Published in Methods Mol Biol on January 01, 2005
Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif. J Am Chem Soc (2007) 1.02
Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex. J Am Chem Soc (2007) 0.92
Unusually strong binding to the DNA minor groove by a highly twisted benzimidazole diphenylether: induced fit and bound water. Biochemistry (2007) 0.84
Induction of unique structural changes in guanine-rich DNA regions by the triazoloacridone C-1305, a topoisomerase II inhibitor with antitumor activities. Nucleic Acids Res (2005) 0.80
A 96-well DNase I footprinting screen for drug-DNA interactions. Nucleic Acids Res (2007) 0.77
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science (2006) 6.47
A developmental perspective on alcohol and youths 16 to 20 years of age. Pediatrics (2008) 4.32
Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A (2006) 2.31
Circulating levels of inflammatory cytokines and risk of colorectal adenomas. Cancer Res (2008) 2.13
Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial. Gastroenterology (2003) 1.70
Reduced polyp detection as endoscopy shift progresses: experience with screening colonoscopy at a tertiary-care hospital. J Clin Gastroenterol (2011) 1.66
Diet, lifestyle, and genomic instability in the North Carolina Colon Cancer Study. Cancer Epidemiol Biomarkers Prev (2005) 1.45
Cannabis withdrawal is common among treatment-seeking adolescents with cannabis dependence and major depression, and is associated with rapid relapse to dependence. Addict Behav (2008) 1.41
5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. Cancer Epidemiol Biomarkers Prev (2002) 1.39
Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem (2014) 1.36
Conjugated equine estrogen influence on mammographic density in postmenopausal women in a substudy of the women's health initiative randomized trial. J Clin Oncol (2009) 1.35
'Inappropriate' attendance at an accident and emergency department by adults registered in local general practices: how is it related to their use of primary care? J Health Serv Res Policy (2002) 1.33
Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR). J Med Chem (2013) 1.33
Social ties and colorectal cancer screening among Blacks and Whites in North Carolina. Cancer Epidemiol Biomarkers Prev (2005) 1.31
Directed dihydroxylation of cyclic allylic alcohols and trichloroacetamides using OsO4/TMEDA. J Org Chem (2002) 1.19
Rural-urban differences in colon cancer risk in blacks and whites: the North Carolina Colon Cancer Study. J Rural Health (2006) 1.16
Constipation, laxative use, and colon cancer in a North Carolina population. Am J Gastroenterol (2003) 1.16
Association of industry sponsorship to published outcomes in gastrointestinal clinical research. Clin Gastroenterol Hepatol (2006) 1.15
Underage alcohol use: summary of developmental processes and mechanisms: ages 16-20. Alcohol Res Health (2009) 1.13
Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease. Inflamm Bowel Dis (2010) 1.13
Energetics of echinomycin binding to DNA. Nucleic Acids Res (2003) 1.08
Intake of polyunsaturated fatty acids and distal large bowel cancer risk in whites and African Americans. Am J Epidemiol (2010) 1.05
Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules. Bioorg Med Chem Lett (2011) 1.05
The influence of DNA stiffness upon nucleosome formation. J Struct Biol (2004) 1.02
Race and colorectal cancer screening: a population-based study in North Carolina. N C Med J (2004) 1.02
Echinomycin inhibits chromosomal DNA replication and embryonic development in vertebrates. Nucleic Acids Res (2004) 1.02
Alcohol use frequency as a screen for alcohol use disorders in adolescents. Int J Adolesc Med Health (2006) 1.01
Increased risk of pneumonia among patients with inflammatory bowel disease. Am J Gastroenterol (2013) 1.00
Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates. J Med Chem (2006) 0.99
Dietary patterns and colon cancer risk in Whites and African Americans in the North Carolina Colon Cancer Study. Nutr Cancer (2009) 0.98
Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux. Cancer Lett (2005) 0.95
Tight binding of the antitumor drug ditercalinium to quadruplex DNA. Chembiochem (2002) 0.95
Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies. Biochemistry (2005) 0.93
Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors. Bioorg Med Chem Lett (2008) 0.91
Practical application of the virtual crossmatch. Pediatr Transplant (2007) 0.89
Gastric cancer incidence estimation in a resource-limited nation: use of endoscopy registry methodology. Cancer Causes Control (2012) 0.89
Initial experience with bendamustine in patients with recurrent primary central nervous system lymphoma: a case report. J Neurooncol (2012) 0.89
Apoptosis in normal rectal mucosa, baseline adenoma characteristics, and risk of future adenomas. Cancer Epidemiol Biomarkers Prev (2008) 0.87
Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans. Am J Epidemiol (2008) 0.86
Advancement of the vastus lateralis muscle for the treatment of hip abductor discontinuity. J Arthroplasty (2004) 0.86
Hierarchy of evidence: differences in results between non-randomized studies and randomized trials in patients with femoral neck fractures. Arch Orthop Trauma Surg (2003) 0.86
Functional health literacy, chemotherapy decisions, and outcomes among a colorectal cancer cohort. Cancer Control (2015) 0.86
Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One (2011) 0.85
Operative treatment of extra-articular proximal tibial fractures. J Orthop Trauma (2003) 0.84
At-line bioprocess monitoring by immunoassay with rotationally controlled serial siphoning and integrated supercritical angle fluorescence optics. Anal Chim Acta (2013) 0.84
