Published in J Neurochem on June 01, 2004
Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity. J Biol Chem (2009) 1.16
Multiple synaptic and membrane sites of anesthetic action in the CA1 region of rat hippocampal slices. BMC Neurosci (2004) 1.08
Selection for drinking in the dark alters brain gene coexpression networks. Alcohol Clin Exp Res (2013) 1.04
Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development? Br J Pharmacol (2008) 1.04
Molecular targets and mechanisms for ethanol action in glycine receptors. Pharmacol Ther (2010) 1.03
Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors. J Neurochem (2008) 1.02
Zinc enhances ethanol modulation of the alpha1 glycine receptor. Neuropharmacology (2009) 0.99
Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcohol Clin Exp Res (2011) 0.99
A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors. J Neurochem (2009) 0.95
Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. J Biol Chem (2008) 0.90
Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors. J Pharmacol Exp Ther (2012) 0.90
Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics. Pharmacol Rev (2014) 0.90
Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. Alcohol Clin Exp Res (2013) 0.88
Zinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol. Alcohol Clin Exp Res (2013) 0.85
Glycine as a neurotransmitter in the forebrain: a short review. J Neural Transm (Vienna) (2009) 0.84
Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research. Mol Pharmacol (2014) 0.78
Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol. Neuroscience (2015) 0.75
Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci (2005) 2.91
Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature (2003) 2.89
Ethanol's molecular targets. Sci Signal (2008) 2.06
Structural basis for alcohol modulation of a pentameric ligand-gated ion channel. Proc Natl Acad Sci U S A (2011) 1.52
Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor. Biophys J (2011) 1.42
Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors. J Neurochem (2007) 1.26
Charged residues in the beta2 subunit involved in GABAA receptor activation. J Biol Chem (2003) 1.18
Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity. J Biol Chem (2009) 1.16
Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent. Alcohol Clin Exp Res (2002) 1.16
Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors. J Pharmacol Exp Ther (2003) 1.14
The common chemical motifs within anesthetic binding sites. Anesth Analg (2007) 1.13
Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics. J Biol Chem (2004) 1.10
Ethanol differentially affects ATP-gated P2X(3) and P2X(4) receptor subtypes expressed in Xenopus oocytes. Neuropharmacology (2005) 1.10
A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists. J Biol Chem (2004) 1.09
Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. Neuropharmacology (2002) 1.08
Accessibility to residues in transmembrane segment four of the glycine receptor. Neuropharmacology (2005) 1.08
Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation. J Neurochem (2007) 1.08
Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4. J Chem Inf Model (2010) 1.05
Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant. J Neurosci (2003) 1.04
General anesthetics have additive actions on three ligand gated ion channels. Anesth Analg (2008) 1.03
Molecular targets and mechanisms for ethanol action in glycine receptors. Pharmacol Ther (2010) 1.03
Endothelial fate mapping in mice with pulmonary hypertension. Circulation (2013) 1.02
Ivermectin reduces alcohol intake and preference in mice. Neuropharmacology (2012) 1.02
Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors. J Neurochem (2008) 1.02
Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors. J Pharmacol Exp Ther (2010) 1.01
Homology modeling of a human glycine alpha 1 receptor reveals a plausible anesthetic binding site. J Chem Inf Model (2005) 1.01
Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis. Neurobiol Dis (2013) 1.00
Anesthetic and ethanol effects on spontaneously opening glycine receptor channels. J Neurochem (2002) 1.00
Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther (2011) 0.99
Zinc enhances ethanol modulation of the alpha1 glycine receptor. Neuropharmacology (2009) 0.99
Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcohol Clin Exp Res (2011) 0.99
Cross-linking of glycine receptor transmembrane segments two and three alters coupling of ligand binding with channel opening. J Neurochem (2004) 0.97
Single-channel analysis of ethanol enhancement of glycine receptor function. J Pharmacol Exp Ther (2009) 0.97
An animal model of cortical and callosal pathology in multiple sclerosis. Brain Pathol (2010) 0.97
