Published in Neurology on May 25, 2004
ACTHAR Gel for Drug REsistant Nephrotic Syndrome in Children (ADRENL) | NCT03408405
The role of inflammation in epilepsy. Nat Rev Neurol (2010) 3.89
A pulse rapamycin therapy for infantile spasms and associated cognitive decline. Neurobiol Dis (2011) 1.26
Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. J Clin Invest (2008) 1.23
Role of brain inflammation in epileptogenesis. Yonsei Med J (2008) 1.09
A model of symptomatic infantile spasms syndrome. Neurobiol Dis (2009) 1.08
Identification of pharmacoresistant epilepsy. Neurol Clin (2009) 1.08
Immune mechanisms in epileptogenesis. Front Cell Neurosci (2013) 1.05
Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. Epilepsia (2012) 1.02
Validation of the rat model of cryptogenic infantile spasms. Epilepsia (2011) 0.99
Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms. Curr Opin Neurobiol (2012) 0.98
Corticosteroids in the management of the paediatric epilepsies. Arch Dis Child (2005) 0.96
Models for infantile spasms: an arduous journey to the Holy Grail... Ann Neurol (2007) 0.95
Basic mechanisms of catastrophic epilepsy -- overview from animal models. Brain Dev (2013) 0.94
New generation anticonvulsants for the treatment of epilepsy in children. NeuroRx (2006) 0.93
Mechanisms of epileptogenesis in pediatric epileptic syndromes: Rasmussen encephalitis, infantile spasms, and febrile infection-related epilepsy syndrome (FIRES). Neurotherapeutics (2014) 0.92
Epileptic encephalopathies: an overview. Epilepsy Res Treat (2012) 0.89
Priorities in pediatric epilepsy research: improving children's futures today. Neurology (2013) 0.89
Topiramate and adrenocorticotropic hormone (ACTH) as initial treatment for infantile spasms. J Child Neurol (2009) 0.88
Modeling new therapies for infantile spasms. Epilepsia (2010) 0.87
Infantile spasms (West syndrome): update and resources for pediatricians and providers to share with parents. BMC Pediatr (2012) 0.87
Choosing the correct antiepileptic drugs: from animal studies to the clinic. Pediatr Neurol (2008) 0.85
"Epileptic encephalopathy" of infancy and childhood: electro-clinical pictures and recent understandings. Curr Neuropharmacol (2010) 0.85
Does the effectiveness of the ketogenic diet in different epilepsies yield insights into its mechanisms? Epilepsia (2008) 0.84
GABA(A) receptor properties in catastrophic infantile epilepsy. Epilepsy Res (2008) 0.84
Issues for new antiepilepsy drug development. Curr Opin Neurol (2013) 0.84
CPP-115, a vigabatrin analogue, decreases spasms in the multiple-hit rat model of infantile spasms. Epilepsia (2013) 0.83
Optimal management of seizures associated with tuberous sclerosis complex: current and emerging options. Neuropsychiatr Dis Treat (2014) 0.83
Multiple sclerosis, relapses, and the mechanism of action of adrenocorticotropic hormone. Front Neurol (2013) 0.83
Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms. Neuropsychiatr Dis Treat (2010) 0.83
Reduced grating acuity associated with retinal toxicity in children with infantile spasms on vigabatrin therapy. Invest Ophthalmol Vis Sci (2009) 0.83
Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms. Epilepsia (2011) 0.82
Current trends in the treatment of infantile spasms. Neuropsychiatr Dis Treat (2009) 0.82
Model of cryptogenic infantile spasms after prenatal corticosteroid priming. Epilepsia (2010) 0.82
Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies. Neurobiol Dis (2015) 0.81
Management of infantile spasms. Transl Pediatr (2015) 0.81
West syndrome treatment: new roads for an old syndrome. Front Neurol (2013) 0.81
Safety and efficacy of vigabatrin for the treatment of infantile spasms. J Cent Nerv Syst Dis (2011) 0.80
Hyper-excitability and epilepsy generated by chronic early-life stress. Neurobiol Stress (2015) 0.80
H.p. Acthar gel and cosyntropin review: clinical and financial implications. P T (2009) 0.79
