Published in Toxicon on June 15, 2004
Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain. Cell Mol Life Sci (2008) 1.67
K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J (2005) 1.11
Structural basis of the selective block of Kv1.2 by maurotoxin from computer simulations. PLoS One (2012) 0.87
Differential molecular information of maurotoxin peptide recognizing IK(Ca) and Kv1.2 channels explored by computational simulation. BMC Struct Biol (2011) 0.83
K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration. Front Pharmacol (2012) 0.82
Scorpion peptides: potential use for new drug development. J Toxicol (2013) 0.81
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev (2005) 3.50
International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev (2005) 2.39
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem (2007) 1.85
Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro. Mol Pharmacol (2004) 1.44
Diversity of folds in animal toxins acting on ion channels. Biochem J (2004) 1.43
Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol (2004) 1.31
Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells. J Biol Chem (2003) 1.22
Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanism. J Biol Chem (2003) 1.17
Animal toxins acting on voltage-gated potassium channels. Curr Pharm Des (2008) 1.16
Maurocalcine and domain A of the II-III loop of the dihydropyridine receptor Cav 1.1 subunit share common binding sites on the skeletal ryanodine receptor. J Biol Chem (2004) 1.15
K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J (2005) 1.11
Resistance of hepatitis C virus to NS3-4A protease inhibitors: mechanisms of drug resistance induced by R155Q, A156T, D168A and D168V mutations. Antivir Ther (2006) 1.10
Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta (2006) 1.10
Transduction of the scorpion toxin maurocalcine into cells. Evidence that the toxin crosses the plasma membrane. J Biol Chem (2005) 1.06
Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation. J Neurochem (2006) 1.06
Mapping of maurotoxin binding sites on hKv1.2, hKv1.3, and hIKCa1 channels. Mol Pharmacol (2004) 1.02
Formation of cellular projections in neural progenitor cells depends on SK3 channel activity. J Neurochem (2007) 1.00
Protein-protein recognition control by modulating electrostatic interactions. J Proteome Res (2010) 1.00
Design of a disulfide-less, pharmacologically inert, and chemically competent analog of maurocalcine for the efficient transport of impermeant compounds into cells. J Biol Chem (2008) 0.99
The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochem J (2004) 0.98
Structure of the BgK-Kv1.1 complex based on distance restraints identified by double mutant cycles. Molecular basis for convergent evolution of Kv1 channel blockers. J Biol Chem (2002) 0.98
Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels. Biochem J (2004) 0.97
Differential effects of maurocalcine on Ca2+ release events and depolarization-induced Ca2+ release in rat skeletal muscle. J Physiol (2005) 0.97
Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins. J Biol Chem (2004) 0.97
The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner. J Biol Chem (2002) 0.94
Contribution of the functional dyad of animal toxins acting on voltage-gated Kv1-type channels. J Pept Sci (2005) 0.92
Interactions of N-terminal and C-terminal parts of the small conductance Ca2+ activated K+ channel, hSK3. Cell Physiol Biochem (2006) 0.91
Toxin determinants required for interaction with voltage-gated K+ channels. Toxicon (2004) 0.91
Blockade of NMDA receptors enhances spontaneous sharp waves in rat hippocampal slices. Neurosci Lett (2005) 0.90
Investigation of the phenylalkylamine binding site in hKv1.3 (H399T), a mutant with a reduced C-type inactivated state. Mol Pharmacol (2005) 0.90
An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel. Mol Pharmacol (2004) 0.90
Substance P receptor blockade decreases stretch-induced lung cytokines and lung injury in rats. J Physiol (2010) 0.89
Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem (2013) 0.88
Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels. Eur J Biochem (2003) 0.88
Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain. Mol Pharmacol (2005) 0.86
Endogenous animal toxin-like human β-defensin 2 inhibits own K(+) channels through interaction with channel extracellular pore region. Cell Mol Life Sci (2014) 0.86
A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels. J Biol Chem (2003) 0.85
Characterization of the outer pore region of the apamin-sensitive Ca2+-activated K+ channel rSK2. Toxicon (2004) 0.85
Block of neural Kv1.1 potassium channels for neuroinflammatory disease therapy. Ann Neurol (2006) 0.84
