Published in Biochem J on August 15, 2004
The transcriptional repressor DEC2 regulates sleep length in mammals. Science (2009) 3.12
Molecular architecture of the mammalian circadian clock. Trends Cell Biol (2013) 2.26
DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol (2008) 1.31
Circadian rhythm disruption in cancer biology. Mol Med (2012) 1.31
The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels. PLoS Genet (2012) 1.25
Expression levels of estrogen receptor beta are modulated by components of the molecular clock. Mol Cell Biol (2007) 1.01
SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability. PLoS One (2011) 1.00
The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior. PLoS One (2013) 0.90
A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans. Sleep (2014) 0.89
A fluorescence spotlight on the clockwork development and metabolism of bone. J Bone Miner Metab (2011) 0.84
Suppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancer. BMC Cancer (2014) 0.82
SHARP1 suppresses angiogenesis of endometrial cancer by decreasing hypoxia-inducible factor-1α level. PLoS One (2014) 0.82
Circadian gene variants in cancer. Ann Med (2014) 0.81
DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression. J Cancer (2016) 0.79
Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age. J Biol Chem (2015) 0.78
DEC2-E4BP4 Heterodimer Represses the Transcriptional Enhancer Activity of the EE Element in the Per2 Promoter. Front Neurol (2015) 0.77
Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells. Mol Cell Biol (2015) 0.77
Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function. Curr Opin Neurobiol (2013) 0.76
DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. Biochem Pharmacol (2012) 0.75
CLOCKWORK ORANGE Enhances PERIOD Mediated Rhythms in Transcriptional Repression by Antagonizing E-box Binding by CLOCK-CYCLE. PLoS Genet (2016) 0.75
Bone muscle crosstalk targets muscle regeneration pathway regulated by core circadian transcriptional repressors DEC1 and DEC2. Bonekey Rep (2016) 0.75
Retinoid X Receptors Intersect the Molecular Clockwork in the Regulation of Liver Metabolism. Front Endocrinol (Lausanne) (2017) 0.75
Coordination of circadian timing in mammals. Nature (2002) 18.47
Molecular bases for circadian clocks. Cell (1999) 13.96
Role of the CLOCK protein in the mammalian circadian mechanism. Science (1998) 10.03
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell (2002) 9.92
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell (1999) 8.38
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science (1994) 7.83
Interacting molecular loops in the mammalian circadian clock. Science (2000) 6.90
A transcription factor response element for gene expression during circadian night. Nature (2002) 6.55
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell (2002) 6.05
The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A (1998) 4.20
A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell (1999) 4.08
Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature (2002) 3.75
Targeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol Cell Biol (2000) 2.69
Stopping time: the genetics of fly and mouse circadian clocks. Annu Rev Neurosci (2001) 2.44
Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells. Genes Dev (1997) 2.03
The network of time: understanding the molecular circadian system. Curr Biol (2003) 1.83
Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms. Proc Natl Acad Sci U S A (2000) 1.73
Defective T cell activation and autoimmune disorder in Stra13-deficient mice. Nat Immunol (2001) 1.51
The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription. Genomics (2000) 1.51
Role of DBP in the circadian oscillatory mechanism. Mol Cell Biol (2000) 1.44
mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression. J Biol Chem (2003) 1.35
Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. Biochem Biophys Res Commun (1997) 1.35
Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation. Biochem J (2002) 1.29
CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J Biol Chem (2000) 1.27
Stra13 homodimers repress transcription through class B E-box elements. J Biol Chem (2002) 1.25
Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. J Biol Chem (2002) 1.23
DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J Biol Chem (2003) 1.21
Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain. J Biol Chem (1999) 1.20
The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs. J Biol Chem (2003) 1.19
Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. Biochem Biophys Res Commun (2001) 1.12
A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun (2004) 1.10
SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Mol Cell Neurosci (1997) 1.07
Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization. Am J Physiol Cell Physiol (2002) 1.04
Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP. Genes Cells (2004) 0.97
Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/Sharp2 in response to the cyclic adenosine monophosphate pathway. Eur J Cell Biol (2001) 0.94
The basic helix-loop-helix protein, sharp-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism. J Biol Chem (2001) 0.88
Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of Clock mutant mice. J Biol Rhythms (2004) 0.82
Circadian rhythms: finer clock control. Nature (2002) 0.79
Effects of overexpression of membrane-bound transferrin-like protein (MTf) on chondrogenic differentiation in Vitro. J Biol Chem (2002) 0.78
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med (2009) 11.28
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med (2007) 5.89
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem (2006) 5.57
Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem (2002) 4.79
Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med (2002) 4.25
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem (2002) 4.16
Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem (2003) 4.08
Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes (2007) 3.87
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature (2008) 3.82
Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature (2002) 3.75
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab (2005) 3.49
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab (2007) 3.43
Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem (2002) 3.05
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes (2002) 3.04
The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature (2007) 3.01
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest (2007) 2.81
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest (2008) 2.78
Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care (2006) 2.77
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med (2002) 2.61
Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy. Circ Res (2002) 2.59
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology (2003) 2.52
Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res (2003) 2.47
Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest (2009) 2.46
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab (2011) 2.42
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem (2002) 2.40
Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production. DNA Res (2008) 2.37
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther (2002) 2.36
Clinical profiles and outcomes of acute type B aortic dissection in the current era: lessons from the International Registry of Aortic Dissection (IRAD). Circulation (2003) 2.32
Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes. J Cell Biol (2003) 2.24
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. Nat Med (2008) 2.16
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem (2004) 2.15
G-CSF stimulates angiogenesis and promotes tumor growth: potential contribution of bone marrow-derived endothelial progenitor cells. Biochem Biophys Res Commun (2002) 2.13
Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. Nature (2002) 2.09
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med (2010) 2.08
Mid-term results and costs of coronary artery bypass vs drug-eluting stents for unprotected left main coronary artery disease. Circ J (2010) 2.08
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem (2006) 1.93
Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening. Lancet (2002) 1.92
Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem Biophys Res Commun (2004) 1.92
The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages. Circ Res (2010) 1.92
A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. Gastroenterology (2003) 1.91
Age and preoperative total bilirubin level can stratify prognosis after extracorporeal pulsatile left ventricular assist device implantation. Circ J (2010) 1.91
Staphylococcus aureus susceptibility to innate antimicrobial peptides, beta-defensins and CAP18, expressed by human keratinocytes. Infect Immun (2003) 1.90
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest (2004) 1.88
In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension (2002) 1.88
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab (2008) 1.86
Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity. Proc Natl Acad Sci U S A (2007) 1.84
Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages. Circulation (2010) 1.83
Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals. Arterioscler Thromb Vasc Biol (2005) 1.82
Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5. Circ Res (2005) 1.82
Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries. Circ Res (2003) 1.80
Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway. J Biol Chem (2006) 1.78
Characterization of the mouse aortic carboxypeptidase-like protein promoter reveals activity in differentiated and dedifferentiated vascular smooth muscle cells. Circ Res (2002) 1.78
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell Metab (2012) 1.77
PPARgamma ligand inhibits osteopontin gene expression through interference with binding of nuclear factors to A/T-rich sequence in THP-1 cells. Circ Res (2002) 1.75
DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell (2006) 1.75
Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol (2011) 1.74
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. J Am Soc Nephrol (2009) 1.70
Ultrasound-microbubble-mediated intercellular adhesion molecule-1 small interfering ribonucleic acid transfection attenuates neointimal formation after arterial injury in mice. J Am Coll Cardiol (2010) 1.68
Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A (2012) 1.61
Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals. J Rheumatol (2009) 1.58
Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c. Endocrinology (2004) 1.58
Novel risk scoring system with preoperative objective parameters gives a good prediction of 1-year mortality in patients with a left ventricular assist device. Circ J (2012) 1.56
The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response. Arterioscler Thromb Vasc Biol (2011) 1.56
Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice. J Clin Invest (2011) 1.56
Relationship between the structure of SET/TAF-Ibeta/INHAT and its histone chaperone activity. Proc Natl Acad Sci U S A (2007) 1.55
Fatty liver incidence and predictive variables. Hypertens Res (2010) 1.54
Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats. Arterioscler Thromb Vasc Biol (2005) 1.54
Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis. J Hepatol (2013) 1.52
Klf5 is involved in self-renewal of mouse embryonic stem cells. J Cell Sci (2008) 1.51
Preoperative levels of bilirubin or creatinine adjusted by age can predict their reversibility after implantation of left ventricular assist device. Circ J (2012) 1.51
Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells. J Antimicrob Chemother (2005) 1.50
Incidence and prognostic value of early repolarization pattern in the 12-lead electrocardiogram. Circulation (2011) 1.49
Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene. Circ Res (2002) 1.49
Comprehensive analysis of chemotactic factors for bone marrow mesenchymal stem cells. Stem Cells Dev (2007) 1.49
Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. J Biol Chem (2002) 1.48
Differences in body temperature variability between subjects with and without diabetes and predictive value for cardiovascular events. Circ J (2013) 1.47
Regulation of smooth muscle cell differentiation by AT-rich interaction domain transcription factors Mrf2alpha and Mrf2beta. Circ Res (2002) 1.47
Relationship between renal dysfunction and severity of coronary artery disease in Japanese patients. Circ J (2010) 1.46
Combination evaluation of preoperative risk indices predicts requirement of biventricular assist device. Circ J (2012) 1.46
Intensively lowering both low-density lipoprotein cholesterol and blood pressure does not reduce cardiovascular risk in Japanese coronary artery disease patients. Circ J (2011) 1.45
iMap-Intravascular Ultrasound Radiofrequency Signal Analysis Reflects Plaque Components of Optical Coherence Tomography-Derived Thin-Cap Fibroatheroma. Circ J (2015) 1.45
Vascular implications of the Krüppel-like family of transcription factors. Arterioscler Thromb Vasc Biol (2005) 1.45
Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy. Clin Sci (Lond) (2004) 1.44