Published in J Mol Cell Cardiol on December 01, 2004
Recurrent intrauterine fetal loss due to near absence of HERG: clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation. Heart Rhythm (2008) 1.62
Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome. Circulation (2007) 1.43
Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome. J Biol Chem (2005) 1.38
The GABRG2 mutation, Q351X, associated with generalized epilepsy with febrile seizures plus, has both loss of function and dominant-negative suppression. J Neurosci (2009) 1.30
Viral infection and human disease--insights from minimotifs. Front Biosci (2008) 1.26
Genetic polymorphisms in KCNQ1, HERG, KCNE1 and KCNE2 genes in the Chinese, Malay and Indian populations of Singapore. Br J Clin Pharmacol (2006) 1.02
Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperature. BMC Biotechnol (2007) 0.92
A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome. J Mol Cell Cardiol (2008) 0.90
Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects. Acta Pharmacol Sin (2014) 0.88
Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome. PLoS One (2012) 0.86
Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutation. PLoS One (2011) 0.85
Identification and characterization of a novel genetic mutation with prolonged QT syndrome in an unexplained postoperative death. Int J Legal Med (2013) 0.84
The G604S-hERG mutation alters the biophysical properties and exerts a dominant-negative effect on expression of hERG channels in HEK293 cells. Pflugers Arch (2008) 0.84
LQT2 nonsense mutations generate trafficking defective NH2-terminally truncated channels by the reinitiation of translation. Am J Physiol Heart Circ Physiol (2013) 0.82
Multiple splicing defects caused by hERG splice site mutation 2592+1G>A associated with long QT syndrome. Am J Physiol Heart Circ Physiol (2010) 0.82
Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome. Gene (2014) 0.82
Early LQT2 nonsense mutation generates N-terminally truncated hERG channels with altered gating properties by the reinitiation of translation. J Mol Cell Cardiol (2012) 0.82
The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains. J Biol Chem (2014) 0.81
A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope. Heart Rhythm (2008) 0.80
Insights into hERG K+ channel structure and function from NMR studies. Eur Biophys J (2012) 0.79
Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking. Expert Rev Cardiovasc Ther (2010) 0.78
Partially dominant mutant channel defect corresponding with intermediate LQT2 phenotype. Pacing Clin Electrophysiol (2011) 0.76
Association of the hERG mutation with long‑QT syndrome type 2, syncope and epilepsy. Mol Med Rep (2016) 0.75
Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Circulation (2006) 3.23
Recurrent intrauterine fetal loss due to near absence of HERG: clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation. Heart Rhythm (2008) 1.62
Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome. Circulation (2007) 1.43
Postmortem molecular screening in unexplained sudden death. J Am Coll Cardiol (2004) 1.39
Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome. J Biol Chem (2005) 1.38
Role of glycosylation in cell surface expression and stability of HERG potassium channels. Am J Physiol Heart Circ Physiol (2002) 1.38
Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway. J Biol Chem (2005) 1.35
A major role for HERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer. Circ Res (2010) 1.21
Design and performance of capping layers for extreme-ultraviolet multilayer mirrors. Appl Opt (2003) 1.07
Pharmacological rescue of trafficking defective HERG channels formed by coassembly of wild-type and long QT mutant N470D subunits. Am J Physiol Heart Circ Physiol (2004) 1.03
A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome. J Mol Cell Cardiol (2008) 0.90
Inhibition of nonsense-mediated mRNA decay by antisense morpholino oligonucleotides restores functional expression of hERG nonsense and frameshift mutations in long-QT syndrome. J Mol Cell Cardiol (2010) 0.90
A strategy for searching antigenic regions in the SARS-CoV spike protein. Genomics Proteomics Bioinformatics (2003) 0.88
Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms. J Biol Chem (2010) 0.88
Nonsense-mediated mRNA decay caused by a frameshift mutation in a large kindred of type 2 long QT syndrome. Heart Rhythm (2011) 0.87
Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome. PLoS One (2012) 0.86
Mixed pollutant degradation by Methylosinus trichosporium OB3b expressing either soluble or particulate methane monooxygenase: can the tortoise beat the hare? Appl Environ Microbiol (2006) 0.86
The epitope study on the SARS-CoV nucleocapsid protein. Genomics Proteomics Bioinformatics (2003) 0.85
LQT2 nonsense mutations generate trafficking defective NH2-terminally truncated channels by the reinitiation of translation. Am J Physiol Heart Circ Physiol (2013) 0.82
Multiple splicing defects caused by hERG splice site mutation 2592+1G>A associated with long QT syndrome. Am J Physiol Heart Circ Physiol (2010) 0.82
Early LQT2 nonsense mutation generates N-terminally truncated hERG channels with altered gating properties by the reinitiation of translation. J Mol Cell Cardiol (2012) 0.82
A novel approach for identifying the heme-binding proteins from mouse tissues. Genomics Proteomics Bioinformatics (2003) 0.79
Fat and cardiotoxicity in hereditary pulmonary hypertension. Am J Respir Crit Care Med (2014) 0.76
Updated approach for the assessment of ventilator-associated pneumonia. Crit Care Med (2013) 0.75
Microbial fouling of a reverse osmosis municipal water treatment system. Water Environ Res (2008) 0.75