Charybdotoxin unbinding from the mKv1.3 potassium channel: a combined computational and experimental study. J Phys Chem B (2011) 0.84
Chloride influx provokes lamellipodium formation in microglial cells. Cell Physiol Biochem (2008) 0.84
The impact of the fourth disulfide bridge in scorpion toxins of the alpha-KTx6 subfamily. Proteins (2005) 0.83
Identification and characterization of a novel, shorter isoform of the small conductance Ca2+ -activated K+ channel SK2. J Neurochem (2008) 0.83
Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts. Am J Physiol Cell Physiol (2003) 0.83
Interaction of d-tubocurarine with potassium channels: molecular modeling and ligand binding. Mol Pharmacol (2006) 0.83
Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett (2009) 0.82
Evolution of maurotoxin conformation and blocking efficacy towards Shaker B channels during the course of folding and oxidation in vitro. Biochem J (2002) 0.82
Small efficient cell-penetrating peptides derived from scorpion toxin maurocalcine. J Biol Chem (2012) 0.81
A novel current pathway parallel to the central pore in a mutant voltage-gated potassium channel. J Biol Chem (2011) 0.80
cAMP-dependent chloride conductance evokes ammonia-induced blebbing in the microglial cell line, BV-2. Cell Physiol Biochem (2009) 0.80
AQP4 expression in striatal primary cultures is regulated by dopamine--implications for proliferation of astrocytes. Eur J Neurosci (2008) 0.79
Liposomal encapsulation enhances antiviral efficacy of SPC3 against human immunodeficiency virus type-1 infection in human lymphocytes. Antiviral Res (2002) 0.79
Molecular modeling and docking simulations of scorpion toxins and related analogs on human SKCa2 and SKCa3 channels. Peptides (2005) 0.79
Protein content analysis and antimicrobial activity of the crude venom of Montivipera bornmuelleri; a viper from Lebanon. Infect Disord Drug Targets (2014) 0.78
A Shaker homologue encodes an A-type current in Xenopus laevis. Brain Res (2002) 0.78
Modelling of the III-IV loop, a domain involved in calcium channel Ca(v)2.1 inactivation, highlights a structural homology with the gamma subunit of G proteins. Eur J Neurosci (2002) 0.78
Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins. Protein Sci (2007) 0.78
Increasing the molecular contacts between maurotoxin and Kv1.2 channel augments ligand affinity. Proteins (2005) 0.78
Cell penetration properties of a highly efficient mini maurocalcine Peptide. Pharmaceuticals (Basel) (2013) 0.78
Why does the inner-helix mutation A413C double the stoichiometry of Kv1.3 channel block by emopamil but not by verapamil? Mol Pharmacol (2011) 0.77
Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison. J Phys Chem B (2012) 0.77
The deciphered genome of Mesobuthus martensii uncovers the resistance mysteries of scorpion to its own venom and toxins at the ion channel level. Toxins (Basel) (2013) 0.77
Analysis of the interacting surface of maurotoxin with the voltage-gated Shaker B K(+) channel. J Pept Sci (2011) 0.77
Animal venoms: from deadly arsenals (toxins) to therapeutic drug candidates. Inflamm Allergy Drug Targets (2011) 0.77
CD26 modulates nociception in mice via its dipeptidyl-peptidase IV activity. Behav Brain Res (2005) 0.77
Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channels. Protein Sci (2003) 0.76
Verapamil- and state-dependent effect of 2-aminoethylmethanethiosulphonate (MTSEA) on hK(v)1.3 channels. Br J Pharmacol (2012) 0.76
The human Ca2+-activated K+ channel, IK, can be blocked by the tricyclic antihistamine promethazine. Neuropharmacology (2005) 0.75
First chemical synthesis of a scorpion alpha-toxin affecting sodium channels: the Aah I toxin of Androctonus australis hector. J Pept Sci (2004) 0.75
Synthesis, 3-D structure, and pharmacology of a reticulated chimeric peptide derived from maurotoxin and Tsk scorpion toxins. Biochem Biophys Res Commun (2002) 0.75
SKCa Channels Blockage Increases the Expression of Adenosine A2A Receptor in Jurkat Human T Cells. Biores Open Access (2013) 0.75
Evidence for the interaction of endophilin a3 with endogenous Kca2.3 channels in PC12 cells. Cell Physiol Biochem (2014) 0.75
Drug targets in viral infections. Infect Disord Drug Targets (2009) 0.75
Toxins and potassium channels. Toxicon (2004) 0.75
Chemical synthesis and characterization of J46 peptide, an atypical class IIa bacteriocin from Lactococcus lactis subsp. cremoris J46 Strain. J Antibiot (Tokyo) (2008) 0.75
Kinetic Aspects of Verapamil Binding (On-Rate) on Wild-Type and Six hKv1.3 Mutant Channels. Cell Physiol Biochem (2017) 0.75
Bacteriocins active against multi-resistant gram negative bacteria implicated in nosocomial infections. Infect Disord Drug Targets (2015) 0.75
A novel non-neuronal hSK3 isoform with a dominant-negative effect on hSK3 currents. Cell Physiol Biochem (2004) 0.75