Genes, proteins, and neurotoxins involved in Parkinson's disease.

Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.60

Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. BMC Genomics (2007) 1.09

Bone marrow-derived mesenchymal stem cell therapy as a candidate disease-modifying strategy in Parkinson's disease and multiple system atrophy. J Clin Neurol (2009) 0.99

Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. J Alzheimers Dis (2009) 0.94

Bilateral transplantation of allogenic adult human bone marrow-derived mesenchymal stem cells into the subventricular zone of Parkinson's disease: a pilot clinical study. Stem Cells Int (2012) 0.91

Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines. PLoS One (2012) 0.86

PACAP protects against salsolinol-induced toxicity in dopaminergic SH-SY5Y cells: implication for Parkinson's disease. J Mol Neurosci (2013) 0.84

Metabolomics and in-silico analysis reveal critical energy deregulations in animal models of Parkinson's disease. PLoS One (2013) 0.84

Genetic variants ofLRRK2 in Taiwanese Parkinson's disease. PLoS One (2013) 0.83

Evaluation of toxicological and antioxidant potential of Nardostachys jatamansi in reversing haloperidol-induced catalepsy in rats. Int J Gen Med (2010) 0.79

Neuroproteomics as a promising tool in Parkinson's disease research. J Neural Transm (Vienna) (2008) 0.79

A network view on Parkinson's disease. Comput Struct Biotechnol J (2013) 0.78

UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma. Int J Clin Exp Pathol (2015) 0.76

Signaling with homeoprotein transcription factors in development and throughout adulthood. Curr Genomics (2013) 0.76

STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan. Medicine (Baltimore) (2015) 0.76

Non-Linear EMG Parameters for Differential and Early Diagnostics of Parkinson's Disease. Front Neurol (2013) 0.76

Neuroprotective roles of pituitary adenylate cyclase-activating polypeptide in neurodegenerative diseases. BMB Rep (2014) 0.76

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease. Neurogenetics (2010) 0.76

Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders. Med Hypotheses (2016) 0.75

Spontaneously Hypertensive Rats (SHR) Are Resistant to a Reserpine-Induced Progressive Model of Parkinson's Disease: Differences in Motor Behavior, Tyrosine Hydroxylase and α-Synuclein Expression. Front Aging Neurosci (2017) 0.75

Chronic salsolinol administration prevents the behavioral and neurochemical effects of L-DOPA in rats. Neurotox Res (2015) 0.75

Dangguijakyak-San Protects against 1-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-Induced Neuronal Damage via Anti-Inflammatory Action. Evid Based Complement Alternat Med (2013) 0.75

Associations of Matrix Metalloproteinase-9 and Tissue Inhibitory Factor-1 Polymorphisms With Parkinson Disease in Taiwan. Medicine (Baltimore) (2016) 0.75

Berberine chloride pretreatment exhibits neuroprotective effect against 6-hydroxydopamine-induced neuronal insult in rat. Iran J Pharm Res (2015) 0.75

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases. Pharmacol Ther (2017) 0.75

Hypericum Perforatum Hydroalcoholic Extract Mitigates Motor Dysfunction and is Neuroprotective in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease. Cell Mol Neurobiol (2015) 0.75

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev (1995) 3.41

Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis. Eur J Biochem (2000) 1.44

Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res (1999) 1.37

Nucleotide sequence of the gene encoding Clostridium botulinum neurotoxin type D. Nucleic Acids Res (1990) 1.26

The transforming growth factor-betas: structure, signaling, and roles in nervous system development and functions. J Neurochem (2000) 1.22

Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo. J Neurosci (2000) 1.20

The role of microRNAs in arterial remodelling. Thromb Haemost (2012) 1.12

Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. Development (1999) 1.09

Intracoronary infusion of autologous bone marrow cells and left ventricular function after acute myocardial infarction: a meta-analysis. J Cell Mol Med (2006) 1.07

GDF-15/MIC-1 a novel member of the TGF-beta superfamily. J Neural Transm Suppl (2000) 1.03

