Published in Microbiology on June 01, 2004
Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs). Nucleic Acids Res (2005) 4.15
Automated genome mining for natural products. BMC Bioinformatics (2009) 2.29
Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution. BMC Evol Biol (2007) 1.97
The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity. PLoS One (2012) 1.84
Structural aspects of non-ribosomal peptide biosynthesis. Curr Opin Struct Biol (2004) 1.34
Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships. BMC Evol Biol (2010) 1.23
AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. Nat Chem Biol (2009) 1.21
Genome sequence of the pattern forming Paenibacillus vortex bacterium reveals potential for thriving in complex environments. BMC Genomics (2010) 1.20
Triggers and cues that activate antibiotic production by actinomycetes. J Ind Microbiol Biotechnol (2013) 1.14
Module evolution and substrate specificity of fungal nonribosomal peptide synthetases involved in siderophore biosynthesis. BMC Evol Biol (2008) 1.02
Recurrent adenylation domain replacement in the microcystin synthetase gene cluster. BMC Evol Biol (2007) 1.02
Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models. PLoS One (2013) 0.98
Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs. Mar Drugs (2010) 0.96
Evidence for positive selection acting on microcystin synthetase adenylation domains in three cyanobacterial genera. BMC Evol Biol (2008) 0.95
Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis. PLoS One (2013) 0.95
Agrobacterium-mediated disruption of a nonribosomal peptide synthetase gene in the invertebrate pathogen Metarhizium anisopliae reveals a peptide spore factor. Appl Environ Microbiol (2008) 0.93
Role of MbtH-like proteins in the adenylation of tyrosine during aminocoumarin and vancomycin biosynthesis. J Biol Chem (2011) 0.92
Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus. J Ind Microbiol Biotechnol (2005) 0.88
Comparative genomics and metabolic profiling of the genus Lysobacter. BMC Genomics (2015) 0.85
Unusual Biosynthesis and Structure of Locillomycins from Bacillus subtilis 916. Appl Environ Microbiol (2015) 0.81
Metabolic profiling as a tool for prioritizing antimicrobial compounds. J Ind Microbiol Biotechnol (2015) 0.78
Systematic analysis of the kalimantacin assembly line NRPS module using an adapted targeted mutagenesis approach. Microbiologyopen (2015) 0.75
The presence of two cyclase thioesterases expands the conformational freedom of the cyclic Peptide occidiofungin. J Nat Prod (2013) 0.75
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biol (2009) 3.63
The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. PLoS Genet (2006) 3.33
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining. Nat Chem Biol (2005) 3.17
The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics (2010) 2.37
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proc Natl Acad Sci U S A (2011) 2.05
Strategies for the discovery of new natural products by genome mining. Chembiochem (2009) 2.04
Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nat Chem (2011) 1.82
The Scottish Structural Proteomics Facility: targets, methods and outputs. J Struct Funct Genomics (2010) 1.66
New natural product biosynthetic chemistry discovered by genome mining. Nat Prod Rep (2009) 1.60
Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J Am Chem Soc (2006) 1.48
Identification of a cluster of genes that directs desferrioxamine biosynthesis in Streptomyces coelicolor M145. J Am Chem Soc (2004) 1.43
MbtH-like protein-mediated cross-talk between non-ribosomal peptide antibiotic and siderophore biosynthetic pathways in Streptomyces coelicolor M145. Microbiology (2007) 1.39
Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chem Biol (2008) 1.27
A new family of ATP-dependent oligomerization-macrocyclization biocatalysts. Nat Chem Biol (2007) 1.25
AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. Nat Chem Biol (2009) 1.21
Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis. Nat Chem Biol (2012) 1.17
2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proc Natl Acad Sci U S A (2008) 1.16
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877. Microbiology (2006) 1.14
Recent advances in siderophore biosynthesis. Curr Opin Chem Biol (2009) 1.06