Roles of religious involvement and social support in the risk of colon cancer among Blacks and Whites. Am J Epidemiol (2003) 0.84
Sequential double α-arylation of N-allylureas by asymmetric deprotonation and N→C aryl migration. Org Lett (2010) 0.83
Assessment of serum proteomics to detect large colon adenomas. Cancer Epidemiol Biomarkers Prev (2008) 0.83
Atomic force microscopy study of the structural effects induced by echinomycin binding to DNA. J Mol Biol (2005) 0.83
Effects of varying pulsatile lavage pressure on cancellous bone structure and fracture healing. J Orthop Trauma (2006) 0.81
Structural perturbations in DNA caused by bis-intercalation of ditercalinium visualised by atomic force microscopy. Nucleic Acids Res (2002) 0.81
Mitomycin dimers: polyfunctional cross-linkers of DNA. J Med Chem (2004) 0.80
Etomidate use in severe sepsis and septic shock patients does not contribute to mortality. Intern Emerg Med (2011) 0.79
DNA sequence recognition by the antitumor drug ditercalinium. Biochemistry (2002) 0.79
The binding mode of the DNA bisintercalator luzopeptin investigated using atomic force microscopy. J Struct Biol (2003) 0.79
Potential strategies for increasing drug-discovery productivity. Future Med Chem (2014) 0.78
Increased risk of pneumocystis jiroveci pneumonia among patients with inflammatory bowel disease. Inflamm Bowel Dis (2013) 0.78
Metabolic features of melanoma: a gold mine of new therapeutic targets? Curr Cancer Drug Targets (2014) 0.78
Healable supramolecular polymers as organic metals. J Am Chem Soc (2014) 0.78
Tea intake and risk of colon cancer in African-Americans and whites: North Carolina colon cancer study. Cancer Causes Control (2003) 0.78
Scope of the directed dihydroxylation: application to cyclic homoallylic alcohols and trihaloacetamides. Org Biomol Chem (2003) 0.78
Improvement in health-related quality of life among adults with serious mental illness receiving inpatient treatment: a prospective cohort study. J Clin Psychiatry (2015) 0.77
Molecular recognition of DNA by rigid [N]-polynorbornane-derived bifunctional intercalators: synthesis and evaluation of their binding properties. J Med Chem (2007) 0.77
Preferential binding to DNA sequences of peptides related to a novel XPRK motif. Bioorg Med Chem (2003) 0.77
Risk factors for advanced disease in colorectal cancer. Am J Gastroenterol (2004) 0.77
Initial management of pelvic and femoral fractures in the multiply injured patient. Crit Care Clin (2004) 0.76
Enthalpy-driven nuclease-like activity and mechanism of peptide-chlorambucil conjugates. Org Biomol Chem (2014) 0.76
Energetic studies on DNA-peptide interaction in relation to the enthalpy-entropy compensation paradox. Org Biomol Chem (2013) 0.76
Response: an insidious dependence. Addict Sci Clin Pract (2007) 0.75
Investigator-Initiated IBD Trials in the United States: Facts, Obstacles, and Answers. Inflamm Bowel Dis (2016) 0.75
Semiquinone footprinting. J Am Chem Soc (2004) 0.75
Synthetic studies on the cornexistins: synthesis of (+/-)-5-epi-hydroxycornexistin. Org Biomol Chem (2008) 0.75
Unusually strong positive cooperativity in binding of peptides to latent membrane protein-1 DNA fragments of the Epstein-Barr viral gene. Chembiochem (2006) 0.75
O-021 A New Domain Structure for the IMPACT-III, a Pediatric Inflammatory Bowel Disease (IBD) Health Reported Quality of Life (HRQOL) Tool. Inflamm Bowel Dis (2016) 0.75
Visualising DNA: footprinting and 1-2D gels. Mol Biosyst (2005) 0.75
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold. Bioorg Med Chem Lett (2012) 0.75
Cost and outcome analyses on the timing of first independent medical evaluation in patients with work-related lumbosacral sprain. J Occup Environ Med (2007) 0.75
Novel DNA-peptide interaction networks. Bioorg Med Chem (2010) 0.75
In situ observation of homogeneous nucleation of nanosized zeolite A. Phys Chem Chem Phys (2006) 0.75
Synthesis of diphenylcarbazoles as cytotoxic DNA binding agents. Org Biomol Chem (2004) 0.75
Property-based design in the optimisation of benzamide glucokinase activators: from hit to clinic. Prog Med Chem (2013) 0.75
Detection of multiple network-based allosteric interactions between peptides and arrays of DNA binding sites. Bioorg Med Chem (2009) 0.75
Self-assembly of supramolecular triarylamine nanowires in mesoporous silica and biocompatible electrodes thereof. Nanoscale (2016) 0.75
Perfect polar stacking of parallel beloamphiphile layers. Synthesis, structure and solid-state optical properties of the unsymmetrical acetophenone azine DCA. Dalton Trans (2006) 0.75
Determination of a clinical value for the repair half-time (T1/2) of the trigeminal nerve based on outcome data from gamma knife radiosurgery for facial pain. Radiat Res (2007) 0.75
Olanzapine-associated Edema Decreasing Serum Lithium Concentrations: A Case Report. J Clin Psychopharmacol (1) 0.75
Utility of an integrated electronic suicide alert system in a psychiatric hospital. Qual Manag Health Care (2015) 0.75
Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. J Med Chem (2017) 0.75
An Integrated Circuit for Chip-Based Analysis of Enzyme Kinetics and Metabolite Quantification. IEEE Trans Biomed Circuits Syst (2016) 0.75
DIABETIC KETOACIDOSIS CRITICAL CARE PATHWAY IMPLEMENTATION: INCORPORATION INTO EMR SIGNIFICANTLY DECREASES LENGTH OF STAY. Endocr Pract (2016) 0.75
Editorial: Potential Therapeutic Agents based on DNA Sequence- Selective Binding Substances. Curr Top Med Chem (2015) 0.75
Femoral neck/shaft fracture. J Orthop Trauma (2003) 0.75
Plasma stability of two glycosyl indolocarbazole antitumor agents. Biochem Pharmacol (2003) 0.75