Diagnosis delay in West syndrome: misdiagnosis and consequences. Eur J Pediatr (2012) 0.79
A new generation of anticonvulsants for the treatment of epilepsy in children. Paediatr Child Health (2007) 0.78
Prenatal corticosteroids modify glutamatergic and GABAergic synapse genomic fabric: insights from a novel animal model of infantile spasms. J Neuroendocrinol (2013) 0.78
West syndrome: response to valproate. Front Neurol (2012) 0.78
An effective initial polytherapy for children with West syndrome. Neural Regen Res (2013) 0.77
Clinical profile and treatment of infantile spasms using vigabatrin and ACTH--a developing country perspective. BMC Pediatr (2010) 0.77
Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms. Epilepsy Res (2013) 0.77
Animal models of infantile spasms: is the Holy Grail finally in sight? Epilepsy Curr (2008) 0.77
Epileptic encephalopathies in adults and childhood. Epilepsy Res Treat (2012) 0.77
Infantile spasms and epilepsy currents. Epilepsy Curr (2005) 0.77
Effect of price increase of adrenocorticotropic hormone on treatment practices of infantile spasms. Pediatr Neurol (2010) 0.77
Neurofibromatosis type 1 and infantile spasms. Childs Nerv Syst (2008) 0.76
Short term outcomes of topiramate monotherapy as a first-line treatment in newly diagnosed West syndrome. Korean J Pediatr (2011) 0.76
Infantile spasms: the devil is in the details, but do we see the forest for the trees? Epilepsy Curr (2011) 0.76
ACTH gel in the treatment of multiple sclerosis exacerbation: a case study. Int Med Case Rep J (2015) 0.75
"Electro-clinical syndromes" with onset in paediatric age: the highlights of the clinical-EEG, genetic and therapeutic advances. Ital J Pediatr (2011) 0.75
Early-onset epileptic encephalopathies and the diagnostic approach to underlying causes. Korean J Pediatr (2015) 0.75
Case 2: Seizures as a clue to... Paediatr Child Health (2008) 0.75
Epileptic Encephalopathy in Infants and Children. Epilepsy Curr (2016) 0.75
Epilepsy: Update to guidelines on treatment of infantile spasms. Nat Rev Neurol (2012) 0.75
Effectiveness and Safety of Different Once-Daily Doses of Adrenocorticotropic Hormone for Infantile Spasms. Paediatr Drugs (2017) 0.75
Preclinical Screening for Treatments for Infantile Spasms in the Multiple Hit Rat Model of Infantile Spasms: An Update. Neurochem Res (2017) 0.75
Infantile Spasms Treated with Intravenous Methypredinsolone Pulse. Iran J Child Neurol (2017) 0.75
Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia (1989) 13.54
Vigabatrin-associated retinal cone system dysfunction: electroretinogram and ophthalmologic findings. Neurology (1998) 4.01
A simple, effective and well-tolerated treatment regime for West syndrome. Dev Med Child Neurol (1994) 2.07
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics (1996) 2.03
Randomized trial of vigabatrin in patients with infantile spasms. Neurology (2001) 1.96
Double-blind study of ACTH vs prednisone therapy in infantile spasms. J Pediatr (1983) 1.74
Diagnosis and prognosis of hypsarhythmia and infantile spasms. Pediatrics (1954) 1.64
Visual impairment in children with epilepsy treated with vigabatrin. Ann Neurol (2000) 1.60
Vigabatrin versus ACTH as first-line treatment for infantile spasms: a randomized, prospective study. Epilepsia (1997) 1.38
A prospective study of infantile spasms: clinical and therapeutic correlations. Epilepsia (1983) 1.36
High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms. J Pediatr (1994) 1.28
ACTH and prednisone in childhood seizure disorders. Neurology (1983) 1.24
Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms. Epilepsia (1999) 1.23
A comparative study of high-dose and low-dose ACTH therapy for West syndrome. Brain Dev (1999) 1.22
Prevalence of the epilepsies in children and adolescents. Epilepsia (1989) 1.20
ACTH versus vigabatrin therapy in infantile spasms: a retrospective study. Neurology (1999) 1.18
The epidemiology and natural history of infantile spasms. J Child Neurol (1991) 1.12
