Published in Fam Cancer on January 01, 2004
Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy. Cancer Biol Ther (2010) 0.92
The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers. Hered Cancer Clin Pract (2015) 0.85
Familial pancreatic cancer and hereditary syndromes: screening strategy for high-risk individuals. J Gastroenterol (2011) 0.84
Genetics and pathology of pancreatic cancer. HPB (Oxford) (2006) 0.82
Familial pancreatic cancer: Concept, management and issues. World J Gastroenterol (2017) 0.82
Surveillance for neoplasia in the pancreas. Best Pract Res Clin Gastroenterol (2016) 0.78
Asymptomatic pancreatic lesions: new insights and clinical implications. World J Gastroenterol (2012) 0.75
The Prevalence of Founder Mutations among Individuals from Families with Familial Pancreatic Cancer Syndrome. Cancer Res Treat (2016) 0.75
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med (2001) 24.51
Identification of the breast cancer susceptibility gene BRCA2. Nature (1996) 17.14
Identification and characterization of the familial adenomatous polyposis coli gene. Cell (1991) 14.46
The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med (1997) 13.96
Cancer statistics, 2003. CA Cancer J Clin (2003) 13.46
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med (2001) 11.88
Identification of FAP locus genes from chromosome 5q21. Science (1991) 11.41
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature (1998) 10.35
Global cancer statistics. CA Cancer J Clin (1999) 8.82
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science (1994) 8.73
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet (1996) 7.94
Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med (2001) 7.88
Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med (1993) 7.67
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet (1998) 7.36
Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology (2000) 5.40
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet (1994) 4.63
Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med (1987) 4.55
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet (1997) 4.27
Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst (1997) 4.23
Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. N Engl J Med (1995) 4.10
Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res (1996) 3.60
BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst (2003) 3.37
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res (1997) 3.17
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res (1997) 2.88
Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. Gastroenterology (1997) 2.84
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet (1998) 2.80
Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer. Ann Intern Med (1999) 2.77
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol (1999) 2.59
Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. Cancer Res (2002) 2.23
Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer. Clin Cancer Res (2001) 1.98
Malignant neoplasms in the families of patients with ataxia-telangiectasia. Cancer Res (1976) 1.96
Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden). Int J Cancer (2000) 1.90
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol (2001) 1.89
Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis. Gut (1993) 1.85
Inherited predisposition to pancreatic adenocarcinoma: role of family history and germ-line p16, BRCA1, and BRCA2 mutations. Cancer Res (2000) 1.57
Frequent somatic mutations of the APC gene in human pancreatic cancer. Cancer Res (1992) 1.55
Epidemiology of pancreatic cancer: an overview. Cancer Detect Prev (2003) 1.54
Life-style risk factors for pancreatic cancer in Louisiana: a case-control study. Am J Epidemiol (1988) 1.54
DNA mismatch repair defects: role in colorectal carcinogenesis. Biochimie (2002) 1.52
The role of genetic factors in the etiology of pancreatic adenocarcinoma: an update. Cancer Invest (2001) 1.51
Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol (1998) 1.42
Family history and the risk of liver, gallbladder, and pancreatic cancer. Cancer Epidemiol Biomarkers Prev (1994) 1.39
Pancreatic carcinoma and hereditary nonpolyposis colorectal cancer: a family study. Br J Cancer (1985) 1.34
Family studies of malignant melanoma and associated cancer. Surg Gynecol Obstet (1975) 1.34
Familial pancreatic cancer: clinicopathologic study of 18 nuclear families. Am J Gastroenterol (1990) 1.31
Familial pancreatic cancer: a review. Semin Oncol (1996) 1.30
Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors. Am J Pathol (2000) 1.28
Risk factors for cancer in hereditary pancreatitis. International Hereditary Pancreatitis Study Group. Med Clin North Am (2000) 1.26
Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa. Cancer (2001) 1.24
A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34. Am J Hum Genet (2002) 1.21
Reported family aggregation of pancreatic cancer within a population-based case-control study in the Francophone community in Montreal, Canada. Int J Pancreatol (1992) 1.21
Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer. J Clin Oncol (2000) 1.16
Systemic cancer and the FAMMM syndrome. Br J Cancer (1990) 1.12
An update on DNA-based BRCA1/BRCA2 genetic counseling in hereditary breast cancer. Cancer Genet Cytogenet (1999) 1.12
Neoplastic diseases in families of breast cancer patients. J Med Genet (1994) 1.11
Mutations of the adenomatous polyposis coli gene in the mutation cluster region: comparison of human pancreatic and colorectal cancers. Int J Cancer (1994) 1.11
Pathology of incipient pancreatic cancer. Ann Oncol (1999) 1.10
Genetics of pancreatic cancer. From genes to families. Surg Oncol Clin N Am (1998) 1.05
Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene. Gastroenterology (2002) 1.04
The rate of the 6174delT founder Jewish mutation in BRCA2 in patients with non-colonic gastrointestinal tract tumours in Israel. Br J Cancer (2001) 1.01
Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas. Int J Cancer (2002) 1.01
Familial pancreatic cancer: where are we in 2003? J Natl Cancer Inst (2003) 1.01
BRCA2 and pancreatic cancer. Int J Gastrointest Cancer (2002) 0.98
Epidemiology of pancreas cancer in Los Angeles. Cancer (1981) 0.97
Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome. Pancreas (1991) 0.96
Familial pancreatic cancer. Br J Surg (2003) 0.96
Genetic testing. Counseling, laboratory, and regulatory issues and the EUROPAC protocol for ethical research in multicenter studies of inherited pancreatic diseases. Med Clin North Am (2000) 0.95
Hereditary pancreatic cancer. Pancreatology (2001) 0.94
Pancreatic cancer. Curr Probl Surg (1999) 0.93
Inhibition of cancer cell growth by BRCA2. Cancer Res (2002) 0.93
Cancer in United States Jews. Cancer Res (1975) 0.87
Update of familial pancreatic cancer in Germany. Pancreatology (2001) 0.85
Multiple primary tumors as an indicator for p16INK4a germline mutations in pancreatic cancer patients? Pancreas (2000) 0.85
Novel germline p16(INK4) allele (Asp145Cys) in a family with multiple pancreatic carcinomas. Mutations in brief no. 148. Online. Hum Mutat (1998) 0.84
Familial pancreatic cancer (Part 1): Genetic pathology review. Nebr Med J (1989) 0.81
Religion and cancer in Los Angeles County. Natl Cancer Inst Monogr (1985) 0.81
[Familial pancreatic cancer--concept for study of the National Case Collection and early diagnosis program for high risk people]. Z Arztl Fortbild Qualitatssich (2002) 0.78
Genetic polymorphisms in the Hmong population: implications for cancer etiology and survival. Cancer (2004) 0.77
A BRCA2 germ-line mutation in familial pancreatic carcinoma. Int J Cancer (2001) 0.75
Impact of p16 expression on surgical management of malignant melanoma and pancreatic carcinoma. Am J Surg (1999) 0.75
Associations between the age at diagnosis and location of colorectal cancer and the use of alcohol and tobacco: implications for screening. Arch Intern Med (2006) 3.32
Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats. Am J Gastroenterol (2006) 2.51
Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis. Clin Gastroenterol Hepatol (2010) 2.46
Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med (2009) 2.23
Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies. Pancreas (2005) 2.23
Optical markers in duodenal mucosa predict the presence of pancreatic cancer. Clin Cancer Res (2007) 2.10
Multiplexed analysis of glycan variation on native proteins captured by antibody microarrays. Nat Methods (2007) 2.06
Partial-wave microscopic spectroscopy detects subwavelength refractive index fluctuations: an application to cancer diagnosis. Opt Lett (2009) 2.04
Familial myeloma. N Engl J Med (2008) 1.96
Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy. Cancer Res (2009) 1.91
Multicenter approach to recurrent acute and chronic pancreatitis in the United States: the North American Pancreatitis Study 2 (NAPS2). Pancreatology (2008) 1.87
Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management. Fam Cancer (2007) 1.82
Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene. Am J Hum Genet (2003) 1.80
The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays. Mol Cell Proteomics (2009) 1.77
Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk. Gastroenterology (2008) 1.73
Elevated serum neutrophil gelatinase-associated lipocalin is an early predictor of severity and outcome in acute pancreatitis. Am J Gastroenterol (2010) 1.65
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet (2012) 1.63
Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management. Mol Oncol (2009) 1.61
Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications. Eur J Hum Genet (2006) 1.59
Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation. Biomed Opt Express (2013) 1.56
Familial sarcoma: challenging pedigrees. Cancer (2003) 1.54
Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8⁺ T cells. Clin Cancer Res (2011) 1.54
Association between rectal optical signatures and colonic neoplasia: potential applications for screening. Cancer Res (2009) 1.53
Hereditary breast-ovarian cancer at the bedside: role of the medical oncologist. J Clin Oncol (2003) 1.53
MUC4-expressing pancreatic adenocarcinomas show elevated levels of both T1 and T2 cytokines: potential pathobiologic implications. Am J Gastroenterol (2006) 1.48
Transcriptional profiling of peripheral blood mononuclear cells in pancreatic cancer patients identifies novel genes with potential diagnostic utility. PLoS One (2011) 1.43
Hereditary nonpolyposis colorectal carcinoma (HNPCC) and HNPCC-like families: Problems in diagnosis, surveillance, and management. Cancer (2004) 1.39
Chemoprevention strategies for pancreatic cancer. Nat Rev Gastroenterol Hepatol (2010) 1.38
Spatial-domain low-coherence quantitative phase microscopy for cancer diagnosis. Opt Lett (2010) 1.30
Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis. Gastroenterology (2010) 1.27
A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States. JAMA (2004) 1.26
Who should be sent for genetic testing in hereditary colorectal cancer syndromes? J Clin Oncol (2007) 1.26
Quantification of nanoscale nuclear refractive index changes during the cell cycle. J Biomed Opt (2011) 1.25
Patient responses to the disclosure of BRCA mutation tests in hereditary breast-ovarian cancer families. Cancer Genet Cytogenet (2006) 1.25
Smoking is underrecognized as a risk factor for chronic pancreatitis. Pancreatology (2011) 1.19
Nanoscale nuclear architecture for cancer diagnosis beyond pathology via spatial-domain low-coherence quantitative phase microscopy. J Biomed Opt (2011) 1.16
Mass spectrometric assay for analysis of haptoglobin fucosylation in pancreatic cancer. J Proteome Res (2011) 1.14
Pancreatic cancer and the FAMMM syndrome. Fam Cancer (2007) 1.13
Integration of KRAS testing in the diagnosis of pancreatic cystic lesions: a clinical experience of 618 pancreatic cysts. Mod Pathol (2013) 1.12
BRCA1 and pancreatic cancer: pedigree findings and their causal relationships. Cancer Genet Cytogenet (2005) 1.09
Endoluminal delivery of radiofrequency energy to the gastroesophageal junction in uncomplicated GERD: efficacy and potential mechanism of action. Am J Gastroenterol (2002) 1.07
Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers. PLoS One (2011) 1.07
Origins and prevalence of the American Founder Mutation of MSH2. Cancer Res (2008) 1.06
Multiplex targeted proteomic assay for biomarker detection in plasma: a pancreatic cancer biomarker case study. J Proteome Res (2012) 1.06
Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy. Cancer (2008) 1.06
Physical and mental quality of life in chronic pancreatitis: a case-control study from the North American Pancreatitis Study 2 cohort. Pancreas (2013) 1.06
Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: role of serine protease inhibitor Kazal 1type and alcohol. World J Gastroenterol (2008) 1.04
Diagnosis and management of hereditary colorectal cancer syndromes: Lynch syndrome as a model. CMAJ (2009) 1.03
Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering. Anal Chem (2011) 1.03
Hereditary breast cancer: part I. Diagnosing hereditary breast cancer syndromes. Breast J (2007) 1.02
Using optical markers of nondysplastic rectal epithelial cells to identify patients with ulcerative colitis-associated neoplasia. Inflamm Bowel Dis (2011) 1.01
Value of preoperative upper endoscopy in patients undergoing laparoscopic gastric bypass. Obes Surg (2006) 0.99
An insight into statistical refractive index properties of cell internal structure via low-coherence statistical amplitude microscopy. Opt Express (2010) 0.99
