|
1
|
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.
|
Nat Chem Biol
|
2006
|
3.30
|
|
2
|
Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding.
|
Mol Endocrinol
|
2008
|
1.70
|
|
3
|
Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta.
|
Bioorg Med Chem
|
2004
|
1.67
|
|
4
|
The soy isoflavone genistein decreases adipose deposition in mice.
|
Endocrinology
|
2003
|
1.43
|
|
5
|
Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice.
|
Cancer Res
|
2002
|
1.41
|
|
6
|
The phytoestrogen genistein induces thymic and immune changes: a human health concern?
|
Proc Natl Acad Sci U S A
|
2002
|
1.14
|
|
7
|
Acute and chronic effects of oral genistein administration in neonatal mice.
|
Biol Reprod
|
2010
|
1.12
|
|
8
|
Soy processing influences growth of estrogen-dependent breast cancer tumors.
|
Carcinogenesis
|
2004
|
1.08
|
|
9
|
Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice.
|
Carcinogenesis
|
2006
|
1.05
|
|
10
|
Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats.
|
Carcinogenesis
|
2003
|
1.04
|
|
11
|
Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations.
|
Carcinogenesis
|
2006
|
1.04
|
|
12
|
Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors.
|
Angew Chem Int Ed Engl
|
2012
|
1.03
|
|
13
|
Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice.
|
J Agric Food Chem
|
2005
|
0.96
|
|
14
|
Genistein and a soy extract differentially affect three-dimensional bone parameters and bone-specific gene expression in ovariectomized mice.
|
J Nutr
|
2009
|
0.94
|
|
15
|
Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo.
|
Carcinogenesis
|
2008
|
0.94
|
|
16
|
Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells.
|
Exp Biol Med (Maywood)
|
2010
|
0.93
|
|
17
|
beta-Sitosterol, beta-Sitosterol Glucoside, and a Mixture of beta-Sitosterol and beta-Sitosterol Glucoside Modulate the Growth of Estrogen-Responsive Breast Cancer Cells In Vitro and in Ovariectomized Athymic Mice.
|
J Nutr
|
2004
|
0.92
|
|
18
|
Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens.
|
FASEB J
|
2013
|
0.92
|
|
19
|
Selective Delivery of an Anticancer Drug with Aptamer-Functionalized Liposomes to Breast Cancer Cells in Vitro and in Vivo.
|
J Mater Chem B Mater Biol Med
|
2013
|
0.92
|
|
20
|
Effects of chronic estradiol treatment on delayed spatial alternation and differential reinforcement of low rates of responding.
|
Behav Neurosci
|
2008
|
0.91
|
|
21
|
Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats.
|
J Nutr
|
2009
|
0.87
|
|
22
|
Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice.
|
Biol Reprod
|
2004
|
0.86
|
|
23
|
Total synthesis of (S)-equol.
|
Org Lett
|
2006
|
0.86
|
|
24
|
Impact of dietary genistein and aging on executive function in rats.
|
Neurotoxicol Teratol
|
2009
|
0.84
|
|
25
|
Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats.
|
Horm Behav
|
2012
|
0.84
|
|
26
|
Genistein administered as a once-daily oral supplement had no beneficial effect on the tibia in rat models for postmenopausal bone loss.
|
Menopause
|
2013
|
0.83
|
|
27
|
Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells.
|
Endocrinology
|
2008
|
0.82
|
|
28
|
Effects of multiple daily genistein treatments on delayed alternation and a differential reinforcement of low rates of responding task in middle-aged rats.
|
Neurotoxicol Teratol
|
2011
|
0.81
|
|
29
|
Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats.
|
Toxicol Sci
|
2013
|
0.81
|
|
30
|
Dietary soy isoflavones increase metastasis to lungs in an experimental model of breast cancer with bone micro-tumors.
|
Clin Exp Metastasis
|
2015
|
0.81
|
|
31
|
Estradiol increases ER-negative breast cancer metastasis in an experimental model.
|
Clin Exp Metastasis
|
2013
|
0.80
|
|
32
|
Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice.
|
Carcinogenesis
|
2012
|
0.80
|
|
33
|
Absolute bioavailability of isoflavones from soy protein isolate-containing food in female BALB/c mice.
|
J Agric Food Chem
|
2010
|
0.80
|
|
34
|
A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice.
|
Food Chem Toxicol
|
2007
|
0.79
|
|
35
|
Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model.
|
Mol Nutr Food Res
|
2014
|
0.79
|
|
36
|
Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells.
|
In Vitro Cell Dev Biol Anim
|
2014
|
0.75
|
|
37
|
Development of a point-of-use fortification technology for delivery of micronutrients in Honduras.
|
J Sci Food Agric
|
2014
|
0.75
|