| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action.
|
Eur J Cancer
|
2001
|
2.02
|
|
2
|
The combination of yondelis and cisplatin is synergistic against human tumor xenografts.
|
Eur J Cancer
|
2003
|
1.63
|
|
3
|
Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways.
|
Int J Cancer
|
2001
|
1.31
|
|
4
|
Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.
|
Leukemia
|
2003
|
1.15
|
|
5
|
In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells.
|
Br J Cancer
|
1998
|
1.09
|
|
6
|
Effect of Aplidin in acute lymphoblastic leukaemia cells.
|
Br J Cancer
|
2003
|
0.98
|
|
7
|
Antiangiogenic activity of aplidine, a new agent of marine origin.
|
Br J Cancer
|
2004
|
0.97
|
|
8
|
High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer.
|
Ann Oncol
|
1999
|
0.95
|
|
9
|
Cytotoxicity and neurocytotoxicity of new marine anticancer agents evaluated using in vitro assays.
|
Cancer Chemother Pharmacol
|
1999
|
0.94
|
|
10
|
In vitro cytotoxicity of aplidin and crossresistance with other cytotoxic drugs in childhood leukemic and normal bone marrow and blood samples: a rational basis for clinical development.
|
Leukemia
|
2003
|
0.89
|
|
11
|
Changes in gene expression profile induced by the anticancer agent Aplidine in Molt-4 leukemic cell lines.
|
J Biol Regul Homeost Agents
|
2002
|
0.82
|
|
12
|
Molecular characterisation of two human cancer cell lines selected in vitro for their chemotherapeutic drug resistance to ET-743.
|
Eur J Cancer
|
2005
|
0.81
|
|
13
|
Immunosuppressive cyclolignans.
|
J Med Chem
|
1996
|
0.79
|
|
14
|
The unique biological features of the marine product Yondelis (ET-743, trabectedin) are shared by its analog ET-637, which lacks the C ring.
|
Oncol Res
|
2004
|
0.79
|
|
15
|
In vitro interaction between ecteinascidin 743 (ET-743) and radiation, in relation to its cell cycle effects.
|
Br J Cancer
|
2003
|
0.79
|
|
16
|
Evaluation of the use of in vitro methodologies as tools for screening new compounds for potential in vivo toxicity.
|
Toxicol In Vitro
|
2001
|
0.76
|
|
17
|
Differential subcellular distribution of bioactive human chorionic gonadotropin in pseudopregnant rat ovary.
|
Endocrinology
|
1986
|
0.75
|
|
18
|
Metabolism of luteinizing hormone by the pseudopregnant rat ovary.
|
Endocrinology
|
1984
|
0.75
|