Published in Am J Kidney Dis on October 01, 2004
Uric acid and cardiovascular risk. N Engl J Med (2008) 12.20
Risk factors for end-stage renal disease: 25-year follow-up. Arch Intern Med (2009) 4.05
Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol (2008) 3.42
Uric acid and long-term outcomes in CKD. Am J Kidney Dis (2009) 2.86
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev (2009) 2.65
Uric acid and incident kidney disease in the community. J Am Soc Nephrol (2008) 2.44
High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up. Diabetes Care (2010) 2.12
Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan. J Am Soc Nephrol (2008) 1.93
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. Am J Physiol Renal Physiol (2008) 1.68
The relationship between serum uric acid and chronic kidney disease among Appalachian adults. Nephrol Dial Transplant (2010) 1.60
Rasburicase improves hyperuricemia in infants with acute kidney injury. Pediatr Nephrol (2009) 1.44
A randomized study of allopurinol on endothelial function and estimated glomular filtration rate in asymptomatic hyperuricemic subjects with normal renal function. Clin J Am Soc Nephrol (2011) 1.40
Early onset hyperuricemia is a prognostic marker for kidney graft failure: Propensity score matching analysis in a Korean multicenter cohort. PLoS One (2017) 1.39
Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative. Ann Rheum Dis (2013) 1.39
Uric acid, hyperuricemia and vascular diseases. Front Biosci (Landmark Ed) (2012) 1.38
Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function. Diabetes Care (2011) 1.23
Uric acid as a target of therapy in CKD. Am J Kidney Dis (2012) 1.22
Association of incident gout and mortality in dialysis patients. J Am Soc Nephrol (2008) 1.20
Uric acid lowering to prevent kidney function loss in diabetes: the preventing early renal function loss (PERL) allopurinol study. Curr Diab Rep (2013) 1.09
Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial. Clin Exp Nephrol (2015) 1.03
Fructose and uric acid in diabetic nephropathy. Diabetologia (2015) 0.99
Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link? Arthritis Res Ther (2009) 0.98
Risk of end-stage renal disease associated with gout: a nationwide population study. Arthritis Res Ther (2012) 0.98
Uric acid levels have no significant effect on renal function in adult renal transplant recipients: evidence from the symphony study. Clin J Am Soc Nephrol (2009) 0.97
Impact of serum uric acid on renal function and cardiovascular events in hypertensive patients treated with losartan. Hypertens Res (2012) 0.96
Do thiazides worsen metabolic syndrome and renal disease? The pivotal roles for hyperuricemia and hypokalemia. Curr Opin Nephrol Hypertens (2008) 0.95
Urate lowering therapy to improve renal outcomes in patients with chronic kidney disease: systematic review and meta-analysis. BMC Nephrol (2015) 0.94
Uric acid levels, kidney function, and cardiovascular mortality in US adults: National Health and Nutrition Examination Survey (NHANES) 1988-1994 and 1999-2002. Am J Kidney Dis (2014) 0.93
Serum uric acid level and endothelial dysfunction in patients with nondiabetic chronic kidney disease. Am J Nephrol (2011) 0.92
Endothelin-A receptor antagonism modifies cardiovascular risk factors in CKD. J Am Soc Nephrol (2012) 0.91
Serum uric acid is an independent predictor of metabolic syndrome in a Japanese health screening population. Heart Vessels (2013) 0.91
Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals. BMC Cardiovasc Disord (2014) 0.90
Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout. QJM (2013) 0.90
Challenges of conducting a trial of uric-acid-lowering therapy in CKD. Nat Rev Nephrol (2011) 0.90
Four-week effects of allopurinol and febuxostat treatments on blood pressure and serum creatinine level in gouty men. J Korean Med Sci (2014) 0.88
Chapter 3: Management of progression and complications of CKD. Kidney Int Suppl (2011) (2013) 0.88
Association of kidney disease with prevalent gout in the United States in 1988-1994 and 2007-2010. Semin Arthritis Rheum (2013) 0.88
Association between asymptomatic hyperuricemia and new-onset chronic kidney disease in Japanese male workers: a long-term retrospective cohort study. BMC Nephrol (2011) 0.87
