Published in Dev Biol on August 15, 2004
A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature (2013) 3.52
Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nat Genet (2012) 2.43
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell (2010) 2.37
Myosin VI stabilizes an actin network during Drosophila spermatid individualization. Mol Biol Cell (2006) 1.18
A nonsense mutation in the gene encoding a zebrafish myosin VI isoform causes defects in hair-cell mechanotransduction. Proc Natl Acad Sci U S A (2004) 1.17
Differential expression of unconventional myosins in apoptotic and regenerating chick hair cells confirms two regeneration mechanisms. J Comp Neurol (2006) 1.15
Myosin VI and its cargo adaptors - linking endocytosis and autophagy. J Cell Sci (2013) 1.12
Chemical screening for hair cell loss and protection in the zebrafish lateral line. Zebrafish (2010) 1.11
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS Genet (2008) 1.07
Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss. Drug Discov Today (2010) 1.04
Usher protein functions in hair cells and photoreceptors. Int J Biochem Cell Biol (2013) 0.91
Myosins in cell junctions. Bioarchitecture (2012) 0.89
Cargos and genes: insights into vesicular transport from inherited human disease. J Med Genet (2007) 0.88
Myosin VI deafness mutation prevents the initiation of processive runs on actin. Proc Natl Acad Sci U S A (2015) 0.84
A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear. PLoS One (2009) 0.83
Identification and localization of myosin superfamily members in fish retina and retinal pigmented epithelium. J Comp Neurol (2009) 0.83
Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes. Hear Res (2007) 0.80
MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform. Hum Mutat (2016) 0.79
Expression of unconventional myosin genes during neuronal development in zebrafish. Gene Expr Patterns (2007) 0.76
Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish. PLoS One (2015) 0.75
Saccular Transcriptome Profiles of the Seasonal Breeding Plainfin Midshipman Fish (Porichthys notatus), a Teleost with Divergent Sexual Phenotypes. PLoS One (2015) 0.75
Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin Protrusions. J Biol Chem (2016) 0.75
Identification of sensory hair-cell transcripts by thiouracil-tagging in zebrafish. BMC Genomics (2015) 0.75
Hearing sensitivity differs between zebrafish lines used in auditory research. Hear Res (2016) 0.75
Functional Analysis of the Transmembrane and Cytoplasmic Domains of Pcdh15a in Zebrafish Hair Cells. J Neurosci (2017) 0.75
Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. Am J Hum Genet (2010) 4.95
Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells. Nature (2004) 3.02
GJB2 mutations and degree of hearing loss: a multicenter study. Am J Hum Genet (2005) 2.63
Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in Middle Eastern families. Genome Biol (2011) 2.62
The neural basis of Drosophila gravity-sensing and hearing. Nature (2009) 2.60
Promoting Arab and Israeli cooperation: peacebuilding through health initiatives. Lancet (2005) 2.48
Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells. J Neurosci (2008) 2.36
Control of crystal size and lattice formation by starmaker in otolith biomineralization. Science (2003) 2.35
NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science (2003) 2.31
Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nat Genet (2002) 2.31
Hearing loss: mechanisms revealed by genetics and cell biology. Annu Rev Genet (2009) 2.30
From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. Proc Natl Acad Sci U S A (2002) 2.17
Prevalence and evolutionary origins of the del(GJB6-D13S1830) mutation in the DFNB1 locus in hearing-impaired subjects: a multicenter study. Am J Hum Genet (2003) 1.79
Sodium and calcium currents shape action potentials in immature mouse inner hair cells. J Physiol (2003) 1.75
A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression. J Neurosci (2006) 1.73
Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum Mol Genet (2004) 1.73
PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell (2012) 1.71
Five novel loci for inherited hearing loss mapped by SNP-based homozygosity profiles in Palestinian families. Eur J Hum Genet (2009) 1.67
MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A (2009) 1.67
Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Proc Natl Acad Sci U S A (2002) 1.65
Mouse models to study inner ear development and hereditary hearing loss. Int J Dev Biol (2007) 1.65
Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality. Neuron (2003) 1.63
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1. J Cell Biol (2008) 1.58
Hearing impairment: a panoply of genes and functions. Neuron (2010) 1.55
Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond. Zebrafish (2013) 1.52
Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss. Am J Hum Genet (2003) 1.43
CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol Cancer (2009) 1.42
A mutation of PCDH15 among Ashkenazi Jews with the type 1 Usher syndrome. N Engl J Med (2003) 1.38
Characterization of peripherin/rds and rom-1 transport in rod photoreceptors of transgenic and knockout animals. Invest Ophthalmol Vis Sci (2006) 1.37
USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses. Eur J Hum Genet (2002) 1.36
CLRN1 is nonessential in the mouse retina but is required for cochlear hair cell development. PLoS Genet (2009) 1.34
Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51. Am J Hum Genet (2010) 1.31
Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells. Proc Natl Acad Sci U S A (2005) 1.28
Kinocilia mediate mechanosensitivity in developing zebrafish hair cells. Dev Cell (2012) 1.27
Lifestyle factors of people with exceptional longevity. J Am Geriatr Soc (2011) 1.27
SPIKE: a database of highly curated human signaling pathways. Nucleic Acids Res (2010) 1.23
The LINC complex is essential for hearing. J Clin Invest (2013) 1.22
Hereditary hearing loss: from human mutation to mechanism. Hear Res (2011) 1.22
Large-scale mapping of mutations affecting zebrafish development. BMC Genomics (2007) 1.21
Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development. EMBO Rep (2006) 1.21
Duplicated genes with split functions: independent roles of protocadherin15 orthologues in zebrafish hearing and vision. Development (2005) 1.21
Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. Am J Hum Genet (2005) 1.20
Presynaptic CaV1.3 channels regulate synaptic ribbon size and are required for synaptic maintenance in sensory hair cells. J Neurosci (2012) 1.17
Genetics of congenital deafness in the Palestinian population: multiple connexin 26 alleles with shared origins in the Middle East. Hum Genet (2002) 1.17
Ribeye is required for presynaptic Ca(V)1.3a channel localization and afferent innervation of sensory hair cells. Development (2011) 1.17
Expression of prestin-homologous solute carrier (SLC26) in auditory organs of nonmammalian vertebrates and insects. Proc Natl Acad Sci U S A (2003) 1.17
gemini encodes a zebrafish L-type calcium channel that localizes at sensory hair cell ribbon synapses. J Neurosci (2004) 1.17
A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication. J Biol Chem (2004) 1.16
Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear. PLoS One (2011) 1.15
Myo3A, one of two class III myosin genes expressed in vertebrate retina, is localized to the calycal processes of rod and cone photoreceptors and is expressed in the sacculus. Mol Biol Cell (2003) 1.14
A randomized study in diabetic patients undergoing cardiac surgery comparing computer-guided glucose management with a standard sliding scale protocol. J Cardiothorac Vasc Anesth (2007) 1.13
Localization of a class III myosin to filopodia tips in transfected HeLa cells requires an actin-binding site in its tail domain. Mol Biol Cell (2003) 1.10
Voltage-sensitive prestin orthologue expressed in zebrafish hair cells. J Physiol (2007) 1.10
Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation. J Biol Chem (2010) 1.08
Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing. Development (2012) 1.08
Kinetic mechanism of human myosin IIIA. J Biol Chem (2006) 1.08
High-throughput sequencing to decipher the genetic heterogeneity of deafness. Genome Biol (2012) 1.07
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS Genet (2008) 1.07
Nonsense mutation of the stereociliar membrane protein gene PTPRQ in human hearing loss DFNB84. J Med Genet (2010) 1.07
