Published in Br J Pharmacol on May 17, 2004
The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. Int J Mol Sci (2013) 1.07
Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes. Am J Physiol Cell Physiol (2008) 1.02
Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review). Exp Ther Med (2011) 0.93
Edaravone inhibits apoptosis caused by ischemia/reperfusion injury in a porcine hepatectomy model. World J Gastroenterol (2012) 0.83
Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart. Heart Vessels (2009) 0.80
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks. Sci Rep (2017) 0.75
Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals. Circ Res (2000) 3.19
Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther (1994) 2.61
Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure. Congest Heart Fail (2002) 2.18
Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1. Circulation (2001) 2.06
Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone. J Clin Invest (1988) 2.02
Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion. Circ Res (2000) 1.47
Myocardial protection of MCI-186 in rabbit ischemia-reperfusion. Life Sci (2002) 1.40
Activation of mitochondrial ATP-dependent potassium channels by nitric oxide. Circulation (2000) 1.39
Mechanistically distinct steps in the mitochondrial death pathway triggered by oxidative stress in cardiac myocytes. Circ Res (2003) 1.26
Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction. Circulation (1994) 1.21
Mitochondrial electron transport can become a significant source of oxidative injury in cardiomyocytes. J Mol Cell Cardiol (1997) 1.21
Hospital-based study of the care and cost of acute ischemic stroke in Japan. Stroke (2003) 1.14
Free radicals and reperfusion-induced arrhythmias: protection by spin trap agent PBN in the rat heart. Circ Res (1987) 1.08
Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion. Free Radic Biol Med (1999) 1.07
Cellular electrophysiological basis for oxygen radical-induced arrhythmias. A patch-clamp study in guinea pig ventricular myocytes. Circulation (1991) 1.03
Adenosine primes the opening of mitochondrial ATP-sensitive potassium channels: a key step in ischemic preconditioning? Circulation (2000) 0.97
Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol (2003) 0.96
Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver. Eur J Pharmacol (2003) 0.95
Lecithinized Cu, Zn-superoxide dismutase limits the infarct size following ischemia-reperfusion injury in rat hearts in vivo. Biochem Biophys Res Commun (2001) 0.93
Superoxide dismutase conjugated to polyethylene glycol provides sustained protection against myocardial ischemia/reperfusion injury in canine heart. Circ Res (1988) 0.93
An in vitro model of myocardial ischemia utilizing isolated adult rat myocytes. J Mol Cell Cardiol (1990) 0.93
Reperfusion-induced arrhythmias and free radicals: studies in the rat heart with DMPO. J Cardiovasc Pharmacol (1987) 0.91
Reperfusion-induced injury: a possible role for oxidant stress and its manipulation. Cardiovasc Drugs Ther (1991) 0.90
Free radical generation coupled with arachidonate lipoxygenase reaction relates to reoxygenation induced myocardial cell injury. Cardiovasc Res (1993) 0.87
MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning. Circulation (2003) 0.84
Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart. Free Radic Res (1996) 0.83
Sarcomere length during contraction of isolated guinea-pig ventricular myocytes. Pflugers Arch (1999) 0.83
Demonstration of hydroxyl radical and its role in hydrogen peroxide-induced myocardial injury: hydroxyl radical dependent and independent mechanisms. Free Radic Biol Med (1993) 0.82
Water-soluble antioxidant specificity against free radical injury using cultured human ventricular myocytes and fibroblasts and saphenous vein endothelial cells. J Mol Cell Cardiol (1990) 0.82
Correlation between direct ESR spectroscopic measurements and electromechanical and biochemical assessments of exogenous free radical injury in isolated rat cardiac myocytes. Free Radic Biol Med (1998) 0.80
Inverse relationship between ESR spin trapping of oxyradicals and degree of functional recovery during myocardial reperfusion in isolated working rat heart. Cardiovasc Res (1990) 0.79
Superoxide dismutase does protect the cultured rat cardiac myocytes against hypoxia/reoxygenation injury. Free Radic Res (1997) 0.77
Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice. J Clin Invest (2002) 2.74
Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography. J Am Coll Cardiol (2008) 2.33
Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J Biol Chem (2008) 2.09
Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell. Am J Physiol Heart Circ Physiol (2002) 1.94
Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol (2010) 1.88
Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion. J Am Soc Nephrol (2004) 1.87
Appropriate use of nasal continuous positive airway pressure decreases elevated C-reactive protein in patients with obstructive sleep apnea. Chest (2009) 1.75
Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study. Circ Heart Fail (2009) 1.73
Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia. Circ J (2015) 1.55
Transient left ventricular apical ballooning in a patient with bicuspid aortic valve created a left ventricular thrombus leading to acute renal infarction. Circ J (2004) 1.52
Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin. J Hum Genet (2006) 1.48
Electrophysiological properties of prion-positive cardiac progenitors derived from murine embryonic stem cells. Circ J (2012) 1.40
Addition of losartan to angiotensin-converting enzyme inhibitors improves insulin resistance in patients with chronic heart failure treated without β-blockers. Circ J (2010) 1.38
Left atrial branches of coronary arteries; clinical implications related to linear catheter ablation for atrial fibrillation. J Interv Card Electrophysiol (2009) 1.38
Brachiocephalic vein perforation on three-dimensional computed tomography. Europace (2007) 1.38
Hepatocyte growth factor exerts a proliferative effect on oval cells through the PI3K/AKT signaling pathway. Biochem Biophys Res Commun (2003) 1.17
Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients. Am J Hypertens (2008) 1.15
Ubiquitin-proteasome system impairment caused by a missense cardiac myosin-binding protein C mutation and associated with cardiac dysfunction in hypertrophic cardiomyopathy. J Mol Biol (2008) 1.15
Status of endothelial dependent vasodilation in patients with hyperuricemia. Am J Cardiol (2005) 1.14
Lentiviral vectors bearing the cardiac promoter of the Na+-Ca2+ exchanger report cardiogenic differentiation in stem cells. Mol Ther (2008) 1.13
Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout. Clin Exp Nephrol (2014) 1.09
Roles of L-type Ca2+ and delayed-rectifier K+ currents in sinoatrial node pacemaking: insights from stability and bifurcation analyses of a mathematical model. Am J Physiol Heart Circ Physiol (2003) 1.03
Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1. Biochem Biophys Res Commun (2004) 1.00
Dynamical mechanisms of pacemaker generation in IK1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical model. Biophys J (2005) 0.99
Regional difference in dynamical property of sinoatrial node pacemaking: role of na+ channel current. Biophys J (2008) 0.99
Pharmacogenetic determinants of variability in lipid-lowering response to pravastatin therapy. J Hum Genet (2006) 0.99
Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells. J Clin Endocrinol Metab (2002) 0.98
Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells. Mol Cell Endocrinol (2013) 0.96
Abnormally high expression of proteasome activator-gamma in thyroid neoplasm. J Clin Endocrinol Metab (2003) 0.96
Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts. Circ J (2003) 0.95
Mechanism of iodide/chloride exchange by pendrin. Endocrinology (2004) 0.93
Hepatic differentiation of human bone marrow-derived UE7T-13 cells: Effects of cytokines and CCN family gene expression. Hepatol Res (2007) 0.93
Allopurinol reduces neointimal hyperplasia in the carotid artery ligation model in spontaneously hypertensive rats. Hypertens Res (2006) 0.92
Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ Res (2010) 0.92
Genetic analysis of expression profile involved in retinoid metabolism in non-alcoholic fatty liver disease. Hepatol Res (2010) 0.92
A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells. Am J Physiol Gastrointest Liver Physiol (2007) 0.91
Plasma endothelin-1 levels and clinical correlates in patients with chronic heart failure. J Card Fail (2003) 0.91
Disrupted plasma membrane localization of equilibrative nucleoside transporter 2 in the chemoresistance of human pancreatic cells to gemcitabine (dFdCyd). Cancer Sci (2011) 0.90
Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload. FASEB J (2002) 0.88
Effects of pacemaker currents on creation and modulation of human ventricular pacemaker: theoretical study with application to biological pacemaker engineering. Am J Physiol Heart Circ Physiol (2006) 0.87
Impairment of ubiquitin-proteasome system by E334K cMyBPC modifies channel proteins, leading to electrophysiological dysfunction. J Mol Biol (2011) 0.87
Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: insights from bifurcation analysis of mathematical models. Am J Physiol Heart Circ Physiol (2012) 0.86
Metaboli-Net: online groupware system providing counseling guidance for patients with metabolic syndrome. Stud Health Technol Inform (2010) 0.86
Analyses to clarify rich fractions in hepatic progenitor cells from human umbilical cord blood and cell fusion. Biochem Biophys Res Commun (2004) 0.85
Floating thrombus arising from left sinus of Valsalva induced intermittent occlusion of left coronary artery and caused cardiogenic shock. Int J Cardiol (2006) 0.85
Chemical chaperone therapy: chaperone effect on mutant enzyme and cellular pathophysiology in β-galactosidase deficiency. Hum Mutat (2011) 0.85
Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins. Cardiovasc Res (2013) 0.85
Age-related BM-MNC dysfunction hampers neovascularization. Mech Ageing Dev (2007) 0.85
c-Jun N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cells. Cancer Sci (2011) 0.84
Evidence for proteasomal degradation of Kv1.5 channel protein. Biochem Biophys Res Commun (2005) 0.84
Proinflammatory cytokine activation is linked to apoptotic mediator, soluble Fas level in patients with chronic heart failure. Int Heart J (2012) 0.84
The status of hypertension management in Japan in 2000. Hypertens Res (2002) 0.84
Subtype switching of T-type Ca 2+ channels from Cav3.2 to Cav3.1 during differentiation of embryonic stem cells to cardiac cell lineage. Circ J (2005) 0.84