PubRank

David B Savage

Author PubWeight™ 50.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012 4.37
2 The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A 2007 3.76
3 Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci U S A 2007 2.85
4 Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet 2011 2.73
5 Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 2002 2.72
6 Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J Biol Chem 2007 2.55
7 Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. J Clin Invest 2009 2.53
8 TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population. Diabetes 2007 2.20
9 Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med 2009 1.80
10 Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA. Nat Genet 2012 1.74
11 Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma. Endocrinology 2003 1.69
12 Perilipin deficiency and autosomal dominant partial lipodystrophy. N Engl J Med 2011 1.61
13 Lipodystrophy: metabolic insights from a rare disorder. J Endocrinol 2010 1.60
14 Genetic syndromes of severe insulin resistance. Endocr Rev 2011 1.54
15 Plasma adiponectin as a marker of insulin receptor dysfunction: clinical utility in severe insulin resistance. Diabetes Care 2008 1.39
16 Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia. J Clin Invest 2010 1.27
17 Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma. Diabetes 2005 1.26
18 Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5). J Biol Chem 2011 1.24
19 A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia. Proc Natl Acad Sci U S A 2009 1.23
20 Mitochondrial dysfunction in patients with primary congenital insulin resistance. J Clin Invest 2011 1.19
21 An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nat Genet 2013 1.09
22 The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation. J Clin Endocrinol Metab 2003 1.02
23 Proteinuric nephropathy in acquired and congenital generalized lipodystrophy: baseline characteristics and course during recombinant leptin therapy. J Clin Endocrinol Metab 2004 1.01
24 Fatty acid metabolism in patients with PPARgamma mutations. J Clin Endocrinol Metab 2008 0.86
25 An amino acid profile to predict diabetes? Nat Med 2011 0.86
26 Early Diagnosis of Werner's Syndrome Using Exome-Wide Sequencing in a Single, Atypical Patient. Front Endocrinol (Lausanne) 2011 0.84
27 Metabolic insights from extreme human insulin resistance phenotypes. Best Pract Res Clin Endocrinol Metab 2012 0.83
28 Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy. J Clin Endocrinol Metab 2012 0.82
29 Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial. BMC Endocr Disord 2009 0.82
30 Human congenital perilipin deficiency and insulin resistance. Endocr Dev 2013 0.81
31 Sex hormone-binding globulin and risk of type 2 diabetes. N Engl J Med 2009 0.78
32 Congenital syndromes of severe insulin resistance. Pediatr Endocrinol Rev 2011 0.76
33 Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals. Int J Endocrinol 2013 0.75
34 Corrigendum: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet 2017 0.75