Generation of pluripotent stem cells and their differentiation to the chondrocytic phenotype.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMID 15280587)

Published in Methods Mol Med on January 01, 2004

Authors

Luis A Solchaga1, Jean F Welter, Donald P Lennon, Arnold I Caplan

Author Affiliations

1: Department of Orthopedics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA.

Associated clinical trials:

Stem Cell Transplantation for the Treatment of Knee Osteoarthritis | NCT00550524

Mesenchymal Stem Cells for Lumbar Degenerative Disc Disease | NCT03692221

Articles citing this

Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells. Tissue Eng Part A (2010) 1.38

High-throughput aggregate culture system to assess the chondrogenic potential of mesenchymal stem cells. Biotechniques (2005) 1.35

Mesenchymal stem cells in tissue repair. Front Immunol (2013) 1.35

Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond) (2010) 1.06

Engineered cartilage via self-assembled hMSC sheets with incorporated biodegradable gelatin microspheres releasing transforming growth factor-β1. J Control Release (2011) 0.96

Simplification of aggregate culture of human mesenchymal stem cells as a chondrogenic screening assay. Biotechniques (2007) 0.93

Myostatin (GDF-8) inhibits chondrogenesis and chondrocyte proliferation in vitro by suppressing Sox-9 expression. Growth Factors (2011) 0.92

Concentrated collagen-chondroitin sulfate scaffolds for tissue engineering applications. J Biomed Mater Res A (2010) 0.88

Effect of Arthritic Synovial Fluids on the Expression of Immunomodulatory Factors by Mesenchymal Stem Cells: An Explorative in vitro Study. Front Immunol (2012) 0.87

microRNAs, Gap Junctional Intercellular Communication and Mesenchymal Stem Cells in Breast Cancer Metastasis. Curr Cancer Ther Rev (2011) 0.86

Assessing adipogenic potential of mesenchymal stem cells: a rapid three-dimensional culture screening technique. Stem Cells Int (2013) 0.77

Articles by these authors

A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med (2004) 4.37

In search of the in vivo identity of mesenchymal stem cells. Stem Cells (2008) 4.17

Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev (2009) 3.73

Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol (2011) 3.65

Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia (2009) 2.66

Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med (2013) 2.60

FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J Cell Physiol (2005) 2.31

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat Med (2009) 2.31

The STRO-1+ marrow cell population is multipotential. Cells Tissues Organs (2002) 1.95

Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models. Nat Neurosci (2012) 1.86

Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. Cells Tissues Organs (2006) 1.82

Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials (2007) 1.78

Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone. Tissue Eng Part A (2008) 1.70

Isolation of human marrow-derived mesenchymal stem cells. Exp Hematol (2006) 1.60

Immunochemical and mechanical characterization of cartilage subtypes in rabbit. J Histochem Cytochem (2002) 1.56

Adult stem cell driven genesis of human-shaped articular condyle. Ann Biomed Eng (2004) 1.56

Fibroblast heterogeneity: more than skin deep. J Cell Sci (2004) 1.55

Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol (2010) 1.46

Optimizing mesenchymal stem cell-based therapeutics. Curr Opin Biotechnol (2009) 1.46

Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix. Tissue Eng Part A (2010) 1.45

Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells. Tissue Eng Part A (2010) 1.38

High-throughput aggregate culture system to assess the chondrogenic potential of mesenchymal stem cells. Biotechniques (2005) 1.35

Mesenchymal stem cells in tissue repair. Front Immunol (2013) 1.35

MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation. Stem Cells Int (2013) 1.30

Isolation of rat marrow-derived mesenchymal stem cells. Exp Hematol (2006) 1.29

Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther (2010) 1.28

Fibroblasts-a diverse population at the center of it all. Int Rev Cell Mol Biol (2009) 1.27

Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Eng Part A (2009) 1.22

MSC frequency correlates with blood vessel density in equine adipose tissue. Tissue Eng Part A (2009) 1.21

Treatment of osteochondral defects with autologous bone marrow in a hyaluronan-based delivery vehicle. Tissue Eng (2002) 1.20

Cartilage tissue engineering for laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbit. Tissue Eng (2007) 1.19

Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites. J Biomed Mater Res A (2009) 1.18

