Published in Infect Immun on September 01, 2004
Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. J Exp Med (2007) 1.21
Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease. Infect Immun (2005) 1.15
Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype. Obesity (Silver Spring) (2008) 1.12
Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain). J Infect Dis (2012) 1.09
Pathogenesis of Chagas disease: time to move on. Front Biosci (Elite Ed) (2012) 1.01
Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy. Br J Pharmacol (2012) 0.99
Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling. BMC Genomics (2009) 0.98
Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection. Genomics (2008) 0.97
Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease. Am J Pathol (2012) 0.96
Immune Evasion Strategies of Trypanosoma cruzi. J Immunol Res (2015) 0.95
Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells. Infect Immun (2006) 0.94
Perspectives on the Trypanosoma cruzi-host cell receptor interactions. Parasitol Res (2009) 0.92
Endothelin-1 and its role in the pathogenesis of infectious diseases. Life Sci (2014) 0.86
Molecular analysis of early host cell infection by Trypanosoma cruzi. Front Biosci (2008) 0.85
Trypanosoma cruzi infection results in the reduced expression of caveolin-3 in the heart. Cell Cycle (2010) 0.82
The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids. Front Microbiol (2016) 0.80
Trypanosoma cruzi infection and host lipid metabolism. Mediators Inflamm (2014) 0.78
Recent developments in the interactions between caveolin and pathogens. Adv Exp Med Biol (2012) 0.78
The vasculature in chagas disease. Adv Parasitol (2011) 0.78
Trypanosoma cruzi SSP4 Amastigote Protein Induces Expression of Immunoregulatory and Immunosuppressive Molecules in Peripheral Blood Mononuclear Cells. J Trop Med (2012) 0.76
Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction. Cell Cycle (2011) 0.76
Mammalian cellular culture models of Trypanosoma cruzi infection: a review of the published literature. Parasite (2014) 0.75
The Role of Sialic Acid-Binding Receptors (Siglecs) in the Immunomodulatory Effects of Trypanosoma cruzi Sialoglycoproteins on the Protective Immunity of the Host. Scientifica (Cairo) (2013) 0.75
The enigmatic role of cholinergic reflex in the pathogenesis of Chagas disease. Parasitol Res (2014) 0.75
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem (1995) 14.14
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev (2001) 13.15
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta (1991) 11.78
The MAPK signaling cascade. FASEB J (1995) 10.81
A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A (1995) 10.25
The mitogen-activated protein kinase signal transduction pathway. J Biol Chem (1993) 8.77
Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol (1996) 5.99
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med (Berl) (1996) 5.77
Chagas' disease. Clin Microbiol Rev (1992) 2.30
Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle. Circulation (1999) 1.94
Chemokines, inflammation and Trypanosoma cruzi infection. Trends Parasitol (2002) 1.88
Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol (1999) 1.83
Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy. J Biol Chem (2000) 1.60
The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol (1996) 1.47
Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery. J Clin Invest (1997) 1.47
ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells. Am J Respir Crit Care Med (2002) 1.39
Long-term culture of human endothelial cells. In Vitro (1983) 1.39
Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability. J Neurochem (2003) 1.35
Gap junction-mediated intercellular diffusion of Ca2+ in cultured human corporal smooth muscle cells. Am J Physiol (1992) 1.31
Activation of the NF-kappa B and I kappa B system in smooth muscle cells after rat arterial injury. Induction of vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1. Am J Pathol (1997) 1.26
Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1/2 during infection of naive macrophages. Eur J Immunol (2000) 1.23
Infection of endothelial cells with Trypanosoma cruzi activates NF-kappaB and induces vascular adhesion molecule expression. Infect Immun (1999) 1.21
Enhanced platelet adherence and aggregation in Chagas' disease: a potential pathogenic mechanism for cardiomyopathy. Am J Trop Med Hyg (1990) 1.18
Parasitic diseases of the heart. Front Biosci (2004) 1.17
The role of endothelin in the pathogenesis of Chagas' disease. Int J Parasitol (2001) 1.15
Cell replication in the arterial wall: activation of signaling pathway following in vivo injury. Circ Res (1998) 1.11
Human connexin 43 gap junction channel gating: evidence for mode shifts and/or heterogeneity. Am J Physiol (1996) 1.10
