PubRank

L Aravind

Author PubWeight™ 724.28‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Initial sequencing and analysis of the human genome. Nature 2001 212.86
2 Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009 32.97
3 Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements. Nucleic Acids Res 2001 22.33
4 Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 1998 13.64
5 De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004 12.41
6 AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res 1999 11.30
7 Bacterial rhodopsin: evidence for a new type of phototrophy in the sea. Science 2000 10.82
8 Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010 8.87
9 Horizontal gene transfer in prokaryotes: quantification and classification. Annu Rev Microbiol 2001 8.14
10 Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. Science 1999 8.01
11 Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science 2002 7.49
12 IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices. Bioinformatics 1999 6.91
13 Classification and evolution of P-loop GTPases and related ATPases. J Mol Biol 2002 6.85
14 Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs). Genome Biol 2000 6.50
15 Comparison of the complete protein sets of worm and yeast: orthology and divergence. Science 1998 6.28
16 Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science 2004 5.64
17 Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 2002 4.95
18 Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics. Microbiol Mol Biol Rev 2001 4.75
19 Evolutionary history and higher order classification of AAA+ ATPases. J Struct Biol 2004 4.68
20 Evolutionary genomics of nucleo-cytoplasmic large DNA viruses. Virus Res 2006 4.49
21 Structure and evolution of transcriptional regulatory networks. Curr Opin Struct Biol 2004 4.48
22 A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis. Nucleic Acids Res 2002 4.39
23 Common origin of four diverse families of large eukaryotic DNA viruses. J Virol 2001 4.28
24 The role of lineage-specific gene family expansion in the evolution of eukaryotes. Genome Res 2002 4.28
25 Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle 2009 4.14
26 Evidence for massive gene exchange between archaeal and bacterial hyperthermophiles. Trends Genet 1998 4.10
27 Comparative genomics and evolution of proteins involved in RNA metabolism. Nucleic Acids Res 2002 4.00
28 Construction and analysis of bacterial artificial chromosome libraries from a marine microbial assemblage. Environ Microbiol 2000 3.99
29 Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. Biol Direct 2011 3.92
30 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science 1998 3.83
31 The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens. Proc Natl Acad Sci U S A 2002 3.72
32 Comparative genomics of the Archaea (Euryarchaeota): evolution of conserved protein families, the stable core, and the variable shell. Genome Res 1999 3.62
33 Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. Genome Res 1999 3.44
34 Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains. Nucleic Acids Res 2005 3.36
35 Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. J Mol Biol 1999 3.28
36 Multiple transporters associated with malaria parasite responses to chloroquine and quinine. Mol Microbiol 2003 3.26
37 The impact of comparative genomics on our understanding of evolution. Cell 2000 3.25
38 PAS: a multifunctional domain family comes to light. Curr Biol 1997 3.20
39 TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol 2013 3.18
40 Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase. Nat Immunol 2007 3.14
41 Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol 2006 3.10
42 Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells. Cell 2011 3.06
43 Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes. Genome Biol 2003 3.02
44 Novel families of putative protein kinases in bacteria and archaea: evolution of the "eukaryotic" protein kinase superfamily. Genome Res 1998 2.91
45 START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins. Trends Biochem Sci 1999 2.89
46 Rickettsiae and Chlamydiae: evidence of horizontal gene transfer and gene exchange. Trends Genet 1999 2.87
47 New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system. Genome Biol 2003 2.77
48 The U box is a modified RING finger - a common domain in ubiquitination. Curr Biol 2000 2.73
