Published in Methods on September 01, 2004
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol (2010) 6.64
Folding versus aggregation: polypeptide conformations on competing pathways. Arch Biochem Biophys (2007) 1.97
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. Biochemistry (2006) 1.88
Diversity, biogenesis and function of microbial amyloids. Trends Microbiol (2011) 1.86
The bacterial curli system possesses a potent and selective inhibitor of amyloid formation. Mol Cell (2015) 1.68
Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils-current status. J Chem Biol (2009) 1.55
Mechanisms of protein fibril formation: nucleated polymerization with competing off-pathway aggregation. Biophys J (2007) 1.48
Candida albicans Als adhesins have conserved amyloid-forming sequences. Eukaryot Cell (2007) 1.45
Yeast cell adhesion molecules have functional amyloid-forming sequences. Eukaryot Cell (2009) 1.42
A Peptide Derived from the HIV-1 gp120 Coreceptor-Binding Region Promotes Formation of PAP248-286 Amyloid Fibrils to Enhance HIV-1 Infection. PLoS One (2015) 1.41
CsgE is a curli secretion specificity factor that prevents amyloid fibre aggregation. Mol Microbiol (2011) 1.34
Protein aggregation processes: In search of the mechanism. Protein Sci (2007) 1.32
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass. Proc Natl Acad Sci U S A (2007) 1.29
Understanding amyloid aggregation by statistical analysis of atomic force microscopy images. Nat Nanotechnol (2010) 1.26
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. J Mol Biol (2009) 1.21
Active protein aggregates induced by terminally attached self-assembling peptide ELK16 in Escherichia coli. Microb Cell Fact (2011) 1.16
Curli biogenesis: order out of disorder. Biochim Biophys Acta (2013) 1.14
Arsenic(III) species inhibit oxidative protein folding in vitro. Biochemistry (2009) 1.11
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun (2014) 1.08
Octapeptide repeat insertions increase the rate of protease-resistant prion protein formation. Protein Sci (2006) 1.07
Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis. Cell (2015) 1.05
E6 proteins from diverse papillomaviruses self-associate both in vitro and in vivo. J Mol Biol (2009) 1.05
Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy. J Am Chem Soc (2013) 1.04
Defined DNA sequences promote the assembly of a bacterial protein into distinct amyloid nanostructures. Proc Natl Acad Sci U S A (2007) 1.01
Amyloid-like Self-Assembly of a Cellular Compartment. Cell (2016) 1.01
Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase. J Biol Chem (2012) 0.98
Functional amyloid formation by Streptococcus mutans. Microbiology (2012) 0.97
Dye-binding assays for evaluation of the effects of small molecule inhibitors on amyloid (aβ) self-assembly. ACS Chem Neurosci (2012) 0.96
Investigating the mechanism of peptide aggregation: insights from mixed monte carlo-molecular dynamics simulations. Biophys J (2008) 0.95
Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions. Biophys J (2011) 0.94
Population of nonnative states of lysozyme variants drives amyloid fibril formation. J Am Chem Soc (2011) 0.93
Amyloidogenesis abolished by proline substitutions but enhanced by lipid binding. PLoS Comput Biol (2009) 0.91
The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17. Phys Chem Chem Phys (2011) 0.90
Structure-activity relationships in peptide modulators of β-amyloid protein aggregation: variation in α,α-disubstitution results in altered aggregate size and morphology. ACS Chem Neurosci (2010) 0.89
Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrils. Biophys J (2009) 0.89
Large proteins have a great tendency to aggregate but a low propensity to form amyloid fibrils. PLoS One (2011) 0.89
Amylin uncovered: a review on the polypeptide responsible for type II diabetes. Biomed Res Int (2013) 0.89
Protein-folding landscapes in multichain systems. Proc Natl Acad Sci U S A (2005) 0.88
Detection of populations of amyloid-like protofibrils with different physical properties. Biophys J (2010) 0.88
A generic crystallization-like model that describes the kinetics of amyloid fibril formation. J Biol Chem (2012) 0.88
ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43. PLoS Biol (2016) 0.87
Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursors. J Biol Chem (2013) 0.87
Polyanionic candidate microbicides accelerate the formation of semen-derived amyloid fibrils to enhance HIV-1 infection. PLoS One (2013) 0.86
Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state. Biochemistry (2011) 0.86
Diaryl hydrazones as multifunctional inhibitors of amyloid self-assembly. Biochemistry (2013) 0.86
The Glycine-Alanine Dipeptide Repeat from C9orf72 Hexanucleotide Expansions Forms Toxic Amyloids Possessing Cell-to-Cell Transmission Properties. J Biol Chem (2016) 0.86
Relationship between prion propensity and the rates of individual molecular steps of fibril assembly. J Biol Chem (2011) 0.85
Between Amyloids and Aggregation Lies a Connection with Strength and Adhesion. New J Sci (2014) 0.85
Fluorescent N-arylaminonaphthalene sulfonate probes for amyloid aggregation of alpha-synuclein. Biophys J (2008) 0.84
Binding of β-amyloid (1-42) peptide to negatively charged phospholipid membranes in the liquid-ordered state: modeling and experimental studies. Biophys J (2012) 0.84
Coexistence of ribbon and helical fibrils originating from hIAPP(20-29) revealed by quantitative nanomechanical atomic force microscopy. Proc Natl Acad Sci U S A (2013) 0.83
