Published in Oncogene on October 14, 2004
Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer (2012) 1.79
5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation. EMBO J (2004) 1.42
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy. Curr Cancer Drug Targets (2008) 1.40
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. EMBO J (2005) 1.32
Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia. Blood (2007) 1.32
Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy. Cancers (Basel) (2011) 1.25
Human agonistic TRAIL receptor antibodies Mapatumumab and Lexatumumab induce apoptosis in malignant mesothelioma and act synergistically with cisplatin. Mol Cancer (2007) 1.02
Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells. Cancer Res (2009) 1.02
Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model. Clin Cancer Res (2009) 0.97
The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis. Mol Cancer Ther (2008) 0.94
KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels. Am J Pathol (2011) 0.91
Characterization of human malignant mesothelioma cell lines orthotopically implanted in the pleural cavity of immunodeficient mice for their ability to grow and form metastasis. BMC Cancer (2006) 0.90
Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma. Cancer Biol Ther (2009) 0.89
MicroRNA-126 suppresses mesothelioma malignancy by targeting IRS1 and interfering with the mitochondrial function. Antioxid Redox Signal (2014) 0.86
HBx-induced NF-κB signaling in liver cells is potentially mediated by the ternary complex of HBx with p22-FLIP and NEMO. PLoS One (2013) 0.85
Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence. PLoS One (2012) 0.83
Phosphorylation drives an apoptotic protein to activate antiapoptotic genes: paradigm of influenza A matrix 1 protein function. J Biol Chem (2013) 0.81
Diagnostic value of microRNAs in asbestos exposure and malignant mesothelioma: systematic review and qualitative meta-analysis. Oncotarget (2016) 0.80
B lymphocytes are resistant to death receptor 5-induced apoptosis. Clin Immunol (2011) 0.79
Carbon nanotubes induce apoptosis resistance of human lung epithelial cells through FLICE-inhibitory protein. Toxicol Sci (2014) 0.78
Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis. Aging Cell (2014) 0.78
Overexpression of cFLIP in head and neck squamous cell carcinoma and its clinicopathologic correlations. J Cancer Res Clin Oncol (2007) 0.77
The Emerging Role of TRAF7 in Tumor Development. J Cell Physiol (2016) 0.77
MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma. Oncotarget (2016) 0.76
Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95. Oncotarget (2016) 0.76
Familial Mediterranean fever is no longer a rare disease in Italy. Eur J Hum Genet (2003) 2.08
The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study. Transfusion (2004) 1.80
Serum mesothelin for diagnosing malignant pleural mesothelioma: an individual patient data meta-analysis. J Clin Oncol (2012) 1.59
5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation. EMBO J (2004) 1.42
Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells. J Biol Chem (2004) 1.28
Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function. Blood (2005) 1.22
A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance. Blood (2013) 1.19
Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts. Blood (2007) 1.14
Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silent. Mol Pharmacol (2007) 1.11
Leukocyte telomere shortening in elderly Type2DM patients with previous myocardial infarction. Atherosclerosis (2009) 1.09
Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. Int J Cancer (2006) 1.08
SILAC-based proteomic analysis to dissect the "histone modification signature" of human breast cancer cells. Amino Acids (2010) 1.07
Cross-talk between vascular endothelial growth factor and semaphorin-3A pathway in the regulation of normal and malignant mesothelial cell proliferation. FASEB J (2003) 1.04
Relationship of job satisfaction, psychological distress and stress-related biological parameters among healthy nurses: a longitudinal study. J Occup Health (2009) 1.02
Association of MiR-126 with soluble mesothelin-related peptides, a marker for malignant mesothelioma. PLoS One (2011) 1.01
Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species. Antioxid Redox Signal (2007) 1.00
alpha-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy. Biochem Biophys Res Commun (2005) 0.99
Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate. Mol Nutr Food Res (2006) 0.98
Human neoplastic mesothelial cells express voltage-gated sodium channels involved in cell motility. Int J Biochem Cell Biol (2006) 0.97
Role of nitric oxide concentrations on human sperm motility. J Androl (2004) 0.95
Preclinical evaluation of the nonsteroidal anti-inflammatory agent celecoxib on malignant mesothelioma chemoprevention. Int J Cancer (2004) 0.95
Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. J Biol Chem (2005) 0.93
Enhanced antitumor therapy by inhibition of p21waf1 in human malignant mesothelioma. Clin Cancer Res (2008) 0.92
Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects. Curr Cancer Drug Targets (2004) 0.91
Characterization of human malignant mesothelioma cell lines orthotopically implanted in the pleural cavity of immunodeficient mice for their ability to grow and form metastasis. BMC Cancer (2006) 0.90
The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells. Cancer Res (2009) 0.90
Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis. FEBS Lett (2006) 0.90
The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy. Clin Nutr (2011) 0.89
Molecular targets and targeted therapies for malignant mesothelioma. Curr Med Chem (2008) 0.88
Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk. Mutat Res (2008) 0.87
Profiling tumor-associated markers for early detection of malignant mesothelioma: an epidemiologic study. Cancer Epidemiol Biomarkers Prev (2008) 0.87