Abnormalities of the coronary microcirculation in acute murine Chagas' disease. Am J Trop Med Hyg (1985) 1.09
Compromised microcirculation in acute murine Trypanosoma cruzi infection. J Parasitol (1996) 1.09
Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis. Infect Immun (2003) 1.07
Myocardial expression of endothelin-1 in murine Trypanosoma cruzi infection. Cardiovasc Pathol (2000) 1.05
Expression of major histocompatibility complex antigens and adhesion molecules in hearts of patients with chronic Chagas' disease. Am J Trop Med Hyg (1993) 1.03
Microvascular changes as a cause of chronic cardiomyopathy in Chagas' disease. Am Heart J (1990) 1.03
A cytokine reborn? Endothelin-1 in pulmonary inflammation and fibrosis. Am J Respir Cell Mol Biol (2000) 1.03
Expression of endothelin-1, endothelin-3, endothelin-converting enzyme-1, and endothelin-A and endothelin-B receptor mRNA after angioplasty-induced neointimal formation in the rat. Circ Res (1996) 1.03
Inhibition of muscle differentiation by trypanosoma cruzi. Proc Natl Acad Sci U S A (1983) 1.02
Cytokine gene expression of endothelial cells infected with Trypanosoma cruzi. J Infect Dis (1992) 1.00
Activation of mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats. Cardiovasc Res (1998) 1.00
Role for interleukin-1 beta in Trypanosoma cruzi-induced cardiomyocyte hypertrophy. Infect Immun (2003) 1.00
The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochem Biophys Res Commun (1991) 0.99
Activation of mitogen-activated protein kinases in in vivo ischemia/reperfused myocardium in rats. J Mol Cell Cardiol (1999) 0.95
Stress and vascular responses: mitogen-activated protein kinases and activator protein-1 as promising therapeutic targets of vascular remodeling. J Pharmacol Sci (2003) 0.95
Theileria parva: taking control of host cell proliferation and survival mechanisms. Cell Microbiol (2000) 0.94
Activation of the cellular mitogen-activated protein kinase pathways ERK, P38 and JNK during Toxoplasma gondii invasion. Parasite (2003) 0.93
The putative mechanistic basis for the modulatory role of endothelin-1 in the altered vascular tone induced by Trypanosoma cruzi. Endothelium (1999) 0.93
A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Protective effects of the novel nonpeptide endothelin receptor antagonist SB 209670. Circ Res (1994) 0.90
Signalling via stress-activated mitogen-activated protein kinases in the cardiovascular system. Cardiovasc Res (2000) 0.89
Inhibition of tumor necrosis factor alpha-mediated NFkappaB activation and leukocyte adhesion, with enhanced endothelial apoptosis, by G protein-linked receptor (TP) ligands. J Biol Chem (2003) 0.89
Trypanosoma cruzi induces endothelin release from endothelial cells. J Infect Dis (1995) 0.89
Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence. Clin Sci (Lond) (2002) 0.88
Upregulation of endothelin 1 and its precursor by IL-1beta, TNF-alpha, and TGF-beta in the PC3 human prostate cancer cell line. Cytokine (1999) 0.87
Cell cycle in vasculoproliferative diseases: potential interventions and routes of delivery. Circulation (2001) 0.87
IL-1 induced release of Ca2+ from internal stores is dependent on cell-matrix interactions and regulates ERK activation. FASEB J (2003) 0.87
Cellular and cytokine characterization of vascular inflammation in CBA/J mice chronically infected with Trypanosoma cruzi. Scand J Immunol (1998) 0.86
Differential regulation of nitric oxide synthase isoforms in experimental acute chagasic cardiomyopathy. Clin Exp Immunol (2000) 0.86
Doxazosin inhibits retinoblastoma protein phosphorylation and G(1)-->S transition in human coronary smooth muscle cells. Arterioscler Thromb Vasc Biol (2000) 0.86
The T. cruzi trans-sialidase induces PC12 cell differentiation via MAPK/ERK pathway. Neuroreport (2001) 0.85
Chagas' heart disease: clinical-pathological correlation. Front Biosci (2003) 0.85
Expression of interleukin-1beta, interleukin-1 receptor, and interleukin-1 receptor antagonist mRNA in rat carotid artery after balloon angioplasty. Biochem Biophys Res Commun (2000) 0.83
Endothelin-1 promoted proliferation of vascular smooth muscle cell through pathway of extracellular signal-regulated kinase and cyclin D1. Acta Pharmacol Sin (2003) 0.83
Endothelin-1 as a putative modulator of erectile dysfunction. II. Calcium mobilization in cultured human corporal smooth muscle cells. J Urol (1995) 0.82
Death-defying pathways linking cell cycle and apoptosis. Circ Res (2001) 0.80
Myocardial G proteins in murine Chagas' disease. J Parasitol (1997) 0.79
Doxazosin blocks the angiotensin II-induced smooth muscle cell DNA synthesis in the media, but not in the neointima of the rat carotid artery after balloon injury. Cardiovasc Res (1996) 0.79
Leishmania major induces deactivation of extracellular signal regulated kinases 2 in human U937 macrophage like cells. Arch Inst Pasteur Tunis (2000) 0.77
