Published in J Bioenerg Biomembr on August 01, 2004
Endogenous synthesis of coenzyme Q in eukaryotes. Mitochondrion (2007) 2.30
The role of mitochondria in reactive oxygen species metabolism and signaling. Ann N Y Acad Sci (2008) 2.27
Antioxidants in central nervous system diseases: preclinical promise and translational challenges. J Alzheimers Dis (2008) 1.88
Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients. Resuscitation (2012) 1.47
Redox imbalance in Parkinson's disease. Biochim Biophys Acta (2008) 1.39
Human coenzyme Q10 deficiency. Neurochem Res (2006) 1.34
Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol (2012) 1.32
Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications. Biochim Biophys Acta (2009) 1.26
Mitochondria: a therapeutic target in neurodegeneration. Biochim Biophys Acta (2009) 1.25
Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease. J Neurochem (2008) 1.24
Mitochondria as a therapeutic target for aging and neurodegenerative diseases. Curr Alzheimer Res (2011) 1.17
iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease. PLoS One (2008) 1.16
Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study. BMC Neurol (2010) 1.15
Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease. J Neurosci (2011) 1.11
Oxidative stress in neurodegeneration. Adv Pharmacol Sci (2011) 1.09
Human immunodeficiency virus type 1 Vpr inhibits axonal outgrowth through induction of mitochondrial dysfunction. J Virol (2007) 1.02
Oxidative stress and NAD+ in ischemic brain injury: current advances and future perspectives. Curr Med Chem (2010) 1.00
Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice. Free Radic Biol Med (2011) 0.96
The heme precursor delta-aminolevulinate blocks peripheral myelin formation. J Neurochem (2008) 0.95
Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage. Int J Biol Sci (2007) 0.94
Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity. Hum Mol Genet (2014) 0.94
Statins, plasma cholesterol, and risk of Parkinson's disease: a prospective study. Mov Disord (2015) 0.93
CoQ10 deficiency diseases in adults. Mitochondrion (2007) 0.93
Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy. Neurobiol Dis (2015) 0.92
Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure. Aging (Albany NY) (2014) 0.91
The role of thyroid hormones as inductors of oxidative stress and neurodegeneration. Oxid Med Cell Longev (2013) 0.91
The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start? Adv Drug Deliv Rev (2009) 0.85
Antioxidant treatment with coenzyme Q-ter in prevention of gentamycin ototoxicity in an animal model. Acta Otorhinolaryngol Ital (2012) 0.85
Novel therapeutics for Alzheimer's disease: an update. Curr Opin Drug Discov Devel (2010) 0.84
Frontiers in Alzheimer's disease therapeutics. Ther Adv Chronic Dis (2011) 0.84
Suppression of the proinflammatory response of metastatic melanoma cells increases TRAIL-induced apoptosis. J Cell Biochem (2011) 0.83
Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine. J Neural Transm (Vienna) (2009) 0.83
Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae. Biochim Biophys Acta (2009) 0.82
Nutraceuticals against Neurodegeneration: A Mechanistic Insight. Curr Neuropharmacol (2016) 0.81
The role of DMQ(9) in the long-lived mutant clk-1. Mech Ageing Dev (2011) 0.81
Evidence of early involvement of apoptosis inducing factor-induced neuronal death in Alzheimer brain. Anat Cell Biol (2012) 0.81
Recent advances on the neuroprotective potential of antioxidants in experimental models of Parkinson's disease. Int J Mol Sci (2012) 0.80
Early nerve ending rescue from oxidative damage and energy failure by L: -carnitine as post-treatment in two neurotoxic models in rat: recovery of antioxidant and reductive capacities. Exp Brain Res (2009) 0.79
Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.79
Neuroproteomics as a promising tool in Parkinson's disease research. J Neural Transm (Vienna) (2008) 0.79
Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice. J Alzheimers Dis (2012) 0.78
Kynurenines impair energy metabolism in rat cerebral cortex. Cell Mol Neurobiol (2006) 0.78
Mitochondrial avid radioprobes. Preparation and evaluation of 7'(Z)-[125I]iodorotenone and 7'(Z)-[125I]iodorotenol. Nucl Med Biol (2006) 0.77
Improvement of coenzyme Q10 production: mutagenesis induced by high hydrostatic pressure treatment and optimization of fermentation conditions. J Biomed Biotechnol (2012) 0.77
Mitochondrial Drugs for Alzheimer Disease. Pharmaceuticals (Basel) (2009) 0.76
Structural insights into the methyl donor recognition model of a novel membrane-binding protein UbiG. Sci Rep (2016) 0.75
Acetate supplementation modulates brain adenosine metabolizing enzymes and adenosine A₂A receptor levels in rats subjected to neuroinflammation. J Neuroinflammation (2014) 0.75
L-carnitine contributes to enhancement of neurogenesis from mesenchymal stem cells through Wnt/β-catenin and PKA pathway. Exp Biol Med (Maywood) (2017) 0.75
Cytochrome b5 reductase, a plasma membrane redox enzyme, protects neuronal cells against metabolic and oxidative stress through maintaining redox state and bioenergetics. Age (Dordr) (2015) 0.75
Paraquat-Induced Movement Disorder in Relation to Oxidative Stress-Mediated Neurodegeneration in the Brain of Drosophila melanogaster. Neurochem Res (2017) 0.75
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science (1996) 19.72
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron (2003) 14.03
Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci (2000) 10.62
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature (1999) 8.28
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med (1997) 7.56
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature (1998) 7.43
Oxidative stress in Parkinson's disease. Ann Neurol (2003) 5.93
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A (1997) 5.66
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science (2000) 5.62
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature (1996) 5.50
Superoxide activates mitochondrial uncoupling proteins. Nature (2002) 5.43
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron (1996) 5.30
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A (1993) 4.86
Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol (2001) 4.80
Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol (2002) 4.60
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem (2001) 4.51
