Published in Biochem J on August 15, 2004
MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. J Clin Invest (2007) 2.90
MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathog (2009) 1.69
Membrane-tethered mucins have multiple functions on the ocular surface. Exp Eye Res (2010) 1.54
Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis. Semin Cell Dev Biol (2007) 1.50
A minimal fragment of MUC1 mediates growth of cancer cells. PLoS One (2008) 1.19
Release of membrane-associated mucins from ocular surface epithelia. Invest Ophthalmol Vis Sci (2008) 1.18
MUC1* mediates the growth of human pluripotent stem cells. PLoS One (2008) 1.10
Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation. J Anat (2009) 1.05
Effect of pro-inflammatory mediators on membrane-associated mucins expressed by human ocular surface epithelial cells. Exp Eye Res (2009) 1.05
Molecular markers for breast cancer: prediction on tumor behavior. Dis Markers (2014) 1.01
The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases. J Immunol (2010) 1.00
MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling. Mol Cancer Res (2011) 1.00
Role of epithelial mucins during airway infection. Pulm Pharmacol Ther (2011) 0.89
MUC1 is a substrate for gamma-secretase. J Cell Biochem (2009) 0.88
The hamster as a model for embryo implantation: insights into a multifaceted process. Semin Cell Dev Biol (2007) 0.88
An integrated view of L-selectin and trophinin function in human embryo implantation. J Obstet Gynaecol Res (2008) 0.87
C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells. PLoS One (2011) 0.87
Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer. Br J Cancer (2012) 0.86
Post-translational regulation of signaling mucins. Curr Opin Struct Biol (2011) 0.85
MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway. Oncotarget (2014) 0.85
Peroxisome proliferator-activated receptor gamma activation inhibits progesterone-stimulated human MUC1 expression. Mol Endocrinol (2010) 0.84
Antiproteases as therapeutics to target inflammation in cystic fibrosis. Open Respir Med J (2010) 0.84
Cytokine and progesterone receptor interplay in the regulation of MUC1 gene expression. Mol Endocrinol (2010) 0.83
Immunological aspects of intestinal mucus and mucins. Nat Rev Immunol (2016) 0.83
Transmembrane mucins as novel therapeutic targets. Expert Rev Endocrinol Metab (2011) 0.82
Evidence for core 2 to core 1 O-glycan remodeling during the recycling of MUC1. Glycobiology (2013) 0.80
Novel non-invasive biomarkers that distinguish between benign prostate hyperplasia and prostate cancer. BMC Cancer (2015) 0.80
NEU1 Sialidase Regulates Membrane-tethered Mucin (MUC1) Ectodomain Adhesiveness for Pseudomonas aeruginosa and Decoy Receptor Release. J Biol Chem (2015) 0.78
Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB. Oncotarget (2016) 0.77
Mucins help to avoid alloreactivity at the maternal fetal interface. Clin Dev Immunol (2013) 0.77
Selecting Targets for Tumor Imaging: An Overview of Cancer-Associated Membrane Proteins. Biomark Cancer (2016) 0.77
HPV16 oncoproteins promote cervical cancer invasiveness by upregulating specific matrix metalloproteinases. PLoS One (2013) 0.76
SheddomeDB: the ectodomain shedding database for membrane-bound shed markers. BMC Bioinformatics (2017) 0.75
Overexpression of the A Disintegrin and Metalloproteinase ADAM15 is linked to a Small but Highly Aggressive Subset of Prostate Cancers. Neoplasia (2017) 0.75
Pre-operative evaluation of circulating KL-6 levels as a biomarker for epithelial ovarian carcinoma and its correlation with tumor MUC1 expression. Oncol Lett (2017) 0.75
Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer. J Innate Immun (2017) 0.75
An essential role for ectodomain shedding in mammalian development. Science (1998) 9.14
Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell (1999) 5.01
The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev (2003) 4.47
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A (1999) 3.85
Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol (2001) 3.32
The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol (2001) 3.22
Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem (2002) 3.03
Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme. J Biol Chem (2000) 2.92
Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J Cell Sci (1999) 2.82
Membrane protein secretases. Biochem J (1997) 2.70
The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3. J Biol Chem (1996) 2.45
Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature (1995) 2.40
Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. J Clin Invest (2000) 2.39
The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. FEBS Lett (2000) 2.03