Chemical and biophysical insights into the propagation of prion strains. HFSP J (2008) 0.83
Supramolecular amplification of amyloid self-assembly by iodination. Nat Commun (2015) 0.82
Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly. J Biol Chem (2011) 0.82
Analysis of core region from egg white lysozyme forming amyloid fibrils. Int J Biol Sci (2013) 0.81
Dissociation from the oligomeric state is the rate-limiting step in fibril formation by kappa-casein. J Biol Chem (2008) 0.81
In vitro aggregation assays for the characterization of α-synuclein prion-like properties. Prion (2014) 0.81
Measurement of amyloid formation by turbidity assay-seeing through the cloud. Biophys Rev (2016) 0.81
Structure-activity relationships of organofluorine inhibitors of β-amyloid self-assembly. ChemMedChem (2012) 0.81
Amyloid-associated nucleic acid hybridisation. PLoS One (2011) 0.81
Effects of peptides derived from terminal modifications of the aβ central hydrophobic core on aβ fibrillization. ACS Chem Neurosci (2010) 0.80
Transmission electron microscopy characterization of fluorescently labelled amyloid β 1-40 and α-synuclein aggregates. BMC Biotechnol (2011) 0.80
Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity. PLoS One (2011) 0.80
Biochemical stabilization of glucagon at alkaline pH. Diabetes Technol Ther (2014) 0.80
Formation of amyloid-like fibrils by Y-box binding protein 1 (YB-1) is mediated by its cold shock domain and modulated by disordered terminal domains. PLoS One (2012) 0.80
Multivalent protein polymers with controlled chemical and physical properties. Adv Drug Deliv Rev (2010) 0.80
In vitro aggregation behavior of a non-amyloidogenic λ light chain dimer deriving from U266 multiple myeloma cells. PLoS One (2012) 0.80
Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease. J Biol Chem (2015) 0.79
Pyroglutamylated amyloid-β peptide reverses cross β-sheets by a prion-like mechanism. J Phys Chem B (2014) 0.79
True and apparent inhibition of amyloid fibril formation. Prion (2012) 0.79
Computational modeling of the relationship between amyloid and disease. Biophys Rev (2012) 0.79
Photo-activity induced by amyloidogenesis. Protein Sci (2007) 0.79
Amyloid triangles, squares, and loops of apolipoprotein C-III. Biochemistry (2014) 0.79
Amyloid-like properties of Saccharomyces cerevisiae cell wall glucantransferase Bgl2p: prediction and experimental evidences. Prion (2008) 0.79
Enhanced stability of human prion proteins with two disulfide bridges. Biophys J (2006) 0.79
Screening strategies to identify HSP70 modulators to treat Alzheimer's disease. Drug Des Devel Ther (2015) 0.78
Aza-BODIPY: improved synthesis and interaction with soluble Aβ1-42 oligomers. Bioorg Med Chem Lett (2013) 0.78
Quantifying prefibrillar amyloids in vitro by using a "thioflavin-like" spectroscopic method. Chembiochem (2010) 0.78
Truncation of a β-barrel scaffold dissociates intrinsic stability from its propensity to aggregation. Biophys J (2012) 0.78
Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms. J Biol Chem (2015) 0.78
Amyloid fibril-like structure underlies the aggregate structure across the pH range for beta-lactoglobulin. Biophys J (2009) 0.78
Identification and characterization of a compound from Cuminum cyminum essential oil with antifibrilation and cytotoxic effect. Res Pharm Sci (2015) 0.77
Tracking the heterogeneous distribution of amyloid spherulites and their population balance with free fibrils. Eur Phys J E Soft Matter (2010) 0.77
Multivalency in the inhibition of oxidative protein folding by arsenic(III) species. Biochemistry (2014) 0.77
Kinetics of Thermal Denaturation and Aggregation of Bovine Serum Albumin. PLoS One (2016) 0.77
A closer look at prion strains: characterization and important implications. Prion (2013) 0.77
Aqueous, Unfolded OmpA Forms Amyloid-Like Fibrils upon Self-Association. PLoS One (2015) 0.77
Spatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrils. Sci Rep (2016) 0.76
The influence of phospholipid membranes on bovine calcitonin secondary structure and amyloid formation. Protein Sci (2005) 0.76
Few-layer bismuth selenides exfoliated by hemin inhibit amyloid-β1-42 fibril formation. Sci Rep (2015) 0.76
Injection of insulin amyloid fibrils in the hippocampus of male Wistar rats: report on memory impairment and formation of amyloid plaques. Neurol Sci (2015) 0.76
Techniques for Monitoring Protein Misfolding and Aggregation in Vitro and in Living Cells. Korean J Chem Eng (2012) 0.76
Hydrogen exchange mass spectrometry as an analytical tool for the analysis of amyloid fibrillogenesis. Int J Mass Spectrom (2011) 0.76
An azobenzene photoswitch sheds light on turn nucleation in amyloid-β self-assembly. ACS Chem Neurosci (2012) 0.76
Characterization of heat induced spherulites of lysozyme reveals new insight on amyloid initiation. Sci Rep (2016) 0.76
Identification of Key Amino Acid Residues Modulating Intracellular and In vitro Microcin E492 Amyloid Formation. Front Microbiol (2016) 0.76
Looking for a generic inhibitor of amyloid-like fibril formation among flavone derivatives. PeerJ (2015) 0.75
Molecular tandem repeat strategy for elucidating mechanical properties of high-strength proteins. Proc Natl Acad Sci U S A (2016) 0.75
Oligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols. PLoS One (2015) 0.75
Protection by beta-Hydroxybutyric acid against insulin glycation, lipid peroxidation and microglial cell apoptosis. Daru (2015) 0.75