Douglas F Nixon

Author PubWeight™ 153.55‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med 2008 5.94
2 Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 2008 5.76
3 Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. J Virol 2004 3.58
4 Expansion of a unique CD57⁺NKG2Chi natural killer cell subset during acute human cytomegalovirus infection. Proc Natl Acad Sci U S A 2011 3.53
5 CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset. Blood 2010 3.32
6 Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol 2005 3.07
7 Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4. Blood 2009 2.43
8 Optimization of methods to assess human mucosal T-cell responses to HIV infection. J Immunol Methods 2003 2.32
9 Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells. J Immunol Methods 2003 2.28
10 Tregs control the development of symptomatic West Nile virus infection in humans and mice. J Clin Invest 2009 2.18
11 Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation. J Immunol 2007 1.87
12 Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood 2012 1.81
13 Regulation of T cell responses in the developing human fetus. J Immunol 2006 1.78
14 Immunologic and virologic evolution during periods of intermittent and persistent low-level viremia. AIDS 2004 1.75
15 Selective loss of innate CD4(+) V alpha 24 natural killer T cells in human immunodeficiency virus infection. J Virol 2002 1.74
16 Strong HIV-1-specific T cell responses in HIV-1-exposed uninfected infants and neonates revealed after regulatory T cell removal. PLoS One 2006 1.73
17 Trafficking of human immunodeficiency virus type 1-specific CD8+ T cells to gut-associated lymphoid tissue during chronic infection. J Virol 2003 1.71
18 T cell responses to human endogenous retroviruses in HIV-1 infection. PLoS Pathog 2007 1.70
19 Seroreversion in subjects receiving antiretroviral therapy during acute/early HIV infection. Clin Infect Dis 2006 1.65
20 Highly effective control of an AIDS virus challenge in macaques by using vesicular stomatitis virus and modified vaccinia virus Ankara vaccine vectors in a single-boost protocol. J Virol 2004 1.58
21 Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes. PLoS One 2010 1.49
22 FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection. J Leukoc Biol 2007 1.47
23 Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection. J Virol 2008 1.47
24 Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point. J Virol 2007 1.46
25 Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection. J Immunol 2004 1.46
26 Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part I: Panel design by an empiric approach. Cytometry A 2008 1.40
27 CD56negCD16⁺ NK cells are activated mature NK cells with impaired effector function during HIV-1 infection. Retrovirology 2013 1.30
28 Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape. PLoS One 2007 1.30
29 Amplification of low-frequency antiviral CD8 T cell responses using autologous dendritic cells. AIDS 2002 1.27
30 Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity. J Immunol 2007 1.25
31 Broadly immunogenic HLA class I supertype-restricted elite CTL epitopes recognized in a diverse population infected with different HIV-1 subtypes. J Immunol 2008 1.25
32 HIV-specific CD8+ T cell function in children with vertically acquired HIV-1 infection is critically influenced by age and the state of the CD4+ T cell compartment. J Immunol 2003 1.25
33 Expression profile of host restriction factors in HIV-1 elite controllers. Retrovirology 2013 1.24
34 T cell immunity in acute HIV-1 infection. J Infect Dis 2010 1.22
35 Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7. Proc Natl Acad Sci U S A 2004 1.21
36 Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease gene. J Virol 2003 1.19
37 Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection. J Virol 2011 1.19
38 Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection. AIDS 2008 1.14
39 Increased adhesion molecule and chemokine receptor expression on CD8+ T cells trafficking to cerebrospinal fluid in HIV-1 infection. J Infect Dis 2004 1.14
40 HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates. J Clin Invest 2012 1.14
41 Dominant effector memory characteristics, capacity for dynamic adaptive expansion, and sex bias in the innate Valpha24 NKT cell compartment. Eur J Immunol 2003 1.13
42 Enhanced ELISPOT detection of antigen-specific T cell responses from cryopreserved specimens with addition of both IL-7 and IL-15--the Amplispot assay. J Immunol Methods 2002 1.13
43 Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition. PLoS One 2008 1.11
44 Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease. PLoS Genet 2012 1.10
45 Increased expression of intrinsic antiviral genes in HLA-B*57-positive individuals. J Leukoc Biol 2013 1.09
46 Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. J Immunol 2002 1.08