49 Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. J Mol Biol 2001 2.68
50 Adaptations of the helix-grip fold for ligand binding and catalysis in the START domain superfamily. Proteins 2001 2.65
51 Prediction of the archaeal exosome and its connections with the proteasome and the translation and transcription machineries by a comparative-genomic approach. Genome Res 2001 2.65
52 Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex. Cell Cycle 2004 2.65
53 Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging. Nucleic Acids Res 2004 2.62
54 The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Biochem Sci 2000 2.58
55 Diversification and spectral tuning in marine proteorhodopsins. EMBO J 2003 2.53
56 Evolution and classification of P-loop kinases and related proteins. J Mol Biol 2003 2.52
57 Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new members. Nucleic Acids Res 2005 2.49
58 Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J Mol Biol 2006 2.44
59 Did DNA replication evolve twice independently? Nucleic Acids Res 1999 2.44
60 Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels. Genome Biol 2004 2.39
61 The bacterial replicative helicase DnaB evolved from a RecA duplication. Genome Res 2000 2.39
62 Comprehensive analysis of combinatorial regulation using the transcriptional regulatory network of yeast. J Mol Biol 2006 2.36
63 Comparative genomic analysis of archaeal genotypic variants in a single population and in two different oceanic provinces. Appl Environ Microbiol 2002 2.24
64 Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily. Proc Natl Acad Sci U S A 1999 2.15
65 Comparative genomics of transcription factors and chromatin proteins in parasitic protists and other eukaryotes. Int J Parasitol 2007 2.15
66 An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin. Mol Microbiol 2007 2.11
67 STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer. J Mol Biol 2004 2.10
68 Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily. Nucleic Acids Res 2002 2.08
69 Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease. Front Genet 2012 2.08
70 The STAS domain - a link between anion transporters and antisigma-factor antagonists. Curr Biol 2000 2.07
71 Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics. Biol Direct 2012 2.05
72 Origin and evolution of eukaryotic apoptosis: the bacterial connection. Cell Death Differ 2002 2.04
73 A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Trends Biochem Sci 2000 2.01
74 Classification and evolutionary history of the single-strand annealing proteins, RecT, Redbeta, ERF and RAD52. BMC Genomics 2002 1.99
75 SPOUT: a class of methyltransferases that includes spoU and trmD RNA methylase superfamilies, and novel superfamilies of predicted prokaryotic RNA methylases. J Mol Microbiol Biotechnol 2002 1.95
76 A specialized version of the HD hydrolase domain implicated in signal transduction. J Mol Microbiol Biotechnol 1999 1.86
77 The C. elegans Polycomb gene SOP-2 encodes an RNA binding protein. Mol Cell 2004 1.85
78 Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol 2009 1.84
79 Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors. Trends Biochem Sci 2000 1.84
80 The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains. Genome Biol 2006 1.82
81 Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases. BMC Struct Biol 2003 1.80
82 Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins. BMC Genomics 2003 1.76
83 A database of bacterial lipoproteins (DOLOP) with functional assignments to predicted lipoproteins. J Bacteriol 2006 1.76
84 Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture. Mol Syst Biol 2009 1.73
85 Bacterial-type DNA holliday junction resolvases in eukaryotic viruses. Proc Natl Acad Sci U S A 2000 1.71
86 Comparative analysis of apicomplexa and genomic diversity in eukaryotes. Genome Res 2004 1.71
87 Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation. Genetics 2001 1.65
88 Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature 2013 1.65
89 The natural history of the WRKY-GCM1 zinc fingers and the relationship between transcription factors and transposons. Nucleic Acids Res 2006 1.62
90 Unraveling the biochemistry and provenance of pupylation: a prokaryotic analog of ubiquitination. Biol Direct 2008 1.61
