Published in Ann Biomed Eng on May 01, 2004
Multiscale models of angiogenesis. IEEE Eng Med Biol Mag (2009) 1.26
Dimerization of VEGF receptors and implications for signal transduction: a computational study. Biophys Chem (2007) 1.18
Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches. PLoS Comput Biol (2006) 1.17
A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap. PLoS One (2009) 1.09
Module-based multiscale simulation of angiogenesis in skeletal muscle. Theor Biol Med Model (2011) 1.04
VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model. Am J Physiol Heart Circ Physiol (2010) 0.93
Integration of angiogenesis modules at multiple scales: from molecular to tissue. Pac Symp Biocomput (2009) 0.87
Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic signal-response profiles. Cell Commun Signal (2014) 0.86
Fibroblast growth factor 2 induced proliferation in osteoblasts and bone marrow stromal cells: a whole cell model. Biophys J (2006) 0.84
A two-compartment model of VEGF distribution in the mouse. PLoS One (2011) 0.84
Vascular regeneration by local growth factor release is self-limited by microvascular clearance. Circulation (2009) 0.80
Phospholipase C-delta extends intercellular signalling range and responses to injury-released growth factors in non-excitable cells. Cell Prolif (2008) 0.80
Using an Agent-Based Model to Examine the Role of Dynamic Bacterial Virulence Potential in the Pathogenesis of Surgical Site Infection. Adv Wound Care (New Rochelle) (2013) 0.79
Systems biology of the microvasculature. Integr Biol (Camb) (2015) 0.77
Modeling of growth factor-receptor systems from molecular-level protein interaction networks to whole-body compartment models. Methods Enzymol (2009) 0.77
A computational model of FGF-2 binding and HSPG regulation under flow. IEEE Trans Biomed Eng (2008) 0.77
A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands. PLoS Comput Biol (2017) 0.75
Endothelial cell capture of heparin-binding growth factors under flow. PLoS Comput Biol (2010) 0.75
Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions. J Natl Cancer Inst (2013) 1.75
A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use. J Cell Mol Med (2009) 1.59
A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2. J Biol Chem (2004) 1.51
A compartment model of VEGF distribution in blood, healthy and diseased tissues. BMC Syst Biol (2008) 1.50
Temporal and spatial variations of cell-free layer width in arterioles. Am J Physiol Heart Circ Physiol (2007) 1.46
Systems biology of vascular endothelial growth factors. Microcirculation (2008) 1.41
Computational fluid dynamic simulation of aggregation of deformable cells in a shear flow. J Biomech Eng (2005) 1.40
Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cells. Am J Physiol Heart Circ Physiol (2003) 1.33
Anti-angiogenic peptides for cancer therapeutics. Curr Pharm Biotechnol (2011) 1.32
Multiscale models of angiogenesis. IEEE Eng Med Biol Mag (2009) 1.26
Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows. Microvasc Res (2009) 1.24
Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model. Cancer Res (2010) 1.22
Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer and ischemia. Mol Cell Biol (2008) 1.21
Interactions of VEGF isoforms with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal muscle. Am J Physiol Heart Circ Physiol (2006) 1.21
Effect of aggregation and shear rate on the dispersion of red blood cells flowing in venules. Am J Physiol Heart Circ Physiol (2002) 1.20
VEGF gradients, receptor activation, and sprout guidance in resting and exercising skeletal muscle. J Appl Physiol (1985) (2006) 1.20
A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1 alpha. J Cell Sci (2006) 1.20
Blood flow and cell-free layer in microvessels. Microcirculation (2010) 1.19
A biochemical model of matrix metalloproteinase 9 activation and inhibition. J Biol Chem (2007) 1.18
Experimental and theoretical studies of oxygen gradients in rat pial microvessels. J Cereb Blood Flow Metab (2008) 1.18
Dimerization of VEGF receptors and implications for signal transduction: a computational study. Biophys Chem (2007) 1.18
Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches. PLoS Comput Biol (2006) 1.17
A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A (2008) 1.16
Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective. Antioxid Redox Signal (2008) 1.16
Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model. J Theor Biol (2005) 1.16
Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells. Free Radic Biol Med (2006) 1.15
Red blood cell aggregation and dissociation in shear flows simulated by lattice Boltzmann method. J Biomech (2007) 1.14
Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms. AAPS J (2012) 1.14
Quantification and cell-to-cell variation of vascular endothelial growth factor receptors. Exp Cell Res (2010) 1.14
Effect of outer hair cell piezoelectricity on high-frequency receptor potentials. J Acoust Soc Am (2003) 1.13
Erythrocyte consumption of nitric oxide in presence and absence of plasma-based hemoglobin. Am J Physiol Heart Circ Physiol (2002) 1.13
Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1: a computational model. Am J Physiol Heart Circ Physiol (2005) 1.11
Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting. BMC Syst Biol (2009) 1.10
Computational model of vascular endothelial growth factor spatial distribution in muscle and pro-angiogenic cell therapy. PLoS Comput Biol (2006) 1.10
Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts. Neoplasia (2009) 1.10
A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap. PLoS One (2009) 1.09
Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure. J Appl Physiol (1985) (2004) 1.07
Systems biology of pro-angiogenic therapies targeting the VEGF system. Wiley Interdiscip Rev Syst Biol Med (2010) 1.06
A computer-based method for determination of the cell-free layer width in microcirculation. Microcirculation (2006) 1.06
Wall shear stress differentially affects NO level in arterioles for volume expanders and Hb-based O2 carriers. Microvasc Res (2003) 1.05
Module-based multiscale simulation of angiogenesis in skeletal muscle. Theor Biol Med Model (2011) 1.04
Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes. Nitric Oxide (2007) 1.03
Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutes. Am J Physiol Heart Circ Physiol (2002) 1.03
Identification of novel short peptides derived from the alpha 4, alpha 5, and alpha 6 fibrils of type IV collagen with anti-angiogenic properties. Biochem Biophys Res Commun (2007) 1.03
Multi-scale computational models of pro-angiogenic treatments in peripheral arterial disease. Ann Biomed Eng (2007) 1.03
A computational model of oxygen transport in skeletal muscle for sprouting and splitting modes of angiogenesis. J Theor Biol (2006) 1.00
Calculations of oxygen transport by red blood cells and hemoglobin solutions in capillaries. Artif Cells Blood Substit Immobil Biotechnol (2002) 1.00
Relationship between erythrocyte aggregate size and flow rate in skeletal muscle venules. Am J Physiol Heart Circ Physiol (2003) 1.00
Intracoronary administration of FGF-2: a computational model of myocardial deposition and retention. Am J Physiol Heart Circ Physiol (2004) 1.00
Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice. Front Oncol (2013) 0.99
A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networks. J Theor Biol (2007) 0.98
Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies. BMC Syst Biol (2011) 0.98
Three autocrine feedback loops determine HIF1 alpha expression in chronic hypoxia. Biochim Biophys Acta (2007) 0.97
An immersed boundary lattice Boltzmann approach to simulate deformable liquid capsules and its application to microscopic blood flows. Phys Biol (2007) 0.97
Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise. Am J Physiol Heart Circ Physiol (2007) 0.97
Aggregate formation of erythrocytes in postcapillary venules. Am J Physiol Heart Circ Physiol (2004) 0.96
The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling. PLoS Comput Biol (2009) 0.96
Theoretical models for coronary vascular biomechanics: progress & challenges. Prog Biophys Mol Biol (2010) 0.96
Inhibition of lymphangiogenesis and angiogenesis in breast tumor xenografts and lymph nodes by a peptide derived from transmembrane protein 45A. Neoplasia (2013) 0.96
A theoretical model of nitric oxide transport in arterioles: frequency- vs. amplitude-dependent control of cGMP formation. Am J Physiol Heart Circ Physiol (2003) 0.94
Multiscale imaging and computational modeling of blood flow in the tumor vasculature. Ann Biomed Eng (2012) 0.94
Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis. BMC Syst Biol (2011) 0.94
