Published in Eur Respir J on May 01, 2004
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol (2007) 6.33
Economic burden of asthma: a systematic review. BMC Pulm Med (2009) 3.10
Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax (2005) 2.19
Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. Am J Respir Crit Care Med (2010) 1.62
Qualitative analysis of high-resolution CT scans in severe asthma. Chest (2009) 1.52
Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting β(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands. PLoS One (2015) 1.41
Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial. BMC Pulm Med (2011) 1.24
Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax (2010) 1.19
A review of anti-IgE monoclonal antibody (omalizumab) as add on therapy for severe allergic (IgE-mediated) asthma. Ther Clin Risk Manag (2007) 1.11
Therapeutic options for severe asthma. Arch Med Sci (2012) 1.11
Direct health care costs associated with asthma in British Columbia. Can Respir J (2010) 1.03
Sleep quality and asthma control and quality of life in non-severe and severe asthma. Sleep Breath (2011) 0.94
Comorbidities in severe asthma: frequency of rhinitis, nasal polyposis, gastroesophageal reflux disease, vocal cord dysfunction and bronchiectasis. Clinics (Sao Paulo) (2009) 0.89
The efficacy of tiotropium as a steroid-sparing agent in severe asthma. Can Respir J (2009) 0.82
Recommendation for optimal management of severe refractory asthma. J Asthma Allergy (2010) 0.81
The role of omalizumab in the treatment of severe allergic asthma. Can Respir J (2006) 0.81
Development of a novel severe triple allergen asthma model in mice which is resistant to dexamethasone and partially resistant to TLR7 and TLR9 agonist treatment. PLoS One (2014) 0.80
Physical activity and other health-related factors predict health care utilisation in older adults: the ActiFE Ulm study. Z Gerontol Geriatr (2012) 0.80
A pilot study of polymorphism of adrenergic Beta-2 receptor and mild asthma: a clinical and pharmacogenetic study. Iran J Pharm Res (2013) 0.80
Difficult-to-control asthma management through the use of a specific protocol. Clinics (Sao Paulo) (2010) 0.78
Patterns of inhaled corticosteroid use and asthma control in the Childhood Asthma Management Program Continuation Study. Ann Allergy Asthma Immunol (2010) 0.78
Can severe asthmatic patients achieve asthma control? A systematic approach in patients with difficult to control asthma followed in a specialized clinic. BMC Pulm Med (2016) 0.77
L-carnitine improves the asthma control in children with moderate persistent asthma. J Allergy (Cairo) (2011) 0.77
Randomised evaluation of the Italian medicines use review provided by community pharmacists using asthma as a model (RE I-MUR). BMC Health Serv Res (2015) 0.77
Efficacy of omalizumab (Xolair®) in patients with moderate to severe predominately chronic oral steroid dependent asthma in Taiwan: a retrospective, population-based database cohort study. BMC Pulm Med (2016) 0.76
Asthma costs and social impact. Asthma Res Pract (2017) 0.75
Risk factors related to persistent airflow obstruction in severe asthma in Chinese Han population. Int J Clin Exp Med (2014) 0.75
Asthma Economic Costs in Adult Asthmatic Patients in Tehran, Iran. Iran J Public Health (2015) 0.75
Health-care cost reduction resulting from primary-care allergy testing in children in Italy. Ital J Pediatr (2010) 0.75
Weekly low-dose methotrexate for reduction of Global Initiative for Asthma Step 5 treatment in severe refractory asthma: study protocol for a randomized controlled trial. Trials (2014) 0.75
Patient preferences in severe COPD and asthma: a comprehensive literature review. Int J Chron Obstruct Pulmon Dis (2015) 0.75
Biologic therapy in the management of asthma. Curr Opin Allergy Clin Immunol (2016) 0.75
Role of biologics in severe eosinophilic asthma - focus on reslizumab. Ther Clin Risk Manag (2016) 0.75
The economic burden of adult asthma in Cyprus; a prevalence-based cost of illness study. BMC Public Health (2017) 0.75
Phenotypes and endotypes of severe asthma in children. Korean J Pediatr (2013) 0.75
Unusual asthma syndromes and their management. Ther Adv Chronic Dis (2011) 0.75
The Clinical and Health Economic Value of Clinical Laboratory Diagnostics. EJIFCC (2015) 0.75
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A (1998) 39.20
A whole-genome assembly of Drosophila. Science (2000) 38.48
Gene therapy restores vision in a canine model of childhood blindness. Nat Genet (2001) 7.88
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science (1995) 5.65
Evolution of organic aerosols in the atmosphere. Science (2009) 4.82
Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid. Proc Natl Acad Sci U S A (1997) 4.38
Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly. Nat Cell Biol (2001) 4.08