Contractile activity of human skeletal muscle cells prevents insulin resistance by inhibiting pro-inflammatory signalling pathways. Diabetologia (2012) 1.02

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) regulates survival of midbrain dopaminergic neurons. J Neural Transm (Vienna) (2002) 0.99

TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla. J Neurosci (1998) 0.97

MicroRNAs in arterial remodelling, inflammation and atherosclerosis. Curr Drug Targets (2010) 0.96

TGFbeta induces GDNF responsiveness in neurons by recruitment of GFRalpha1 to the plasma membrane. J Cell Biol (2002) 0.95

TGF-beta modulates programmed cell death in the retina of the developing chick embryo. Development (2001) 0.95

A small molecule CXCR4 antagonist inhibits neointima formation and smooth muscle progenitor cell mobilization after arterial injury. J Thromb Haemost (2008) 0.95

Bone morphogenetic proteins: neurotrophic roles for midbrain dopaminergic neurons and implications of astroglial cells. Eur J Neurosci (1997) 0.94

Balance of pro-apoptotic transforming growth factor-beta and anti-apoptotic insulin effects in the control of cell death in the postnatal mouse retina. Eur J Neurosci (2005) 0.93

[Epidemiology of chronic hepatitis C in Germany--an analysis of 10,326 patients in hepatitis centres and outpatient units]. Z Gastroenterol (2008) 0.93

Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo. J Neurosci (1999) 0.92

Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-XL expression. J Neural Transm (Vienna) (2007) 0.90

Optimizing doped libraries by using genetic algorithms. J Comput Aided Mol Des (1997) 0.90

Activity-dependent release of transforming growth factor-beta in a neuronal network in vitro. Neuroscience (2007) 0.89

Deposition of radon progeny on skin surfaces and resulting radiation doses in radon therapy. Radiat Environ Biophys (2010) 0.89

Possible sources and sites of action of the nitric oxide involved in synaptic plasticity at spinal lamina I projection neurons. Neuroscience (2006) 0.88

Solid-phase radioimmunoassay for detection of alcoholic hyalin antigen (AHAg) and antibody (anti-AH). Clin Exp Immunol (1981) 0.87

MicroRNAs in vascular biology--metabolism and atherosclerosis. Thromb Haemost (2012) 0.86

The cysteine proteinase inhibitor chicken cystatin is a phosphoprotein. FEBS Lett (1989) 0.86

[Serological subtypes of hepatitis-B antigen (Australia antigen). Local hepatitis-B epidemic of the subtype "Y" with regionally predominating subtype "D"]. Dtsch Med Wochenschr (1972) 0.84

Immunological aspects of alcoholic hepatitis. Gastroenterology (1978) 0.84

Co-activation of TGF-ss and cytokine signaling pathways are required for neurotrophic functions. Cytokine Growth Factor Rev (2000) 0.84

Measurement of the nonlinear coefficient of orientation-patterned GaAs and demonstration of highly efficient second-harmonic generation. Opt Lett (2002) 0.83

Midbrain dopaminergic neurons are protected from radical induced damage by GDF-5 application. Short communication. J Neural Transm (Vienna) (1999) 0.83

Differential regulation of distinct phenotypic features of serotonergic neurons by bone morphogenetic proteins. Eur J Neurosci (1999) 0.83

GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. Exp Neurol (2000) 0.83

Chains and fragments of tetanus toxin, and their contribution to toxicity. J Physiol (Paris) (1990) 0.82

Direct solid-phase radioimmunoassay (dSP-RIA) for detection of antibody to hepatitis B surface (HBs) antigen. Dev Biol Stand (1975) 0.82

Reduction of endogenous TGF-beta increases proliferation of developing adrenal chromaffin cells in vivo. J Neurosci Res (2000) 0.82

[Determination of antibodies against subtypes of hepatitis B surface antigens (HBsAg) (proceedings)]. Zentralbl Bakteriol Orig A (1976) 0.82

Expression of neurotrophin receptors trkB and trkC and their ligands in rat adrenal gland and the intermediolateral column of the spinal cord. Cell Tissue Res (1999) 0.82

