Published in J Cell Sci on September 21, 2004
Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function. PLoS Biol (2007) 1.92
The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. PLoS Pathog (2010) 1.73
Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem (2009) 1.61
GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis. Cancer Cell (2016) 1.39
Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol Biol Cell (2006) 1.37
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab. Cancer Biol Ther (2011) 1.31
An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor. J Cell Biol (2008) 1.08
Eps15: a multifunctional adaptor protein regulating intracellular trafficking. Cell Commun Signal (2009) 1.06
Eps15 mediates vesicle trafficking from the trans-Golgi network via an interaction with the clathrin adaptor AP-1. Mol Biol Cell (2008) 1.02
Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury. Am J Pathol (2013) 1.01
Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase. J Biol Chem (2008) 0.96
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells. PLoS One (2013) 0.93
Activation of epidermal growth factor receptor mediates mucin production stimulated by p40, a Lactobacillus rhamnosus GG-derived protein. J Biol Chem (2014) 0.89
Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice. Proc Natl Acad Sci U S A (2006) 0.86
Epidermal growth factor cytoplasmic domain affects ErbB protein degradation by the lysosomal and ubiquitin-proteasome pathway in human cancer cells. Neoplasia (2012) 0.81
D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis. PLoS One (2011) 0.79
Glucocorticoid regulates TrkB protein levels via c-Cbl dependent ubiquitination: a decrease in c-Cbl mRNA in the prefrontal cortex of suicide subjects. Psychoneuroendocrinology (2014) 0.78
UIM domain-dependent recruitment of the endocytic adaptor protein Eps15 to ubiquitin-enriched endosomes. BMC Cell Biol (2014) 0.78
CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets. Nat Immunol (2009) 3.00
CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool. J Exp Med (2003) 2.62
Ceramide: second messenger or modulator of membrane structure and dynamics? Biochem J (2003) 2.06
Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Nat Immunol (2002) 1.97
During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion. J Immunol (2005) 1.81
Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax. J Biol Chem (2002) 1.75
Expression of the murine CD27 ligand CD70 in vitro and in vivo. J Immunol (2003) 1.66
Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment. J Cell Biol (2007) 1.50
Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway. J Exp Med (2013) 1.42
Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity. Immunity (2008) 1.40
CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production. J Clin Invest (2009) 1.29
CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation. J Immunol (2004) 1.25
The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice. J Clin Invest (2010) 1.24
CD27 instructs CD4+ T cells to provide help for the memory CD8+ T cell response after protein immunization. J Immunol (2008) 1.15
OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. J Immunol (2008) 1.12
Costimulatory ligand CD70 allows induction of CD8+ T-cell immunity by immature dendritic cells in a vaccination setting. Blood (2009) 1.10
The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity. Immunity (2012) 1.09
The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions. Nat Commun (2012) 1.04
Virus-induced polyclonal B cell activation improves protective CTL memory via retained CD27 expression on memory CTL. Eur J Immunol (2005) 1.03
Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma. Blood (2009) 1.02
Profiling proteasome activity in tissue with fluorescent probes. Mol Pharm (2007) 1.01
Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment. J Biol Chem (2004) 1.00
Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens. J Biol Chem (2004) 0.99
TRAIL receptor and CD95 signal to mitochondria via FADD, caspase-8/10, Bid, and Bax but differentially regulate events downstream from truncated Bid. J Biol Chem (2002) 0.97
Ubiquitination by the membrane-associated RING-CH-8 (MARCH-8) ligase controls steady-state cell surface expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor 1. J Biol Chem (2013) 0.94
Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules. Proc Natl Acad Sci U S A (2007) 0.94
The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation. J Immunol (2010) 0.92
c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination. J Immunol (2002) 0.92
Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis. J Immunol (2009) 0.91
CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection. J Virol (2013) 0.91
Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity. Blood (2014) 0.90
Immune stimulatory effects of CD70 override CD70-mediated immune cell apoptosis in rodent glioma models and confer long-lasting antiglioma immunity in vivo. Int J Cancer (2006) 0.87
Dexamethasone treatment during the expansion phase maintains stemness of bone marrow mesenchymal stem cells. J Tissue Eng Regen Med (2010) 0.86
The invariant chain transports TNF family member CD70 to MHC class II compartments in dendritic cells. J Cell Sci (2010) 0.86
TRAIL enhances efficacy of radiotherapy in a p53 mutant, Bcl-2 overexpressing lymphoid malignancy. Radiother Oncol (2006) 0.85
The curative outcome of radioimmunotherapy in a mouse breast cancer model relies on mTOR signaling. Radiat Res (2014) 0.85
CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool. J Immunol (2013) 0.84
Control of peripheral T cell survival: a delicate division of labor between cytokines and costimulatory molecules. Hum Immunol (2006) 0.82
Combining radiotherapy with APO010 in cancer treatment. Clin Cancer Res (2009) 0.81
Osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by CD70 on activated immune cells. Proc Natl Acad Sci U S A (2013) 0.79
CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome. Int Immunol (2006) 0.77
CD70 limits atherosclerosis and promotes macrophage function. Thromb Haemost (2016) 0.75