Published in Free Radic Biol Med on December 01, 2004
Oxidative stress and covalent modification of protein with bioactive aldehydes. J Biol Chem (2008) 2.09
Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors. Br J Pharmacol (2007) 1.90
Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev (2007) 1.72
Transduction of redox signaling by electrophile-protein reactions. Sci Signal (2009) 1.62
A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. Nat Methods (2013) 1.48
Nitro-fatty acid metabolome: saturation, desaturation, beta-oxidation, and protein adduction. J Biol Chem (2008) 1.35
Oxidative stress in diabetes and Alzheimer's disease. J Alzheimers Dis (2009) 1.29
Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radic Biol Med (2008) 1.23
Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease. J Gastroenterol (2007) 1.13
Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells. Redox Rep (2007) 1.13
4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells. Arch Biochem Biophys (2008) 1.10
SHP-1 inhibition by 4-hydroxynonenal activates Jun N-terminal kinase and glutamate cysteine ligase. Am J Respir Cell Mol Biol (2008) 1.01
Proteomic profiling of acrolein adducts in human lung epithelial cells. J Proteomics (2011) 1.00
Detoxification reactions: relevance to aging. Ageing Res Rev (2008) 0.98
Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress. Clin Biochem Rev (2009) 0.96
Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart. Clin Exp Pharmacol Physiol (2012) 0.94
Substoichiometric hydroxynonenylation of a single protein recapitulates whole-cell-stimulated antioxidant response. J Am Chem Soc (2014) 0.93
Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-hydroxynonenal (4-HNE). Aging (Albany NY) (2008) 0.93
The "two-faced" effects of reactive oxygen species and the lipid peroxidation product 4-hydroxynonenal in the hallmarks of cancer. Cancers (Basel) (2010) 0.93
Neutrophil-dependent oxidative stress in ulcerative colitis. J Clin Biochem Nutr (2007) 0.93
A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling. J Am Chem Soc (2015) 0.90
Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function. Microvasc Res (2011) 0.88
Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1). Chem Biol Interact (2011) 0.87
Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal. Free Radic Biol Med (2012) 0.87
Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes. PLoS One (2012) 0.86
Role of oxidative stress in adaptive responses in special reference to atherogenesis. J Clin Biochem Nutr (2008) 0.84
The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicol Appl Pharmacol (2013) 0.83
Regulation of signal transduction by glutathione transferases. Int J Hepatol (2012) 0.82
Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome. Free Radic Res (2012) 0.80
4-Hydroxy-2-nonenal enhances tissue factor activity in human monocytic cells via p38 mitogen-activated protein kinase activation-dependent phosphatidylserine exposure. Arterioscler Thromb Vasc Biol (2013) 0.79
Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38, ERK/AP-1 Signaling and COX-2 Expression in YPEN-1 Cells. PLoS One (2015) 0.78
Activation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys. Oncotarget (2016) 0.75
An overview of the role of lipid peroxidation-derived 4-hydroxynonenal in osteoarthritis. Inflamm Res (2017) 0.75
IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med (2005) 12.07
Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A (2004) 2.06
AT1 receptor antagonist Candesartan in selected cirrhotic patients: effect on portal pressure and liver fibrosis markers. J Hepatol (2007) 1.63
Tumor suppressor genes and ROS: complex networks of interactions. Free Radic Biol Med (2011) 1.57
Pathological aspects of lipid peroxidation. Free Radic Res (2010) 1.56
Estrogen-stimulated endothelial repair requires osteopontin. Arterioscler Thromb Vasc Biol (2008) 1.50
4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis. Mol Nutr Food Res (2005) 1.28