Complete genomic sequence of Pasteurella multocida, Pm70. Proc Natl Acad Sci U S A (2001) 3.51
Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. Science (2001) 3.39
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J Exp Med (1997) 3.32
DNA-DNA hybridization assay for detection of Salmonella spp. in foods. Appl Environ Microbiol (1983) 3.24
Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma. Am J Respir Crit Care Med (1998) 3.22
Detection of preinvasive cancer cells. Nature (2000) 3.20
Giant electrocaloric effect in thin-film PbZr(0.95)Ti(0.05)O3. Science (2006) 3.17
A major lung cancer susceptibility locus maps to chromosome 6q23-25. Am J Hum Genet (2004) 3.05
Advances in statistical methods to map quantitative trait loci in outbred populations. Genetics (1997) 2.90
Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature (1995) 2.88
The MYCN oncogene is a direct target of miR-34a. Oncogene (2008) 2.80
Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature (1999) 2.80
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis (2013) 2.52
Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett's esophagus. Gastroenterology (2001) 2.46
Diagnosis of Hymenoptera venom allergy. Allergy (2005) 2.34
Fluorous mixture synthesis: a fluorous-tagging strategy for the synthesis and separation of mixtures of organic compounds. Science (2001) 2.31
High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and normal QRS duration. Heart (2003) 2.25
Patterns of cytosine methylation in an elite rice hybrid and its parental lines, detected by a methylation-sensitive amplification polymorphism technique. Mol Gen Genet (1999) 2.23
Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology (1999) 2.16
The MITE family heartbreaker (Hbr): molecular markers in maize. Proc Natl Acad Sci U S A (2000) 2.08
Five-year maintenance treatment with ranitidine: effects on the natural history of duodenal ulcer disease. Am J Gastroenterol (1994) 2.07
Genome-wide association scan for childhood caries implicates novel genes. J Dent Res (2011) 2.05
Treatment of refractory chronic GVHD with rituximab: a GITMO study. Bone Marrow Transplant (2007) 2.03
Intrinsic fluorescence spectroscopy in turbid media: disentangling effects of scattering and absorption. Appl Opt (2001) 1.98
Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide. Nat Struct Biol (1999) 1.95
Exhaled nitric oxide and impaired oxygenation in cirrhotic patients before and after liver transplantation. Ann Intern Med (1998) 1.94
Molecular characterization of a porcine enteric calicivirus genetically related to Sapporo-like human caliciviruses. J Virol (1999) 1.90
Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits. Circulation (1998) 1.90
Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans. Antimicrob Agents Chemother (1996) 1.83
Chemical and microphysical characterization of ambient aerosols with the aerodyne aerosol mass spectrometer. Mass Spectrom Rev (2007) 1.80
P instability factor: an active maize transposon system associated with the amplification of Tourist-like MITEs and a new superfamily of transposases. Proc Natl Acad Sci U S A (2001) 1.79
Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. Mol Cell Biol (2000) 1.78
Proposal of an improved score method for the diagnosis of pulmonary tuberculosis in childhood in developing countries. Tuber Lung Dis (1992) 1.77
Causes of death among people with convulsive epilepsy in rural West China: a prospective study. Neurology (2011) 1.77
Extraordinarily polymorphic microsatellite DNA in barley: species diversity, chromosomal locations, and population dynamics. Proc Natl Acad Sci U S A (1994) 1.77
Nicotine effects on eicosanoid formation and hemostatic function: comparison of transdermal nicotine and cigarette smoking. J Am Coll Cardiol (1993) 1.76
Exhaled nitric oxide and oxygenation abnormalities in hepatic cirrhosis. Hepatology (1997) 1.74
Wolbachia infection shared among planthoppers (Homoptera: Delphacidae) and their endoparasite (Strepsiptera: Elenchidae): a probable case of interspecies transmission. Mol Ecol (2001) 1.72
The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila. Proc Natl Acad Sci U S A (2001) 1.72
Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region. J Virol (1993) 1.71
Atrophy of relay neurons in magno- and parvocellular layers in the lateral geniculate nucleus in experimental glaucoma. Invest Ophthalmol Vis Sci (2001) 1.68
Memory rehabilitation in Alzheimer's disease: a review of progress. Int J Geriatr Psychiatry (2001) 1.67
Chronic myeloid leukemia and interferon-alpha: a study of complete cytogenetic responders. Blood (2001) 1.67
Circadian variation of granulocyte colony stimulating factor levels in man. Br J Haematol (1999) 1.65
Pain control in inflammation governed by selectins. Nat Med (1998) 1.65