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Minireview: Cyclin D1: normal and abnormal functions. Endocrinology (2004) 5.22
The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle (2009) 4.69
ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells. Am J Pathol (2011) 4.59
Role of caveolae and caveolins in health and disease. Physiol Rev (2004) 4.55
Caveolae: from cell biology to animal physiology. Pharmacol Rev (2002) 4.45
Gene expression phenotypic models that predict the activity of oncogenic pathways. Nat Genet (2003) 3.78
Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J Biol Chem (2001) 3.54
Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells. Cell Cycle (2011) 3.49
Caveolin-1 in oncogenic transformation, cancer, and metastasis. Am J Physiol Cell Physiol (2005) 3.20
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell (2009) 3.16
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle (2010) 3.15
An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. Am J Pathol (2009) 3.15
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol (2008) 3.02
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle (2010) 3.00
Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis. Cell Cycle (2011) 2.92
Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Cell Cycle (2011) 2.91
Microsporidiosis: current status. Curr Opin Infect Dis (2006) 2.81
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle (2010) 2.80
Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J Biol Chem (2004) 2.76
The Caveolin genes: from cell biology to medicine. Ann Med (2004) 2.68
Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator. Cell Cycle (2011) 2.68
Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A (2007) 2.67
Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers. Cell Cycle (2011) 2.67
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers. Cell Cycle (2012) 2.55
Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. Cell Cycle (2011) 2.39
Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest (2005) 2.38
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem (2004) 2.37
Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler Thromb Vasc Biol (2003) 2.33
Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors. Cell Cycle (2010) 2.32
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene (2003) 2.27
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle (2010) 2.26
Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation. Diabetes (2004) 2.26
Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer. Cancer Biol Ther (2009) 2.25
Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice. J Biol Chem (2002) 2.23
The caveolin proteins. Genome Biol (2004) 2.23
CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Am J Pathol (2002) 2.22
Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol (2003) 2.22
Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. J Cell Biol (2006) 2.21
Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. J Biol Chem (2002) 2.21
E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination. Mol Cell (2002) 2.20
Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5. Mol Cell Biol (2002) 2.15
Toxoplasma gondii: the model apicomplexan. Int J Parasitol (2004) 2.10
The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox. Cell Cycle (2010) 2.10
The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts. Cell Cycle (2010) 2.07
Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue. Am J Physiol Cell Physiol (2003) 2.06
Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxid Redox Signal (2011) 2.04
Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms. Annu Rev Pathol (2011) 2.03
Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem (2005) 2.01
Blastocystis: to treat or not to treat... Clin Infect Dis (2011) 2.01
Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers. Cancer Biol Ther (2010) 1.99
Z-score reference ranges for normal fetal heart sizes throughout pregnancy derived from fetal echocardiography. Prenat Diagn (2014) 1.98
Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment. Int J Biochem Cell Biol (2011) 1.97
microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A (2010) 1.97
Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci U S A (2006) 1.96
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol (2006) 1.95
Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem (2002) 1.95
Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol (2002) 1.93
Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. Cell Cycle (2011) 1.92
Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91
Caveolin, caveolae, and endothelial cell function. Arterioscler Thromb Vasc Biol (2003) 1.90
Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth. Mol Cell Biol (2003) 1.89