Published in Physiol Genomics on July 08, 2004
Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev (2008) 5.28
Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am (2010) 2.06
Vitamin D and the intracrinology of innate immunity. Mol Cell Endocrinol (2010) 1.50
Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease. Front Neuroendocrinol (2009) 1.16
Clinical implications of a possible role of vitamin D in multiple sclerosis. J Neurol (2009) 1.08
Vitamins E and D3 attenuate demyelination and potentiate remyelination processes of hippocampal formation of rats following local injection of ethidium bromide. Cell Mol Neurobiol (2009) 1.03
Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species. J Biol Chem (2013) 0.98
The neuropathology of obesity: insights from human disease. Acta Neuropathol (2013) 0.91
Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease. Front Immunol (2015) 0.91
Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis. Ther Adv Neurol Disord (2013) 0.89
1,25-Dihydroxyvitamin D3 suppresses TLR8 expression and TLR8-mediated inflammatory responses in monocytes in vitro and experimental autoimmune encephalomyelitis in vivo. PLoS One (2013) 0.88
Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis. J Neuroinflammation (2008) 0.87
1,25-Dihydroxyvitamin D3 selectively and reversibly impairs T helper-cell CNS localization. Proc Natl Acad Sci U S A (2013) 0.86
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures. J Neuroinflammation (2009) 0.83
Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice. PLoS One (2013) 0.82
Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. Am J Pathol (2012) 0.81
1,25-Dihydroxyvitamin D3-Conditioned CD11c+ Dendritic Cells are Effective Initiators of CNS Autoimmune Disease. Front Immunol (2015) 0.77
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A (2002) 6.00
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell (2010) 5.73
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell (2010) 5.14
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet (2007) 3.53
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One (2008) 3.25
Bayesian model selection for genome-wide epistatic quantitative trait loci analysis. Genetics (2005) 3.10
Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circ Res (2011) 2.99
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet (2008) 2.77
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet (2008) 2.63
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell (2012) 2.54
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci U S A (2009) 2.33
The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med (2003) 2.30
The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet (2007) 2.25
Evolution of the aging brain transcriptome and synaptic regulation. PLoS One (2008) 2.23
Inferring causal phenotype networks from segregating populations. Genetics (2008) 2.23
Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Nat Genet (2006) 1.97
Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc Natl Acad Sci U S A (2002) 1.97
Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. BMC Genomics (2007) 1.94
Combined expression trait correlations and expression quantitative trait locus mapping. PLoS Genet (2006) 1.93
A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis. Genetics (2008) 1.91
Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome (2009) 1.87
Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response. Aging Cell (2007) 1.87
An efficient Bayesian model selection approach for interacting quantitative trait loci models with many effects. Genetics (2007) 1.82
Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proc Natl Acad Sci U S A (2011) 1.81
Bayesian quantitative trait loci mapping for multiple traits. Genetics (2008) 1.80
Development of vocal tract length during early childhood: a magnetic resonance imaging study. J Acoust Soc Am (2005) 1.71
Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction. FASEB J (2003) 1.66
Dimension reduction for mapping mRNA abundance as quantitative traits. Genetics (2003) 1.63
CAUSAL GRAPHICAL MODELS IN SYSTEMS GENETICS: A UNIFIED FRAMEWORK FOR JOINT INFERENCE OF CAUSAL NETWORK AND GENETIC ARCHITECTURE FOR CORRELATED PHENOTYPES. Ann Appl Stat (2010) 1.62
Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility. Diabetes (2003) 1.61
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS One (2010) 1.57
Impact of nonsense-mediated mRNA decay on the global expression profile of budding yeast. PLoS Genet (2006) 1.55
Phenotypic and transcriptomic changes associated with potato autopolyploidization. Genetics (2007) 1.49
Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice. J Immunol (2005) 1.48
Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell (2010) 1.47
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J Gerontol A Biol Sci Med Sci (2007) 1.47
Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell (2009) 1.44
Empirical Bayes estimation of gene-specific effects in micro-array research. Funct Integr Genomics (2004) 1.39
Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis. Neurobiol Aging (2006) 1.37
Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction. Blood (2009) 1.37
Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. J Nutr (2006) 1.36
1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by inhibiting chemokine synthesis and monocyte trafficking. J Neurosci Res (2007) 1.35
Selective phenotyping for increased efficiency in genetic mapping studies. Genetics (2004) 1.34
SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse. Diabetes (2007) 1.30
IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J Immunol (2006) 1.30
1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur J Immunol (2011) 1.27
FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol Endocrinol (2010) 1.23
Retinoic acid enhances the T helper 2 cell development that is essential for robust antibody responses through its action on antigen-presenting cells. J Nutr (2002) 1.22
Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hear Res (2006) 1.21
Enforced bcl-xL gene expression restored splenic B lymphocyte development in BAFF-R mutant mice. J Immunol (2003) 1.21
Gene expression profiling of aging using DNA microarrays. Mech Ageing Dev (2002) 1.19
The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma. Neurobiol Aging (2007) 1.19
Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart. Physiol Genomics (2003) 1.19
Bayesian mapping of genomewide interacting quantitative trait loci for ordinal traits. Genetics (2007) 1.17
Mitochondrial oxidative damage and apoptosis in age-related hearing loss. Mech Ageing Dev (2010) 1.17
A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab (2012) 1.16
The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers. Cell Metab (2010) 1.16
Gene expression profiling studies of aging in cardiac and skeletal muscles. Cardiovasc Res (2005) 1.14
Lessons learned from gene expression profile studies of aging and caloric restriction. Ageing Res Rev (2004) 1.12
The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radic Biol Med (2004) 1.12
Estrogen controls vitamin D3-mediated resistance to experimental autoimmune encephalomyelitis by controlling vitamin D3 metabolism and receptor expression. J Immunol (2009) 1.12
Major regulatory genes in maize contribute to standing variation in teosinte (Zea mays ssp. parviglumis). Genetics (2007) 1.10
Mitochondrial DNA mutations and apoptosis in mammalian aging. Cancer Res (2006) 1.10
Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. PLoS Genet (2011) 1.10
Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain. Aging Cell (2013) 1.05
Identification of major quantitative trait loci controlling body weight variation in ob/ob mice. Diabetes (2004) 1.04
The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell (2010) 1.03
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. Hum Mol Genet (2012) 1.02
The emerging role of iron dyshomeostasis in the mitochondrial decay of aging. Mech Ageing Dev (2010) 1.00
Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets. PLoS Genet (2012) 0.98
A model selection approach for expression quantitative trait loci (eQTL) mapping. Genetics (2010) 0.98
Genes encoding mitochondrial respiratory chain components are profoundly down-regulated with aging in the cochlea of DBA/2J mice. Brain Res (2007) 0.97
A Bayesian approach for constructing genetic maps when markers are miscoded. Genet Sel Evol (2002) 0.95
Abdominal obesity in BTBR male mice is associated with peripheral but not hepatic insulin resistance. Am J Physiol Endocrinol Metab (2006) 0.94
Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice. Mitochondrion (2013) 0.94
Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells. Mol Cell Biol (2004) 0.93
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging. PLoS One (2013) 0.92
Rank-based statistical methodologies for quantitative trait locus mapping. Genetics (2003) 0.91
Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival. Endocrinology (2010) 0.91
Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice. Ann N Y Acad Sci (2004) 0.91
Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice. Exp Gerontol (2006) 0.91
Systemic autoimmunity in BAFF-R-mutant A/WySnJ strain mice. Eur J Immunol (2008) 0.90
Age and vitamin E-induced changes in gene expression profiles of T cells. J Immunol (2006) 0.90
Major QTL for carrot color are positionally associated with carotenoid biosynthetic genes and interact epistatically in a domesticated x wild carrot cross. Theor Appl Genet (2009) 0.88
Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. Am J Physiol Gastrointest Liver Physiol (2012) 0.88
Modeling causality for pairs of phenotypes in system genetics. Genetics (2013) 0.88
Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activity. DNA Repair (Amst) (2005) 0.87
Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys. Curr Aging Sci (2010) 0.86
Nonparametric estimation of the effects of quantitative trait loci. Biostatistics (2004) 0.86
Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice. BMC Neurosci (2008) 0.86