Mucosal tolerance as therapy of type I allergy: intranasal application of recombinant Bet v 1, the major birch pollen allergen, leads to the suppression of allergic immune responses and airway inflammation in sensitized mice. Clin Exp Allergy (2002) 1.63
Multivesicular exocytosis in rat pancreatic beta cells. Diabetologia (2011) 1.63
Field performance of transgenic elite commercial hybrid rice expressing bacillus thuringiensis delta-endotoxin. Nat Biotechnol (2000) 1.62
Loss of neurons in magnocellular and parvocellular layers of the lateral geniculate nucleus in glaucoma. Arch Ophthalmol (2000) 1.62
Depression and substance use in minority middle-school students. Am J Public Health (2001) 1.61
Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide. Circ Res (1997) 1.61
Snoring in children: association with respiratory symptoms and passive smoking. BMJ (1989) 1.61
Mutational analysis of a fatty acyl-coenzyme A synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity. J Biol Chem (1997) 1.61
Iron deficiency decreases dopamine D1 and D2 receptors in rat brain. Pharmacol Biochem Behav (2001) 1.59
Comparison of two methods of processing induced sputum: selected versus entire sputum. Am J Respir Crit Care Med (1998) 1.56
Limiting hepatitis C virus progression in liver transplant recipients using sirolimus-based immunosuppression. Am J Transplant (2011) 1.56
Effects of hyperinsulinemia on plasma levels of circulating adhesion molecules. J Clin Endocrinol Metab (2000) 1.56
Chloroplast DNA diversity in populations of wild and cultivated barley. Genetics (1988) 1.55
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia (2012) 1.55
Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells. Cell Death Dis (2010) 1.55
The bZIP transactivator of Epstein-Barr virus, BZLF1, functionally and physically interacts with the p65 subunit of NF-kappa B. Mol Cell Biol (1994) 1.54
Penetration of moxifloxacin into peripheral compartments in humans. Antimicrob Agents Chemother (1999) 1.54
Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor. Mol Cell Endocrinol (2010) 1.53
Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia. Neurology (2004) 1.51
bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat Med (1998) 1.50
Influence of mastication on gastric emptying. J Dent Res (2002) 1.50
Exhaled nitric oxide and pulmonary response to iloprost in systemic sclerosis with pulmonary hypertension. Lancet (1998) 1.50
Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock. Crit Care Med (2001) 1.50
Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument. Phys Med Biol (2001) 1.50
Oral nitric oxide during plaque deposition. Eur J Clin Invest (2001) 1.50
Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects. Kidney Int (2006) 1.50
Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. Clin Pharmacol Ther (1999) 1.50
Comparative evaluation of the E test, agar dilution, and broth microdilution for testing susceptibilities of Helicobacter pylori strains to 20 antimicrobial agents. J Clin Microbiol (1997) 1.50
Comparative analysis of microsatellite DNA polymorphism in landraces and cultivars of rice. Mol Gen Genet (1994) 1.48
Turbidity-free fluorescence spectroscopy of biological tissue. Opt Lett (2000) 1.48
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis. Proc Natl Acad Sci U S A (2000) 1.48
A randomized, placebo-controlled, double-blind crossover study of the effect of pentoxifylline on ocular fundus pulsations. Am J Ophthalmol (1996) 1.47
Immunogenicity of influenza vaccine (1993-94 winter season) in HIV-seropositive and -seronegative ex-intravenous drug users. Vaccine (1997) 1.46
Paroxetine decreases platelet serotonin storage and platelet function in human beings. Clin Pharmacol Ther (2000) 1.46
Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. Diabetologia (2009) 1.46
Relationship between vitamin D status, body composition and physical exercise of adolescent girls in Beijing. Osteoporos Int (2008) 1.45
Infection density of Wolbachia and incompatibility level in two planthopper species, Laodelphax striatellus and Sogatella furcifera. Insect Biochem Mol Biol (2001) 1.45
Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans. Blood (2000) 1.45
Inhalation scintigraphy with iodine-123-labeled interferon gamma-1b: pulmonary deposition and dose escalation study in healthy volunteers. J Nucl Med (1997) 1.44
Application of microdialysis to clinical pharmacokinetics in humans. Clin Pharmacol Ther (1995) 1.44
Modulation of beta1A integrin functions by tyrosine residues in the beta1 cytoplasmic domain. J Cell Biol (1998) 1.44
Effect of cardiac resynchronization therapy in patients with moderate left ventricular systolic dysfunction and wide QRS complex: a prospective study. J Cardiovasc Electrophysiol (2006) 1.44
Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain. J Mol Biol (2000) 1.43
Hemodynamic effects of parathyroid hormone-related peptide-(1-34) in humans. J Clin Endocrinol Metab (1997) 1.42