Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMC 2364795)

Published in Br J Cancer on August 16, 2004

Authors

S-W Park1, J Ludes-Meyers, D B Zimonjic, M E Durkin, N C Popescu, C M Aldaz

Author Affiliations

1: Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4262, USA.

Articles citing this

Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci U S A (2007) 2.37

WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome. BMC Cancer (2005) 1.22

WWOX protein expression in normal human tissues. J Mol Histol (2006) 1.22

WWOX gene and gene product: tumor suppression through specific protein interactions. Future Oncol (2010) 1.16

WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes Cancer (2007) 1.13

Tumor suppressor and hepatocellular carcinoma. World J Gastroenterol (2008) 1.09

Chronic hepatitis B in hepatocarcinogenesis. Postgrad Med J (2006) 1.07

Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review). Int J Oncol (2012) 1.05

Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas. Int J Cancer (2006) 1.05

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies. Biochim Biophys Acta (2014) 0.98

Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR. Mol Carcinog (2005) 0.95

Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma. BMC Med Genomics (2013) 0.88

The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX. J Hepatol (2008) 0.87

MicroRNA-153 promotes Wnt/β-catenin activation in hepatocellular carcinoma through suppression of WWOX. Oncotarget (2015) 0.85

Common fragile genes and digestive tract cancers. Surg Today (2006) 0.85

Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours. Histopathology (2008) 0.85

Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias. Oral Oncol (2007) 0.84

The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype. J Cancer Res Clin Oncol (2010) 0.83

MYO5B is epigenetically silenced and associated with MET signaling in human gastric cancer. Dig Dis Sci (2013) 0.81

Oncosuppressor proteins of fragile sites are reduced in cervical cancer. Cancer Lett (2009) 0.81

Alteration of WWOX in human cancer: a clinical view. Exp Biol Med (Maywood) (2015) 0.80

Diverse effect of WWOX overexpression in HT29 and SW480 colon cancer cell lines. Tumour Biol (2014) 0.80

Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster. PLoS One (2015) 0.78

WWOX, large common fragile site genes, and cancer. Exp Biol Med (Maywood) (2015) 0.78

Molecular Pathogenesis of Hepatitis-B-virus-associated Hepatocellular Carcinoma. Gut Liver (2007) 0.77

Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductase. Exp Biol Med (Maywood) (2014) 0.77

Loss of WWOX expression in human extrahepatic cholangiocarcinoma. J Cancer Res Clin Oncol (2008) 0.76

Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk. PLoS One (2017) 0.75

Expression of WW domain-containing oxidoreductase WWOX in pterygium. Mol Vis (2015) 0.75

Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer. Oncotarget (2016) 0.75

Articles cited by this

The hallmarks of cancer. Cell (2000) 113.05

A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet (1997) 12.94

Simplified mammalian DNA isolation procedure. Nucleic Acids Res (1991) 12.56

Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet (2002) 7.67

The molecular genetics of cancer. Science (1987) 7.64

ATR regulates fragile site stability. Cell (2002) 4.74

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res (2000) 4.07

DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum Genet (1984) 2.92

WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A (2001) 2.79

FRA3B and other common fragile sites: the weakest links. Nat Rev Cancer (2001) 2.61

Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China. Hepatology (2002) 2.38

Common fragile sites. Cytogenet Genome Res (2003) 2.15

WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res (2001) 2.12

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A (2004) 1.91

DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity. Oncogene (2003) 1.76

Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction. Hum Mol Genet (1998) 1.65

Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells. Oncogene (2004) 1.65

Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma. Cancer Res (2002) 1.62

Role of FHIT in human cancer. J Clin Oncol (1999) 1.61

Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization. Hepatology (1999) 1.50

WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer. Cancer Res (2003) 1.42

Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Mol Cancer Res (2003) 1.32

Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors. Oncogene (2002) 1.31

Genetic alterations in cancer as a result of breakage at fragile sites. Cancer Lett (2003) 1.30

WWOX, the common chromosomal fragile site, FRA16D, cancer gene. Cytogenet Genome Res (2003) 1.28

An opposing view on WWOX protein function as a tumor suppressor. Cancer Res (2003) 1.27

The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers. Cancer Res (2002) 1.17

