Published in Oncogene on May 24, 2004
The regulation of IgA class switching. Nat Rev Immunol (2008) 2.92
Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β. Nat Immunol (2011) 1.94
Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem (2010) 1.69
Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci (2007) 1.61
USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol (2011) 1.61
Metastatic bone disease: role of transcription factors and future targets. Bone (2010) 1.30
Novel RING E3 ubiquitin ligases in breast cancer. Neoplasia (2006) 1.14
Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis. Proc Natl Acad Sci U S A (2005) 1.13
Signaling networks that control the lineage commitment and differentiation of bone cells. Crit Rev Eukaryot Gene Expr (2009) 1.11
Age-dependent alteration of TGF-β signalling in osteoarthritis. Cell Tissue Res (2011) 1.10
TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development. Dev Biol (2008) 1.07
Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts. Cancer Res (2007) 1.07
Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein. Mol Cell Biol (2005) 1.03
Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes. Arthritis Res Ther (2012) 1.02
Differential requirements for HIV-1 Vif-mediated APOBEC3G degradation and RUNX1-mediated transcription by core binding factor beta. J Virol (2012) 0.99
Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes. J Cell Physiol (2009) 0.97
TGF-β superfamily gene expression and induction of the Runx1 transcription factor in adult neurogenic regions after brain injury. PLoS One (2013) 0.97
Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells. J Cell Physiol (2009) 0.95
Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src. Am J Respir Cell Mol Biol (2007) 0.94
Wnt and the Wnt signaling pathway in bone development and disease. Front Biosci (Landmark Ed) (2014) 0.94
Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals. J Biol Chem (2012) 0.93
Is Runx a linchpin for developmental signaling in metazoans? J Cell Biochem (2009) 0.90
Genomic and proteomic profiling II: comparative assessment of gene expression profiles in leiomyomas, keloids, and surgically-induced scars. Reprod Biol Endocrinol (2007) 0.88
Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway. J Biol Chem (2011) 0.88
RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression. Mol Cancer (2015) 0.87
Segmental bone defects: from cellular and molecular pathways to the development of novel biological treatments. J Cell Mol Med (2010) 0.87
The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes. Int J Mol Sci (2015) 0.86
Runx expression is mitogenic and mutually linked to Wnt activity in blastula-stage sea urchin embryos. PLoS One (2008) 0.85
Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes. PLoS One (2014) 0.85
The genetics of systemic lupus erythematosus: understanding how SNPs confer disease susceptibility. Springer Semin Immunopathol (2006) 0.84
TGF-beta1 modulates focal adhesion kinase expression in rat intestinal epithelial IEC-6 cells via stimulatory and inhibitory Smad binding elements. Biochim Biophys Acta (2008) 0.83
The predictive value of genes of the TGF-beta1 pathway in multimodally treated squamous cell carcinoma of the esophagus. Int J Colorectal Dis (2009) 0.82
Distinct contributions of conserved modules to Runt transcription factor activity. Mol Biol Cell (2010) 0.82
JAK2-STAT5B pathway and osteoblast differentiation. JAKSTAT (2013) 0.79
Associations between genetic variants in the TGF-β signaling pathway and breast cancer risk among Hispanic and non-Hispanic white women. Breast Cancer Res Treat (2013) 0.78
Investigation of methylation and protein expression of the Runx3 gene in colon carcinogenesis. Biomed Rep (2015) 0.77
RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells. Oncotarget (2015) 0.77
Taking cues from the extracellular matrix to design bone-mimetic regenerative scaffolds. Matrix Biol (2016) 0.75
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell (2008) 10.49
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell (2010) 8.69
BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev (2005) 3.97
JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem (2005) 2.76
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol (2008) 2.73
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun (2013) 2.31
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 2.25
Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. J Natl Cancer Inst (2005) 2.23
Clinical implications of reconnection between the left atrium and isolated pulmonary veins provoked by adenosine triphosphate after extensive encircling pulmonary vein isolation. J Cardiovasc Electrophysiol (2007) 1.88
Role of Ras signaling in the induction of snail by transforming growth factor-beta. J Biol Chem (2008) 1.83
Regulation of TGF-beta family signaling by E3 ubiquitin ligases. Cancer Sci (2008) 1.79
Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Mol Biol Cell (2003) 1.78
Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J (2004) 1.77
Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol (2008) 1.77
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol (2004) 1.75
Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. EMBO J (2003) 1.68
The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci (2005) 1.67
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J Biol Chem (2002) 1.61
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. J Biol Chem (2005) 1.60
Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats. J Clin Invest (2004) 1.57
Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling. Int J Cancer (2003) 1.54
Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line. Cancer Sci (2007) 1.45
Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol Biol Cell (2002) 1.45
Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Hypertens Res (2010) 1.43
Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Oncogene (2004) 1.42
Regulation of TGF-beta signaling and its roles in progression of tumors. Cancer Sci (2003) 1.42
Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells. Proc Natl Acad Sci U S A (2008) 1.41
Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation. Mol Cell Biol (2007) 1.41
Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling. J Biol Chem (2007) 1.35
Differential ubiquitination defines the functional status of the tumor suppressor Smad4. J Biol Chem (2003) 1.33
FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes. J Biol Chem (2009) 1.29
Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes. Endocrinology (2006) 1.28
CCAAT/enhancer-binding protein beta promotes osteoblast differentiation by enhancing Runx2 activity with ATF4. Mol Biol Cell (2008) 1.27
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. J Biol Chem (2008) 1.24
Runx1 and Runx2 cooperate during sternal morphogenesis. Development (2010) 1.24
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol (2005) 1.23
Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma. Oncol Rep (2011) 1.21
Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab (2007) 1.21
Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. Cancer Res (2007) 1.21
CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation. Mol Cell Biol (2006) 1.20
Two-photon voltage imaging using a genetically encoded voltage indicator. Sci Rep (2013) 1.20
Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Am J Physiol Endocrinol Metab (2009) 1.19
Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia. J Cell Biol (2004) 1.19
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. Cancer Res (2003) 1.18
Promoter-wide analysis of Smad4 binding sites in human epithelial cells. Cancer Sci (2009) 1.18
Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. Diabetes (2005) 1.18
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins. J Biol Chem (2009) 1.16
Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors. J Biol Chem (2007) 1.15
Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Mol Cell Biol (2002) 1.12
Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes. J Biol Chem (2003) 1.10
SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells. J Biol Chem (2008) 1.10
GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J (2004) 1.10
Estrogen inhibits transforming growth factor beta signaling by promoting Smad2/3 degradation. J Biol Chem (2010) 1.09
Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. Proc Natl Acad Sci U S A (2004) 1.08
Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol (2002) 1.05
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem (2004) 1.05
Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7. J Biol Chem (2003) 1.05
Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res (2002) 1.00
Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem (2005) 1.00
Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex. J Biol Chem (2007) 1.00
Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN. J Biol Chem (2002) 0.99
HTLV-1 bZIP factor enhances TGF-β signaling through p300 coactivator. Blood (2011) 0.99
Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. Mol Biol Cell (2003) 0.97
Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling. J Biol Chem (2004) 0.97
Regulation of RANKL-induced osteoclastogenesis by TGF-β through molecular interaction between Smad3 and Traf6. J Bone Miner Res (2011) 0.97
Bioluminescent system for dynamic imaging of cell and animal behavior. Biochem Biophys Res Commun (2012) 0.96
Self-oscillating gel as novel biomimetic materials. J Control Release (2009) 0.95
Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation. Bone (2009) 0.94
Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells. J Biol Chem (2011) 0.94
Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells. Autophagy (2011) 0.93
Self-oscillating soluble-insoluble changes of a polymer chain including an oxidizing agent induced by the Belousov-Zhabotinsky reaction. J Phys Chem B (2005) 0.92
SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways. J Biol Chem (2012) 0.92
In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives. BMC Neurosci (2010) 0.91
Design of a mass transport surface utilizing peristaltic motion of a self-oscillating gel. Langmuir (2009) 0.90
Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts. PLoS One (2010) 0.90
Intravital multiphoton fluorescence imaging and optical manipulation of spinal cord in mice, using a compact fiber laser system. Lasers Surg Med (2014) 0.89
Molecular typing of Salmonella enterica serotype Typhimurium and serotype 4,5,12:i:- isolates from cattle by multiple-locus variable-number tandem-repeats analysis. Vet Microbiol (2012) 0.89
Nuclear and cytoplasmic c-Ski differently modulate cellular functions. Genes Cells (2006) 0.89
Laparoscopic-assisted limited liver resection: technique, indications and results. J Hepatobiliary Pancreat Surg (2009) 0.89
Surgery for advanced gastric cancer after coronary artery bypass grafting using the right gastroepiploic artery: report of a case. Surg Today (2004) 0.87
Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5. Genes Cells (2004) 0.87
RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity. J Biol Chem (2011) 0.87
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Mol Cell Biol (2004) 0.86
Genomewide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis. J Bone Miner Res (2015) 0.86
Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes. Endocrinology (2004) 0.85
Cylindrical osteochondral graft for osteochondritis dissecans of the knee: a report of three cases. Am J Sports Med (2002) 0.85
Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth. Int J Oncol (2011) 0.85
Pitx2 prevents osteoblastic transdifferentiation of myoblasts by bone morphogenetic proteins. J Biol Chem (2007) 0.84
Control of autonomous swelling-deswelling behavior for a polymer gel. J Phys Chem B (2009) 0.84
Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling. J Biochem (2010) 0.84
Adenosine triphosphate-induced atrial fibrillation: the clinical significance and relevance to spontaneous atrial fibrillation. J Interv Card Electrophysiol (2013) 0.84
Smad7-deficient mice show growth retardation with reduced viability. J Biochem (2012) 0.83
Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanism. Biochim Biophys Acta (2007) 0.83
ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo. Eur J Cancer (2011) 0.83
Functional in vivo optical imaging of tumor angiogenesis, growth, and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells. Cancer Sci (2009) 0.83