Published in J Clin Endocrinol Metab on December 07, 2004
Molecular and therapeutic potential and toxicity of valproic acid. J Biomed Biotechnol (2010) 2.13
Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial. Br J Cancer (2007) 1.52
Emerging therapeutics for advanced thyroid malignancies: rationale and targeted approaches. Expert Opin Investig Drugs (2011) 1.18
Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res (2008) 0.99
Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma. J Hematol Oncol (2013) 0.94
Inhibitory effect of valproic acid on bladder cancer in combination with chemotherapeutic agents in vitro and in vivo. Oncol Lett (2013) 0.89
Epigenetics modifications and therapeutic prospects in human thyroid cancer. Front Endocrinol (Lausanne) (2012) 0.89
Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin. J Biol Chem (2013) 0.85
Alternative medical treatment for radioiodine-refractory thyroid cancers. Nucl Med Mol Imaging (2011) 0.85
The Beneficial Effects of Valproic Acid in Thyroid Cancer Are Mediated through Promoting Redifferentiation and Reducing Stemness Level: An In Vitro Study. J Thyroid Res (2014) 0.85
Novel dichlorophenyl urea compounds inhibit proliferation of human leukemia HL-60 cells by inducing cell cycle arrest, differentiation and apoptosis. Invest New Drugs (2011) 0.82
Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-α on pancreatic cancer cells. Int J Clin Oncol (2011) 0.81
Induction of iodide uptake in transformed thyrocytes: a compound screening in cell lines. Eur J Nucl Med Mol Imaging (2008) 0.80
Valproic acid overcomes hypoxia-induced resistance to apoptosis. Oncol Rep (2011) 0.78
Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells. Oncotarget (2015) 0.78
Activation of the intrinsic apoptosis pathway contributes to the induction of apoptosis in hepatocellular carcinoma cells by valproic acid. Oncol Lett (2014) 0.78
Prospective evaluation of (68)Ga-DOTANOC PET-CT in differentiated thyroid cancer patients with raised thyroglobulin and negative (131)I-whole body scan: comparison with (18)F-FDG PET-CT. Eur J Nucl Med Mol Imaging (2014) 0.78
Assessment of Interactions between Cisplatin and Two Histone Deacetylase Inhibitors in MCF7, T47D and MDA-MB-231 Human Breast Cancer Cell Lines - An Isobolographic Analysis. PLoS One (2015) 0.78
Inverse Association between Sodium Channel-Blocking Antiepileptic Drug Use and Cancer: Data Mining of Spontaneous Reporting and Claims Databases. Int J Med Sci (2016) 0.77
Efficacy of Anti-Epileptic Drugs in the Treatment of Tumor and Its Associated Epilepsy: An in vitro Perspective. Ann Neurosci (2016) 0.75
In vitro anticancer drug test: A new method emerges from the model of glioma stem cells. Toxicol Rep (2014) 0.75
Novel histone deacetylase inhibitor AR-42 exhibits antitumor activity in pancreatic cancer cells by affecting multiple biochemical pathways. PLoS One (2017) 0.75
Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. Cardiovasc Res (2003) 1.51
Valproic acid, a histone deacetylase inhibitor, enhances sensitivity to doxorubicin in anaplastic thyroid cancer cells. J Endocrinol (2006) 1.32
Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats. Endocrinology (2007) 1.26
Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines. Endocr Relat Cancer (2007) 1.24
AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation. Neurobiol Aging (2010) 1.21
Muscle wasting in diabetic and in tumor-bearing rats: role of oxidative stress. Free Radic Biol Med (2007) 1.13
Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta. Diabetes (2008) 1.04
Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation. Br J Pharmacol (2010) 1.01
Anaplastic thyroid carcinoma: clinical outcome of 30 consecutive patients referred to a single institution in the past 5 years. Eur J Endocrinol (2007) 1.01
Oxidative stress impairs skeletal muscle repair in diabetic rats. Diabetes (2004) 1.01
Oxidative stress-dependent impairment of cardiac-specific transcription factors in experimental diabetes. Endocrinology (2006) 0.99
Valproic acid induces the expression of the Na+/I- symporter and iodine uptake in poorly differentiated thyroid cancer cells. J Clin Endocrinol Metab (2004) 0.99
Oxidative stress and kidney dysfunction due to ischemia/reperfusion in rat: attenuation by dehydroepiandrosterone. Kidney Int (2003) 0.99
Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats. Endocrinology (2002) 0.98
Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. Mod Pathol (2006) 0.98
Mechanisms of the priming effect of low doses of lipopoly-saccharides on leukocyte-dependent platelet aggregation in whole blood. Thromb Haemost (2003) 0.97
The androgen receptor CAG repeat: a modifier of carcinogenesis? Mol Cell Endocrinol (2002) 0.95
SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats. Free Radic Biol Med (2009) 0.95
Cytotoxic activity of the histone deacetylase inhibitor panobinostat (LBH589) in anaplastic thyroid cancer in vitro and in vivo. Int J Cancer (2011) 0.95
Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis. Am J Pathol (2004) 0.95
Histone deacetylase inhibition modulates E-cadherin expression and suppresses migration and invasion of anaplastic thyroid cancer cells. J Clin Endocrinol Metab (2012) 0.93
Up-regulation of advanced glycated products receptors in the brain of diabetic rats is prevented by antioxidant treatment. Endocrinology (2005) 0.90
Pro-inflammatory cytokines and oxidative stress/antioxidant parameters characterize the bio-humoral profile of early cachexia in lung cancer patients. Oncol Rep (2007) 0.90
Epigenetics modifications and therapeutic prospects in human thyroid cancer. Front Endocrinol (Lausanne) (2012) 0.89
Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. Br J Nutr (2011) 0.89
Estrogen receptor alpha is a novel marker expressed by follicular dendritic cells in lymph nodes and tumor-associated lymphoid infiltrates. Am J Pathol (2003) 0.87
Pro-oxidant effect of dehydroepiandrosterone in rats is mediated by PPAR activation. Life Sci (2003) 0.87
Oxytocin modulates estrogen receptor alpha expression and function in MCF7 human breast cancer cells. Int J Oncol (2002) 0.87
Emerging molecular therapies of advanced thyroid cancer. Mol Aspects Med (2010) 0.86
Histone deacetylase inhibition affects sodium iodide symporter expression and induces 131I cytotoxicity in anaplastic thyroid cancer cells. Thyroid (2013) 0.86
Thrombopoietin contributes to enhanced platelet activation in patients with unstable angina. J Am Coll Cardiol (2006) 0.86
Thrombopoietin contributes to enhanced platelet activation in cigarette smokers. Atherosclerosis (2009) 0.86
Valproic acid is a selective antiproliferative agent in estrogen-sensitive breast cancer cells. Cancer Lett (2007) 0.85
Endocrine late effects after total body irradiation in patients who received hematopoietic cell transplantation during childhood: a retrospective study from a single institution. J Cancer Res Clin Oncol (2011) 0.83
Ultrasound screening for thyroid carcinoma in childhood cancer survivors: a case series. J Clin Endocrinol Metab (2008) 0.83
Thrombopoietin modulates cardiac contractility in vitro and contributes to myocardial depressing activity of septic shock serum. Basic Res Cardiol (2010) 0.82
High energy shock waves (HESW) enhance paclitaxel cytotoxicity in MCF-7 cells. Breast Cancer Res Treat (2003) 0.82
Advanced glycation end products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose-drinking mice. Am J Physiol Gastrointest Liver Physiol (2013) 0.82
Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients. Diabetes Care (2007) 0.80
High energy shock waves (HESW) for sonodynamic therapy: effects on HT-29 human colon cancer cells. Anticancer Res (2006) 0.79
Effects of the histone deacetylase inhibitor valproic acid on the sensitivity of anaplastic thyroid cancer cell lines to imatinib. Oncol Rep (2009) 0.78
Thrombopoietin as biomarker and mediator of cardiovascular damage in critical diseases. Mediators Inflamm (2012) 0.78
Modulations of the calcineurin/NF-AT pathway in skeletal muscle atrophy. Biochim Biophys Acta (2007) 0.78
Early surgery and survival of patients with anaplastic thyroid carcinoma: analysis of a case series referred to a single institution between 1999 and 2012. Thyroid (2014) 0.78
Selective up-regulation of tumor necrosis factor receptor I in tumor-bearing rats with cancer-related cachexia. Int J Oncol (2003) 0.78
May thrombopoietin be a useful marker of sepsis severity assessment in patients with SIRS entering the emergency department? Clin Chem Lab Med (2014) 0.77
Dysregulation of SREBP2 induces BACE1 expression. Neurobiol Dis (2011) 0.77
Molecular mechanisms of the D327N SHBG protective role on breast cancer development after estrogen exposure. Breast Cancer Res Treat (2008) 0.76
Meningiomas after cranial radiotherapy for childhood cancer: a single institution experience. J Cancer Res Clin Oncol (2015) 0.76
Treatment of Oral Lesions in Dystrophic Epidermolysis Bullosa: A Case Series of Cord Blood Platelet Gel and Low-level Laser Therapy. Acta Derm Venereol (2017) 0.75
Intratracheal Administration of Small Interfering RNA Targeting Fas Reduces Lung Ischemia-Reperfusion Injury. Crit Care Med (2016) 0.75
Mixed micellar aggregates of nonionic and anionic surfactants with short hydrophobic tails: a microcalorimetric study. J Colloid Interface Sci (2002) 0.75
Thrombopoietin as Early Biomarker of Disease Severity in Patients With Acute Pancreatitis. Pancreas (2017) 0.75
Thyroid Autoimmunity and Cancer. Front Horm Res (2017) 0.75