47 Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells. J Virol 2013 1.05
48 CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets. J Immunol 2003 1.03
49 Lower cytokine secretion ex vivo by natural killer T cells in HIV-infected individuals is associated with higher CD161 expression. AIDS 2009 1.03
50 HIV-1/HSV-2 co-infected adults in early HIV-1 infection have elevated CD4+ T cell counts. PLoS One 2007 1.03
51 Single-cell, phosphoepitope-specific analysis demonstrates cell type- and pathway-specific dysregulation of Jak/STAT and MAPK signaling associated with in vivo human immunodeficiency virus type 1 infection. J Virol 2008 1.03
52 ELISPOT cell rescue. J Immunol Methods 2004 1.02
53 Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects. J Virol 2011 1.01
54 Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic. J Immunol 2012 1.01
55 Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus. J Immunol 2002 1.00
56 Individuals with pulmonary tuberculosis have lower levels of circulating CD1d-restricted NKT cells. J Infect Dis 2007 1.00
57 A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-α and MIP1-β, a lack of IL-17, and a Th1-bias in males. PLoS One 2010 1.00
58 IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells. AIDS Res Ther 2006 0.99
59 Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma. AIDS Res Hum Retroviruses 2006 0.99
60 Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin-2. Blood 2005 0.98
61 R5 human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in primary CD4+ T-cell cultures than X4 HIV-1. J Virol 2004 0.98
62 Human endogenous retrovirus K106 (HERV-K106) was infectious after the emergence of anatomically modern humans. PLoS One 2011 0.97
63 Residual viral replication during antiretroviral therapy boosts human immunodeficiency virus type 1-specific CD8+ T-cell responses in subjects treated early after infection. J Virol 2002 0.97
64 Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus. Clin Vaccine Immunol 2007 0.97
65 Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. J Infect Dis 2002 0.96
66 Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions. AIDS 2002 0.96
67 Relevance of HIV-1-specific CD4+ helper T-cell responses during structured treatment interruptions in patients with CD4+ T-cell nadir above 400/mm3. J Acquir Immune Defic Syndr 2004 0.95
68 Immunity to HIV-1 is influenced by continued natural exposure to exogenous virus. PLoS Pathog 2008 0.95
69 Immune reconstitution of CD56(dim) NK cells in individuals with primary HIV-1 infection treated with interleukin-2. J Infect Dis 2008 0.94
70 Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part II: Panel performance across different instrument platforms. Cytometry A 2008 0.94
71 Higher frequency of HIV-1-specific T cell immune responses in African American children vertically infected with HIV-1. J Infect Dis 2005 0.94
72 Differentiation and functional regulation of human fetal NK cells. J Clin Invest 2013 0.94
73 The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis. BMC Immunol 2008 0.93
74 Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses. Clin Vaccine Immunol 2009 0.92
75 HIV-1-specific CD4+ T cell responses in chronically HIV-1 infected blippers on antiretroviral therapy in relation to viral replication following treatment interruption. J Clin Immunol 2006 0.92
76 A decreased frequency of regulatory T cells in patients with common variable immunodeficiency. PLoS One 2009 0.91
77 Expansion of CD8+ T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity. Blood 2011 0.91
78 Changes in CD4+ T-cell differentiation phenotype during structured treatment interruption in patients with chronic HIV-1 infection. J Acquir Immune Defic Syndr 2003 0.91
79 Skewed distribution of circulating activated natural killer T (NKT) cells in patients with common variable immunodeficiency disorders (CVID). PLoS One 2010 0.90
80 Partial treatment interruption of protease inhibitors augments HIV-specific immune responses in vertically infected pediatric patients. AIDS 2005 0.90
81 Cross-sectional dating of novel haplotypes of HERV-K 113 and HERV-K 115 indicate these proviruses originated in Africa before Homo sapiens. Mol Biol Evol 2009 0.90
82 IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery. J Clin Immunol 2010 0.89
83 Poorly soluble peptides can mimic authentic ELISPOT responses. J Immunol Methods 2004 0.89
84 A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties. Eur J Immunol 2010 0.89
85 The calm mouse: an animal model of stress reduction. Mol Med 2012 0.89
86 Dendritic cell amplification of HIV type 1-specific CD8+ T cell responses in exposed, seronegative heterosexual women. AIDS Res Hum Retroviruses 2002 0.88
87 Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques. Retrovirology 2006 0.88
88 Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression. J Infect Dis 2003 0.87
