Published in Am J Physiol Cell Physiol on June 22, 2004
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J (2010) 2.91
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol Rev (2013) 1.50
Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines. J Am Soc Nephrol (2014) 1.42
Emerging roles of alkali cation/proton exchangers in organellar homeostasis. Curr Opin Cell Biol (2007) 1.20
NHE3 regulatory complexes. J Exp Biol (2009) 1.19
Renal NHE3 and NaPi2 partition into distinct membrane domains. Am J Physiol Cell Physiol (2009) 1.12
Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli. Am J Physiol Renal Physiol (2009) 1.08
Sitagliptin augments sympathetic enhancement of the renovascular effects of angiotensin II in genetic hypertension. Hypertension (2008) 1.01
Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice. Am J Physiol Renal Physiol (2012) 1.00
The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics. Mol Cell Proteomics (2013) 0.89
The calcineurin homologous protein-1 increases Na(+)/H(+) -exchanger 3 trafficking via ezrin phosphorylation. J Am Soc Nephrol (2009) 0.89
Coexpression of MAST205 inhibits the activity of Na+/H+ exchanger NHE3. Am J Physiol Renal Physiol (2005) 0.85
Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule. J Am Soc Nephrol (2014) 0.83
Dipeptidyl Peptidase 4 Inhibitors and the Risk of Cardiovascular Disease in Patients with Type 2 Diabetes: A Tale of Three Studies. Diabetes Metab J (2015) 0.83
Long-term regulation of vacuolar H(+)-ATPase by angiotensin II in proximal tubule cells. Pflugers Arch (2009) 0.83
Modulation of angiotensin II-induced inflammatory cytokines by the Epac1-Rap1A-NHE3 pathway: implications in renal tubular pathobiology. Am J Physiol Renal Physiol (2014) 0.81
Chronic regulation of the renal Na(+)/H(+) exchanger NHE3 by dopamine: translational and posttranslational mechanisms. Am J Physiol Renal Physiol (2013) 0.80
Dipeptidyl peptidase IV inhibitor lowers PPARγ agonist-induced body weight gain by affecting food intake, fat mass, and beige/brown fat but not fluid retention. Am J Physiol Endocrinol Metab (2013) 0.80
Molecular mechanisms and regulation of urinary acidification. Compr Physiol (2014) 0.78
Potential role of dipeptidyl peptidase IV in the pathophysiology of heart failure. Int J Mol Sci (2015) 0.76
Cut to the chase: a review of CD26/dipeptidyl peptidase-4's (DPP4) entanglement in the immune system. Clin Exp Immunol (2016) 0.76
Intestinal regulation of urinary sodium excretion and the pathophysiology of diabetic kidney disease: a focus on glucagon-like peptide 1 and dipeptidyl peptidase 4. Exp Physiol (2014) 0.76
Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet (2006) 2.89
Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1. Biochem Biophys Res Commun (2002) 2.28
The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest (2010) 2.28
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor. Proc Natl Acad Sci U S A (2007) 2.13
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med (2008) 2.01
Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab (2011) 1.98
NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney Int (2013) 1.97
Cholinergic signaling inhibits oxalate transport by human intestinal T84 cells. Am J Physiol Cell Physiol (2011) 1.87
Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites. Am J Physiol Renal Physiol (2005) 1.84
Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. Proc Natl Acad Sci U S A (2002) 1.80
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nature (2012) 1.77
Phenotypic and functional analysis of human SLC26A6 variants in patients with familial hyperoxaluria and calcium oxalate nephrolithiasis. Am J Kidney Dis (2008) 1.77
Specificity of anion exchange mediated by mouse Slc26a6. J Biol Chem (2002) 1.73
On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry (2006) 1.72
WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia. Proc Natl Acad Sci U S A (2004) 1.71
Renal and intestinal transport defects in Slc26a6-null mice. Am J Physiol Cell Physiol (2004) 1.68
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism. Proc Natl Acad Sci U S A (2003) 1.62
Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model. Acta Neuropathol (2009) 1.44
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes (2003) 1.37
Prestin's anion transport and voltage-sensing capabilities are independent. Biophys J (2009) 1.36
Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents? Regul Pept (2005) 1.32
Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status. Kidney Int (2002) 1.32
The Cl-/HCO3- exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance. Am J Physiol Renal Physiol (2004) 1.31
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions. FEBS Lett (2004) 1.30
Renal expression of novel Na+/H+ exchanger isoform NHE8. Am J Physiol Renal Physiol (2002) 1.28
Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion. J Am Soc Nephrol (2011) 1.28
Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides. Biochemistry (2009) 1.25
Immunolocalization of NHE8 in rat kidney. Am J Physiol Renal Physiol (2004) 1.24
NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity. Am J Physiol Renal Physiol (2007) 1.22
Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution. Biol Chem (2008) 1.20
Pendrin regulation in mouse kidney primarily is chloride-dependent. J Am Soc Nephrol (2006) 1.19
Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD. Am J Physiol Renal Physiol (2003) 1.18
Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta. Biochemistry (2008) 1.18
Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat. Biochem Biophys Res Commun (2007) 1.17
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice. J Biol Chem (2010) 1.16
Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase. Endocrinology (2003) 1.13
The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates. Biochem J (2006) 1.11
Ontogeny of NHE8 in the rat proximal tubule. Am J Physiol Renal Physiol (2007) 1.10
Specificity and regulation of renal sulfate transporters. Annu Rev Physiol (2007) 1.09
Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proc Natl Acad Sci U S A (2005) 1.08
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation. J Neurosci (2011) 1.08
Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol (2005) 1.05
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells. Biochim Biophys Acta (2006) 1.04
Regulation of anion exchanger Slc26a6 by protein kinase C. Am J Physiol Cell Physiol (2006) 1.01
Regulation of expression and function of dipeptidyl peptidase 4 (DP4), DP8/9, and DP10 in allergic responses of the lung in rats. J Histochem Cytochem (2007) 1.01
N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation. J Neurochem (2012) 1.01
Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition. Eur J Biochem (2002) 1.00
Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells. Am J Physiol Renal Physiol (2007) 1.00
ESRD as a window into America's cost crisis in health care. J Am Soc Nephrol (2009) 0.99
Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease. J Biol Chem (2012) 0.99
Overexpression of pendrin in intercalated cells produces chloride-sensitive hypertension. J Am Soc Nephrol (2013) 0.99
Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model. Int J Alzheimers Dis (2010) 0.98
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions. EMBO Mol Med (2011) 0.96
Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease. Biol Chem (2008) 0.96
Passive immunization against pyroglutamate-3 amyloid-β reduces plaque burden in Alzheimer-like transgenic mice: a pilot study. Neurodegener Dis (2012) 0.95
Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. J Mol Biol (2008) 0.95
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms. Acta Neuropathol (2011) 0.95
Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion. J Neurochem (2005) 0.94
Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus. Int J Biochem Cell Biol (2006) 0.94
The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem (2006) 0.93
Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer's disease. Neurochem Res (2005) 0.93
Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol (2013) 0.93
Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ. J Neurochem (2008) 0.93
Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4. Peptides (2007) 0.93
Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators. J Biol Chem (2003) 0.92
Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. Diabetes (2002) 0.92
Membrane curvature alters the activation kinetics of the epithelial Na+/H+ exchanger, NHE3. J Biol Chem (2007) 0.92
Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study. Diabetes (2002) 0.91
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging (2011) 0.90
Substrate specificity of glutaminyl cyclases from plants and animals. Biol Chem (2003) 0.90
NHE2-mediated bicarbonate reabsorption in the distal tubule of NHE3 null mice. J Physiol (2004) 0.90
Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates. Biochemistry (2009) 0.89
Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain. Int J Dev Neurosci (2009) 0.88
Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity. Biochemistry (2002) 0.88
Isoaspartate residues dramatically influence substrate recognition and turnover by proteases. Biol Chem (2008) 0.88
Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones. Biol Chem (2002) 0.87
Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy. J Pept Sci (2012) 0.86
Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3. PLoS One (2013) 0.86
Sat1 is dispensable for active oxalate secretion in mouse duodenum. Am J Physiol Cell Physiol (2012) 0.86
Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center. Biochemistry (2011) 0.85
Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases. Biol Chem (2008) 0.85
In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide. Life Sci (2004) 0.84
Structure-function analysis of a series of novel GIP analogues containing different helical length linkers. Biochemistry (2003) 0.84
Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement. J Med Chem (2009) 0.84
Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics. FEBS J (2009) 0.84
Continuous spectrometric assays for glutaminyl cyclase activity. Anal Biochem (2002) 0.84
Inhibiting dipeptidyl peptidase activity partially ameliorates colitis in mice. Front Biosci (2008) 0.83
Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization. Biochemistry (2007) 0.83
Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. Acta Neuropathol (2010) 0.83
Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice. Int J Exp Pathol (2013) 0.83
Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions. Biol Chem (2007) 0.83
Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential. Adv Exp Med Biol (2003) 0.82
Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme. Biol Chem (2003) 0.82
Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development. J Biol Chem (2011) 0.81
Immunolocalization of anion transporter Slc26a7 in mouse kidney. Am J Physiol Renal Physiol (2005) 0.81
Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus. Biol Chem (2010) 0.81
Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development. Chem Biol Drug Des (2012) 0.81
Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV. J Mol Biol (2005) 0.81
Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway. J Neuroinflammation (2011) 0.80