PubRank

Raymond A Sobel

Author PubWeight™ 146.05‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 2007 7.73
2 Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med 2003 6.73
3 Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 2002 6.58
4 IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 2008 6.41
5 The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002 5.24
6 Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med 2004 5.13
7 PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A 2004 4.75
8 Induction and molecular signature of pathogenic TH17 cells. Nat Immunol 2012 4.43
9 Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature 2007 3.92
10 Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol 2009 3.88
11 Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature 2008 3.48
12 Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat Immunol 2006 3.21
13 Type II monocytes modulate T cell-mediated central nervous system autoimmune disease. Nat Med 2007 3.09
14 CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. J Immunol 2005 2.83
15 Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest 2006 2.75
16 Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science 2005 2.41
17 Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2004 2.34
18 Lipid microarrays identify key mediators of autoimmune brain inflammation. Nat Med 2005 2.31
19 Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity 2011 2.11
20 Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci U S A 2009 2.07
21 Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med 2007 1.93
22 MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med 2013 1.88
23 Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation. J Clin Invest 2007 1.67
24 Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J Immunol 2010 1.66
25 Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med 2005 1.63
26 Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation. Sci Transl Med 2013 1.62
27 TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol 2008 1.58
28 Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo. Mol Biol Cell 2010 1.49
29 Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med 2012 1.48
30 Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J Exp Med 2007 1.47
31 Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity. J Clin Invest 2006 1.43
32 Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity. PLoS One 2012 1.39
33 Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A 2012 1.35
34 Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. J Cereb Blood Flow Metab 2003 1.35
35 Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol 2005 1.28
36 Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination. Proc Natl Acad Sci U S A 2003 1.23
37 Efficacy of intravenous liposomal amphotericin B (AmBisome) against coccidioidal meningitis in rabbits. Antimicrob Agents Chemother 2002 1.22
38 Development of a murine model of cerebral aspergillosis. J Infect Dis 2002 1.19
39 IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis. J Immunol 2004 1.18
40 Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. J Clin Invest 2008 1.17
41 The ICOS molecule plays a crucial role in the development of mucosal tolerance. J Immunol 2005 1.13
42 Expression of varicella-zoster virus immediate-early regulatory protein IE63 in neurons of latently infected human sensory ganglia. J Virol 2010 1.08
43 Somatic instability of the NF2 gene in schwannomatosis. Arch Neurol 2003 1.08
44 IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol 2004 1.07
45 Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol 2013 1.05
46 Apparent expression of varicella-zoster virus proteins in latency resulting from reactivity of murine and rabbit antibodies with human blood group a determinants in sensory neurons. J Virol 2011 1.04
47 Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med 2012 1.04
48 The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. J Immunol 2004 1.03
49 Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo. Proc Natl Acad Sci U S A 2008 1.03
50 Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis. J Biol Chem 2012 1.02
51 Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease. J Immunol 2009 1.01
52 Levels of matrix metalloproteinase-9 within cerebrospinal fluid in a rabbit model of coccidioidal meningitis and vasculitis. J Infect Dis 2002 1.00
53 Cytokine and inducible nitric oxide synthase mRNA expression during experimental murine cryptococcal meningoencephalitis. Infect Immun 2004 1.00
54 Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. J Exp Med 2010 0.99
55 B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity. Ann Neurol 2015 0.98
56 Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice. Eur J Immunol 2003 0.96
57 A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease. J Immunol 2005 0.94
58 Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity. J Exp Med 2013 0.93
59 Clonal expansion of IgA-positive plasma cells and axon-reactive antibodies in MS lesions. J Neuroimmunol 2005 0.93
60 Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J Immunol 2004 0.93
61 I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis. J Immunol 2007 0.92
62 Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice. Proc Natl Acad Sci U S A 2002 0.92
63 Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis. J Clin Immunol 2011 0.91
64 The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells. J Immunol 2006 0.90
65 A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells. J Immunol 2012 0.89
66 Efficacy of amphotericin B lipid complex in a rabbit model of coccidioidal meningitis. J Antimicrob Chemother 2007 0.88
67 Monoclonal antibodies to distinct regions of human myelin proteolipid protein simultaneously recognize central nervous system myelin and neurons of many vertebrate species. J Neurosci Res 2006 0.87
68 Efficacy of amphotericin B or itraconazole in a murine model of central nervous system Aspergillus infection. Antimicrob Agents Chemother 2003 0.87
69 A murine model of coccidioidal meningitis. J Infect Dis 2003 0.86
70 Axon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosis. J Clin Immunol 2005 0.85
71 Gene therapy and hypothermia for stroke treatment. Ann N Y Acad Sci 2003 0.84
72 Uncovering cryptic glycan markers in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Drug Dev Res 2014 0.84
73 Podoplanin negatively regulates CD4+ effector T cell responses. J Clin Invest 2014 0.82
74 Experimental systemic infection with Cryptococcus neoformans var. grubii and Cryptococcus gattii in normal and immunodeficient mice. Med Mycol 2006 0.82
75 Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. Eur J Immunol 2002 0.82
76 Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background. Int Immunol 2007 0.80
77 Opportunistic enteroviral meningoencephalitis: an unusual treatable complication of rituximab therapy. Leuk Lymphoma 2009 0.79
78 Comparative efficacies of lipid-complexed amphotericin B and liposomal amphotericin B against coccidioidal meningitis in rabbits. Antimicrob Agents Chemother 2009 0.79
79 Interferon-beta counteracts inflammatory mediator-induced effects on brain endothelial cell tight junction molecules-implications for multiple sclerosis. J Neuropathol Exp Neurol 2002 0.79
80 IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis. J Clin Invest 2015 0.79
81 Aspergillus fumigatus invasion increases with progressive airway ischemia. PLoS One 2013 0.78
82 Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. Antimicrob Agents Chemother 2006 0.76
83 Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2(s) congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes. Eur J Immunol 2004 0.76
84 A novel unifying hypothesis of multiple sclerosis. J Neuropathol Exp Neurol 2008 0.75
85 Neuropathology--for the living and the future. J Neuropathol Exp Neurol 2007 0.75
86 Mechanisms of injury in multiple sclerosis: involvement of antineuroaxonal humoral autoimmunity. Expert Rev Clin Immunol 2007 0.75
87 Lysia K.S. Forno, MD February 14, 1918-May 8, 2015. J Neuropathol Exp Neurol 2015 0.75
88 Editor's Note: Transitions at the JNEN. J Neuropathol Exp Neurol 2017 0.75