Synaptojanin1 is required for temporal fidelity of synaptic transmission in hair cells. PLoS Genet (2009) 1.07
A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment. Mamm Genome (2004) 1.07
Mutated otopetrin 1 affects the genesis of otoliths and the localization of Starmaker in zebrafish. Dev Genes Evol (2004) 1.06
Genomic analysis of a heterogeneous Mendelian phenotype: multiple novel alleles for inherited hearing loss in the Palestinian population. Hum Genomics (2006) 1.06
Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia. Hum Mol Genet (2003) 1.02
The deafness gene dfna5 is crucial for ugdh expression and HA production in the developing ear in zebrafish. Development (2004) 1.02
The kinase domain alters the kinetic properties of the myosin IIIA motor. Biochemistry (2008) 1.02
A class III myosin expressed in the retina is a potential candidate for Bardet-Biedl syndrome. Genomics (2002) 1.01
Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system. Eur J Neurosci (2007) 1.00
Hearing loss: a common disorder caused by many rare alleles. Ann N Y Acad Sci (2010) 1.00
The DFNA15 deafness mutation affects POU4F3 protein stability, localization, and transcriptional activity. Mol Cell Biol (2003) 0.99
Collaborative genomics for human health and cooperation in the Mediterranean region. Nat Genet (2010) 0.99
Deafness genes in Israel: implications for diagnostics in the clinic. Pediatr Res (2009) 0.98
Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ. J Neurosci (2011) 0.97
The R245X mutation of PCDH15 in Ashkenazi Jewish children diagnosed with nonsyndromic hearing loss foreshadows retinitis pigmentosa. Pediatr Res (2004) 0.97
Physiological recordings from zebrafish lateral-line hair cells and afferent neurons. Methods Cell Biol (2010) 0.97
Quantification of vestibular-induced eye movements in zebrafish larvae. BMC Neurosci (2010) 0.96
MuD: an interactive web server for the prediction of non-neutral substitutions using protein structural data. Nucleic Acids Res (2010) 0.96
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA. Mamm Genome (2010) 0.96
Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity. Biochem Biophys Res Commun (2004) 0.96
Rabconnectin3α promotes stable activity of the H+ pump on synaptic vesicles in hair cells. J Neurosci (2012) 0.94
Retina-specific protein fascin 2 is an actin cross-linker associated with actin bundles in photoreceptor inner segments and calycal processes. Invest Ophthalmol Vis Sci (2007) 0.93
MicroRNAs and epigenetic regulation in the mammalian inner ear: implications for deafness. Mamm Genome (2009) 0.93
An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome (2004) 0.92
Fascin 2b is a component of stereocilia that lengthens actin-based protrusions. PLoS One (2011) 0.92
Connexin-associated deafness and speech perception outcome of cochlear implantation. Arch Otolaryngol Head Neck Surg (2006) 0.91
Both pre- and postsynaptic activity of Nsf prevents degeneration of hair-cell synapses. PLoS One (2011) 0.91
Chromosomal mapping and phenotypic characterization of hereditary otosclerosis linked to the OTSC4 locus. Arch Otolaryngol Head Neck Surg (2006) 0.91
Therapeutics of hearing loss: expectations vs reality. Drug Discov Today (2005) 0.91
Myosin 3A transgene expression produces abnormal actin filament bundles in transgenic Xenopus laevis rod photoreceptors. J Cell Sci (2004) 0.90
A novel SLC26A4 (PDS) deafness mutation retained in the endoplasmic reticulum. Arch Otolaryngol Head Neck Surg (2008) 0.89
Mouse models for human deafness: current tools for new fashions. Trends Mol Med (2002) 0.88
Disruption of kinesin II function using a dominant negative-acting transgene in Xenopus laevis rods results in photoreceptor degeneration. Invest Ophthalmol Vis Sci (2003) 0.88
Cytoplasmic mislocalization of POU3F4 due to novel mutations leads to deafness in humans and mice. Hum Mutat (2013) 0.86
A mutation in GJB3 is associated with recessive erythrokeratodermia variabilis (EKV) and leads to defective trafficking of the connexin 31 protein. Hum Mol Genet (2002) 0.85
Salicylate alters the expression of calcium response transcription factor 1 in the cochlea: implications for brain-derived neurotrophic factor transcriptional regulation. Mol Pharmacol (2008) 0.85