Published in Cancer Cell on May 01, 2004
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Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres. Am J Pathol (2010) 1.86
Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood (2005) 1.74
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Mol Cell Biol (2008) 1.46
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer (2015) 1.43
Oxidative stress, tumor microenvironment, and metabolic reprogramming: a diabolic liaison. Int J Cell Biol (2012) 1.29
HDAC4 protein regulates HIF1α protein lysine acetylation and cancer cell response to hypoxia. J Biol Chem (2011) 1.25
hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines. Br J Cancer (2005) 1.24
Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors. J Biomed Biotechnol (2010) 1.02
Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species. PLoS One (2012) 0.98
The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance. Oxid Med Cell Longev (2015) 0.97
HIF1α protein stability is increased by acetylation at lysine 709. J Biol Chem (2012) 0.96
Overexpression of hypoxia-inducible factor-1 alpha in gastric adenocarcinoma. Gastric Cancer (2006) 0.95
Stable tumor vessel normalization with pO₂ increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment. J Mol Med (Berl) (2013) 0.94
Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation. Nat Cell Biol (2014) 0.94
HAF : the new player in oxygen-independent HIF-1alpha degradation. Cell Cycle (2009) 0.90
The anti-EGFR antibody cetuximab sensitizes human head and neck squamous cell carcinoma cells to radiation in part through inhibiting radiation-induced upregulation of HIF-1α. Cancer Lett (2012) 0.90
Human apurinic/apyrimidinic endonuclease siRNA inhibits the angiogenesis induced by X-ray irradiation in lung cancer cells. Int J Med Sci (2013) 0.90
Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis. Am J Pathol (2011) 0.89
Hypoxia preconditioning protects corneal stromal cells against induced apoptosis. Exp Eye Res (2005) 0.87
Hypoxia-regulated overexpression of soluble VEGFR2 controls angiogenesis and inhibits tumor growth. Mol Cancer Ther (2013) 0.86
Stressing mitosis to death. Front Oncol (2014) 0.84
HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGFβ-signaling in hypoxic microenvironment. Sci Rep (2015) 0.83
Activation of AMP-Activated Protein Kinase α and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells. Evid Based Complement Alternat Med (2013) 0.81
Significant prognostic impact of chemoradiotherapy-induced hemoglobin decrease on treatment outcomes of nasopharyngeal carcinoma. J Cancer (2015) 0.80
Perspectives in cell cycle regulation: lessons from an anoxic vertebrate. Curr Genomics (2009) 0.80
Dequalinium blocks macrophage-induced metastasis following local radiation. Oncotarget (2015) 0.78
Hypoxia-Inducible Factor-1: A Critical Player in the Survival Strategy of Stressed Cells. J Cell Biochem (2016) 0.78
HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis. J Cancer Res Clin Oncol (2012) 0.78
Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia. PLoS One (2015) 0.78
In vivo visualization of heterogeneous intratumoral distribution of hypoxia-inducible factor-1α activity by the fusion of high-resolution SPECT and morphological imaging tests. J Biomed Biotechnol (2012) 0.77
Retrospective growth kinetics and radiosensitivity analysis of various human xenograft models. Lab Anim Res (2016) 0.76
Radiation-induced immune responses: mechanisms and therapeutic perspectives. Blood Res (2016) 0.76
Friend leukemia virus integration 1 expression has prognostic significance in nasopharyngeal carcinoma. Transl Oncol (2014) 0.75
Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity. Exp Mol Med (2015) 0.75
Gold nanoparticles enhance anti-tumor effect of radiotherapy to hypoxic tumor. Radiat Oncol J (2016) 0.75
Differential effects of patient-related factors on the outcome of radiation therapy for rectal cancer. J Radiat Oncol (2016) 0.75
Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent Transcriptional Activation of the Long Non-coding RNA GAPLINC. Front Physiol (2016) 0.75
Molecular characteristics of residual cancer and stromal cells after chemoradiotherapy for gastric cancer: report of four cases. Clin Case Rep (2014) 0.75
The relationship between the preoperative plasma level of HIF-1α and clinic pathological features, prognosis in non-small cell lung cancer. Sci Rep (2016) 0.75
Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound. Oncotarget (2017) 0.75
Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells. Sci Rep (2016) 0.75
Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients. Mol Clin Oncol (2012) 0.75
CRLX101, a nanoparticle-drug conjugate containing camptothecin, improves rectal cancer chemoradiotherapy by inhibiting DNA repair and HIF-1α. Cancer Res (2016) 0.75
HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer. Oncotarget (2017) 0.75