Phenotypic development of neonatal rat chromaffin cells in response to adrenal growth factors and glucocorticoids: focus on pituitary adenylate cyclase activating polypeptide. Neurosci Lett (1995) 0.82

Microencapsulated ciliary neurotrophic factor: physical properties and biological activities. Exp Neurol (1996) 0.81

Growth/differentiation factor-15 (GDF-15), a novel member of the TGF-beta superfamily, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is induced in neurons following cortical lesioning. J Neural Transm Suppl (2003) 0.81

Expression, localization, and function of transforming growth factor-beta s in embryonic chick spinal cord, hindbrain, and dorsal root ganglia. J Neurobiol (1996) 0.81

Screening for autoantibodies in chronic hepatitis C patients has no effect on treatment initiation or outcome. J Viral Hepat (2012) 0.81

Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation. J Neurosci (2001) 0.81

Noradrenergic neurons in the locus coeruleus of birds express TrkA, transport NGF, and respond to NGF. J Neurosci (1995) 0.80

[Australia (SH) antigen findings in patients with liver diseases and blood donors]. Dtsch Med Wochenschr (1970) 0.80

Microlenses as Amplification for CCD-Based Detection Devices for Screening Applications in Biology, Biochemistry, and Chemistry. Appl Opt (1998) 0.80

Characterization of growth/differentiation factor 5 (GDF-5) as a neurotrophic factor for cultured neurons from chicken dorsal root ganglia. Neurosci Lett (1997) 0.79

5,7-Dihydroxytryptamine uptake discriminates living serotonergic cells from dopaminergic cells in rat midbrain culture. Neurosci Lett (1995) 0.79

[Australia(SH)-antigen findings in florid and cured chronic-persistent hepatites]. Dtsch Med Wochenschr (1971) 0.79

Characterization of bone morphogenetic protein family members as neurotrophic factors for cultured sensory neurons. Neuroscience (1999) 0.79

Tubular peroxisomes in HepG2 cells: selective induction by growth factors and arachidonic acid. Eur J Cell Biol (1998) 0.79

Growth factors in chromaffin cells. Prog Neurobiol (1996) 0.78

TGF-β in aging and disease. Cell Tissue Res (2011) 0.78

[Australia antibodies in normal persons and in patients recovering from serum hepatitis]. Dtsch Med Wochenschr (1972) 0.78

[Endemia of Australia (SH) antigen-positive hepatitis in a dialysis center]. Dtsch Med Wochenschr (1971) 0.77

GDNF-related factor persephin is widely distributed throughout the nervous system. J Neurosci Res (1998) 0.77

Calcitonin gene-related peptide promotes differentiation, but not survival, of rat mesencephalic dopaminergic neurons in vitro. Neuroscience (1998) 0.77

Mutual induction of TGFbeta1 and NGF after treatment with NGF or TGFbeta1 in grafted chromaffin cells of the adrenal medulla. Exp Neurol (2000) 0.76

FGF-2 deficiency does not alter vulnerability of the dopaminergic nigrostriatal system towards MPTP intoxication in mice. Eur J Neurosci (2006) 0.76

Generation of cell diversity in the peripheral autonomic nervous system: the sympathoadrenal cell lineage revisited. Ann Anat (1997) 0.76

Nitric oxide synthase in learning-relevant nuclei of the chick brain: morphology, distribution, and relation to transmitter phenotypes. J Comp Neurol (1997) 0.76

Growth factor function in the development and maintenance of midbrain dopaminergic neurons: concepts, facts and prospects for TGF-beta. Ciba Found Symp (1996) 0.76

Reduction of endogenous TGF-beta does not affect phenotypic development of sympathoadrenal progenitors into adrenal chromaffin cells. Mech Dev (2001) 0.76

Screening of interleukins for survival-promoting effects on cultured mesencephalic dopaminergic neurons from embryonic rat brain. Brain Res Dev Brain Res (1995) 0.76