Human hepatocellular carcinoma is characterized by a highly consistent pattern of genomic imbalances, including frequent loss of 16q23.1-24.1. Genes Chromosomes Cancer (2001) 1.10

The role of late/slow replication of the FRA16D in common fragile site induction. Genes Chromosomes Cancer (2004) 1.05

Amplification and overexpression of the EMS 1 oncogene, a possible prognostic marker, in human hepatocellular carcinoma. J Mol Diagn (2003) 1.05

Alterations of the FHIT gene in human hepatocellular carcinoma. Cancer Res (2000) 1.02

Common fragile sites and cancer (review). Int J Oncol (1998) 1.01

Identification of homozygous deletions at chromosome 16q23 in aflatoxin B1 exposed hepatocellular carcinoma. Oncogene (2001) 0.95

Nonrandom breakpoints of unbalanced chromosome translocations in human hepatocellular carcinoma cell lines. Cancer Genet Cytogenet (1999) 0.89

DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma. Int J Oncol (2003) 0.88

SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma. Neoplasia (2003) 0.86

How common are common fragile sites in humans: interindividual variation in the distribution of aphidicolin-induced fragile sites. Cytogenet Genome Res (2003) 0.85

Articles by these authors

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev (2001) 11.25

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J (1987) 4.33

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A (1989) 4.17

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res (2000) 4.07

Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene (2009) 3.51

Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. Cancer Res (1998) 2.59

NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol Cell Biol (1996) 2.51

A bovine papillomavirus E1-related protein binds specifically to bovine papillomavirus DNA. J Virol (1991) 2.43

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev (1995) 2.41

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc Natl Acad Sci U S A (1997) 2.36

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation. Oncogene (1998) 2.28

WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res (2001) 2.12

Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Nat Med (2001) 2.04

Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Res (2000) 1.98

Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors. Oncogene (2007) 1.95

Human mitochondrial topoisomerase I. Proc Natl Acad Sci U S A (2001) 1.67

Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes. Cytogenet Cell Genet (1987) 1.62

Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase. Brain Res Mol Brain Res (1998) 1.58

Genomic organization and chromosomal localization of the human cathepsin G gene. J Biol Chem (1989) 1.52

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics (2001) 1.50

Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization. Hepatology (1999) 1.50

Induction of human cervical squamous cell carcinoma by sequential transfection with human papillomavirus 16 DNA and viral Harvey ras. Oncogene (1989) 1.46

UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. Mol Endocrinol (2001) 1.38

Human papillomavirus type 18 DNA is integrated at a single chromosome site in cervical carcinoma cell line SW756. J Virol (1987) 1.38

Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain. Mol Cell Biol (1998) 1.36

Chromosomal localization of three human ras genes by in situ molecular hybridization. Somat Cell Mol Genet (1985) 1.35

Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene. Cancer Res (1997) 1.35

Refined localization of the erbB-3 proto-oncogene by direct visualization of FISH signals on LUT-inverted and contrast-enhanced digital images of DAPI-banded chromosomes. Cancer Genet Cytogenet (1995) 1.34

Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice. Proc Natl Acad Sci U S A (2000) 1.30

Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression. J Biol Chem (1995) 1.30

Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans. Proc Natl Acad Sci U S A (1997) 1.29

WWOX, the common chromosomal fragile site, FRA16D, cancer gene. Cytogenet Genome Res (2003) 1.28

Deletion map of chromosome 16q in ductal carcinoma in situ of the breast: refining a putative tumor suppressor gene region. Cancer Res (1996) 1.28

Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13. Oncogene (1998) 1.25

Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. Proc Natl Acad Sci U S A (1985) 1.22

Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells. Cancer Res (1995) 1.22

Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors. Proc Natl Acad Sci U S A (1990) 1.20

TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron (1997) 1.20

Synthesis of laminin and entactin by F9 cells induced with retinoic acid and dibutyryl cyclic AMP. J Biol Chem (1983) 1.20

Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy. Proc Natl Acad Sci U S A (1987) 1.19

Chromosome-mediated alterations of the MYC gene in human cancer. J Cell Mol Med (2002) 1.17