Cell-associated episialin is a complex containing two proteins derived from a common precursor. J Biol Chem (1992) 1.90
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases. Mol Biol Cell (2000) 1.90
Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site. J Biol Chem (1997) 1.86
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion. J Biol Chem (2001) 1.69
Polyarginines are potent furin inhibitors. J Biol Chem (2000) 1.60
Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. Cancer Res (1999) 1.59
Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme. J Biol Chem (2001) 1.54
Suppression of cellular aggregation by high levels of episialin. Cancer Res (1992) 1.52
Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. J Biol Chem (1997) 1.52
Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J Biol Chem (2000) 1.48
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding. J Biol Chem (2002) 1.36
Identification of MUC1 proteolytic cleavage sites in vivo. Biochem Biophys Res Commun (2001) 1.34
Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. Cell Res (1999) 1.34
A cellular striptease act. Science (1998) 1.32
Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors. Cancer Res (1999) 1.29
Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2. J Biol Chem (2000) 1.28
Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem (2002) 1.28
Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biol Reprod (2001) 1.23
Purification of ADAM 10 from bovine spleen as a TNFalpha convertase. FEBS Lett (1997) 1.22
MUC1/episialin: a critical barrier in the female reproductive tract. J Reprod Immunol (1999) 1.22
The polymorphic epithelial mucin MUC1 in human endometrium is regulated with maximal expression in the implantation phase. J Clin Endocrinol Metab (1994) 1.20
Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase. J Biol Chem (2001) 1.17
Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases. Eur J Biochem (1997) 1.16
The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Lett (2002) 1.13
Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins. Protein Sci (2002) 1.10
Mutagenesis of a Gly-Ser cleavage site in MUC1 inhibits ectodomain shedding. Biochem Biophys Res Commun (2003) 1.09
Catalytic properties of ADAM19. J Biol Chem (2003) 1.09
Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation. Eur J Biochem (2003) 1.04
Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells. Biochem Biophys Res Commun (2002) 0.99
The product of the human MUC1 gene when secreted by mouse cells transfected with the full-length cDNA lacks the cytoplasmic tail. Biochem Biophys Res Commun (1992) 0.98
Progesterone and implanting blastocysts regulate Muc1 expression in rabbit uterine epithelium. Endocrinology (1998) 0.95
Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin. J Biol Chem (1998) 0.94
Mucins and blastocyst attachment. Rev Endocr Metab Disord (2002) 0.91
Elevated soluble MUC1 levels and decreased anti-MUC1 antibody levels in patients with multiple myeloma. Blood (2000) 0.91
Progesterone inhibits activation of latent matrix metalloproteinase (MMP)-2 by membrane-type 1 MMP: enzymes coordinately expressed in human endometrium. Biol Reprod (2000) 0.88
Regional specialization of the cell membrane-associated, polymorphic mucin (MUC1) in human uterine epithelia. Hum Reprod (1998) 0.87
Blastocyst-dependent upregulation of metalloproteinase/disintegrin MDC9 expression in rabbit endometrium. Cell Tissue Res (1998) 0.86
MUC1: a multifunctional cell surface component of reproductive tissue epithelia. Reprod Biol Endocrinol (2004) 1.52
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding. J Biol Chem (2002) 1.36
Heparanase degrades syndecan-1 and perlecan heparan sulfate: functional implications for tumor cell invasion. J Biol Chem (2003) 1.23
Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans. Cell Mol Life Sci (2009) 1.22
Synergistic stimulation of MUC1 expression in normal breast epithelia and breast cancer cells by interferon-gamma and tumor necrosis factor-alpha. J Cell Biochem (2002) 1.20
Perlecan--a multifunctional extracellular proteoglycan scaffold. Glycobiology (2007) 1.19
Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29. Dev Dyn (2007) 1.15
Chondrogenic activity of the heparan sulfate proteoglycan perlecan maps to the N-terminal domain I. J Bone Miner Res (2002) 1.09
Chondrogenic differentiation on perlecan domain I, collagen II, and bone morphogenetic protein-2-based matrices. Tissue Eng (2006) 1.06
Perlecan knockdown in metastatic prostate cancer cells reduces heparin-binding growth factor responses in vitro and tumor growth in vivo. Clin Exp Metastasis (2005) 1.05