Small peptides derived from somatotropin domain-containing proteins inhibit blood and lymphatic endothelial cell proliferation, migration, adhesion and tube formation. Int J Biochem Cell Biol (2011) 0.94
Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model. BMC Cancer (2010) 0.93
VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model. Am J Physiol Heart Circ Physiol (2010) 0.93
Hypotonic swelling of salicylate-treated cochlear outer hair cells. Hear Res (2007) 0.93
Quantitative fluorescent profiling of VEGFRs reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts. Cancer Med (2014) 0.92
Vascular smooth muscle NO exposure from intraerythrocytic SNOHb: a mathematical model. Antioxid Redox Signal (2007) 0.92
Quantifying the proteolytic release of extracellular matrix-sequestered VEGF with a computational model. PLoS One (2010) 0.92
Effect of erythrocyte aggregation at normal human levels on functional capillary density in rat spinotrapezius muscle. Am J Physiol Heart Circ Physiol (2005) 0.92
Novel peptide-specific quantitative structure-activity relationship (QSAR) analysis applied to collagen IV peptides with antiangiogenic activity. J Med Chem (2011) 0.91
An experimental and theoretical study on the dissolution of mural fibrin clots by tissue-type plasminogen activator. Biotechnol Bioeng (2002) 0.90
A model of nitric oxide capillary exchange. Microcirculation (2003) 0.90
Expression of VEGF receptors on endothelial cells in mouse skeletal muscle. PLoS One (2012) 0.90
Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines. J Cell Biochem (2008) 0.90
Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport. Physiol Genomics (2009) 0.90
Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia. Am J Physiol Heart Circ Physiol (2013) 0.90
Anti-angiogenic peptides identified in thrombospondin type I domains. Biochem Biophys Res Commun (2007) 0.89
Blood-plasma separation in Y-shaped bifurcating microfluidic channels: a dissipative particle dynamics simulation study. Phys Biol (2012) 0.89
Monte Carlo simulations of VEGF binding to cell surface receptors in vitro. Biochim Biophys Acta (2005) 0.88
Peptides derived from type I thrombospondin repeat-containing proteins of the CCN family inhibit proliferation and migration of endothelial cells. Int J Biochem Cell Biol (2007) 0.87
Gene therapy from the perspective of systems biology. Curr Opin Mol Ther (2010) 0.87
Computational models of VEGF-associated angiogenic processes in cancer. Math Med Biol (2011) 0.87
Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model. Clin Exp Metastasis (2013) 0.87
Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3). Free Radic Biol Med (2006) 0.87
Trans-scleral delivery of antiangiogenic proteins. J Ocul Pharmacol Ther (2008) 0.87
Analysis of VEGF--a regulated gene expression in endothelial cells to identify genes linked to angiogenesis. PLoS One (2011) 0.87
Integration of angiogenesis modules at multiple scales: from molecular to tissue. Pac Symp Biocomput (2009) 0.87
Systems biology and physiome projects. Wiley Interdiscip Rev Syst Biol Med (2010) 0.86
Development of a biomimetic peptide derived from collagen IV with anti-angiogenic activity in breast cancer. Cancer Biol Ther (2011) 0.86
Effects of chlorpromazine on mechanical properties of the outer hair cell plasma membrane. Biophys J (2005) 0.86
Venular endothelium-derived NO can affect paired arteriole: a computational model. Am J Physiol Heart Circ Physiol (2005) 0.86
A peptide derived from type 1 thrombospondin repeat-containing protein WISP-1 inhibits corneal and choroidal neovascularization. Invest Ophthalmol Vis Sci (2009) 0.86
Protein transport to choroid and retina following periocular injection: theoretical and experimental study. Ann Biomed Eng (2007) 0.86
Computational analysis of the tether-pulling experiment to probe plasma membrane-cytoskeleton interaction in cells. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 0.86
A systems biology view of blood vessel growth and remodelling. J Cell Mol Med (2013) 0.86
Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking. Cell Signal (2013) 0.85
Synergy between a collagen IV mimetic peptide and a somatotropin-domain derived peptide as angiogenesis and lymphangiogenesis inhibitors. Angiogenesis (2012) 0.85
Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation. PLoS One (2013) 0.84