The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus. Chem Biol (2011) 1.05
Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of Kinamycins. J Bacteriol (2010) 1.01
A novel streptococcal integrative conjugative element involved in iron acquisition. Mol Microbiol (2008) 0.99
Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis. Chem Commun (Camb) (2006) 0.99
Enacyloxins are products of an unusual hybrid modular polyketide synthase encoded by a cryptic Burkholderia ambifaria Genomic Island. Chem Biol (2011) 0.98
Enzymatic logic of anthrax stealth siderophore biosynthesis: AsbA catalyzes ATP-dependent condensation of citric acid and spermidine. J Am Chem Soc (2007) 0.97
Genome mining of Streptomyces ambofaciens. J Ind Microbiol Biotechnol (2013) 0.96
Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation. Biochemistry (2004) 0.94
Identification of a gene cluster that directs putrebactin biosynthesis in Shewanella species: PubC catalyzes cyclodimerization of N-hydroxy-N-succinylputrescine. J Am Chem Soc (2008) 0.92
The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis. Chem Commun (Camb) (2009) 0.92
Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites. J Ind Microbiol Biotechnol (2005) 0.91
Bisucaberin biosynthesis: an adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine. Chem Commun (Camb) (2008) 0.91
Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis. Chem Commun (Camb) (2008) 0.91
Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N8-citryl-spermidine and its N1-(3,4-dihydroxybenzoyl) derivative. Chem Commun (Camb) (2008) 0.90
Evidence for the unusual condensation of a diketide with a pentulose in the methylenomycin biosynthetic pathway of Streptomyces coelicolor A3(2). Chembiochem (2005) 0.90
Unusual odd-electron fragments from even-electron protonated prodiginine precursors using positive-ion electrospray tandem mass spectrometry. J Am Soc Mass Spectrom (2008) 0.90
Antimalarial activity of natural and synthetic prodiginines. J Med Chem (2011) 0.89
Stereochemical elucidation of streptorubin B. J Am Chem Soc (2010) 0.89
Non-linear enzymatic logic in natural product modular mega-synthases and -synthetases. Curr Opin Drug Discov Devel (2007) 0.89
Distinct extracytoplasmic siderophore binding proteins recognize ferrioxamines and ferricoelichelin in Streptomyces coelicolor A3(2). Biochemistry (2010) 0.88
Chapter 17. Siderophore biosynthesis a substrate specificity assay for nonribosomal peptide synthetase-independent siderophore synthetases involving trapping of acyl-adenylate intermediates with hydroxylamine. Methods Enzymol (2009) 0.86
The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin. PLoS One (2012) 0.85
Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor. J Biol Chem (2011) 0.83
Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from Bacillus anthracis. J Biol Chem (2012) 0.82
Structure and biosynthesis of scabichelin, a novel tris-hydroxamate siderophore produced by the plant pathogen Streptomyces scabies 87.22. Org Biomol Chem (2013) 0.82
Heavy tools for genome mining. Chem Biol (2007) 0.81
Tailoring reactions catalyzed by heme-dependent enzymes: spectroscopic characterization of the L-tryptophan-nitrating cytochrome P450 TxtE. Methods Enzymol (2012) 0.81
Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.80
Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases. ACS Catal (2013) 0.80
The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family proteins. Microbiology (2011) 0.79
Structural basis for acyl acceptor specificity in the achromobactin biosynthetic enzyme AcsD. J Mol Biol (2011) 0.79
Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA. Chem Commun (Camb) (2009) 0.79
A sweet origin for the key congocidine precursor 4-acetamidopyrrole-2-carboxylate. Angew Chem Int Ed Engl (2012) 0.77
Oxidative tailoring reactions catalyzed by nonheme iron-dependent enzymes: streptorubin B biosynthesis as an example. Methods Enzymol (2012) 0.77
Engineering Escherichia coli to produce nonribosomal peptide antibiotics. Nat Chem Biol (2006) 0.76
A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols. Chem Commun (Camb) (2010) 0.75
The catalytic mechanism of aromatic nitration by cytochrome P450 TxtE: Involvement of a ferric-peroxynitrite intermediate. J Am Chem Soc (2020) 0.75
Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. J Am Chem Soc (2017) 0.75