Progesterone receptor isoforms A and B differentially regulate MUC1 expression in uterine epithelial cells. Mol Endocrinol (2006) 1.03
Repression of HIP/RPL29 expression induces differentiation in colon cancer cells. J Cell Physiol (2006) 1.01
Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells. Biochem Biophys Res Commun (2002) 0.99
Heparan sulfate proteoglycans: key players in cartilage biology. Crit Rev Eukaryot Gene Expr (2005) 0.98
Tumor necrosis factor alpha stimulates MUC1 synthesis and ectodomain release in a human uterine epithelial cell line. Endocrinology (2004) 0.98
Improved cellular specificity of plasmonic nanobubbles versus nanoparticles in heterogeneous cell systems. PLoS One (2012) 0.94
Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes. Differentiation (2005) 0.94
Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway. J Cell Biochem (2005) 0.92
A novel peptide sequence in perlecan domain IV supports cell adhesion, spreading and FAK activation. Matrix Biol (2007) 0.92
Heparan sulfate proteoglycans: coordinators of multiple signaling pathways during chondrogenesis. Birth Defects Res C Embryo Today (2004) 0.92
Paracrine factors produced by bone marrow stromal cells induce apoptosis and neuroendocrine differentiation in prostate cancer cells. Prostate (2011) 0.92
Mucins and blastocyst attachment. Rev Endocr Metab Disord (2002) 0.91
Hypoxia increases VEGF-A production by prostate cancer and bone marrow stromal cells and initiates paracrine activation of bone marrow endothelial cells. Clin Exp Metastasis (2006) 0.91
Perlecan domain IV peptide stimulates salivary gland cell assembly in vitro. Tissue Eng Part A (2009) 0.90
Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing. Endocrinology (2005) 0.89
MUC1 is a substrate for gamma-secretase. J Cell Biochem (2009) 0.88
The MUC1 Ectodomain: A Novel and Efficient Target for Gold Nanoparticle Clustering and Vapor Nanobubble Generation. Theranostics (2012) 0.88
Coculture with prostate cancer cells alters endoglin expression and attenuates transforming growth factor-beta signaling in reactive bone marrow stromal cells. Mol Cancer Res (2007) 0.88
Activated EGFR stimulates MUC1 expression in human uterine and pancreatic cancer cell lines. J Cell Biochem (2013) 0.85
The MUC1 HMFG1 glycoform is a precursor to the 214D4 glycoform in the human uterine epithelial cell line, HES. Biol Reprod (2007) 0.84
Peroxisome proliferator-activated receptor gamma activation inhibits progesterone-stimulated human MUC1 expression. Mol Endocrinol (2010) 0.84
Heparanase expression and function during early pregnancy in mice. Biol Reprod (2007) 0.84
Expression of human MUC1 during early pregnancy in the human MUC1 transgenic mouse model. Biol Reprod (2009) 0.84
Cytokine and progesterone receptor interplay in the regulation of MUC1 gene expression. Mol Endocrinol (2010) 0.83
Heparan sulfate proteoglycans and their binding proteins in embryo implantation and placentation. Semin Cell Dev Biol (2007) 0.83
MUC1 expression is repressed by protein inhibitor of activated signal transducer and activator of transcription-y. Mol Endocrinol (2007) 0.83
HIP/RPL29 antagonizes VEGF and FGF2 stimulated angiogenesis by interfering with HS-dependent responses. J Cell Biochem (2008) 0.82
Heparin/heparan sulfate interacting protein plays a role in apoptosis induced by anticancer drugs. Carcinogenesis (2004) 0.82
Compartmental distinctions in uterine Muc-1 expression during early pregnancy in cynomolgous macaque (Macaca fascicularis) and baboon (Papio anubis). Hum Reprod (2005) 0.82
Transmembrane mucins as novel therapeutic targets. Expert Rev Endocrinol Metab (2011) 0.82
Perlecan-stimulated nodules undergo chondrogenic maturation in response to rhBMP-2 treatment in vitro. Connect Tissue Res (2003) 0.81
Ribozyme-mediated perlecan knockdown impairs chondrogenic differentiation of C3H10T1/2 fibroblasts. Differentiation (2006) 0.80
A rapid and simple nonradioactive method for in vitro testing of ribozyme activity. Antisense Nucleic Acid Drug Dev (2002) 0.80
Transcriptional activation by NFκB increases perlecan/HSPG2 expression in the desmoplastic prostate tumor microenvironment. J Cell Biochem (2014) 0.80
Perlecan functions in chondrogenesis: insights from in vitro and in vivo models. Cells Tissues Organs (2004) 0.80
Spatiotemporal distribution of heparan sulfate epitopes during murine cartilage growth plate development. Histochem Cell Biol (2006) 0.78
Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells. Biol Reprod (2007) 0.77
A heparin binding synthetic peptide from human HIP / RPL29 fails to specifically differentiate between anticoagulantly active and inactive species of heparin. J Negat Results Biomed (2003) 0.77