91 Interplay between gene expression noise and regulatory network architecture. Trends Genet 2012 1.61
92 Emergence of diverse biochemical activities in evolutionarily conserved structural scaffolds of proteins. Curr Opin Chem Biol 2003 1.59
93 YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics. Biochemistry 2002 1.58
94 Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria. BMC Genomics 2003 1.56
95 Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. Proc Natl Acad Sci U S A 2005 1.56
96 Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites. Infect Immun 2007 1.55
97 A bipolar DNA helicase gene, herA, clusters with rad50, mre11 and nurA genes in thermophilic archaea. Nucleic Acids Res 2004 1.55
98 Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol 2009 1.55
99 Evolution of bacterial RNA polymerase: implications for large-scale bacterial phylogeny, domain accretion, and horizontal gene transfer. Gene 2004 1.52
100 Uncovering a hidden distributed architecture behind scale-free transcriptional regulatory networks. J Mol Biol 2006 1.52
101 Dynein light chains of the Roadblock/LC7 group belong to an ancient protein superfamily implicated in NTPase regulation. Curr Biol 2000 1.51
102 Comparative genome analysis of the pathogenic spirochetes Borrelia burgdorferi and Treponema pallidum. Infect Immun 2000 1.49
103 The GOLD domain, a novel protein module involved in Golgi function and secretion. Genome Biol 2002 1.48
104 Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. BMC Genomics 2004 1.47
105 Discovering functional linkages and uncharacterized cellular pathways using phylogenetic profile comparisons: a comprehensive assessment. BMC Bioinformatics 2007 1.47
106 The CHASE domain: a predicted ligand-binding module in plant cytokinin receptors and other eukaryotic and bacterial receptors. Trends Biochem Sci 2001 1.46
107 The signaling helix: a common functional theme in diverse signaling proteins. Biol Direct 2006 1.46
108 Evolution of cell-cell signaling in animals: did late horizontal gene transfer from bacteria have a role? Trends Genet 2004 1.45
109 A superfamily of archaeal, bacterial, and eukaryotic proteins homologous to animal transglutaminases. Protein Sci 1999 1.43
110 Novel predicted peptidases with a potential role in the ubiquitin signaling pathway. Cell Cycle 2004 1.42
111 A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. Nucleic Acids Res 2011 1.41
112 PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum. Nature 2013 1.40
113 Chitinases of the avian malaria parasite Plasmodium gallinaceum, a class of enzymes necessary for parasite invasion of the mosquito midgut. J Biol Chem 2000 1.39
114 Comparative genomics and evolutionary trajectories of viral ATP dependent DNA-packaging systems. Genome Dyn 2007 1.37
115 Natural history of eukaryotic DNA methylation systems. Prog Mol Biol Transl Sci 2011 1.35
116 Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors. Genome Biol 2002 1.34
117 A multidomain adhesion protein family expressed in Plasmodium falciparum is essential for transmission to the mosquito. J Exp Med 2004 1.33
118 The HIRAN domain and recruitment of chromatin remodeling and repair activities to damaged DNA. Cell Cycle 2006 1.32
119 The NYN domains: novel predicted RNAses with a PIN domain-like fold. RNA Biol 2006 1.32
120 A hemolytic pigment of Group B Streptococcus allows bacterial penetration of human placenta. J Exp Med 2013 1.31
121 Small but versatile: the extraordinary functional and structural diversity of the beta-grasp fold. Biol Direct 2007 1.31
122 Quod erat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences. Genome Biol 2001 1.30
123 SWIM, a novel Zn-chelating domain present in bacteria, archaea and eukaryotes. Trends Biochem Sci 2002 1.30
124 Live virus-free or die: coupling of antivirus immunity and programmed suicide or dormancy in prokaryotes. Biol Direct 2012 1.27
125 The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Dev Cell 2008 1.27
126 Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis. Cancer Cell 2004 1.27
127 Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems. Nucleic Acids Res 2011 1.25
128 Protein fold recognition using sequence profiles and its application in structural genomics. Adv Protein Chem 2000 1.24
129 MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases. Biol Direct 2008 1.23