A structural equation model for assessment of links between changes in serum triglycerides, -urate, and -glucose and changes in serum calcium, -magnesium and -phosphate in type 2 diabetes and non-diabetes metabolism. Cardiovasc Diabetol (2011) 0.87
Febuxostat in the management of hyperuricemia and chronic gout: a review. Ther Clin Risk Manag (2008) 0.87
Uric acid: association with rate of renal function decline and time until start of dialysis in incident pre-dialysis patients. BMC Nephrol (2014) 0.86
Serum uric acid and chronic kidney disease: the role of hypertension. PLoS One (2013) 0.86
Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006. Metabolism (2011) 0.86
Uric acid levels predict future blood pressure and new onset hypertension in the general Japanese population. J Hum Hypertens (2014) 0.86
Serum uric acid and the incidence of CKD and hypertension. Clin Exp Nephrol (2015) 0.84
Effects of xanthine oxidase inhibitors on renal function and blood pressure in hypertensive patients with hyperuricemia. Hypertens Res (2016) 0.83
Obesity-related cardiorenal disease: the benefits of bariatric surgery. Nat Rev Nephrol (2013) 0.83
Uric acid and chronic kidney disease: A time to act? World J Nephrol (2013) 0.83
The association between uric acid and chronic kidney disease in Korean men: a 4-year follow-up study. J Korean Med Sci (2013) 0.83
Uric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with Stage III, IV and V chronic kidney disease. Nephrol Dial Transplant (2015) 0.83
Management of Gout and Hyperuricemia in CKD. Am J Kidney Dis (2017) 0.82
Serum uric acid levels and long-term outcomes in chronic kidney disease. Heart Vessels (2013) 0.82
Hyperuricemia and deterioration of renal function in autosomal dominant polycystic kidney disease. BMC Nephrol (2014) 0.82
Chapter 5: Referral to specialists and models of care. Kidney Int Suppl (2011) (2013) 0.82
Allopurinol for prevention of progression of kidney disease with hyperuricemia. Indian J Nephrol (2013) 0.82
Uric acid level has a U-shaped association with loss of kidney function in healthy people: a prospective cohort study. PLoS One (2015) 0.81
Comorbidities in patients with crystal diseases and hyperuricemia. Rheum Dis Clin North Am (2014) 0.81
Use of uric acid-lowering agents limits experimental cyclosporine nephropathy. Nephron Exp Nephrol (2011) 0.81
Allopurinol is an independent determinant of improved arterial stiffness in chronic kidney disease: a cross-sectional study. PLoS One (2014) 0.81
Uric acid, hypertension, and chronic kidney disease among Alaska Eskimos: the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. J Clin Hypertens (Greenwich) (2012) 0.81
Role of chronic kidney disease in cardiovascular disease: are we different from others? Clin Exp Nephrol (2011) 0.80
Association of renal manifestations with serum uric acid in Korean adults with normal uric acid levels. J Korean Med Sci (2010) 0.80
Hyperuricemia is an independent risk factor for new onset micro-albuminuria in a middle-aged and elderly population: a prospective cohort study in taiwan. PLoS One (2013) 0.80
Comparison of effects of azelnidipine and trichlormethiazide in combination with olmesartan on blood pressure and metabolic parameters in hypertensive type 2 diabetic patients. J Diabetes Investig (2011) 0.79
Uric Acid and Neurocognitive Function in Survivors of Childhood Acute Lymphoblastic Leukemia Treated with Chemotherapy Only. Cancer Epidemiol Biomarkers Prev (2016) 0.79
Comparison of the Renoprotective Effect of Febuxostat for the Treatment of Hyperuricemia between Patients with and without Type 2 Diabetes Mellitus: A Retrospective Observational Study. Intern Med (2016) 0.79
End-stage renal disease. BMJ Clin Evid (2010) 0.78
Hyperuricemia: A non-traditional risk factor for development and progression of chronic kidney disease? Kidney Res Clin Pract (2012) 0.78
Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study. Cardiovasc Diabetol (2016) 0.78
Serum Uric Acid and Progression of Kidney Disease: A Longitudinal Analysis and Mini-Review. PLoS One (2017) 0.77
Associations between serum uric acid levels and the incidence of nonfatal stroke: a nationwide community-based cohort study. Clin Exp Nephrol (2016) 0.77
Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy. BMC Nephrol (2014) 0.77
