Published in Med Hypotheses on January 01, 2004
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NOX activity in brain aging: exacerbation by high fat diet. Free Radic Biol Med (2010) 0.97
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Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease. Antioxid Redox Signal (2012) 0.94
Structural brain changes in normal individuals with a maternal history of Alzheimer's. Neurobiol Aging (2011) 0.94
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Role of mitochondrial homeostasis and dynamics in Alzheimer's disease. Neurobiol Dis (2012) 0.93
Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage. Biochim Biophys Acta (2011) 0.93
Mitochondrial genomic analysis of late onset Alzheimer's disease reveals protective haplogroups H6A1A/H6A1B: the Cache County Study on Memory in Aging. PLoS One (2012) 0.92
Single-molecule LATE-PCR analysis of human mitochondrial genomic sequence variations. PLoS One (2009) 0.92
Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease. Front Neurosci (2016) 0.91
Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation. Neurobiol Dis (2011) 0.91
Diet-induced metabolic disturbances as modulators of brain homeostasis. Biochim Biophys Acta (2008) 0.91
Mitochondrial DNA sequence variation and neurodegeneration. Hum Genomics (2008) 0.91
Lack of association between mtDNA haplogroups and Alzheimer's disease in Tuscany. Neurol Sci (2007) 0.91
Accumulation of exogenous amyloid-beta peptide in hippocampal mitochondria causes their dysfunction: a protective role for melatonin. Oxid Med Cell Longev (2012) 0.91
Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases. Curr Pharm Des (2011) 0.90
Genetics of Alzheimer's disease. Biomed Res Int (2013) 0.90
What have novel imaging techniques revealed about metabolism in the aging brain? Future Neurol (2014) 0.89
Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease. Alzheimers Dement (2013) 0.89
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Signaling pathway cross talk in Alzheimer's disease. Cell Commun Signal (2014) 0.89
Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis (2011) 0.88
Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. PLoS One (2013) 0.88
Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOEɛ4 Carriers. J Alzheimers Dis (2015) 0.87
Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936. Neurobiol Aging (2014) 0.86
Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis. Biochim Biophys Acta (2015) 0.86
Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease. Cell Cycle (2014) 0.85
Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age. Neurobiol Aging (2014) 0.85
Polymorphic variation in cytochrome oxidase subunit genes. J Alzheimers Dis (2010) 0.85
Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction. Free Radic Biol Med (2014) 0.85
May "mitochondrial eve" and mitochondrial haplogroups play a role in neurodegeneration and Alzheimer's disease? Int J Alzheimers Dis (2011) 0.83
Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD, and wild-type mice. Cell Death Dis (2012) 0.83
Alzheimer's disease pathologic cascades: who comes first, what drives what. Neurotox Res (2011) 0.83
Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies. Pharmaceuticals (Basel) (2009) 0.83
Deep Phosphoproteomic Measurements Pinpointing Drug Induced Protective Mechanisms in Neuronal Cells. Front Physiol (2016) 0.83
Associations Between Genetic Variants in 19p13 and 19q13 Regions and Susceptibility to Alzheimer Disease: A Meta-Analysis. Med Sci Monit (2016) 0.82
Transcriptional alterations related to neuropathology and clinical manifestation of Alzheimer's disease. PLoS One (2012) 0.82
A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions. Front Pharmacol (2015) 0.82
Cortical neurons transgenic for human Abeta40 or Abeta42 have similar vulnerability to apoptosis despite their different amyloidogenic properties. Int J Clin Exp Pathol (2008) 0.81
Mitochondria-Targeted Antioxidant SS31 Prevents Amyloid Beta-Induced Mitochondrial Abnormalities and Synaptic Degeneration in Alzheimer's Disease. Pharmaceuticals (Basel) (2012) 0.81
Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials. Biomed Res Int (2014) 0.81
TOMM40 polymorphisms in Italian Alzheimer's disease and frontotemporal dementia patients. Neurol Sci (2013) 0.81
BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease. J Cereb Blood Flow Metab (2015) 0.80
Bioenergetic dysfunction and inflammation in Alzheimer's disease: a possible connection. Front Aging Neurosci (2014) 0.80
Targeting mitochondrial bioenergetics for Alzheimer's prevention and treatment. Curr Pharm Des (2011) 0.80
Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients. Aging (Albany NY) (2015) 0.80
Oxidative stress level in circulating neutrophils is linked to neurodegenerative diseases. J Clin Immunol (2004) 0.80
Promising Genetic Biomarkers of Preclinical Alzheimer's Disease: The Influence of APOE and TOMM40 on Brain Integrity. Int J Alzheimers Dis (2012) 0.80
Vitamin D and Alzheimer's Disease: Neurocognition to Therapeutics. Int J Alzheimers Dis (2015) 0.79
Quantitative proteomic analysis of mitochondria in aging PS-1 transgenic mice. Cell Mol Neurobiol (2009) 0.79
Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease. Front Mol Neurosci (2016) 0.78
Mitochondrial DNA deletions in Alzheimer's brains: a review. Alzheimers Dement (2013) 0.78
The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis. Mult Scler Int (2015) 0.78
Research progress on flavonoids isolated from traditional Chinese medicine in treatment of Alzheimer's disease. Intractable Rare Dis Res (2013) 0.78
Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): a paradigm worth exploring. Biochem Pharmacol (2013) 0.77
Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds. Oxid Med Cell Longev (2015) 0.77
Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936. PLoS One (2013) 0.77
Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology. Neurobiol Aging (2016) 0.77
Tau facilitates Aβ-induced loss of mitochondrial membrane potential independent of cytosolic calcium fluxes in mouse cortical neurons. Neurosci Lett (2015) 0.76
Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer's disease. Eur J Med Chem (2014) 0.76
The association between TOMM40 gene polymorphism and spontaneous brain activity in amnestic mild cognitive impairment. J Neurol (2014) 0.76
An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology. Aging (Albany NY) (2016) 0.75
Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Mol Psychiatry (2016) 0.75
Triad of Risk for Late Onset Alzheimer's: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex. Front Aging Neurosci (2016) 0.75
Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments. Front Aging Neurosci (2016) 0.75
The Alzheimer's disease mitochondrial cascade hypothesis. J Alzheimers Dis (2010) 1.60
DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination. Mitochondrion (2009) 1.50
The Alzheimer's disease mitochondrial cascade hypothesis: an update. Exp Neurol (2009) 1.36
Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model. Hum Gene Ther (2009) 1.14
Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer's disease. Curr Alzheimer Res (2006) 1.07
Mitochondrial microheteroplasmy and a theory of aging and age-related disease. Rejuvenation Res (2005) 0.94
Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin. Mitochondrion (2010) 0.88
RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice. Aging (Albany NY) (2012) 0.85
Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma. J Neurosci Res (2002) 0.83