130 Natural history of the E1-like superfamily: implication for adenylation, sulfur transfer, and ubiquitin conjugation. Proteins 2009 1.20
131 A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey. Proc Natl Acad Sci U S A 2010 1.20
132 Anatomy of the E2 ligase fold: implications for enzymology and evolution of ubiquitin/Ub-like protein conjugation. J Struct Biol 2008 1.19
133 Interplay between network structures, regulatory modes and sensing mechanisms of transcription factors in the transcriptional regulatory network of E. coli. J Mol Biol 2007 1.18
134 Structure of the Plasmodium 6-cysteine s48/45 domain. Proc Natl Acad Sci U S A 2012 1.18
135 Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. Gene 2010 1.15
136 Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing. Biol Direct 2013 1.14
137 BEN: a novel domain in chromatin factors and DNA viral proteins. Bioinformatics 2008 1.14
138 Bacterial GRAS domain proteins throw new light on gibberellic acid response mechanisms. Bioinformatics 2012 1.13
139 MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. FEMS Microbiol Lett 2002 1.12
140 Comparative genomics of protists: new insights into the evolution of eukaryotic signal transduction and gene regulation. Annu Rev Microbiol 2007 1.12
141 OST-HTH: a novel predicted RNA-binding domain. Biol Direct 2010 1.11
142 Adhesion molecules and other secreted host-interaction determinants in Apicomplexa: insights from comparative genomics. Int Rev Cytol 2007 1.10
143 Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling. Curr Biol 1999 1.10
144 Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase. Nucleic Acids Res 2010 1.10
145 Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins. Mol Biosyst 2009 1.10
146 Differential action of natural selection on the N and C-terminal domains of 2'-5' oligoadenylate synthetases and the potential nuclease function of the C-terminal domain. J Mol Biol 2003 1.09
147 The fukutin protein family--predicted enzymes modifying cell-surface molecules. Curr Biol 1999 1.09
148 The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates. BMC Genomics 2002 1.09
149 Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). J Biol Chem 2010 1.09
150 Functional diversification of the RING finger and other binuclear treble clef domains in prokaryotes and the early evolution of the ubiquitin system. Mol Biosyst 2011 1.08
151 Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system. Gene 2010 1.08
152 The ATP-cone: an evolutionarily mobile, ATP-binding regulatory domain. J Mol Microbiol Biotechnol 2000 1.07
153 HPC2 and ubinuclein define a novel family of histone chaperones conserved throughout eukaryotes. Mol Biosyst 2009 1.07
154 Presence of a classical RRM-fold palm domain in Thg1-type 3'- 5'nucleic acid polymerases and the origin of the GGDEF and CRISPR polymerase domains. Biol Direct 2010 1.07
155 Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA. Nucleic Acids Res 2013 1.06
156 TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes. FEMS Microbiol Lett 2001 1.05
157 A new family of polymerases related to superfamily A DNA polymerases and T7-like DNA-dependent RNA polymerases. Biol Direct 2008 1.04
158 The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptors. Sci Signal 2012 1.04
159 Adaptive evolution by optimizing expression levels in different environments. Trends Microbiol 2005 1.02
160 A colipase fold in the carboxy-terminal domain of the Wnt antagonists--the Dickkopfs. Curr Biol 1998 1.02
161 Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites. Cell Cycle 2008 1.01
162 The Shwachman-Bodian-Diamond syndrome gene encodes an RNA-binding protein that localizes to the pseudopod of Dictyostelium amoebae during chemotaxis. J Cell Sci 2006 1.00
163 Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing. Mol Biosyst 2012 1.00
164 Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2). Proc Natl Acad Sci U S A 2010 1.00
165 Methods to reconstruct and compare transcriptional regulatory networks. Methods Mol Biol 2009 0.99
166 The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism. Bioinformatics 2005 0.98
167 MicroRNA targeting in mammalian genomes: genes and mechanisms. Wiley Interdiscip Rev Syst Biol Med 2010 0.98
168 Specific expansion of protein families in the radioresistant bacterium Deinococcus radiodurans. Genetica 2000 0.98
