Published in Bone on October 01, 2004
Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A (2010) 2.20
Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice. J Bone Miner Res (2010) 2.19
Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway. PLoS One (2011) 2.10
Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women. J Clin Endocrinol Metab (2010) 2.05
Update on Wnt signaling in bone cell biology and bone disease. Gene (2011) 2.03
The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS One (2012) 1.76
Control of the SOST bone enhancer by PTH using MEF2 transcription factors. J Bone Miner Res (2007) 1.74
Sclerostin: current knowledge and future perspectives. Calcif Tissue Int (2010) 1.71
Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium. Proc Natl Acad Sci U S A (2013) 1.70
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res (2010) 1.54
Proteomics characterization of extracellular space components in the human aorta. Mol Cell Proteomics (2010) 1.53
Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial. J Bone Miner Res (2015) 1.46
Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways. J Biol Chem (2010) 1.38
Osteocyte control of osteoclastogenesis. Bone (2012) 1.36
Effects of intermittent parathyroid hormone (PTH) administration on SOST mRNA and protein in rat bone. J Mol Histol (2007) 1.19
Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training. J Bone Miner Res (2012) 1.08
Serum sclerostin and risk of hip fracture in older Caucasian women. J Clin Endocrinol Metab (2012) 1.08
Sclerostin binds and regulates the activity of cysteine-rich protein 61. Biochem Biophys Res Commun (2009) 1.05
Determination of serum and plasma sclerostin concentrations by enzyme-linked immunoassays. J Clin Endocrinol Metab (2011) 0.99
Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol (2010) 0.98
BMP2 induces osteoblast apoptosis in a maturation state and noggin-dependent manner. J Cell Biochem (2012) 0.94
Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization. J Cell Biochem (2013) 0.94
Current, new and future treatments of osteoporosis. Rheumatol Int (2010) 0.92
Gremlin enhances the determined path to cardiomyogenesis. PLoS One (2008) 0.90
Cellular and molecular changes in orthodontic tooth movement. ScientificWorldJournal (2011) 0.87
Phenotypic characterization of osteoarthritic osteocytes from the sclerotic zones: a possible pathological role in subchondral bone sclerosis. Int J Biol Sci (2012) 0.87
Roles of the kidney in the formation, remodeling and repair of bone. J Nephrol (2016) 0.86
A novel underuse model shows that inactivity but not ovariectomy determines the deteriorated material properties and geometry of cortical bone in the tibia of adult rats. J Bone Miner Metab (2010) 0.86
Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis. Osteoporos Int (2008) 0.85
Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia. Hum Genet (2011) 0.84
Is interaction between age-dependent decline in mechanical stimulation and osteocyte-estrogen receptor levels the culprit for postmenopausal-impaired bone formation? Osteoporos Int (2012) 0.84
Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition. PLoS One (2013) 0.83
Sclerostin Antibody Treatment Improves the Bone Phenotype of Crtap(-/-) Mice, a Model of Recessive Osteogenesis Imperfecta. J Bone Miner Res (2016) 0.82
Targeting the Wnt signaling pathway to augment bone formation. Curr Osteoporos Rep (2008) 0.82
A model of osteoblast-osteocyte kinetics in the development of secondary osteons in rabbits. J Anat (2012) 0.80
Osteocytic signalling pathways as therapeutic targets for bone fragility. Nat Rev Endocrinol (2016) 0.80
Alterations in vitamin D metabolite, parathyroid hormone and fibroblast growth factor-23 concentrations in sclerostin-deficient mice permit the maintenance of a high bone mass. J Steroid Biochem Mol Biol (2014) 0.79
Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions. Curr Osteoporos Rep (2014) 0.79
TIEG1-NULL OSTEOCYTES DISPLAY DEFECTS IN THEIR MORPHOLOGY, DENSITY AND SURROUNDING BONE MATRIX. J Musculoskelet Res (2009) 0.79
The effect on proliferation and differentiation of cementoblast by using sclerostin as inhibitor. Int J Mol Sci (2013) 0.78
Role of osteocytes in multiple myeloma bone disease. Curr Opin Support Palliat Care (2014) 0.78
Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton. Gene Expr Patterns (2012) 0.77