89 Expansion of CD7(low) and CD7(negative) CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment. Blood 2004 0.87
90 Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2. Immunology 2009 0.86
91 HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications. PLoS Negl Trop Dis 2011 0.86
92 Skewed distribution of natural killer cells in psoriasis skin lesions. Exp Dermatol 2013 0.85
93 Variability of HIV-1 genomes among children and adolescents from São Paulo, Brazil. PLoS One 2013 0.85
94 Human endogenous retrovirus K(HML-2) Gag- and Env-specific T-cell responses are infrequently detected in HIV-1-infected subjects using standard peptide matrix-based screening. Clin Vaccine Immunol 2011 0.84
95 Influence of HAART on alternative reading frame immune responses over the course of HIV-1 infection. PLoS One 2012 0.84
96 HIV-1 Vpu interference with innate cell-mediated immune mechanisms. Curr HIV Res 2012 0.84
97 CD8 T cell effector maturation in HIV-1-infected children. Virology 2006 0.84
98 Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population. Eur J Immunol 2009 0.83
99 Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus. J Gen Virol 2005 0.83
100 Human endogenous retrovirus expression is inversely associated with chronic immune activation in HIV-1 infection. PLoS One 2012 0.83
101 Immunodominance of HIV-1 specific CD8+ T-cell responses is related to disease progression rate in vertically infected adolescents. PLoS One 2011 0.83
102 LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells. J Virol 2013 0.83
103 Herpes simplex virus and HIV-1: deciphering viral synergy. Lancet Infect Dis 2009 0.82
104 Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications. PLoS Negl Trop Dis 2013 0.82
105 Boosting of SIV-specific T cell responses in rhesus macaques that resist repeated intravaginal challenge with SIVmac251. AIDS Res Hum Retroviruses 2002 0.82
106 Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children. PLoS One 2012 0.81
107 Immune escape mutations detected within HIV-1 epitopes associated with viral control during treatment interruption. J Acquir Immune Defic Syndr 2010 0.81
108 Protective effect of human endogenous retrovirus K dUTPase variants on psoriasis susceptibility. J Invest Dermatol 2012 0.81
109 Targeting of conserved gag-epitopes in early HIV infection is associated with lower plasma viral load and slower CD4(+) T cell depletion. AIDS Res Hum Retroviruses 2013 0.80
110 Lower numbers of natural killer T cells in HIV-1 and Mycobacterium leprae co-infected patients. Immunology 2012 0.80
111 Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis. Eur J Immunol 2013 0.80
112 Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda. PLoS One 2012 0.80
113 Human endogenous retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods. J Negat Results Biomed 2013 0.79
114 HIV-1-specific T Cell-dependent natural killer (NK) cell activation: major contribution by NK cells to interferon-gamma production in response to HIV-1 antigens. AIDS Res Hum Retroviruses 2009 0.78
115 T cells target APOBEC3 proteins in human immunodeficiency virus type 1-infected humans and simian immunodeficiency virus-infected Indian rhesus macaques. J Virol 2013 0.78
116 T lymphocyte responses against human parvovirus B19: small virus, big response. Pathol Biol (Paris) 2002 0.78
117 Treatment interruption in chronic HIV-1 infection: does it deliver? Curr Opin HIV AIDS 2007 0.78
118 Multidrug-resistant, dual-tropic HIV-1 and rapid progression. Lancet 2005 0.77
119 Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children. PLoS One 2012 0.77
120 Decay kinetics of HIV-1 specific T cell responses in vertically HIV-1 exposed seronegative infants. Front Immunol 2012 0.77
121 Correction: Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes. PLoS One 2016 0.75
122 CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis. PLoS One 2013 0.75
123 Diminished humoral responses against and reduced gene expression levels of human endogenous retrovirus-K (HERV-K) in psoriasis. J Transl Med 2014 0.75
124 Correction: p16INK4a Expression and Immunologic Aging in Chronic HIV Infection. PLoS One 2017 0.75
125 Inversion of the Vδ1 to Vδ2 γδ T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion. Medicine (Baltimore) 2016 0.75
126 Brief Report: HIV-1 gp120 T-Cell Responses Correspond to Infection Outcomes in the Global iPrEx Chemoprophylaxis Trial. J Acquir Immune Defic Syndr 2016 0.75
127 Differential expression of CD96 surface molecule represents CD8⁺ T cells with dissimilar effector function during HIV-1 infection. PLoS One 2012 0.75
128 Human T-lymphotropic virus 1, breastfeeding, and antiretroviral therapy. AIDS Res Hum Retroviruses 2014 0.75
129 Examining HIV Viral Load in a Matched Cohort of HIV Positive Individuals With and Without Psoriasis. J Drugs Dermatol 2017 0.75
130 A plea for justice for jailed medical workers. Science 2006 0.75