Published in Hum Mol Genet on October 20, 2004
Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: current and developing technologies. Mutat Res (2008) 1.56
Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc Natl Acad Sci U S A (2013) 1.12
Genome-wide and follow-up studies identify CEP68 gene variants associated with risk of aspirin-intolerant asthma. PLoS One (2010) 0.97
Unraveling the genetic basis of aspirin hypersensitivity in asthma beyond arachidonate pathways. Allergy Asthma Immunol Res (2013) 0.93
Prostaglandin E₂ suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells. J Allergy Clin Immunol (2013) 0.92
Gene-environment interactions in asthma. Occup Environ Med (2006) 0.91
Genetic markers for differentiating aspirin-hypersensitivity. Yonsei Med J (2006) 0.90
Pathogenesis of aspirin-exacerbated respiratory disease and reactions. Immunol Allergy Clin North Am (2012) 0.88
Genome-wide association study of aspirin-exacerbated respiratory disease in a Korean population. Hum Genet (2012) 0.87
The role of prostaglandins in allergic lung inflammation and asthma. Expert Rev Respir Med (2014) 0.87
Association study on chromosome 20q11.21-13.13 locus and its contribution to type 2 diabetes susceptibility in Japanese. Hum Genet (2006) 0.86
Aspirin and decreased adult-onset asthma: randomized comparisons from the physicians' health study. Am J Respir Crit Care Med (2006) 0.84
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Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The Pilot Study. J Allergy (Cairo) (2012) 0.80
Modelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencing. PLoS Genet (2012) 0.80
Fatty acid binding protein 1 is related with development of aspirin-exacerbated respiratory disease. PLoS One (2011) 0.78
Genetic mechanisms in aspirin-exacerbated respiratory disease. J Allergy (Cairo) (2011) 0.78
Development of a genetic marker set to diagnose aspirin-exacerbated respiratory disease in a genome-wide association study. Pharmacogenomics J (2015) 0.77
Functional Consequences of Mutations and Polymorphisms in the Coding Region of the PAF Acetylhydrolase (PAF-AH) Gene. Pharmaceuticals (Basel) (2009) 0.76
Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity. Respir Res (2014) 0.76
Exonic variants associated with development of aspirin exacerbated respiratory diseases. PLoS One (2014) 0.76
Variants of CEP68 gene are associated with acute urticaria/angioedema induced by multiple non-steroidal anti-inflammatory drugs. PLoS One (2014) 0.75
Prostaglandins and Their Receptors in Eosinophil Function and As Therapeutic Targets. Front Med (Lausanne) (2017) 0.75
Pharmacogenomics of off-target adverse drug reactions. Br J Clin Pharmacol (2017) 0.75
Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet (2013) 4.61
Risk factors for drug-resistant pathogens in community-acquired and healthcare-associated pneumonia. Am J Respir Crit Care Med (2013) 3.95
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia. N Engl J Med (2015) 3.42
Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity (2004) 3.01
Health-care-associated pneumonia among hospitalized patients in a Japanese community hospital. Chest (2008) 2.83
Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2009) 2.68
ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. J Biol Chem (2002) 2.29
Regulation of the hepatitis C virus genome replication by miR-199a. J Hepatol (2008) 2.26
Pulmonary hypertension as a prognostic indicator at the initial evaluation in idiopathic pulmonary fibrosis. Respiration (2012) 2.23
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat Med (2003) 2.20
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet (2013) 2.14
Somatic SETBP1 mutations in myeloid malignancies. Nat Genet (2013) 2.12
Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads. J Immunol (2008) 1.98
Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol (2012) 1.95
Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations. J Hum Genet (2008) 1.94
Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet (2008) 1.90
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med (2008) 1.88
Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet (2010) 1.86
SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML). Blood (2012) 1.85
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med (2006) 1.84
Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. J Biol Chem (2003) 1.81
Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. Blood (2013) 1.79
Niflumic acid suppresses interleukin-13-induced asthma phenotypes. Am J Respir Crit Care Med (2006) 1.79
Mutations in a thiamine-transporter gene and Wernicke's-like encephalopathy. N Engl J Med (2009) 1.79
Evaluating the performance of Affymetrix SNP Array 6.0 platform with 400 Japanese individuals. BMC Genomics (2008) 1.76
The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat Immunol (2010) 1.72
Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Nat Genet (2013) 1.71
Next-generation sequencing: impact of exome sequencing in characterizing Mendelian disorders. J Hum Genet (2012) 1.70
Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genet (2012) 1.69
Collagen type I alpha2 (COL1A2) is the susceptible gene for intracranial aneurysms. Stroke (2004) 1.68
Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in chromosomes from around the world. Am J Hum Genet (2004) 1.61
B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism. J Immunol (2004) 1.61
Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms. J Hum Genet (2010) 1.61
Gene expression profile for predicting survival in advanced-stage serous ovarian cancer across two independent datasets. PLoS One (2010) 1.58
Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis. N Engl J Med (2009) 1.58
High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. Clin Cancer Res (2012) 1.56
A bilayer cell-free protein synthesis system for high-throughput screening of gene products. FEBS Lett (2002) 1.56