Quantitation of chemically induced neoplastic transformation of BALB-3T3 cloned cell lines. Cancer Res (1972) 1.15

Entactin: structure and function. Am J Respir Cell Mol Biol (1990) 1.15

claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Mol Cell Biol (2001) 1.14

Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth. Oncogene (2007) 1.12

In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules. Hum Genet (1998) 1.12

p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities. Oncogene (2009) 1.12

Preferential loss of expression of p16(INK4a) rather than p19(ARF) in breast cancer. Clin Cancer Res (1996) 1.10

Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis. Cancer Res (1999) 1.10

Tetranectin is a novel marker for myogenesis during embryonic development, muscle regeneration, and muscle cell differentiation in vitro. Dev Biol (1998) 1.10

Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family. Cytogenet Genome Res (2002) 1.09

Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-Myc and transforming growth factor-alpha in the liver. Am J Pathol (1999) 1.09

Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1. J Biol Chem (1998) 1.07

Extrasynaptic location of laminin beta 2 chain in developing and adult human skeletal muscle. Am J Pathol (1997) 1.07

Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. J Biol Chem (1997) 1.06

Profile of genetic alterations and tumorigenicity of human breast cancer cells. Int J Oncol (2000) 1.06

Aneuploidy, an early event in mouse skin tumor development. Carcinogenesis (1986) 1.06

Molecular cloning, chromosomal localization, and expression of murine dipeptidyl peptidase I. J Biol Chem (1997) 1.05

Risk factors for injuries due to the 1990 earthquake in Luzon, Philippines. Bull World Health Organ (1992) 1.05

Expression of alternative forms of Ras exchange factors GRF and SOS1 in different human tissues and cell lines. Oncogene (1996) 1.04

GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc Natl Acad Sci U S A (1998) 1.04

Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. Proc Natl Acad Sci U S A (2000) 1.04

A direct cytogenetic technique for mouse skin carcinomas and papillomas. Cancer Genet Cytogenet (1986) 1.03

Alterations of the FHIT gene in human hepatocellular carcinoma. Cancer Res (2000) 1.02

Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas. Genomics (1994) 1.02

A potential role for tetranectin in mineralization during osteogenesis. J Cell Biol (1994) 1.01

Adenovirus-mediated restoration of expression of the tumor suppressor gene DLC1 inhibits the proliferation and tumorigenicity of aggressive, androgen-independent human prostate cancer cell lines: prospects for gene therapy. Cancer Gene Ther (2008) 1.01

Rapid analysis of gene expression (RAGE) facilitates universal expression profiling. Nucleic Acids Res (1999) 1.01

Terminal differentiation-resistant epidermal cells in mice undergoing two-stage carcinogenesis. Cancer Res (1987) 1.01

A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors. Oncogene (2011) 1.00

Expression cDNA cloning of a serine kinase transforming gene. Oncogene (1993) 1.00

Induction of chromosome banding by trypsin/EDTA for gene mapping by in situ hybridization. Cytogenet Cell Genet (1985) 1.00

An improved procedure for chromosome preparations from solid tumors. Cancer Genet Cytogenet (1994) 0.98

The effect of vitamin E acetate on ultraviolet-induced mouse skin carcinogenesis. Mol Carcinog (1998) 0.96

Chromosome alterations associated with in vitro exposure of human fibroblasts to chemical or physical carcinogens. Cancer Res (1986) 0.96

A novel human gene closely related to the abl proto-oncogene. Science (1986) 0.95

Breast cancer biomarker discovery in the functional genomic age: a systematic review of 42 gene expression signatures. Biomark Insights (2010) 0.94

Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity. Mol Cell Biol (2001) 0.94

Chromosome distribution of intracisternal A-particle sequences in the Syrian hamster and mouse. Chromosoma (1986) 0.93

Polyacrylamide gel electrophoresis and immunoblotting of proteins extracted from paraffin-embedded tissue sections. J Histochem Cytochem (1988) 0.93

Amplification of the integrated viral transforming genes of human papillomavirus 18 and its 5'-flanking cellular sequence located near the myc protooncogene in HeLa cells. Cancer Res (1989) 0.92

Identification of mammaglobin B, a novel member of the uteroglobin gene family. Genomics (1998) 0.92