169 Apoptosis. Searching for FLASH domains. Nature 1999 0.97
170 Structure and evolution of ubiquitin and ubiquitin-related domains. Methods Mol Biol 2012 0.97
171 MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. Cell Rep 2012 0.97
172 Novel eukaryotic enzymes modifying cell-surface biopolymers. Biol Direct 2010 0.96
173 The PRC-barrel: a widespread, conserved domain shared by photosynthetic reaction center subunits and proteins of RNA metabolism. Genome Biol 2002 0.96
174 The SHS2 module is a common structural theme in functionally diverse protein groups, like Rpb7p, FtsA, GyrI, and MTH1598/TM1083 superfamilies. Proteins 2004 0.95
175 Insights from the architecture of the bacterial transcription apparatus. J Struct Biol 2011 0.95
176 Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartment. Cell Cycle 2012 0.95
177 The histone database: a comprehensive WWW resource for histones and histone fold-containing proteins. Nucleic Acids Res 2000 0.95
178 Bacterial homologs of the small subunit of eukaryotic DNA primase. J Mol Microbiol Biotechnol 2000 0.95
179 The DOMON domains are involved in heme and sugar recognition. Bioinformatics 2007 0.95
180 Diversity and evolution of chromatin proteins encoded by DNA viruses. Biochim Biophys Acta 2009 0.94
181 The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.94
182 CYSTM, a novel cysteine-rich transmembrane module with a role in stress tolerance across eukaryotes. Bioinformatics 2009 0.94
183 Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparum. J Biol Chem 2008 0.92
184 Peptide-N-glycanases and DNA repair proteins, Xp-C/Rad4, are, respectively, active and inactivated enzymes sharing a common transglutaminase fold. Hum Mol Genet 2001 0.92
185 Reconstructing the ubiquitin network: cross-talk with other systems and identification of novel functions. Genome Biol 2009 0.92
186 ATP hydrolysis by a domain related to translation factor GTPases drives polymerization of a static bacterial morphogenetic protein. Proc Natl Acad Sci U S A 2012 0.91
187 UMA and MABP domains throw light on receptor endocytosis and selection of endosomal cargoes. Bioinformatics 2010 0.91
188 Lineage-specific expansions of TET/JBP genes and a new class of DNA transposons shape fungal genomic and epigenetic landscapes. Proc Natl Acad Sci U S A 2014 0.90
189 Diversification of catalytic activities and ligand interactions in the protein fold shared by the sugar isomerases, eIF2B, DeoR transcription factors, acyl-CoA transferases and methenyltetrahydrofolate synthetase. J Mol Biol 2005 0.90
190 A novel superfamily containing the beta-grasp fold involved in binding diverse soluble ligands. Biol Direct 2007 0.90
191 Aldolases of the DhnA family: a possible solution to the problem of pentose and hexose biosynthesis in archaea. FEMS Microbiol Lett 2000 0.90
192 A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine. J Am Chem Soc 2014 0.90
193 Identification of novel components of NAD-utilizing metabolic pathways and prediction of their biochemical functions. Mol Biosyst 2012 0.90
194 Comparison of transcription regulatory interactions inferred from high-throughput methods: what do they reveal? Trends Genet 2008 0.90
195 The RAGNYA fold: a novel fold with multiple topological variants found in functionally diverse nucleic acid, nucleotide and peptide-binding proteins. Nucleic Acids Res 2007 0.89
196 Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice. PLoS One 2009 0.89
197 Eukaryotic transcription regulators derive from ancient enzymatic domains. Curr Biol 1998 0.89
198 Gene duplication with displacement and rearrangement: origin of the bacterial replication protein PriB from the single-stranded DNA-binding protein Ssb. J Mol Microbiol Biotechnol 2003 0.88
199 The emergence of catalytic and structural diversity within the beta-clip fold. Proteins 2004 0.87
200 High-confidence mapping of chemical compounds and protein complexes reveals novel aspects of chemical stress response in yeast. Mol Biosyst 2009 0.87
201 Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. Infect Immun 2008 0.87
202 Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells. Proc Natl Acad Sci U S A 2012 0.86
203 Molecular correlates of experimental cerebral malaria detectable in whole blood. Infect Immun 2010 0.86
