PubRank

Hisashi Iwaasa

Author PubWeight™ 28.29‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet. Hepatol Res 2007 1.34
2 Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics 2002 1.20
3 Characterization of MCH-mediated obesity in mice. Am J Physiol Endocrinol Metab 2003 1.16
4 Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone. Am J Physiol Endocrinol Metab 2002 1.16
5 (9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist. J Med Chem 2008 1.09
6 N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist. Bioorg Med Chem Lett 2003 1.04
7 Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B. Bioorg Med Chem Lett 2003 0.99
8 Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice. Endocrinology 2005 0.97
9 Characterization of the bombesin-like peptide receptor family in primates. Genomics 2004 0.90
10 Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp(34)NPY. Endocrinology 2003 0.89
11 Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell Tissue Res 2009 0.88
12 RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice. Endocrinology 2006 0.88
13 Chronic intracerebroventricular infusion of nociceptin/orphanin FQ produces body weight gain by affecting both feeding and energy metabolism in mice. Endocrinology 2009 0.87
14 A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice. Proc Natl Acad Sci U S A 2006 0.87
15 Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice. J Endocrinol 2008 0.83
16 Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives. Bioorg Med Chem Lett 2008 0.82
17 Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect. J Med Chem 2009 0.82
18 A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol 2006 0.82
19 Synergistic interaction between neuropeptide Y1 and Y5 receptor pathways in regulation of energy homeostasis. Eur J Pharmacol 2009 0.82
20 Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur J Pharmacol 2009 0.81
21 Effects of a novel Y5 antagonist in obese mice: combination with food restriction or sibutramine. Obesity (Silver Spring) 2008 0.81
22 Development of nonalcoholic steatohepatitis model through combination of high-fat diet and tetracycline with morbid obesity in mice. Hepatol Res 2006 0.80
23 Novel potent neuropeptide Y Y5 receptor antagonists: synthesis and structure-activity relationships of phenylpiperazine derivatives. Bioorg Med Chem 2006 0.78
24 Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg Med Chem 2010 0.77
25 Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists. Bioorg Med Chem Lett 2008 0.77
26 Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists. Bioorg Med Chem Lett 2009 0.76
27 Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists. Bioorg Med Chem Lett 2009 0.76
28 Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist. Bioorg Med Chem 2009 0.75
29 Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice. Peptides 2009 0.75
30 Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists. Bioorg Med Chem Lett 2009 0.75
31 Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds. Bioorg Med Chem 2009 0.75
32 Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists. Bioorg Med Chem Lett 2009 0.75
33 Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists. Bioorg Med Chem Lett 2009 0.75
34 Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett 2004 0.75
35 Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett 2009 0.75
36 Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor. Bioorg Med Chem 2009 0.75
37 [Development of anorectic NPY antagonists: possible roles of Y1 and Y5 receptors in feeding regulation]. Nihon Yakurigaku Zasshi 2006 0.75
38 Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists. Bioorg Med Chem Lett 2009 0.75
39 Cloning and characterization of rabbit neuropeptide Y receptor subtypes. Peptides 2009 0.75
40 Identification of positron emission tomography ligands for NPY Y5 receptors in the brain. Bioorg Med Chem Lett 2009 0.75
41 Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R). Bioorg Med Chem Lett 2009 0.75