Effect of swelling ratio of injectable hydrogel composites on chondrogenic differentiation of encapsulated rabbit marrow mesenchymal stem cells in vitro. Biomacromolecules (2009) 1.18

Bioreactors mediate the effectiveness of tissue engineering scaffolds. FASEB J (2002) 1.15

Targeted delivery of progenitor cells for cartilage repair. J Orthop Res (2004) 1.15

Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips and tricks. Methods Mol Biol (2011) 1.14

Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds. Osteoarthritis Cartilage (2005) 1.11

Repair of osteochondral defect with tissue-engineered two-phase composite material of injectable calcium phosphate and hyaluronan sponge. Tissue Eng (2002) 1.09

Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54. J Cell Physiol (2006) 1.09

Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond) (2010) 1.06

Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-alpha, inducible nitric oxide synthase, p53, c-myc, and bax-alpha, and suppression of bcl-2. J Cell Biochem (2002) 1.06

In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo. J Orthop Res (2009) 1.05

Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Genomics (2003) 1.05

Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds. Tissue Eng Part A (2010) 1.04

A rapid seeding technique for the assembly of large cell/scaffold composite constructs. Tissue Eng (2006) 1.03

In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(epsilon-caprolactone) scaffolds. Biomaterials (2010) 1.02

The potential of mesenchymal stem cells for neural repair. Discov Med (2010) 1.01

Tissue engineering of autologous cartilage grafts in three-dimensional in vitro macroaggregate culture system. Tissue Eng (2005) 1.00

Fibroblast Growth Factor-2 Enhances Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells without Diminishing Their Immunosuppressive Potential. Stem Cells Int (2011) 0.99

The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. Biomaterials (2013) 0.98

Scaling-up of dental pulp stem cells isolated from multiple niches. PLoS One (2012) 0.98

Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin. J Biol Chem (2003) 0.98

Nondestructive evaluation of hydrogel mechanical properties using ultrasound. Ann Biomed Eng (2011) 0.96

Adult mesenchymal stem cells: an innovative therapeutic for lung diseases. Discov Med (2010) 0.96

Age-related differences in human skin proteoglycans. Glycobiology (2010) 0.96

A self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells. Cells Tissues Organs (2007) 0.96

Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations. Tissue Eng Part B Rev (2014) 0.96

Stem cells in dental pulp of deciduous teeth. Tissue Eng Part B Rev (2011) 0.95

A simple method for stem cell labeling with fluorine 18. Nucl Med Biol (2005) 0.94

Toxic effects of gentamicin on marrow-derived human mesenchymal stem cells. Clin Orthop Relat Res (2006) 0.93

Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells. J Orthop Res (2009) 0.93

The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials (2012) 0.92

Effect of hydroxyapatite/tricalcium-phosphate coating on osseointegration of plasma-sprayed titanium alloy implants. J Biomed Mater Res A (2004) 0.91

Human dermal fibroblast subpopulations; differential interactions with vascular endothelial cells in coculture: nonsoluble factors in the extracellular matrix influence interactions. Wound Repair Regen (2008) 0.91

Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. Bone (2011) 0.90

Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Exp Cell Res (2013) 0.88

Effect of transforming growth factor beta 2 on marrow-infused foam poly(propylene fumarate) tissue-engineered constructs for the repair of critical-size cranial defects in rabbits. Tissue Eng (2005) 0.88

Polybrene inhibits human mesenchymal stem cell proliferation during lentiviral transduction. PLoS One (2011) 0.88

Concentrated collagen-chondroitin sulfate scaffolds for tissue engineering applications. J Biomed Mater Res A (2010) 0.88

Development of a peptide-targeted, myocardial ischemia-homing, mesenchymal stem cell. J Drug Target (2011) 0.87

Clonal characterization of fibroblasts in the superficial layer of the adult human dermis. Cell Tissue Res (2006) 0.87

Controlled release of hyaluronan oligomers from biodegradable polymeric microparticle carriers. J Control Release (2004) 0.87

Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. Biochem J (2012) 0.87

Evaluation of machining methods for trabecular metal implants in a rabbit intramedullary osseointegration model. J Biomed Mater Res B Appl Biomater (2007) 0.87

Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. Biofabrication (2014) 0.86

Osteochondral defect repair by demineralized cortical bone matrix. Clin Orthop Relat Res (2004) 0.86