Vigabatrin as initial therapy for infantile spasms: a European retrospective survey. Sabril IS Investigator and Peer Review Groups. Epilepsia (1996) 1.12
Treatment of infantile spasms with high-dose ACTH: efficacy and plasma levels of ACTH and cortisol. Neurology (1989) 1.11
The natural history of infantile spasms. Arch Dis Child (1961) 1.11
Tuberous sclerosis and infantile spasms. Dev Med Child Neurol (1990) 1.09
Valproate metabolites in serum and urine during antiepileptic therapy in children with infantile spasms: abnormal metabolite pattern associated with reversible hepatotoxicity. Epilepsia (1992) 1.07
Incidence and aetiology of infantile spasms from 1960 to 1976: a population study in Finland. Dev Med Child Neurol (1979) 1.05
A retrospective study of spontaneous remission and long-term outcome in patients with infantile spasms. Epilepsia (1991) 1.04
Ictal clinical electroencephalographic findings of spasms in West syndrome. Epilepsia (1993) 1.03
Efficacy of the ketogenic diet for infantile spasms. Pediatrics (2002) 1.02
A pilot study of topiramate in the treatment of infantile spasms. Epilepsia (1998) 1.00
Hypsarrhythmia: variations on the theme. Epilepsia (1984) 0.98
Therapy of infantile spasms with valproate: results of a prospective study. Epilepsia (1988) 0.95
Vigabatrin as a first-choice drug in the treatment of West syndrome. J Child Neurol (2000) 0.95
Treatment of infantile spasms with high-dosage vitamin B6. Epilepsia (1993) 0.94
A controlled study of ACTH therapy in infantile spasms. Epilepsia (1980) 0.91
Epidemiology of infantile spasms in Sweden. Epilepsia (1995) 0.90
The treatment of infantile spasms and hypsarrhythmia with mogadon. Epilepsia (1967) 0.89
Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndrome. J Child Neurol (1996) 0.89
Treatment of infantile spasms with intravenous gamma-globulins. Brain Dev (1991) 0.88
Liposteroid (dexamethasone palmitate) therapy for West syndrome: a comparative study with ACTH therapy. Pediatr Neurol (1998) 0.87
Vigabatrin in the treatment of infantile spasms. Pediatr Neurol (1999) 0.87
Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone. J Pediatr (1988) 0.86
Zonisamide monotherapy in newly diagnosed infantile spasms. Epilepsia (1997) 0.86
Treatment of infantile spasms: results of a population-based study with vigabatrin as the first drug for spasms. Epilepsia (1999) 0.86
Visual field constriction in children with epilepsy on vigabatrin treatment. Pediatrics (2000) 0.86
Spontaneous remission of spasms in West syndrome--implications of viral infection. Brain Dev (2001) 0.84
Visual field constriction is not limited to children treated with vigabatrin. Neuropediatrics (1999) 0.84
The treatment of infantile spasms by paediatric neurologists in the UK and Ireland. Dev Med Child Neurol (1996) 0.84
The treatment of infantile spasms by child neurologists. J Child Neurol (1994) 0.84
Vigabatrin as first line therapy in infantile spasms: review of seven patients. J Paediatr Child Health (1997) 0.84
The effect of ACTH therapy upon infantile spasms. J Pediatr (1980) 0.84
Treatment of the West syndrome with high-dose pyridoxal phosphate. Brain Dev (1987) 0.83
A controlled study of prednisone therapy in infantile spasms. Epilepsia (1979) 0.83
Long-term response to topiramate in patients with West syndrome. Epilepsia (2000) 0.83
Vigabatrin in the treatment of infantile spasms. Neuropediatrics (1993) 0.83
Long-term outcomes of conventional therapy for infantile spasms. Seizure (1997) 0.81
Vigabatrin as a first-line drug in West syndrome: clinical and electroencephalographic outcome. Neuropediatrics (1998) 0.81
Factors influencing effectiveness of thyrotropin-releasing hormone therapy for severe epilepsy in childhood: significance of serum prolactin levels. Epilepsia (1989) 0.81
Current therapy for West syndrome in Japan. J Child Neurol (2000) 0.81
Therapeutic efficacy of ACTH in symptomatic infantile spasms with hypsarrhythmia. Pediatr Neurol (1995) 0.80