Pulmonary infectious complications associated with anti-TNFalpha therapy (infliximab) for rheumatoid arthritis. Intern Med (2006) 1.55
The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells. Immunity (2006) 1.53
Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells. Cancer Res (2004) 1.52
Cerebral blood flow ratio of the dorsolateral prefrontal cortex to the ventromedial prefrontal cortex as a potential predictor of treatment response to transcranial magnetic stimulation in depression. Brain Stimul (2011) 1.50
ACTN1 mutations cause congenital macrothrombocytopenia. Am J Hum Genet (2013) 1.49
Lung-Dominant Connective Tissue Disease: Clinical, Radiologic, and Histologic Features. Chest (2015) 1.48
Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells. Cancer Lett (2010) 1.47
Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis. Circ Cardiovasc Genet (2013) 1.47
Immunoglobulin G4-related lung disease: clinicoradiological and pathological features. Respirology (2013) 1.47
Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse. J Hum Genet (2009) 1.46
Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma. Hum Mutat (2008) 1.44
Nucleotide diversity and haplotype structure of the human angiotensinogen gene in two populations. Am J Hum Genet (2001) 1.43
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol (2011) 1.41
EGFR mutations and human papillomavirus in lung cancer. Lung Cancer (2012) 1.41
Analysis of the effect of surgical lung biopsy on serum KL-6 Levels in patients with interstitial pneumonia: surgical lung biopsy does not elevate serum KL-6 levels. Intern Med (2006) 1.39
An engineered Escherichia coli tyrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system. Proc Natl Acad Sci U S A (2002) 1.35
GADD34 induces p53 phosphorylation and p21/WAF1 transcription. J Cell Biochem (2003) 1.34
Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways. J Biol Chem (2003) 1.32
Concerted expression of eotaxin-1, eotaxin-2, and eotaxin-3 in human bronchial epithelial cells. Cell Immunol (2003) 1.32
Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease. J Immunol (2008) 1.30
B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma. Biochem Biophys Res Commun (2007) 1.29
Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility. PLoS Genet (2008) 1.28
Pulmonary cryptococcosis in immunocompetent patients: HRCT characteristics. Clin Imaging (2004) 1.25
EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition. Cancer Res (2013) 1.24
An empirical Bayesian framework for somatic mutation detection from cancer genome sequencing data. Nucleic Acids Res (2013) 1.24
Phase-defined complete sequencing of the HLA genes by next-generation sequencing. BMC Genomics (2013) 1.22
Regulation of Geminin and Cdt1 expression by E2F transcription factors. Oncogene (2004) 1.22
Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med (2010) 1.21
Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice. J Immunol (2005) 1.20
Protein adsorption-resistant hollow fibers for blood purification. Artif Organs (2002) 1.16
BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders. Blood (2013) 1.16
Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet (2003) 1.15
Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness. J Immunol (2012) 1.15
CD40 plays a crucial role in lipopolysaccharide-induced acute lung injury. Am J Respir Cell Mol Biol (2003) 1.15
The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4a) and RASSF1A in human lung cancer cell lines. Oncogene (2002) 1.14
The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells. Immunity (2012) 1.14
Hemodynamic and neurohumoral responses to the restriction of femoral blood flow by KAATSU in healthy subjects. Eur J Appl Physiol (2007) 1.13
Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis. Cancer Sci (2009) 1.12
Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. Eur J Appl Physiol (2005) 1.12
YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation. Carcinogenesis (2008) 1.11
Comparison of severity scoring systems A-DROP and CURB-65 for community-acquired pneumonia. Respirology (2008) 1.11
Evaluation of interferon-gamma, interferon-gamma-inducing cytokines, and interferon-gamma-inducible chemokines in tuberculous pleural effusions. J Lab Clin Med (2005) 1.10
Influence of the Pseudomonas quinolone signal on denitrification in Pseudomonas aeruginosa. J Bacteriol (2008) 1.10
Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria. J Clin Invest (2014) 1.09
Emerging evidence of epithelial-to-mesenchymal transition in lung carcinogenesis. Respirology (2012) 1.09
Linkage and association analyses of the osteoprotegerin gene locus with human osteoporosis. J Hum Genet (2002) 1.08
Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways. Am J Respir Crit Care Med (2003) 1.08
Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk. Proc Natl Acad Sci U S A (2011) 1.08
Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma. Carcinogenesis (2012) 1.07
Recurrent vascular catheter-related bacteremia caused by Delftia acidovorans with different antimicrobial susceptibility profiles. J Infect Chemother (2010) 1.07
ANRIL is implicated in the regulation of nucleus and potential transcriptional target of E2F1. Oncol Rep (2010) 1.06
Opr86 is essential for viability and is a potential candidate for a protective antigen against biofilm formation by Pseudomonas aeruginosa. J Bacteriol (2008) 1.06
Exome resequencing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese. J Bone Miner Res (2011) 1.05
Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma. Cancer Res (2009) 1.04
Establishment of a large cell lung cancer cell line (Y-ML-1B) producing granulocyte colony-stimulating factor. Cancer Genet Cytogenet (2002) 1.04
A novel Ca2+ influx pathway activated by mechanical stretch in human airway smooth muscle cells. Am J Respir Cell Mol Biol (2007) 1.04