Hyperglycaemia but not hyperlipidaemia decreases serum amylase and increases neutrophils in the exocrine pancreas of cats. Res Vet Sci (2010) 0.87
RNA-mediated gene silencing of nicotinamide N-methyltransferase is associated with decreased tumorigenicity in human oral carcinoma cells. PLoS One (2013) 0.87
Oleuropein aglycone, an olive oil compound, ameliorates development of arthritis caused by injection of collagen type II in mice. J Pharmacol Exp Ther (2011) 0.87
Effects of a polyphenol present in olive oil, oleuropein aglycone, in a murine model of intestinal ischemia/reperfusion injury. J Leukoc Biol (2012) 0.87
Metronomic administration of zoledronic acid and taxotere combination in castration resistant prostate cancer patients: phase I ZANTE trial. Cancer Biol Ther (2010) 0.86
Immunohistochemistry and molecular diagnostics of pleural malignant mesothelioma. Arch Pathol Lab Med (2012) 0.85
Versatility of one-trocar surgery in children. J Laparoendosc Adv Surg Tech A (2011) 0.85
Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism. J Biol Chem (2011) 0.85
The effects of a polyphenol present in olive oil, oleuropein aglycone, in an experimental model of spinal cord injury in mice. Biochem Pharmacol (2012) 0.84
Complications of pediatric urological laparoscopy: mistakes and risks. J Urol (2003) 0.84
Lipoxygenase inhibitors for cancer prevention: promises and risks. Curr Pharm Des (2010) 0.83
Antioxidant and antigrowth action of peracetylated oleuropein in thyroid cancer cells. J Mol Endocrinol (2013) 0.83
5-lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking. FASEB J (2004) 0.83
Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigen. Oncogene (2002) 0.82
Neuronal semaphorins regulate a primary immune response. Curr Neurovasc Res (2006) 0.82
A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease? Int J Cancer (2004) 0.82
GABAergic miniature spontaneous activity is increased in the CA1 hippocampal region of dystrophic mdx mice. Neuromuscul Disord (2008) 0.82
Phase II escalation study of sorafenib in patients with metastatic renal cell carcinoma who have been previously treated with anti-angiogenic treatment. BJU Int (2012) 0.81
Lymphocyte DNA damage precedes DNA repair or cell death after orthopaedic surgery under general anaesthesia. Mutagenesis (2003) 0.81
Alpha-tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosis. Cancer Lett (2006) 0.80
Laparoscopic reoperation following unsuccessful antireflux surgery in childhood. Semin Laparosc Surg (2002) 0.79
Simple and efficient chemoselective mild deprotection of acetals and ketals using cerium(III) triflate. J Org Chem (2002) 0.79
Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. Biochem Biophys Res Commun (2005) 0.79
In vitro anti-mesothelioma activity of cisplatin-gemcitabine combinations: evidence for sequence-dependent effects. Cancer Chemother Pharmacol (2010) 0.78
Mitochondrial targeting of α-tocopheryl succinate enhances its anti-mesothelioma efficacy. Redox Rep (2013) 0.78
CD38 expression enhances sensitivity of lymphoma T and B cell lines to biochemical and receptor-mediated apoptosis. Cell Biol Int (2006) 0.78
alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy. Mol Med (2008) 0.78
Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity. Biol Chem (2015) 0.77
[The role of molecular biology in the diagnosis and treatment of cardiovascular diseases]. G Ital Cardiol (Rome) (2010) 0.77
Simian virus 40 infection down-regulates the expression of nitric oxide synthase in human mesothelial cells. Cancer Res (2004) 0.77
Effect of ascorbic acid-rich diet on in vivo-induced oxidative stress. Br J Nutr (2011) 0.77
Antioxidants prevent the RhoA inhibition evoked by crocidolite asbestos in human mesothelial and mesothelioma cells. Am J Respir Cell Mol Biol (2011) 0.77
Experimental therapy of malignant mesothelioma: new perspectives from anti-angiogenic treatments. Crit Rev Oncol Hematol (2004) 0.77
Retroperitoneoscopic varicocelectomy in children and adolescents. J Pediatr Surg (2005) 0.77
alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Biochem Biophys Res Commun (2004) 0.76
Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in vitro. Oncol Rep (2001) 0.76
Correction: Characterisation of Mesothelioma-Initiating Cells and Their Susceptibility to Anti-Cancer Agents. PLoS One (2016) 0.75
Genes of human longevity: an endless quest? Curr Vasc Pharmacol (2014) 0.75
Editorial: semaphorins: a further chemotropic family expressed in the thymus. J Leukoc Biol (2012) 0.75
Occupational styrene exposure induces stress-responsive genes involved in cytoprotective and cytotoxic activities. PLoS One (2013) 0.75
Angiogenic effect induced by mineral fibres. Toxicology (2011) 0.75
Interleukin-6 is a determinant of PAI-1 levels in diabetic subjects with the 4 G allele at position -675 of the PAI-1 gene. Thromb Haemost (2006) 0.75
Proteome Speciation by Mass Spectrometry: Characterization of Composite Protein Mixtures in Milk Replacers. Anal Chem (2016) 0.75
Intramolecular cycloadditions of alpha-allyloxycarbonylnitrones: stereoselective synthesis of 3-amino-2(5H)furanones. J Org Chem (2002) 0.75
Biological effects and comparative cytotoxicity of thermal transformed asbestos-containing materials in a human alveolar epithelial cell line. Toxicol In Vitro (2010) 0.75
Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition. Am J Respir Cell Mol Biol (2007) 0.75
In vitro effect of aspartame in angiogenesis induction. Toxicol In Vitro (2010) 0.75
Simple choline esters as potential anti-Alzheimer agents. Curr Pharm Des (2010) 0.75
Retroiliac double ureters in duplex system: incidental retroperitoneoscopic diagnosis. J Laparoendosc Adv Surg Tech A (2007) 0.75
L-arginine reduces mercury accumulation in thymus of mercury-exposed mice: role of nitric oxide synthase activity and metallothioneins. Ind Health (2008) 0.75