| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.
|
J Biol Chem
|
2004
|
3.79
|
|
2
|
Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.
|
Structure
|
2004
|
3.31
|
|
3
|
Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis.
|
J Biol Chem
|
2003
|
2.06
|
|
4
|
Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer.
|
Bioorg Med Chem Lett
|
2011
|
1.20
|
|
5
|
High resolution structure of an alternate form of the ferric ion binding protein from Haemophilus influenzae.
|
J Biol Chem
|
2003
|
0.97
|
|
6
|
Structural basis for iron binding and release by a novel class of periplasmic iron-binding proteins found in gram-negative pathogens.
|
J Bacteriol
|
2004
|
0.95
|
|
7
|
Crystal structure of Pasteurella haemolytica ferric ion-binding protein A reveals a novel class of bacterial iron-binding proteins.
|
J Biol Chem
|
2003
|
0.90
|
|
8
|
Crystal structures of active fully assembled substrate- and product-bound complexes of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) from Haemophilus influenzae.
|
J Bacteriol
|
2003
|
0.89
|
|
9
|
Novel anion-independent iron coordination by members of a third class of bacterial periplasmic ferric ion-binding proteins.
|
J Biol Chem
|
2004
|
0.87
|
|
10
|
Presence of ferric hydroxide clusters in mutants of Haemophilus influenzae ferric ion-binding protein A.
|
Biochemistry
|
2003
|
0.84
|
|
11
|
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: design and synthesis of benzylpyrazole acylsulfonamides.
|
Bioorg Med Chem
|
2011
|
0.83
|
|
12
|
Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.
|
Bioorg Med Chem
|
2009
|
0.81
|
|
13
|
2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.
|
J Med Chem
|
2009
|
0.79
|
|
14
|
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
|
Bioorg Med Chem Lett
|
2010
|
0.79
|
|
15
|
Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors.
|
Bioorg Med Chem Lett
|
2013
|
0.78
|
|
16
|
Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.
|
J Med Chem
|
2013
|
0.77
|
|
17
|
Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.
|
Bioorg Med Chem
|
2013
|
0.76
|
|
18
|
Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
|
Bioorg Med Chem Lett
|
2011
|
0.76
|
|
19
|
Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
|
Bioorg Med Chem
|
2013
|
0.76
|
|
20
|
Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists.
|
Bioorg Med Chem
|
2012
|
0.75
|