Normal-mode analysis of the glycine alpha1 receptor by three separate methods. J Chem Inf Model (2007) 0.96
Inhaled drugs of abuse enhance serotonin-3 receptor function. Drug Alcohol Depend (2003) 0.95
A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors. J Neurochem (2009) 0.95
Molecular mechanism for the dual alcohol modulation of Cys-loop receptors. PLoS Comput Biol (2012) 0.95
Identification of novel specific allosteric modulators of the glycine receptor using phage display. J Biol Chem (2010) 0.95
Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. Alcohol Clin Exp Res (2003) 0.94
A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics. J Pharmacol Exp Ther (2010) 0.94
Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation. Proc Natl Acad Sci U S A (2010) 0.93
Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation. Biochemistry (2004) 0.93
Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors. Neurosci Lett (2004) 0.93
Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin. Int J Neuropsychopharmacol (2012) 0.92
Attenuation of corpus callosum axon myelination and remyelination in the absence of circulating sex hormones. Brain Pathol (2013) 0.91
Ethanol is a fast channel inhibitor of P2X4 receptors. J Pharmacol Exp Ther (2011) 0.90
Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors. Neuropharmacology (2008) 0.90
Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function. J Biol Chem (2005) 0.90
Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics. Pharmacol Rev (2014) 0.90
Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. J Biol Chem (2008) 0.90
Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors. J Pharmacol Exp Ther (2012) 0.90
Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor. Anesthesiology (2013) 0.90
Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin. Biophys J (2013) 0.90
Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors. Biochemistry (2006) 0.89
Are sobriety and consciousness determined by water in protein cavities? Alcohol Clin Exp Res (2004) 0.89
Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives. Biochemistry (2003) 0.88
GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites. J Neurochem (2013) 0.88
Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. Alcohol Clin Exp Res (2013) 0.88
Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein. J Chem Inf Model (2008) 0.86
Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo. J Pharmacol Exp Ther (2012) 0.86
Ethanol enhances taurine-activated glycine receptor function. Alcohol Clin Exp Res (2010) 0.85
Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites. Structure (2013) 0.85
Zinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol. Alcohol Clin Exp Res (2013) 0.85
Positive allosteric modulators differentially affect full versus partial agonist activation of the glycine receptor. J Pharmacol Exp Ther (2012) 0.85
Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice. Neurochem Res (2014) 0.85
Identifying the binding site(s) for antidepressants on the Torpedo nicotinic acetylcholine receptor: [3H]2-azidoimipramine photolabeling and molecular dynamics studies. Biochim Biophys Acta (2008) 0.84
Effects of a mutation in the TM2-TM3 linker region of the glycine receptor alpha1 subunit on gating and allosteric modulation. Brain Res (2007) 0.84
Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor. Int Rev Neurobiol (2003) 0.84
Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors. Alcohol Clin Exp Res (2006) 0.83
The TM2 6' position of GABA(A) receptors mediates alcohol inhibition. J Pharmacol Exp Ther (2011) 0.82
Amino acids in transmembrane domain two influence anesthetic enhancement of serotonin-3A receptor function. Brain Res Mol Brain Res (2003) 0.82
Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human alpha(1)beta glycine receptors. J Physiol (2002) 0.81
Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice. Neuropsychopharmacology (2013) 0.80
Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans. Neuroreport (2014) 0.79
Normal mode gating motions of a ligand-gated ion channel persist in a fully hydrated lipid bilayer model. ACS Chem Neurosci (2010) 0.79
Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice. Anesthesiology (2012) 0.78
Benzodiazepine agonist and inverse agonist coupling in GABAA receptors antagonized by increased atmospheric pressure. Eur J Pharmacol (2003) 0.77
The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms. Anesth Analg (2006) 0.76
Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics. ACS Chem Neurosci (2014) 0.76
Induced changes in protein receptors conferring resistance to anesthetics. Curr Opin Anaesthesiol (2012) 0.75