Time to target uric acid to retard CKD progression. Clin Exp Nephrol (2016) 0.77
Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population. Clin Exp Nephrol (2013) 0.77
Serum uric acid levels and mortality in the Japanese population: the Yamagata (Takahata) study. Clin Exp Nephrol (2016) 0.77
Asymptomatic hyperuricemia is independently associated with coronary artery calcification in the absence of overt coronary artery disease: A single-center cross-sectional study. Medicine (Baltimore) (2017) 0.76
Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study. Hypertension (2017) 0.76
Higher blood hematocrit predicts hyperuricemia: a prospective study of 62,897 person-years of follow-up. Sci Rep (2015) 0.75
Nephrology for the people: Presidential Address at the 42nd Regional Meeting of the Japanese Society of Nephrology in Okinawa 2012. Clin Exp Nephrol (2013) 0.75
Serum Uric Acid and Renal Transplantation Outcomes: At Least 3-Year Post-transplant Retrospective Multivariate Analysis. PLoS One (2015) 0.75
Hyperuricemia as a marker for progression of immunoglobulin A nephropathy. Kidney Res Clin Pract (2012) 0.75
Efficacy and safety of febuxostat in elderly female patients. Clin Interv Aging (2014) 0.75
Lower serum uric acid level predicts mortality in dialysis patients. Medicine (Baltimore) (2016) 0.75
End stage renal disease. BMJ Clin Evid (2007) 0.75
Total saponins from Discorea nipponica makino ameliorate urate excretion in hyperuricemic rats. Pharmacogn Mag (2015) 0.75
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study. BMC Nephrol (2015) 0.75
Targeting urate to reduce oxidative stress in Parkinson disease. Exp Neurol (2017) 0.75
The influence of serum uric acid on renal function in patients with calcium or uric acid stone: A population-based analysis. PLoS One (2017) 0.75
Urate-Lowering Therapy Ameliorates Kidney Function in Type 2 Diabetes Patients With Hyperuricemia. J Clin Med Res (2017) 0.75
ARISTOLOCHIA BRACTEOLATE RETZ. ATTENUATES HYPERURICEMIA IN A METABOLIC ARTHRITIS RAT MODEL. Afr J Tradit Complement Altern Med (2017) 0.75
The grey zone of Hyperuricemia in chronic kidney disease. J Adv Res (2017) 0.75
Any link of gout disease control among hypertensive patients and onset of end-stage renal disease? Results from a population-based study. World J Nephrol (2017) 0.75
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009). Hypertens Res (2009) 5.24
Proteinuria and the risk of developing end-stage renal disease. Kidney Int (2003) 3.73
Body mass index and the risk of development of end-stage renal disease in a screened cohort. Kidney Int (2004) 2.44
Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study. Hypertension (2010) 2.37
Effects of blood pressure levels on case fatality after acute stroke. J Hypertens (2005) 1.89
Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia. J Biol Chem (2004) 1.75
Blood pressure predicts risk of developing end-stage renal disease in men and women. Hypertension (2003) 1.70
Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial. J Hypertens (2014) 1.56
Analysis of drug prescription in chronic haemodialysis patients. Nephrol Dial Transplant (2002) 1.48
Hypocholesterolemia is a significant predictor of death in a cohort of chronic hemodialysis patients. Kidney Int (2002) 1.47
Impact of high coronary artery calcification score (CACS) on survival in patients on chronic hemodialysis. Clin Exp Nephrol (2004) 1.45
Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan. Hypertens Res (2004) 1.44
New-onset hypertension and risk for chronic kidney disease in the Japanese general population. J Hypertens (2014) 1.43
Plasma aldosterone in hypertensive patients on chronic hemodialysis: distribution, determinants and impact on survival. Hypertens Res (2006) 1.43
Relationship between predicted creatinine clearance and proteinuria and the risk of developing ESRD in Okinawa, Japan. Am J Kidney Dis (2004) 1.38
Influence of smoking and obesity on the development of proteinuria. Kidney Int (2002) 1.34
Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa, Japan. Hypertens Res (2004) 1.32
Metabolic syndrome and risk of developing chronic kidney disease in Japanese adults. Hypertens Res (2007) 1.25
