Published in Bioessays on August 01, 2004
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell (2009) 3.36
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol (2006) 3.24
The human plasma lipidome. N Engl J Med (2011) 2.35
International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev (2010) 2.10
Phospholipase A2 biochemistry. Cardiovasc Drugs Ther (2008) 1.93
Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci U S A (2007) 1.87
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators. Nat Struct Mol Biol (2011) 1.87
GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci U S A (2009) 1.81
Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc Natl Acad Sci U S A (2010) 1.80
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab (2012) 1.71
Lipid phosphate phosphatases and signaling. J Lipid Res (2008) 1.70
Phospholipase D: enzymology, functionality, and chemical modulation. Chem Rev (2011) 1.66
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. J Natl Cancer Inst (2008) 1.61
Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). Am J Pathol (2009) 1.50
LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling. EMBO J (2011) 1.48
The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology (2007) 1.42
Dual Action of Lysophosphatidate-Functionalised Titanium: Interactions with Human (MG63) Osteoblasts and Methicillin Resistant Staphylococcus aureus. PLoS One (2015) 1.38
Insights into autotaxin: how to produce and present a lipid mediator. Nat Rev Mol Cell Biol (2011) 1.37
A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem (2010) 1.32
Insights into the pharmacological relevance of lysophospholipid receptors. Br J Pharmacol (2012) 1.31
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell (2009) 1.29
Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect. J Biol Chem (2009) 1.28
Lysophosphatidic acid signaling in airway epithelium: role in airway inflammation and remodeling. Cell Signal (2008) 1.28
Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes. Arthritis Res Ther (2005) 1.28
Therapeutic potential of autotaxin/lysophospholipase d inhibitors. Curr Drug Targets (2008) 1.27
Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol (2009) 1.24
Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. PLoS One (2009) 1.24
Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer. J Natl Cancer Inst (2012) 1.24
An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples. J Lipid Res (2009) 1.23
Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. Mol Cancer (2006) 1.22
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation. FASEB J (2013) 1.18
Lysophospholipid receptors in vertebrate development, physiology, and pathology. J Lipid Res (2008) 1.17
P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. J Cell Biol (2006) 1.16
A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis. Hum Genet (2007) 1.16
Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor. Invest Ophthalmol Vis Sci (2007) 1.14
Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model. Cancer (2010) 1.13
Chemical evolution of autotaxin inhibitors. Chem Rev (2012) 1.12
Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA). Biochem J (2005) 1.10
Reduced expression of autotaxin predicts survival in uveal melanoma. Br J Ophthalmol (2007) 1.10
The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase type. J Lipid Res (2008) 1.10
The effect of inbreeding on the distribution of compound heterozygotes: a lesson from Lipase H mutations in autosomal recessive woolly hair/hypotrichosis. Hum Hered (2009) 1.09
ERK1/2 mediate wounding- and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding. Invest Ophthalmol Vis Sci (2008) 1.08
Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling. J Exp Med (2012) 1.07
Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. Mol Biol Cell (2006) 1.07
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Lett (2008) 1.07
G(q)-dependent signalling by the lysophosphatidic acid receptor LPA(3) in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA. Biochem J (2008) 1.07
Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus. Mol Cell Neurosci (2008) 1.05
Lysophosphatidic acid and renal fibrosis. Biochim Biophys Acta (2008) 1.04
Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy. Biochim Biophys Acta (2012) 1.04
GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction. Mol Biol Cell (2006) 1.04
In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. J Cell Biol (2014) 1.04
Distinctive gene expression of prostatic stromal cells cultured from diseased versus normal tissues. J Cell Physiol (2007) 1.03
S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH. J Biol Chem (2009) 1.01
Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration. Mol Cancer Res (2010) 1.01
Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential anti-inflammatory signaling pathways. Mol Med (2008) 1.00
The role of the lens actin cytoskeleton in fiber cell elongation and differentiation. Semin Cell Dev Biol (2006) 0.98
Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2. BMC Cancer (2008) 0.97
Phosphodiesterase-Ialpha/autotaxin's MORFO domain regulates oligodendroglial process network formation and focal adhesion organization. Mol Cell Neurosci (2007) 0.97
Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5. J Biol Chem (2013) 0.97
Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling. BMC Genomics (2008) 0.97
The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. Am J Physiol Gastrointest Liver Physiol (2010) 0.97
TNF-α potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol (2011) 0.96
β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. PLoS One (2013) 0.95
MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells. Gastroenterology (2010) 0.95
Regulation of the LPA2 receptor signaling through the carboxyl-terminal tail-mediated protein-protein interactions. Biochim Biophys Acta (2008) 0.95
Lysophosphatidic acid (LPA) signaling in vertebrate reproduction. Trends Endocrinol Metab (2010) 0.94
Pivotal role of actin depolymerization in the regulation of cochlear outer hair cell motility. Biophys J (2010) 0.93
Oxytocin stimulates migration and invasion in human endothelial cells. Br J Pharmacol (2007) 0.93
Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits. Genes Brain Behav (2009) 0.93
Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs. Biochim Biophys Acta (2006) 0.92
Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1. PLoS One (2011) 0.91
Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution. J Biol Chem (2011) 0.91
Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors. J Biol Chem (2008) 0.91
Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors. Psychopharmacology (Berl) (2011) 0.90
Lysophosphatidic acid differentially regulates axonal mRNA translation through 5'UTR elements. Mol Cell Neurosci (2012) 0.90
Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet. Am J Physiol Endocrinol Metab (2010) 0.89
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin. Lipids Health Dis (2005) 0.89
Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor. Neurobiol Learn Mem (2010) 0.89
Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA₁ receptor knockout mice. PLoS One (2011) 0.89
Spatiotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA. Mol Biol Cell (2009) 0.89
LPA induces IL-6 secretion from aortic smooth muscle cells via an LPA1-regulated, PKC-dependent, and p38alpha-mediated pathway. Am J Physiol Heart Circ Physiol (2009) 0.88
Rapid and reversible enhancement of blood-brain barrier permeability using lysophosphatidic acid. J Cereb Blood Flow Metab (2013) 0.88
Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody. J Mol Biol (2011) 0.88
Effects of hemagglutinin-neuraminidase protein mutations on cell-cell fusion mediated by human parainfluenza type 2 virus. J Virol (2008) 0.88
Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Arterioscler Thromb Vasc Biol (2011) 0.87
Structure-based design of novel boronic acid-based inhibitors of autotaxin. J Med Chem (2011) 0.87
Inhibition of ROCK activity allows InlF-mediated invasion and increased virulence of Listeria monocytogenes. Mol Microbiol (2008) 0.86
Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1 alpha from human mesenchymal stem cells. Exp Mol Med (2010) 0.86
TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR. BMC Gastroenterol (2013) 0.86
Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology. BMC Neurosci (2008) 0.85
LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis. Biochimie (2012) 0.85
Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure. PLoS One (2012) 0.85
Diabetes disrupts the response of retinal endothelial cells to the angiomodulator lysophosphatidic acid. Diabetes (2012) 0.85
Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest. PLoS One (2011) 0.85
LPA Stimulates the Phosphorylation of p130Cas via Gαi2 in Ovarian Cancer Cells. Genes Cancer (2012) 0.85
The impact of bioactive lipids on cardiovascular development. Stem Cells Int (2011) 0.85
Lipid phosphate phosphatases and their roles in mammalian physiology and pathology. J Lipid Res (2015) 0.83
Structural basis for specific inhibition of Autotaxin by a DNA aptamer. Nat Struct Mol Biol (2016) 0.83
Genetic evidence for antagonism between Pak protein kinase and Rho1 small GTPase signaling in regulation of the actin cytoskeleton during Drosophila oogenesis. Genetics (2010) 0.83
The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction. Am J Physiol Cell Physiol (2012) 0.83
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol (2004) 36.25
Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature (2010) 3.40
Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. Nat Biotechnol (2005) 3.28
Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells. Proc Natl Acad Sci U S A (2002) 2.21
Immunolabeling artifacts and the need for live-cell imaging. Nat Methods (2012) 2.15
Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol (2011) 1.81
Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc Natl Acad Sci U S A (2010) 1.80
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem (2009) 1.78
Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy. Proc Natl Acad Sci U S A (2006) 1.78
Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1. J Biol Chem (2002) 1.57
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. J Med Chem (2005) 1.40
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1). Mol Biol Cell (2003) 1.39
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood (2008) 1.38
Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity. Org Lett (2006) 1.34
Spider and bacterial sphingomyelinases D target cellular lysophosphatidic acid receptors by hydrolyzing lysophosphatidylcholine. J Biol Chem (2004) 1.33
Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1. J Biol Chem (2002) 1.33
Markers for correlated light and electron microscopy. Methods Cell Biol (2007) 1.30
EpCAM: structure and function in health and disease. Biochim Biophys Acta (2013) 1.27
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2007) 1.25
Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging. J Biol Chem (2008) 1.18
Gap junctional channels are parts of multiprotein complexes. Biochim Biophys Acta (2011) 1.13
Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid. J Lipid Res (2011) 1.11
Light and electron microscopic localization of multiple proteins using quantum dots. Methods Mol Biol (2007) 1.03
Discovery and optimization of boronic acid based inhibitors of autotaxin. J Med Chem (2010) 0.97
Destruction of tissue, cells and organelles in type 1 diabetic rats presented at macromolecular resolution. Sci Rep (2013) 0.97
Correlated light microscopy and electron microscopy. Methods Cell Biol (2012) 0.94
A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression. Mol Cancer Res (2010) 0.94
Transforming growth factor β family members in regulation of vascular function: in the light of vascular conditional knockouts. Exp Cell Res (2013) 0.94
Absence of cell-surface EpCAM in congenital tufting enteropathy. Hum Mol Genet (2013) 0.93
Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.90
FLIPPER, a combinatorial probe for correlated live imaging and electron microscopy, allows identification and quantitative analysis of various cells and organelles. Cell Tissue Res (2015) 0.89
Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling. Mol Cancer Res (2008) 0.87
Autotaxin in embryonic development. Biochim Biophys Acta (2012) 0.86
Defective activation of c-Src in cystic fibrosis airway epithelial cells results in loss of tumor necrosis factor-alpha-induced gap junction regulation. J Biol Chem (2002) 0.83
Upregulation of cytokine expression in fibroblasts exposed to loxosceles sphingomyelinase D: what is the trigger? J Invest Dermatol (2007) 0.80
GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2. Angiogenesis (2013) 0.80
The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans. J Biol Chem (2012) 0.78
Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome. Cancer Cell (2016) 0.77
Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantation. Biomed Mater (2016) 0.75