204 Estimating the prevalence and regulatory potential of the telomere looping effect in yeast transcription regulation. Cell Cycle 2006 0.86
205 The natural history of ubiquitin and ubiquitin-related domains. Front Biosci (Landmark Ed) 2012 0.85
206 Filling out the structural map of the NTF2-like superfamily. BMC Bioinformatics 2013 0.85
207 PSI-BLAST tutorial. Methods Mol Biol 2007 0.84
208 Robustness and evolvability in natural chemical resistance: identification of novel systems properties, biochemical mechanisms and regulatory interactions. Mol Biosyst 2010 0.84
209 New perspectives on the diversification of the RNA interference system: insights from comparative genomics and small RNA sequencing. Wiley Interdiscip Rev RNA 2013 0.84
210 Two novel PIWI families: roles in inter-genomic conflicts in bacteria and Mediator-dependent modulation of transcription in eukaryotes. Biol Direct 2013 0.83
211 Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.83
212 An autoinhibitory conformation of the Bacillus subtilis spore coat protein SpoIVA prevents its premature ATP-independent aggregation. FEMS Microbiol Lett 2014 0.82
213 Clinical and molecular aspects of malaria fever. Trends Parasitol 2011 0.82
214 Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant. Nucleic Acids Res 2001 0.82
215 MEDS and PocR are novel domains with a predicted role in sensing simple hydrocarbon derivatives in prokaryotic signal transduction systems. Bioinformatics 2005 0.82
216 Computational analysis of human disease-associated genes and their protein products. Curr Opin Genet Dev 2001 0.82
217 Radiation-induced cellular and molecular alterations in asexual intraerythrocytic Plasmodium falciparum. J Infect Dis 2012 0.82
218 General trends in the evolution of prokaryotic transcriptional regulatory networks. Genome Dyn 2007 0.82
219 AMIN domains have a predicted role in localization of diverse periplasmic protein complexes. Bioinformatics 2008 0.81
220 The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function. Proteins 2008 0.81
221 The bridge-region of the Ku superfamily is an atypical zinc ribbon domain. J Struct Biol 2010 0.81
222 Human DNA polymerase kappa: a novel DNA polymerase of unknown biological function encoded by the DINB1 gene. Cold Spring Harb Symp Quant Biol 2000 0.80
223 Genomics: re-evaluation of translation machinery evolution. Curr Biol 1998 0.79
224 ALOG domains: provenance of plant homeotic and developmental regulators from the DNA-binding domain of a novel class of DIRS1-type retroposons. Biol Direct 2012 0.79
225 Evolutionary and Biochemical Aspects of Chemical Stress Resistance in Saccharomyces cerevisiae. Front Genet 2012 0.79
226 Differences in evolutionary pressure acting within highly conserved ortholog groups. BMC Evol Biol 2008 0.78
227 The Anabaena sensory rhodopsin transducer defines a novel superfamily of prokaryotic small-molecule binding domains. Biol Direct 2009 0.78
228 The Knickkopf DOMON domain is essential for cuticle differentiation in Drosophila melanogaster. Arch Insect Biochem Physiol 2014 0.78
229 [Vertebrate immunity: mutator proteins and their evolution]. Genetika 2007 0.78
230 Reconstructing prokaryotic transcriptional regulatory networks: lessons from actinobacteria. J Biol 2009 0.78
231 Plasmodium falciparum: characterization of a late asexual stage golgi protein containing both ankyrin and DHHC domains. Exp Parasitol 2005 0.78
232 Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila. BMC Bioinformatics 2013 0.76
233 LUD, a new protein domain associated with lactate utilization. BMC Bioinformatics 2013 0.76
234 Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis. BMC Bioinformatics 2014 0.76
235 The two faces of short-range evolutionary dynamics of regulatory modes in bacterial transcriptional regulatory networks. Bioessays 2007 0.76
236 No Sec7-homology domain in guanine-nucleotide-exchange factors that act on Ras and Rho. Trends Biochem Sci 1999 0.75
237 Opening Pandora's Box: making biological discoveries through computational data exploration. Biol Direct 2007 0.75
238 Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex. Cell Cycle 2009 0.75
239 Erratum: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1. Nat Immunol 2017 0.75
240 Global transcriptional effects of PEG-IFN-alpha and ribavirin on peripheral blood cells obtained from patients with chronic hepatitis C. Hepatol Res 2006 0.75