Published in J Leukoc Biol on October 20, 2004
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp Med (2005) 2.64
Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics. J Pharm Sci (2011) 1.24
Innate immune detection of microbial nucleic acids. Trends Microbiol (2013) 1.21
Prophylaxis with cationic liposome-DNA complexes protects hamsters from phleboviral disease: importance of liposomal delivery and CpG motifs. Antiviral Res (2008) 1.02
Advances in the design and delivery of peptide subunit vaccines with a focus on toll-like receptor agonists. Expert Rev Vaccines (2010) 0.96
Electroporation-mediated transfer of plasmids to the lung results in reduced TLR9 signaling and inflammation. Gene Ther (2007) 0.94
Effects of particle size on toll-like receptor 9-mediated cytokine profiles. Biomaterials (2010) 0.92
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA. Nucleic Acids Res (2009) 0.91
The linkage of innate and adaptive immune response during granulomatous development. Front Immunol (2013) 0.89
Ehrlichia chaffeensis induces monocyte inflammatory responses through MyD88, ERK, and NF-κB but not through TRIF, interleukin-1 receptor 1 (IL-1R1)/IL-18R1, or toll-like receptors. Infect Immun (2011) 0.89
Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response. Respir Res (2009) 0.87
A novel micro-linear vector for in vitro and in vivo gene delivery and its application for EBV positive tumors. PLoS One (2012) 0.86
Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes. Pharm Res (2008) 0.86
Potent adjuvant activity of cationic liposome-DNA complexes for genital herpes vaccines. Clin Vaccine Immunol (2009) 0.86
Contribution of interferon-beta to the immune activation induced by double-stranded DNA. Immunology (2006) 0.85
A DNA microarray-based analysis of the host response to a nonviral gene carrier: a strategy for improving the immune response. Mol Ther (2011) 0.84
CpG-ODN enhances ingestion of apoptotic neutrophils by macrophages. Clin Exp Med (2008) 0.83
DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells. Immunology (2006) 0.80
Delivery of calf thymus DNA to tumor by folate receptor targeted cationic liposomes. Biomaterials (2011) 0.79
Treatment with cationic liposome-DNA complexes (CLDCs) protects mice from lethal Western equine encephalitis virus (WEEV) challenge. Antiviral Res (2010) 0.78
Mechanisms of action underlying the immunotherapeutic activity of Allovectin in advanced melanoma. Cancer Gene Ther (2012) 0.77
A non-coding cationic lipid DNA complex produces lasting anti-leukemic effects. Cancer Biol Ther (2010) 0.76
Toll-like receptor 2 promiscuity is responsible for the immunostimulatory activity of nucleic acid nanocarriers. J Control Release (2016) 0.75
Nucleofection of expression vectors induces a robust interferon response and inhibition of cell proliferation. DNA Cell Biol (2013) 0.75
B Cells Produce Type 1 IFNs in Response to the TLR9 Agonist CpG-A Conjugated to Cationic Lipids. J Immunol (2017) 0.75
Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection. J Biotechnol (2013) 1.31
Hydrodynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: implication of a nonspecific process in efficient intracellular gene delivery. J Gene Med (2004) 1.20
Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAi-based gene therapy. Adv Drug Deliv Rev (2009) 1.12
Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis. Adv Drug Deliv Rev (2009) 1.07
Heat shock protein derivatives for delivery of antigens to antigen presenting cells. Int J Pharm (2007) 1.06
Action mechanism of tachyplesin I and effects of PEGylation. Biochim Biophys Acta (2007) 1.03
Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver. Mol Ther (2003) 1.01
PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal. Free Radic Biol Med (2006) 0.96
Quantitative and temporal analysis of gene silencing in tumor cells induced by small interfering RNA or short hairpin RNA expressed from plasmid vectors. J Pharm Sci (2009) 0.96
Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes. Biochem Biophys Res Commun (2002) 0.96
Vector-based in vivo RNA interference: dose- and time-dependent suppression of transgene expression. J Pharmacol Exp Ther (2003) 0.95
Sustained exogenous expression of therapeutic levels of IFN-gamma ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization. J Immunol (2010) 0.95
Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice. Clin Exp Metastasis (2004) 0.95
The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity. Biomaterials (2009) 0.94
Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases. J Control Release (2005) 0.93
Development of polyethylene glycol-conjugated poly-S-nitrosated serum albumin, a novel S-Nitrosothiol for prolonged delivery of nitric oxide in the blood circulation in vivo. J Pharmacol Exp Ther (2005) 0.92
Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor. Int J Pharm (2006) 0.91
Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells. Immunology (2004) 0.91
Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase. J Control Release (2009) 0.91
Prevention of hepatic ischemia/reperfusion injury by prolonged delivery of nitric oxide to the circulating blood in mice. Transplantation (2008) 0.91
Reactivation of silenced transgene expression in mouse liver by rapid, large-volume injection of isotonic solution. Hum Gene Ther (2008) 0.90
Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression. J Gene Med (2009) 0.90
Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation. Immunology (2008) 0.89
Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice. J Pharm Sci (2014) 0.89
Effects of inflammatory response on in vivo transgene expression by plasmid DNA in mice. J Pharm Sci (2008) 0.88
Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: poly C in a murine lung metastasis model. Cancer Gene Ther (2003) 0.88
Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice. Biomaterials (2010) 0.88
Factors affecting drug and gene delivery: effects of interaction with blood components. Crit Rev Ther Drug Carrier Syst (2002) 0.88
SOD derivatives prevent metastatic tumor growth aggravated by tumor removal. Clin Exp Metastasis (2008) 0.87
Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice. Mol Ther (2009) 0.87
Development of safe and effective nonviral gene therapy by eliminating CpG motifs from plasmid DNA vector. Front Biosci (Schol Ed) (2012) 0.87
Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice. J Control Release (2009) 0.87
Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice. J Control Release (2009) 0.87
Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes. J Control Release (2005) 0.87
Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: importance of molecular size and negative charge density for in vivo recognition by receptors. J Pharmacol Exp Ther (2002) 0.87
Restricted cytokine production from mouse peritoneal macrophages in culture in spite of extensive uptake of plasmid DNA. Immunology (2004) 0.86
Hepatic uptake of negatively charged particles in rats: possible involvement of serum proteins in recognition by scavenger receptor. J Control Release (2004) 0.86
Gene silencing of beta-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice. Int J Cancer (2008) 0.86
Targeting efficiency of galactosylated liposomes to hepatocytes in vivo: effect of lipid composition. Pharm Res (2002) 0.86
Increase in CpG DNA-induced inflammatory responses by DNA oxidation in macrophages and mice. Free Radic Biol Med (2011) 0.85
Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: quantitative analysis with firefly luciferase-expressing melanoma cells. Clin Cancer Res (2004) 0.85
Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells. Cancer Sci (2008) 0.85
Characterization of CD56+ dendritic-like cells: a normal counterpart of blastic plasmacytoid dendritic cell neoplasm? PLoS One (2013) 0.84
Enhanced pharmacological activity of recombinant human interleukin-11 (rhIL11) by chemical modification with polyethylene glycol. J Control Release (2007) 0.84
Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory CpG motifs to immune cells. ACS Nano (2012) 0.84
Chronic inflammatory demyelinating polyneuropathy accompanied by chronic myelomonocytic leukemia: possible pathogenesis of autoimmunity in myelodysplastic syndrome. Int J Hematol (2009) 0.84
Significant role of liver sinusoidal endothelial cells in hepatic uptake and degradation of naked plasmid DNA after intravenous injection. Pharm Res (2004) 0.84
Removal of transgene-expressing cells by a specific immune response induced by sustained transgene expression. J Gene Med (2014) 0.83
Improvement of insulin resistance by removal of systemic hydrogen peroxide by PEGylated catalase in obese mice. Mol Pharm (2010) 0.83
The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels. Adv Drug Deliv Rev (2005) 0.83
Targeted and sustained drug delivery using PEGylated galactosylated liposomes. Int J Pharm (2003) 0.83
Hsp-based tumor vaccines: state-of-the-art and future directions. Curr Opin Mol Ther (2007) 0.83
Analysis of in vivo nuclear factor-kappaB activation during liver inflammation in mice: prevention by catalase delivery. Mol Pharmacol (2006) 0.82
Pivotal role of oxidative stress in tumor metastasis under diabetic conditions in mice. J Control Release (2013) 0.82
Insertion of nuclear factor-kappaB binding sequence into plasmid DNA for increased transgene expression in colon carcinoma cells. J Biotechnol (2007) 0.82
Analysis of hepatic disposition of galactosylated cationic liposome/plasmid DNA complexes in perfused rat liver. Pharm Res (2003) 0.82
Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice. Free Radic Biol Med (2011) 0.82
Validation of the chloramine-T induced oxidation of human serum albumin as a model for oxidative damage in vivo. Pharm Res (2003) 0.81
Hydrogen peroxide-mediated nuclear factor kappaB activation in both liver and tumor cells during initial stages of hepatic metastasis. Cancer Sci (2008) 0.81
Use of lipoplex-induced nuclear factor-kappaB activation to enhance transgene expression by lipoplex in mouse lung. J Gene Med (2006) 0.81
The uptake and degradation of DNA is impaired in macrophages and dendritic cells from NZB/W F(1) mice. Immunol Lett (2005) 0.81
Physicochemical, tissue distribution, and vasodilation characteristics of nitrosated serum albumin: delivery of nitric oxide in vivo. J Pharm Sci (2004) 0.81
Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/cationic liposome complex. J Control Release (2006) 0.81
Enhancement of anticancer effect of interferon-γ gene transfer against interferon-γ-resistant tumor by depletion of tumor-associated macrophages. Mol Pharm (2014) 0.81
Cationic charge-dependent hepatic delivery of amidated serum albumin. J Control Release (2005) 0.81
Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine conjugation. J Control Release (2008) 0.80
Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency on stability and transgene expression. J Pharm Sci (2007) 0.80
DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells. Immunology (2006) 0.80