Long-term follow-up study of vigabatrin in pretreated children with West syndrome. Seizure (1998) 0.79
Spontaneous remission of infantile spasms with hypsarhythmia. Arch Neurol (1981) 0.78
The use of vigabatrin in infantile spasms in Asian children. Ann Acad Med Singapore (2001) 0.78
Adrenocorticotropic hormone and vigabatrin treatment of children with infantile spasms underlying cerebral palsy. Brain Dev (1997) 0.78
The effect of non-depot ACTH(1-24) on infantile spasms. Dev Med Child Neurol (1993) 0.78
The minimally conscious state: definition and diagnostic criteria. Neurology (2002) 9.67
Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology (2010) 5.28
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatr Crit Care Med (2012) 4.65
Phenomenology of prolonged febrile seizures: results of the FEBSTAT study. Neurology (2008) 3.83
Practice parameter: screening and diagnosis of autism: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology (2000) 3.70
Evidence-based guideline: treatment of tardive syndromes: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology (2013) 3.61
Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med (2001) 3.44
Position statement regarding the use of embryonic and adult human stem cells in biomedical research. Neurology (2005) 3.18
Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. Nat Med (1999) 3.18
How long does it take for partial epilepsy to become intractable? Neurology (2003) 3.15
Acceptability, benefit and costs of early screening for hearing disability: a study of potential screening tests and models. Health Technol Assess (2007) 3.04
Determinants of mortality in status epilepticus. Epilepsia (1994) 3.03
Position statement on the coverage of anticonvulsant drugs for the treatment of epilepsy. Neurology (2007) 2.99
Semiological seizure classification. Epilepsia (1998) 2.96
Opioids for chronic noncancer pain: a position paper of the American Academy of Neurology. Neurology (2014) 2.94
A comparison of rectal diazepam gel and placebo for acute repetitive seizures. N Engl J Med (1998) 2.82
Long-term prognosis of seizures with onset in childhood. N Engl J Med (1998) 2.74
Tired, weak, or in need of rest: fatigue among general practice attenders. BMJ (1990) 2.70
A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology (1996) 2.69
Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Ann Neurol (2000) 2.55
The ELGAN study of the brain and related disorders in extremely low gestational age newborns. Early Hum Dev (2009) 2.55
Practice parameter: neuroimaging of the neonate: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology (2002) 2.51
Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nat Genet (1998) 2.51
Epidemiology of status epilepticus. J Clin Neurophysiol (1995) 2.48
The risk of seizure recurrence following a first unprovoked seizure: a quantitative review. Neurology (1991) 2.35
Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: report of the guideline development subcommittee of the American Academy of Neurology. Neurology (2012) 2.34
Clinical Policy: Use of intravenous tPA for the management of acute ischemic stroke in the emergency department. Ann Emerg Med (2013) 2.33
Newly diagnosed epilepsy in children: presentation at diagnosis. Epilepsia (1999) 2.31
Cerebral hemispherectomy: hospital course, seizure, developmental, language, and motor outcomes. Neurology (2004) 2.30
Lamotrigine-associated rash: risk/benefit considerations in adults and children. Epilepsia (1999) 2.29
Early development of intractable epilepsy in children: a prospective study. Neurology (2001) 2.25
Susceptibility-weighted MR imaging: a review of clinical applications in children. AJNR Am J Neuroradiol (2007) 2.18
Carbamazepine toxicity resulting from generic substitution. Neurology (1993) 2.14
Randomized, placebo-controlled trial of propranolol added to topiramate in chronic migraine. Neurology (2012) 2.13
Epileptiform EEG abnormalities in children with language regression. Neurology (2005) 2.13