Hepatic stellate cell: a star cell in the liver. Int J Biochem Cell Biol (2009) 1.17
Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning. Free Radic Biol Med (2002) 1.15
Cholesterol oxidation products and disease: an emerging topic of interest in medicinal chemistry. Curr Med Chem (2009) 1.11
Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. Hepatology (2004) 1.10
Detection of intracellular reactive oxygen species in cultured cells using fluorescent probes. Methods Enzymol (2002) 1.09
Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis. Free Radic Biol Med (2011) 1.06
Mitochondrial function in liver disease. Front Biosci (2007) 1.03
Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets. Antioxid Redox Signal (2013) 0.99
The link between altered cholesterol metabolism and Alzheimer's disease. Ann N Y Acad Sci (2012) 0.99
Oxidative stress and kidney dysfunction due to ischemia/reperfusion in rat: attenuation by dehydroepiandrosterone. Kidney Int (2003) 0.99
Osteopontin expression in cardiomyocytes induces dilated cardiomyopathy. Circ Heart Fail (2010) 0.98
Calorie restriction protects against age-related rat aorta sclerosis. FASEB J (2005) 0.96
Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review). J Nutr Biochem (2002) 0.96
Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells. Free Radic Biol Med (2005) 0.94
Ischemic preconditioning attenuates the oxidant-dependent mechanisms of reperfusion cell damage and death in rat liver. Liver Transpl (2002) 0.92
Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging Cell (2011) 0.92
Xanthine oxidase-induced oxidative stress causes activation of NF-kappaB and inflammation in the liver of type I diabetic rats. Free Radic Biol Med (2010) 0.92
Alternate-day fasting protects the rat heart against age-induced inflammation and fibrosis by inhibiting oxidative damage and NF-kB activation. Free Radic Biol Med (2009) 0.90
Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1 signaling. Toxicol Sci (2005) 0.90
Pro-oxidant and proapoptotic effects of cholesterol oxidation products on human colonic epithelial cells: a potential mechanism of inflammatory bowel disease progression. Free Radic Biol Med (2009) 0.89
Early involvement of ROS overproduction in apoptosis induced by 7-ketocholesterol. Antioxid Redox Signal (2006) 0.87
Plaque oxysterols induce unbalanced up-regulation of matrix metalloproteinase-9 in macrophagic cells through redox-sensitive signaling pathways: Implications regarding the vulnerability of atherosclerotic lesions. Free Radic Biol Med (2011) 0.87
Activation of the mitochondrial pathway of apoptosis by oxysterols. Front Biosci (2007) 0.87
4-hydroxynonenal and TGF-beta1 concur in inducing antiproliferative effects on the CaCo-2 human colon adenocarcinoma cell line. Biofactors (2005) 0.86
An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples. Free Radic Res (2010) 0.86
New insights into redox-modulated cell signaling. Curr Pharm Des (2011) 0.85
Role of PKC-delta activity in glutathione-depleted neuroblastoma cells. Free Radic Biol Med (2003) 0.85
Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture. Aging Cell (2008) 0.85
Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation. FASEB J (2004) 0.85
c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-beta1 and 4-hydroxynonenal in colon mucosa. Free Radic Biol Med (2006) 0.85
Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate. Free Radic Biol Med (2010) 0.85
Targeting tissue oxidative damage by means of cell signaling modulators: the antioxidant concept revisited. Pharmacol Ther (2010) 0.84
Calorie restriction and dietary restriction mimetics: a strategy for improving healthy aging and longevity. Curr Pharm Des (2014) 0.84
The contribution of animal fat oxidation products to colon carcinogenesis, through modulation of TGF-beta1 signaling. Carcinogenesis (2008) 0.84
Molecular signaling operated by a diet-compatible mixture of oxysterols in up-regulating CD36 receptor in CD68 positive cells. Mol Nutr Food Res (2010) 0.84