Pulse pressure and risk of total mortality and cardiovascular events in patients on chronic hemodialysis. Kidney Int (2002) 1.23
Triglyceride, but not total cholesterol or low-density lipoprotein cholesterol levels, predict development of proteinuria. Kidney Int (2002) 1.10
Increased pulse wave velocity is associated with low creatinine clearance and proteinuria in a screened cohort. Am J Kidney Dis (2006) 1.07
Optimum selection of an implantable secondary battery for an artificial heart by examination of the cycle life test. ASAIO J (2002) 1.06
Autologous peripheral blood mononuclear cell implantation for patients with peripheral arterial disease improves limb ischemia. Circ J (2005) 1.06
Penicillin G-induced hemorrhagic cystitis with hydronephrosis. Intern Med (2009) 1.05
Relationship between home blood pressure and longitudinal changes in target organ damage in treated hypertensive patients. Hypertens Res (2002) 0.99
The combination therapy of hypertension to prevent cardiovascular events (COPE) trial: rationale and design. Hypertens Res (2005) 0.98
Effects of the creation of arteriovenous fistula for hemodialysis on cardiac function and natriuretic peptide levels in CRF. Am J Kidney Dis (2002) 0.98
Influence of plasma aldosterone on left ventricular geometry and diastolic function in treated essential hypertension. Hypertens Res (2002) 0.97
Role of HCN4 channel in preventing ventricular arrhythmia. J Hum Genet (2009) 0.97
Changes in the demographics and prevalence of chronic kidney disease in Okinawa, Japan (1993 to 2003). Hypertens Res (2007) 0.95
Rationale, study design and implementation of the COLM study: the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patients. Hypertens Res (2009) 0.95
Changes in serum uric acid have a reciprocal effect on eGFR change: a 10-year follow-up study of community-based screening in Okinawa, Japan. Hypertens Res (2013) 0.90
Severe abdominal pain associated with allergic reaction to nafamostat mesilate in a chronic hemodialysis patient. Intern Med (2002) 0.90
Risk of developing low glomerular filtration rate or elevated serum creatinine in a screened cohort in Okinawa, Japan. Hypertens Res (2007) 0.90
Elevated resting heart rate is associated with white blood cell count in middle-aged and elderly individuals without apparent cardiovascular disease. Angiology (2011) 0.88
Haematocrit and the risk of developing end-stage renal disease. Nephrol Dial Transplant (2003) 0.88
Prevalence and outcome of renal artery stenosis in atherosclerotic patients with renal dysfunction. Hypertens Res (2002) 0.87
Prevalence of anemia according to stage of chronic kidney disease in a large screening cohort of Japanese. Clin Exp Nephrol (2009) 0.87
Heart rate as a risk factor for developing chronic kidney disease: longitudinal analysis of a screened cohort. Clin Exp Nephrol (2009) 0.86
Urinary excretion of sodium and potassium in a screened cohort in Okinawa, Japan. Hypertens Res (2002) 0.85
Decreased body mass index as an independent risk factor for developing chronic kidney disease. Clin Exp Nephrol (2008) 0.85
Demographic trends in the Okinawa Dialysis Study (OKIDS) registry (1971-2000). Kidney Int (2002) 0.84
Induction and inhibition of cyclobutane pyrimidine dimer photolyase in etiolated cucumber (Cucumis sativus) cotyledons after ultraviolet irradiation depends on wavelength. J Plant Res (2007) 0.83
Proteinuria as a significant determinant of hypertension in a normotensive screened cohort in Okinawa, Japan. Hypertens Res (2006) 0.83
Dietary intervention with Okinawan vegetables increased circulating endothelial progenitor cells in healthy young women. Atherosclerosis (2008) 0.83
Pioglitazone, a thiazolidinedione derivative, attenuates left ventricular hypertrophy and fibrosis in salt-sensitive hypertension. Hypertens Res (2008) 0.83
Evidence for elevated pulse pressure in patients on chronic hemodialysis: a case-control study. Kidney Int (2002) 0.82
Relationship between dyslipidemia and the risk of developing end-stage renal disease in a screened cohort. Clin Exp Nephrol (2005) 0.82
Impact of multiple risk factor clustering on the elevation of blood pressure. Hypertens Res (2002) 0.81
Beneficial effects of pioglitazone on left ventricular hypertrophy in genetically hypertensive rats. Hypertens Res (2007) 0.81