Mitochondrial abnormalities in Alzheimer's disease. J Neurosci (2001) 4.39
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet (1992) 4.31
Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem (1990) 4.03
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci (2001) 3.92
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature (1991) 3.86
Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. Am J Hum Genet (2003) 3.39
Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci (2001) 2.89
A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA (1997) 2.80
Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J Neurosci (1996) 2.69
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci (2002) 2.54
Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med (2003) 2.35
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol (2003) 2.32
Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol (1999) 2.31
Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature (1996) 2.29
Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. J Biol Chem (1998) 2.28
Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease. J Neurochem (1989) 2.26
Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol (1996) 2.22
Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study. Lancet (1999) 2.18
Induction of alpha-synuclein aggregation by intracellular nitrative insult. J Neurosci (2001) 2.16
A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology (2001) 2.07
Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci (2002) 2.01
Presenile dementia and Alzheimer's disease in mongolism. Brain (1969) 1.98
An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production. Ann Neurol (2000) 1.95
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J Neurochem (1989) 1.94
Parkinson's disease: a disorder due to nigral glutathione deficiency? Neurosci Lett (1982) 1.89
Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol Dis (2002) 1.85
A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease. J Neurochem (1997) 1.83
Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron (2002) 1.82
Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death. Proc Natl Acad Sci U S A (1994) 1.79
Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model. Neurobiol Aging (2003) 1.78
The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol (1998) 1.77
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem (2002) 1.74
Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. Biochem J (1995) 1.72
Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci U S A (1998) 1.68
Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem (1998) 1.68
Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at Ser residue. J Neurochem (1995) 1.65
Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol (2003) 1.54
Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature (2000) 1.54
Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Ann Neurol (1997) 1.53
Oxidative damage and cytogenetic analysis in leukocytes of Parkinson's disease patients. Neurology (2002) 1.51
Protein nitration in Parkinson's disease. J Neuropathol Exp Neurol (1998) 1.45
Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease. Neurosci Lett (1992) 1.44
Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem (1994) 1.40
Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease. Brain (1992) 1.40
Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease. Ann Neurol (1994) 1.36
Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy. Neurobiol Dis (2002) 1.34
Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease. Ann Neurol (1991) 1.32
Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease. Ann Neurol (1998) 1.32
Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia. Heart (2002) 1.32
Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome. J Neuropathol Exp Neurol (2000) 1.31
Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. Am J Pathol (1998) 1.29
An analysis of the role of coenzyme Q in free radical generation and as an antioxidant. Biochem Cell Biol (1992) 1.25
Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem (2003) 1.25
Regulation of ubiquinone metabolism. Free Radic Biol Med (2000) 1.25
A novel mitochondrial 12SrRNA point mutation in parkinsonism, deafness, and neuropathy. Ann Neurol (2000) 1.22
Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Mov Disord (1994) 1.18
Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients. Neurosci Lett (1986) 1.17
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. J Neurochem (2003) 1.14
Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia. Ann Neurol (2001) 1.13
Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease. Neurosci Lett (1994) 1.10
Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease. J Neurochem (1997) 1.08
Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation. Neurology (1999) 1.05
Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease. Neurology (2000) 1.04
Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology (2003) 1.00
Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Ann Neurol (1994) 0.97
Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. Ann Neurol (1994) 0.93
Ubiquinone protects cultured neurons against spontaneous and excitotoxin-induced degeneration. J Cereb Blood Flow Metab (1992) 0.93
The amyloid beta protein induces oxidative damage of mitochondrial DNA. J Neuropathol Exp Neurol (1997) 0.89
Effect of coenzyme Q(10) on biochemical and morphological changes in experimental ischemia in the rat brain. Brain Res Bull (2000) 0.88
Relations between tocopherol depletion and coenzyme Q during lipid peroxidation in rat liver mitochondria. Free Radic Res (1994) 0.86
Assessment of coenzyme Q10 tolerability in Huntington's disease. Mov Disord (1996) 0.83
Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders. J Neuropathol Exp Neurol (2002) 0.83
Presenilin-1 is associated with Alzheimer's disease amyloid. Am J Pathol (1997) 0.80
Detection of nitrosyl complexes in human substantia nigra, in relation to Parkinson's disease. Biochem Biophys Res Commun (1996) 0.80
Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. EMBO J (2003) 0.79
Novel mitochondrial DNA mutations in Parkinson's disease. J Neural Transm (Vienna) (2002) 0.78
Selective increase in cellular A beta 42 is related to apoptosis but not necrosis. Neuroreport (2000) 0.76
Metabolic enzyme expression in dopaminergic neurons in Parkinson's disease: an in situ hybridization study. Ann Neurol (2001) 0.75