Ischaemic preconditioning modulates the activity of Kupffer cells during in vivo reperfusion injury of rat liver. Cell Biochem Funct (2003) 0.83
Progressive increase of matrix metalloprotease-9 and interleukin-8 serum levels during carcinogenic process in human colorectal tract. PLoS One (2012) 0.83
Inflammatory and redox reactions in colorectal carcinogenesis. Ann N Y Acad Sci (2015) 0.83
Molecular mechanisms of calorie restriction's protection against age-related sclerosis. IUBMB Life (2006) 0.82
Trojan horse-like behavior of a biologically representative mixture of oxysterols. Mol Aspects Med (2004) 0.82
Cholesterol and Alzheimer's disease: a still poorly understood correlation. IUBMB Life (2012) 0.82
Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts. Biofactors (2004) 0.82
Potentiation of amyloid-β peptide neurotoxicity in human dental-pulp neuron-like cells by the membrane lipid peroxidation product 4-hydroxynonenal. Free Radic Biol Med (2012) 0.82
Alternate-day fasting reverses the age-associated hypertrophy phenotype in rat heart by influencing the ERK and PI3K signaling pathways. Mech Ageing Dev (2011) 0.82
Dietary lipids and their oxidized products in Alzheimer's disease. Mol Nutr Food Res (2011) 0.81
Role of 4-hydroxy-2,3-nonenal in the pathogenesis of fibrosis. Biofactors (2005) 0.81
Evidence of cell damage induced by major components of a diet-compatible mixture of oxysterols in human colon cancer CaCo-2 cell line. Biochimie (2012) 0.81
Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. Aging Cell (2014) 0.81
Cholesterol and amyloid-β: evidence for a cross-talk between astrocytes and neuronal cells. J Alzheimers Dis (2011) 0.81
Phenolic compounds present in Sardinian wine extracts protect against the production of inflammatory cytokines induced by oxysterols in CaCo-2 human enterocyte-like cells. Biochem Pharmacol (2013) 0.80
Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice. Arterioscler Thromb Vasc Biol (2013) 0.80
Oxidative stress in stable cystic fibrosis patients: do we need higher antioxidant plasma levels? J Cyst Fibros (2012) 0.79
Reduction of oxidative stress in adjuvant arthritis. Comparison of efficacy of two pyridoindoles: stobadine dipalmitate and SMe1.2HCl. Acta Biochim Pol (2010) 0.79
Pancreatic-carcinoma-cell-derived pro-angiogenic factors can induce endothelial-cell differentiation of a subset of circulating CD34+ progenitors. J Transl Med (2013) 0.78
A novel role of protein kinase C-delta in cell signaling triggered by glutathione depletion. Biochem Pharmacol (2003) 0.77
TGFbeta1 expression in colonic mucosa: modulation by dietary lipids. Genes Nutr (2007) 0.77
Metalloproteinases and metalloproteinase inhibitors in age-related diseases. Curr Pharm Des (2014) 0.77
The core-aldehyde 9-oxononanoyl cholesterol increases the level of transforming growth factor beta1-specific receptors on promonocytic U937 cell membranes. Aging Cell (2009) 0.77
Expression and synthesis of TGFbeta1 is induced in macrophages by 9-oxononanoyl cholesterol, a major cholesteryl ester oxidation product. Biofactors (2005) 0.76
The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics. Food Funct (2015) 0.76
Molecular signaling involved in oxysterol-induced β₁-integrin over-expression in human macrophages. Int J Mol Sci (2012) 0.76
Nitric oxide level profile in human liver transplantation. Dig Dis Sci (2002) 0.76
In Memoriam: Mario UmbertoDianzani’s scientific legacy. Free Radic Biol Med (2016) 0.75
Lipid peroxidation and inflammatory molecules as markers of coronary artery disease. Redox Rep (2007) 0.75
Special issue on "molecular mechanisms and new therapeutic targets in human carcinogenesis". Mol Aspects Med (2010) 0.75
Editorial: lifestyle and therapeutics in the elderly. Curr Pharm Des (2014) 0.75
4-Hydroxynonenal is markedly higher in patients on a standard long-term home parenteral nutrition. Free Radic Res (2004) 0.75