Synergistic effects of high dietary calcium and exogenous parathyroid hormone in promoting osteoblastic bone formation in mice. Br J Nutr (2015) 0.75
Sclerostin's role in bone's adaptive response to mechanical loading. Bone (2016) 0.75
Management of trigeminal neuralgia in sclerosteosis. Surg Neurol Int (2013) 0.75
Serum sclerostin levels in renal cell carcinoma patients with bone metastases. Sci Rep (2016) 0.75
Novel therapeutic targets in myeloma bone disease. Br J Pharmacol (2014) 0.75
A Novel Loss-of-Sclerostin Function Mutation in a First Egyptian Family with Sclerosteosis. Biomed Res Int (2015) 0.75
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J (2003) 4.32
Protease-resistant prion protein amplification reconstituted with partially purified substrates and synthetic polyanions. J Biol Chem (2005) 2.29
SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood (2013) 2.26
Gene expression analyzed by high-resolution state array analysis and quantitative proteomics: response of yeast to mating pheromone. Mol Cell Proteomics (2004) 2.22
Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids. Proc Natl Acad Sci U S A (2012) 1.97
Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates. J Biol Chem (2006) 1.96
The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell (2005) 1.94
Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins. J Biol Chem (2004) 1.91
A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin (2012) 1.82
Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome. J Neurosci (2006) 1.69
Species-dependent differences in cofactor utilization for formation of the protease-resistant prion protein in vitro. Biochemistry (2010) 1.68
Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes. Hepatology (2003) 1.58
Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment. Protein Eng Des Sel (2006) 1.29
Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites. Am J Hum Genet (2004) 1.26
Noggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complex. J Biol Chem (2004) 1.26
Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities. Blood (2006) 1.21
The two upstream open reading frames of oncogene mdm2 have different translational regulatory properties. J Biol Chem (2003) 1.19
Copper (II) ions potently inhibit purified PrPres amplification. J Neurochem (2006) 1.16
Short hairpin RNA-mediated inhibition of matrix metalloproteinase-1 in MDA-231 cells: effects on matrix destruction and tumor growth. Cancer Res (2005) 1.13
Dissociation of infectivity from seeding ability in prions with alternate docking mechanism. PLoS Pathog (2011) 1.07
Unique regulation of SOST, the sclerosteosis gene, by BMPs and steroid hormones in human osteoblasts. Bone (2004) 1.06
TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Rheumatology (Oxford) (2009) 1.00
Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index. Mol Cancer Ther (2008) 0.99
Anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia. MAbs (2009) 0.97
RNAi or overexpression: alternative therapies for Spinocerebellar Ataxia Type 1. Neurobiol Dis (2013) 0.94
Sialic acid deposition impairs the utility of AAV9, but not peptide-modified AAVs for brain gene therapy in a mouse model of lysosomal storage disease. Mol Ther (2012) 0.93
Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-α production in a receptor for advanced glycation end product-dependent manner. J Immunol (2010) 0.92
A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J Immunol (2004) 0.90
Structure and catalysis in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB. Biochemistry (2014) 0.78
Correlation of structure and function in the human hotdog-fold enzyme hTHEM4. Biochemistry (2012) 0.78
Effects of alkoxy groups on arene rings of lignin β-O-4 model compounds on the efficiencies of single electron transfer-promoted photochemical and enzymatic C-C Bond Cleavage Reactions. J Org Chem (2013) 0.77
The H2BK123Rgument. J Cell Biol (2009) 0.75
Corrigendum: PI3Kγ is a molecular switch that controls immune suppression. Nature (2016) 0.75
Benzobicyclooctanes as novel inhibitors of TNF-alpha signaling. Bioorg Med Chem Lett (2002) 0.75
Complex responses to a diverse environment. Genome Biol (2008) 0.75
On the horizon: a blood test for prions. Trends Microbiol (2006) 0.75
Regioselectivity of enzymatic and photochemical single electron transfer promoted carbon-carbon bond fragmentation reactions of tetrameric lignin model compounds. J Org Chem (2011) 0.75