermatol (2008) 1.85
A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway. Cell (2013) 1.75
Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents. Cancer Biol Ther (2004) 1.71
Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing. Antimicrob Agents Chemother (2005) 1.61
Sterile inflammation associated with transradial catheterization and hydrophilic sheaths. Catheter Cardiovasc Interv (2003) 1.52
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Biochem J (2006) 1.46
Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin. Mol Pharmacol (2006) 1.42
Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase. J Biol Chem (2009) 1.33
DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics. Hum Mutat (2013) 1.25
Eczema herpeticum: a dermatologic emergency. Dermatol Nurs (2002) 1.25
An analysis of exome sequencing for diagnostic testing of the genes associated with muscle disease and spastic paraplegia. Hum Mutat (2012) 1.25
Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin. Mol Pharmacol (2003) 1.20
Total synthesis and biological evaluation of Amaryllidaceae alkaloids: narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives. J Org Chem (2002) 1.19
Interactions of halichondrin B and eribulin with tubulin. J Chem Inf Model (2011) 1.19
Analysis of group differences in processing speed: Brinley plots, Q-Q plots, and other conspiracies. Psychon Bull Rev (2003) 1.18
The National Institutes of Health undiagnosed diseases program. Curr Opin Pediatr (2014) 1.14
Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage. Clin Cancer Res (2002) 1.10
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays. Biochem J (2007) 1.10
Novel anti-infective compounds from marine bacteria. Mar Drugs (2010) 1.08
Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix. Cancer Res (2003) 1.05
Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogues. The next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine. J Org Chem (2010) 1.05
MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. J Biol Chem (2009) 1.02
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine. J Nat Prod (2006) 1.02
Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate. Anticancer Res (2003) 0.99
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol Pharmacol (2011) 0.99
Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism. J Clin Invest (2011) 0.99
The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. J Biol Chem (2006) 0.98
Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography. Eur J Biochem (2003) 0.97
Cephalostatin 1 inactivates Bcl-2 by hyperphosphorylation independent of M-phase arrest and DNA damage. Mol Pharmacol (2005) 0.97
A beta-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: synthesis and biological evaluation. Angew Chem Int Ed Engl (2004) 0.96
Antibacterial activity of the marine sponge constituent cribrostatin 6. J Med Microbiol (2004) 0.96
Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. J Nat Prod (2013) 0.95
Atypical patterns of inheritance. Semin Pediatr Neurol (2007) 0.95
Isolation and structure of a 20,21-epoxybufenolide series from "Ch'an Su". J Nat Prod (2002) 0.94
Biofilm-specific cross-species induction of antimicrobial compounds in bacilli. Appl Environ Microbiol (2003) 0.94
The development of a marine natural product-based antifouling paint. Biofouling (2003) 0.93
Total synthesis of epi-7-deoxypancratistatin via aza-Payne rearrangement and intramolecular cyclization. Org Lett (2002) 0.93
Design and synthesis of a potent phorboxazole C(11-15) acetal analogue. Org Lett (2006) 0.93
Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503. Anticancer Res (2002) 0.93
High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules. Biochem J (2010) 0.93
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives. Bioorg Med Chem Lett (2008) 0.92
Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents. Bioorg Med Chem (2006) 0.91
Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochem J (2010) 0.91
Application of a high throughput Alamar blue biofilm susceptibility assay to Staphylococcus aureus biofilms. Ann Clin Microbiol Antimicrob (2009) 0.90
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). J Med Chem (2011) 0.90
RACK1 to the future--a historical perspective. Cell Commun Signal (2013) 0.90
Total synthesis of 7-deoxypancratistatin-1-carboxaldehyde and carboxylic acid via solvent-free intramolecular aziridine opening: phenanthrene to phenanthridone cyclization strategy. Org Lett (2007) 0.89
Spa contact dermatitis. Dermatitis (2008) 0.89
Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process. Cell Signal (2003) 0.88
Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription. J Biol Chem (2011) 0.88
Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs. FASEB J (2012) 0.88
A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. FEBS Lett (2009) 0.88
Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate. Clin Cancer Res (2004) 0.87
Free sialic acid storage disease without sialuria. Ann Neurol (2009) 0.87
(+)-Phorboxazole A synthetic studies. Identification of a series of highly cytotoxic C(45-46) analogues. Org Lett (2005) 0.87
E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. Bioorg Med Chem (2009) 0.86
Recombination mapping using Boolean logic and high-density SNP genotyping for exome sequence filtering. Mol Genet Metab (2011) 0.86
Direct photoaffinity labeling by dolastatin 10 of the amino-terminal peptide of beta-tubulin containing cysteine 12. J Biol Chem (2004) 0.86
Comparative effects of single-mode vs. duration-matched concurrent exercise training on body composition, low-grade inflammation, and glucose regulation in sedentary, overweight, middle-aged men. Appl Physiol Nutr Metab (2013) 0.85
QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1). J Med Chem (2002) 0.85
Differential gene expression in auristatin PHE-treated Cryptococcus neoformans. Antimicrob Agents Chemother (2004) 0.85
Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation. Bioorg Med Chem Lett (2011) 0.85
Characterization of the hollow fiber assay for the determination of microtubule disruption in vivo. Clin Cancer Res (2004) 0.85
Cyclotrimerization strategy toward analogues of amaryllidaceae constituents. synthesis of deoxygenated pancratistatin core. Org Lett (2005) 0.85
Synthesis of morphine alkaloids and derivatives. Top Curr Chem (2012) 0.84
Stylopeptide 2, a proline-rich cyclodecapeptide from the sponge Stylotella sp. J Nat Prod (2008) 0.84
Chemoenzymatic synthesis of inositols, conduritols, and cyclitol analogues. Chem Rev (2011) 0.83
p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways. Cell Signal (2010) 0.83
Putting the lid on phosphodiesterase 4. Nat Biotechnol (2010) 0.83
Allopurinol hypersensitivity syndrome. J Drugs Dermatol (2002) 0.83
Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Med (2009) 0.83
Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene. Biochem J (2004) 0.82
Symmetry-based design for the chemoenzymatic synthesis of oseltamivir (Tamiflu) from ethyl benzoate. Angew Chem Int Ed Engl (2009) 0.81
Effect of auristatin PHE on microtubule integrity and nuclear localization in Cryptococcus neoformans. Antimicrob Agents Chemother (2002) 0.81
JM47, a cyclic tetrapeptide HC-toxin analogue from a marine Fusarium species. Phytochemistry (2002) 0.81
Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. Mol Pharmacol (2008) 0.81
Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents. J Nat Prod (2008) 0.81
In vitro and in vivo antifungal activities of the marine sponge constituent spongistatin. Med Mycol (2005) 0.81
Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4. Bioorg Med Chem Lett (2008) 0.80
Sensitization of human breast cancer cells to gemcitabine by the protein kinase C modulator bryostatin 1. Cancer Chemother Pharmacol (2003) 0.80
Selective cytotoxicity against human osteosarcoma cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin is potentiated by curcumin. PLoS One (2011) 0.80
Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1). Eur J Biochem (2003) 0.80
Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity. Bioorg Med Chem (2012) 0.80
Toluene dioxygenase mediated oxidation of halogen-substituted benzoate esters. Org Biomol Chem (2012) 0.80
Genome-scale sequencing to identify genes involved in Mendelian disorders. Curr Protoc Hum Genet (2013) 0.80
Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast. Bioorg Med Chem Lett (2011) 0.79
Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4). Biochem Pharmacol (2013) 0.79
Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth. J Biol Chem (2012) 0.79
Short chemoenzymatic total synthesis of ent-hydromorphone: an oxidative dearomatization/intramolecular [4+2] cycloaddition/amination sequence. Angew Chem Int Ed Engl (2014) 0.79
Investigation of steric and functionality limits in the enzymatic dihydroxylation of benzoate esters. Versatile intermediates for the synthesis of pseudo-sugars, amino cyclitols, and bicyclic ring systems. Org Biomol Chem (2009) 0.79
Stinging nettle dermatitis. Am J Contact Dermat (2003) 0.79
A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids. J Immunoassay Immunochem (2011) 0.79
Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue. J Org Chem (2013) 0.78
Heteroatom analogues of hydrocodone: synthesis and biological activity. J Org Chem (2013) 0.78