Correction of stain variations in nuclear refractive index of clinical histology specimens. J Biomed Opt (2011) 0.98
Hereditary colorectal cancer-part II. Curr Probl Surg (2005) 0.98
MicroRNAs in pancreatic cancer metabolism. Nat Rev Gastroenterol Hepatol (2012) 0.97
Lynch syndrome-associated extracolonic tumors are rare in two extended families with the same EPCAM deletion. Am J Gastroenterol (2011) 0.97
Hereditary colon cancer--part I. Curr Probl Surg (2005) 0.96
Identification of blood-protein carriers of the CA 19-9 antigen and characterization of prevalence in pancreatic diseases. Proteomics (2011) 0.95
Toward a consensus in molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome). J Natl Cancer Inst (2007) 0.95
Diverse monoclonal antibodies against the CA 19-9 antigen show variation in binding specificity with consequences for clinical interpretation. Proteomics (2012) 0.94
Alcohol and tobacco lower the age of presentation in sporadic pancreatic cancer in a dose-dependent manner: a multicenter study. Am J Gastroenterol (2012) 0.93
Nuclear nano-morphology markers of histologically normal cells detect the "field effect" of breast cancer. Breast Cancer Res Treat (2012) 0.93
Hereditary chronic lymphocytic leukemia: an extended family study and literature review. Am J Med Genet (2002) 0.92
PCCR: Pancreatic Cancer Collaborative Registry. Cancer Inform (2011) 0.92
Inherited predisposition to cancer: a historical overview. Am J Med Genet C Semin Med Genet (2004) 0.92
Hereditary pancreatic cancer: a clinical perspective. Best Pract Res Clin Gastroenterol (2009) 0.92
Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking. World J Gastroenterol (2006) 0.91
ABO blood group and chronic pancreatitis risk in the NAPS2 cohort. Pancreas (2011) 0.90
Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical study. Dis Colon Rectum (2008) 0.90
Investigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model. J Biomed Opt (2012) 0.90
Signet ring cell colorectal carcinoma: a distinct subset of mucin-poor microsatellite-stable signet ring cell carcinoma associated with dismal prognosis. Am J Surg Pathol (2013) 0.90
Hereditary breast cancer: part II. Management of hereditary breast cancer: implications of molecular genetics and pathology. Breast J (2007) 0.89
Lynch syndrome: history and current status. Dis Markers (2004) 0.87
Germline MLH1 Mutations Are Frequently Identified in Lynch Syndrome Patients With Colorectal and Endometrial Carcinoma Demonstrating Isolated Loss of PMS2 Immunohistochemical Expression. Am J Surg Pathol (2015) 0.87
Genetic predisposition to pancreatic cancer: a brief review. Am J Gastroenterol (2007) 0.86
Genetic counseling and the advanced practice oncology nursing role in a hereditary cancer prevention clinic: hereditary breast cancer focus (part I). Breast J (2009) 0.85
The MCP-1 -2518 A/G polymorphism is not a susceptibility factor for chronic pancreatitis. Pancreatology (2006) 0.84
Hereditary cancer: family history, diagnosis, molecular genetics, ecogenetics, and management strategies. Biochimie (2002) 0.84
Modulation of glycan detection on specific glycoproteins by lectin multimerization. Anal Chem (2013) 0.84
Familial B-cell chronic lymphocytic leukemia: analysis of cytogenetic abnormalities, immunophenotypic profiles, and immunoglobulin heavy chain gene usage. Am J Clin Pathol (2007) 0.84
Hereditary factors in pancreatic cancer. J Hepatobiliary Pancreat Surg (2002) 0.84
Spectrum of use and effectiveness of endoscopic and surgical therapies for chronic pancreatitis in the United States. Pancreas (2014) 0.83
Hereditary gastrointestinal cancer syndromes. Gastrointest Cancer Res (2011) 0.83
New developments in pancreatic cancer. Curr Gastroenterol Rep (2011) 0.82
Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register. Dis Colon Rectum (2007) 0.81
Depth-selective fiber-optic probe for characterization of superficial tissue at a constant physical depth. Biomed Opt Express (2011) 0.81
Multiple primary cancer, including transitional cell carcinoma of the upper uroepithelial tract in a multigeneration HNPCC family: molecular genetic, diagnostic, and management implications. Am J Gastroenterol (2003) 0.81
Nuclear Nano-architecture Markers of Gastric Cardia and Upper Squamous Esophagus Detect Esophageal Cancer "Field Effect". J Cancer (2013) 0.81
The Marker State Space (MSS) method for classifying clinical samples. PLoS One (2013) 0.81
Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal model. Nutr Cancer (2013) 0.80