Infantile spasms: I. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment. Ann Neurol (1990) 2.12
Function-based isolation of novel enzymes from a large library. Nat Biotechnol (2000) 2.12
Comparison of albuterol delivered by a metered dose inhaler with spacer versus a nebulizer in children with mild acute asthma. J Pediatr (1999) 2.08
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics (1996) 2.03
Low morbidity and mortality of status epilepticus in children. Pediatrics (1989) 2.00
A prospective study of recurrent febrile seizures. N Engl J Med (1992) 1.99
A multicenter study of the efficacy of the ketogenic diet. Arch Neurol (1998) 1.99
Randomized trial of vigabatrin in patients with infantile spasms. Neurology (2001) 1.96
Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model. J Neurosci (1998) 1.95
Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala. Ann Neurol (1992) 1.95
Role of MRI in the differentiation of ADEM from MS in children. Neurology (2008) 1.94
Longitudinal examination of the behavioral, language, and social changes in a population of adolescents and young adults with autistic disorder. Pediatr Neurol (1996) 1.93
Predicting long-term seizure outcome after resective epilepsy surgery: the multicenter study. Neurology (2005) 1.93
Lumping or splitting? "Ophthalmoplegia-plus" or Kearns-Sayre syndrome? Ann Neurol (1977) 1.90
Failure of electroencephalography to diagnose brain death in comatose children. Ann Neurol (1979) 1.88
Neuroimaging in children with newly diagnosed epilepsy: A community-based study. Pediatrics (2000) 1.85
Canadian Acute Respiratory Illness and Flu Scale (CARIFS): development of a valid measure for childhood respiratory infections. J Clin Epidemiol (2000) 1.82
Initial outcomes in the Multicenter Study of Epilepsy Surgery. Neurology (2003) 1.79
Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress. Proc Natl Acad Sci U S A (2001) 1.78
Febrile status epilepticus. Pediatrics (1990) 1.76
MRI in the diagnosis of pediatric multiple sclerosis. Neurology (2008) 1.73
Guidelines for the determination of brain death in infants and children: an update of the 1987 Task Force recommendations. Crit Care Med (2011) 1.72
Prevalence of hippocampal malrotation in a population without seizures. AJNR Am J Neuroradiol (2009) 1.72
Verification of the fetal valproate syndrome phenotype. Am J Med Genet (1988) 1.71
How well can epilepsy syndromes be identified at diagnosis? A reassessment 2 years after initial diagnosis. Epilepsia (2000) 1.70
Immunocytochemical distribution of corticotropin-releasing hormone receptor type-1 (CRF(1))-like immunoreactivity in the mouse brain: light microscopy analysis using an antibody directed against the C-terminus. J Comp Neurol (2000) 1.70
Neisseria meningitidis group B correlates of protection and assay standardization--international meeting report Emory University, Atlanta, Georgia, United States, 16-17 March 2005. Vaccine (2006) 1.67
Infants and children with convulsions and hypotonic-hyporesponsive episodes following diphtheria-tetanus-pertussis immunization: follow-up evaluation. Pediatrics (1988) 1.66
Idiopathic external hydrocephalus: natural history and relationship to benign familial macrocephaly. Pediatrics (1986) 1.64
Relapse following discontinuation of antiepileptic drugs: a meta-analysis. Neurology (1994) 1.63
Corticotropin-releasing hormone mediates the response to cold stress in the neonatal rat without compensatory enhancement of the peptide's gene expression. Endocrinology (1994) 1.63
Optimal outcome measures, research priorities, and international cooperation. Ear Hear (2000) 1.62
Dysfunctional nurturing behavior in rat dams with limited access to nesting material: a clinically relevant model for early-life stress. Neuroscience (2008) 1.62
Risk factors for resistance to "first-line" antimicrobials among urinary tract isolates of Escherichia coli in children. CMAJ (1999) 1.61