Published in J Cell Sci on August 25, 2004
Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am J Physiol Lung Cell Mol Physiol (2008) 1.47
BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev (2004) 1.40
An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney. BMC Dev Biol (2008) 1.12
Endoglin inhibits prostate cancer motility via activation of the ALK2-Smad1 pathway. Oncogene (2007) 1.08
Dynamic smad-mediated BMP signaling revealed through transgenic zebrafish. Dev Dyn (2011) 1.01
BMP signalling in skeletal development, disease and repair. Nat Rev Endocrinol (2016) 0.97
Dynamic analysis of BMP-responsive smad activity in live zebrafish embryos. Dev Dyn (2011) 0.94
Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function. Am J Physiol Endocrinol Metab (2012) 0.93
Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway. Stem Cells (2014) 0.92
Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration. Carcinogenesis (2009) 0.89
Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. J Biol Chem (2012) 0.87
Bmp indicator mice reveal dynamic regulation of transcriptional response. PLoS One (2012) 0.85
BMP signaling controls formation of a primordial germ cell niche within the early genital ridges. Dev Biol (2010) 0.84
Targeting BMP signalling in cardiovascular disease and anaemia. Nat Rev Cardiol (2015) 0.82
A Bmp reporter with ultrasensitive characteristics reveals that high Bmp signaling is not required for cortical hem fate. PLoS One (2012) 0.81
BMP signaling dynamics in embryonic orofacial tissue. J Cell Physiol (2008) 0.81
Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes. Semin Cell Dev Biol (2015) 0.80
Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning. PLoS One (2011) 0.80
Periostin as a biomarker of the amniotic membrane. Stem Cells Int (2012) 0.79
Synergistic interaction between the fibroblast growth factor and bone morphogenetic protein signaling pathways in lens cells. Mol Biol Cell (2015) 0.78
BRITER: a BMP responsive osteoblast reporter cell line. PLoS One (2012) 0.78
Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice. Development (2014) 0.78
Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice. Dis Model Mech (2012) 0.78
Distinct bone morphogenetic proteins activate indistinguishable transcriptional responses in nephron epithelia including Notch target genes. Cell Signal (2011) 0.78
Burst BMP triggered receptor kinase activity drives Smad1 mediated long-term target gene oscillation in C2C12 cells. PLoS One (2013) 0.78
An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. PLoS Genet (2016) 0.75
BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks. BMC Dev Biol (2016) 0.75
A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback. PLoS Biol (2015) 0.75
Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2. Stem Cells Dev (2017) 0.75
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36
MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation (2007) 6.41
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem (2001) 5.89
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J (2002) 5.44
Stem-cell-based therapy and lessons from the heart. Nature (2008) 4.54
Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med (2004) 3.88
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell (2003) 3.80
Recombinant vitronectin is a functionally defined substrate that supports human embryonic stem cell self-renewal via alphavbeta5 integrin. Stem Cells (2008) 3.33
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol (2006) 3.24
Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO J (2004) 3.17
Transforming growth factor-beta1 to the bone. Endocr Rev (2005) 3.13
Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction. Stem Cell Res (2007) 3.04
Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell (2009) 3.03
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res (2007) 3.02
Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat Med (2010) 2.88
The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res (2006) 2.64
Ethics. The ISSCR guidelines for human embryonic stem cell research. Science (2007) 2.62
Induced pluripotent stem cells: the new patient? Nat Rev Mol Cell Biol (2012) 2.50
Negative regulation of TGF-beta receptor/Smad signal transduction. Curr Opin Cell Biol (2007) 2.50
Signaling by members of the TGF-beta family in vascular morphogenesis and disease. Trends Cell Biol (2010) 2.35
Human embryonic stem cell-derived cardiomyocytes and cardiac repair in rodents. Circ Res (2008) 2.31
NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat Methods (2011) 2.29
TGF-beta signaling in vascular biology and dysfunction. Cell Res (2009) 2.25
TGF-β in progression of liver disease. Cell Tissue Res (2011) 2.22
Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Res (2009) 2.13
Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells. Circulation (2002) 2.12
Isl1Cre reveals a common Bmp pathway in heart and limb development. Development (2006) 2.04
Germ cell specification in mice. Science (2007) 2.04
A quest for human and mouse embryonic stem cell-specific proteins. Mol Cell Proteomics (2006) 2.04
Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. Mol Biol Cell (2003) 2.03
TGF-beta1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro. Stem Cell Res (2008) 1.98
Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses. J Biol Chem (2002) 1.89
SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine Growth Factor Rev (2005) 1.88
Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation. J Bone Miner Res (2007) 1.76
Transforming growth factor beta signal transduction. J Leukoc Biol (2002) 1.76
Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. J Biol Chem (2007) 1.73
RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation. Mol Cell (2012) 1.71
Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome. Hum Mol Genet (2007) 1.68
Controlling cell fate by bone morphogenetic protein receptors. Mol Cell Endocrinol (2003) 1.67
TGF-β signalling and its role in cancer progression and metastasis. Cancer Metastasis Rev (2012) 1.67
USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor. Nat Cell Biol (2012) 1.65
An experimental correction for arginine-to-proline conversion artifacts in SILAC-based quantitative proteomics. Nat Methods (2007) 1.59
Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders. Chest (2005) 1.57
Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer Res (2010) 1.56
The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system. Breast Cancer Res Treat (2010) 1.55
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades. Dev Cell (2012) 1.53
Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease. Circulation (2012) 1.53
Regulation of endothelial cell plasticity by TGF-β. Cell Tissue Res (2011) 1.52
Human cardiomyocyte progenitor cell transplantation preserves long-term function of the infarcted mouse myocardium. Cardiovasc Res (2009) 1.52
BMP signaling in vascular diseases. FEBS Lett (2012) 1.51
ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation. J Bone Miner Res (2010) 1.49
Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. J Exp Med (2010) 1.48
Transforming growth factor beta-induced endothelial-to-mesenchymal transition: a switch to cardiac fibrosis? Trends Cardiovasc Med (2008) 1.47
A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol (2007) 1.45
Tracking the progression of the human inner cell mass during embryonic stem cell derivation. Nat Biotechnol (2012) 1.45
Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. Proc Natl Acad Sci U S A (2010) 1.42
Retracted Deficient Smad7 expression: a putative molecular defect in scleroderma. Proc Natl Acad Sci U S A (2002) 1.41
Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Development (2004) 1.40
Action range of BMP is defined by its N-terminal basic amino acid core. Curr Biol (2002) 1.40
BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev (2004) 1.40
Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury. J Immunol (2005) 1.39
Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways. J Biol Chem (2010) 1.38
Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification. Nat Protoc (2008) 1.34
Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. PLoS One (2011) 1.33
Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling. Cancer Res (2003) 1.32
Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Circ Res (2011) 1.31
Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice. J Cell Sci (2007) 1.31
Monitoring of cell therapy and assessment of cardiac function using magnetic resonance imaging in a mouse model of myocardial infarction. Nat Protoc (2007) 1.31
Improved genetic manipulation of human embryonic stem cells. Nat Methods (2008) 1.29
Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells. Hepatology (2006) 1.28
TGF-β signaling in breast cancer cell invasion and bone metastasis. J Mammary Gland Biol Neoplasia (2011) 1.28
Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes. Curr Biol (2002) 1.26
Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation. J Cell Sci (2007) 1.24
Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. EMBO J (2013) 1.24
Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5. Mol Endocrinol (2003) 1.23
Endoglin has a crucial role in blood cell-mediated vascular repair. Circulation (2006) 1.23
Plasma membrane proteomics of human embryonic stem cells and human embryonal carcinoma cells. J Proteome Res (2008) 1.22
VE-cadherin is a critical endothelial regulator of TGF-beta signalling. EMBO J (2008) 1.22
Identification of novel regulators associated with early-phase osteoblast differentiation. J Bone Miner Res (2004) 1.20
Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate. Arthritis Rheum (2008) 1.20
Comprehensive microarray analysis of bone morphogenetic protein 2-induced osteoblast differentiation resulting in the identification of novel markers for bone development. J Bone Miner Res (2002) 1.19
ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes. J Bone Miner Res (2008) 1.18
Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development. Trends Mol Med (2011) 1.18
Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation. J Biol Chem (2013) 1.18
Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts. Bone (2005) 1.17
Animal models of chronic liver diseases. Am J Physiol Gastrointest Liver Physiol (2012) 1.17
Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion. Biochem Biophys Res Commun (2013) 1.16
Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery. Trends Pharmacol Sci (2009) 1.16
Real time monitoring of BMP Smads transcriptional activity during mouse development. Genesis (2008) 1.16
Conversion of mature human β-cells into glucagon-producing α-cells. Diabetes (2013) 1.16
Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination. J Exp Med (2013) 1.15
Transforming growth factor-beta signaling and tumor angiogenesis. Front Biosci (Landmark Ed) (2009) 1.15
Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias. Front Physiol (2012) 1.15
Human embryonic stem cells: genetic manipulation on the way to cardiac cell therapies. Reprod Toxicol (2005) 1.14
Gene array analysis of bone morphogenetic protein type I receptor-induced osteoblast differentiation. J Bone Miner Res (2003) 1.14
Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways. Histol Histopathol (2011) 1.13
A rate equation approach to elucidate the kinetics and robustness of the TGF-beta pathway. Biophys J (2006) 1.13