Trophic factors from chromaffin granules promote survival of peripheral and central nervous system neurons. Neuroscience (1994) 0.76

Influence of osmotic stress on heat shock proteins 25 and 72 in mouse mesangial cells. Kidney Int Suppl (1998) 0.76

Morphology of neurons in the rat basal forebrain nuclei: comparison between NADPH-diaphorase histochemistry and immunohistochemistry of glutamic acid decarboxylase, choline acetyltransferase, somatostatin and parvalbumin. J Hirnforsch (1991) 0.76

Molecular cues for the development of adrenal chromaffin cells and their preganglionic innervation. Eur J Clin Invest (2000) 0.75

Characterization of adrenal chromaffin progenitor cells in mice. Adv Pharmacol (1998) 0.75

[Cellular immunity to HB-antigen (Australia antigen)--in-vitro reactions in guinea pigs and humans (author's transl)]. Med Microbiol Immunol (1974) 0.75

Amyloid beta peptide is not a candidate for the neurotrophic activities released from chromaffin cells. Int J Dev Neurosci (1998) 0.75

[Electrolytic changes in the white mouse under the influence of weak magnetic fields]. Zentralbl Bakteriol Mikrobiol Hyg B (1982) 0.75

Inapparent infections in the course of an epidemic of Australia-SH-antigen positive hepatitis. Am J Dis Child (1972) 0.75

[Nobel prize 1976 for discovery of Australia antigen]. Dtsch Med Wochenschr (1976) 0.75

[Asymptomatic chronic-persisting hepatitis B in a young child as source of infection of hepatitis B within a family (author's transl)]. Dtsch Med Wochenschr (1978) 0.75

[Clinical significance of HB-antibody determination]. Verh Dtsch Ges Inn Med (1974) 0.75

[Nature and demonstration of hepatitis B--(Australia)-antigen and its antibody]. Internist (Berl) (1973) 0.75

Radioimmunoprecipitation assay for Australia antibody. Vox Sang (1973) 0.75

A chromaffin cell-derived protein induces the NADPH-diaphorase phenotype in cultured rat spinal cord neurons. Neuroscience (1996) 0.75

[Preliminary report on the cooperative DFG study "Acute viral hepatitis"]. Verh Dtsch Ges Inn Med (1976) 0.75

[In vitro stimulation of lymphocytes of HB antibody carriers by HB antigen (Australia antigen)]. Dtsch Med Wochenschr (1973) 0.75

[Australia-SH antigen isolation in patients with liver disease]. Bibl Haematol (1971) 0.75

Fibroblast growth factor-2 depresses the impulse activity of rat dorsal horn neurones in vivo. Neurosci Lett (1995) 0.75

Radioimmunoprecipitation assay for Australia antibody. Vox Sang (1973) 0.75

[Bioptic studies of the liver during 4-5 years in clinically healthy HBsAG carriers]. Verh Dtsch Ges Inn Med (1976) 0.75

[Standardization problems in the determination of Australia (SH) antigen]. Dtsch Med Wochenschr (1971) 0.75

[Problems in the standardization of Australia-SH-antigen determinations]. Zentralbl Bakteriol Orig A (1972) 0.75

[Proceedings: Clinical significance of HB-antibody demonstration]. MMW Munch Med Wochenschr (1974) 0.75

Trophic factors made by adrenal chromaffin cells and their putative clinical implications. Restor Neurol Neurosci (1995) 0.75

[Serial biopsies in healthy carriers of hepatitis Bs antigen (author's transl)]. Dtsch Med Wochenschr (1976) 0.75

Determination of equine serum inhibitors for poliovirus by the gel-adsorption technique. Arch Gesamte Virusforsch (1966) 0.75

[Hepatitis risk following transfusion of HB-antibody-positive blood]. Verh Dtsch Ges Inn Med (1974) 0.75

[Effect of a weak magnetic field on the course of an acute inflammation in the rat]. Zentralbl Bakteriol Mikrobiol Hyg B (1984) 0.75

Transforming growth factor-beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary cells in vitro. Neuroscience (1999) 0.75